Substance Dependence Gene Set

Dataset DisGeNET Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description A substance-related disorder that involves the continued use of alcohol or other drugs despite despite problems related to use of the substance. (Human Disease Ontology, DOID_9973)
External Link https://www.disgenet.org/browser/0/1/0/C0038580
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Genes

153 genes associated with the disease Substance Dependence in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ABLIM1 actin binding LIM protein 1
ACHE acetylcholinesterase (Yt blood group)
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional)
ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide
ADH4 alcohol dehydrogenase 4 (class II), pi polypeptide
ADH7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
AFF3 AF4/FMR2 family, member 3
AGBL4 ATP/GTP binding protein-like 4
AKAP7 A kinase (PRKA) anchor protein 7
AKR1A1 aldo-keto reductase family 1, member A1 (aldehyde reductase)
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ANKK1 ankyrin repeat and kinase domain containing 1
ANO4 anoctamin 4
APPL2 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BCAR3 breast cancer anti-estrogen resistance 3
BDNF brain-derived neurotrophic factor
BPIFA2 BPI fold containing family A, member 2
C10ORF11 chromosome 10 open reading frame 11
C10ORF82 chromosome 10 open reading frame 82
C19ORF18 chromosome 19 open reading frame 18
C5ORF63 chromosome 5 open reading frame 63
CADPS2 Ca++-dependent secretion activator 2
CCDC91 coiled-coil domain containing 91
CD274 CD274 molecule
CDCP1 CUB domain containing protein 1
CDH13 cadherin 13
CERS6 ceramide synthase 6
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CHCHD3 coiled-coil-helix-coiled-coil-helix domain containing 3
CHD1L chromodomain helicase DNA binding protein 1-like
CHRM2 cholinergic receptor, muscarinic 2
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal)
CNR1 cannabinoid receptor 1 (brain)
COL25A1 collagen, type XXV, alpha 1
COLEC12 collectin sub-family member 12
COMT catechol-O-methyltransferase
CSMD1 CUB and Sushi multiple domains 1
CSMD3 CUB and Sushi multiple domains 3
CSRNP3 cysteine-serine-rich nuclear protein 3
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein)
CTNNA3 catenin (cadherin-associated protein), alpha 3
CXCL14 chemokine (C-X-C motif) ligand 14
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1
DISC1 disrupted in schizophrenia 1
DNAH8 dynein, axonemal, heavy chain 8
DOCK1 dedicator of cytokinesis 1
DRD1 dopamine receptor D1
DRD2 dopamine receptor D2
DRD4 dopamine receptor D4
DRD5 dopamine receptor D5
DSCAM Down syndrome cell adhesion molecule
EHHADH enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase
EIPR1 EARP complex and GARP complex interacting protein 1
ETV6 ets variant 6
F2R coagulation factor II (thrombin) receptor
FAAH fatty acid amide hydrolase
FAM126A family with sequence similarity 126, member A
FAM184A family with sequence similarity 184, member A
FAM184B family with sequence similarity 184, member B
FAM53B family with sequence similarity 53, member B
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
FHIT fragile histidine triad
FHOD3 formin homology 2 domain containing 3
FKBP15 FK506 binding protein 15, 133kDa
FKBP5 FK506 binding protein 5
FRMD4A FERM domain containing 4A
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2
GBA3 glucosidase, beta, acid 3 (gene/pseudogene)
GRIA4 glutamate receptor, ionotropic, AMPA 4
GRIK2 glutamate receptor, ionotropic, kainate 2
GRM5 glutamate receptor, metabotropic 5
GRM7 glutamate receptor, metabotropic 7
HSPA12A heat shock 70kDa protein 12A
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
INSR insulin receptor
KLF12 Kruppel-like factor 12
LDLRAD3 low density lipoprotein receptor class A domain containing 3
LDOC1L leucine zipper, down-regulated in cancer 1-like
LIMCH1 LIM and calponin homology domains 1
MACROD2 MACRO domain containing 2
MAOA monoamine oxidase A
MKNK1 MAP kinase interacting serine/threonine kinase 1
MPC1 mitochondrial pyruvate carrier 1
MPP7 membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)
MSRA methionine sulfoxide reductase A
MYO5C myosin VC
MYO6 myosin VI
NCAM1 neural cell adhesion molecule 1
NME7 NME/NM23 family member 7
NPY neuropeptide Y
NRCAM neuronal cell adhesion molecule
NRG1 neuregulin 1
NRXN3 neurexin 3
OPRD1 opioid receptor, delta 1
OPRK1 opioid receptor, kappa 1
OPRM1 opioid receptor, mu 1
OR51E1 olfactory receptor, family 51, subfamily E, member 1
PACS1 phosphofurin acidic cluster sorting protein 1
PARVA parvin, alpha
PATJ PATJ crumbs cell polarity complex component
PBX1 pre-B-cell leukemia homeobox 1
PCDH15 protocadherin-related 15
PDE1C phosphodiesterase 1C, calmodulin-dependent 70kDa
PDLIM7 PDZ and LIM domain 7 (enigma)
PDYN prodynorphin
PENK proenkephalin
PIWIL1 piwi-like RNA-mediated gene silencing 1
PKNOX2 PBX/knotted 1 homeobox 2
PLA2R1 phospholipase A2 receptor 1, 180kDa
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
POLR1D polymerase (RNA) I polypeptide D, 16kDa
POMC proopiomelanocortin
PPP1R1B protein phosphatase 1, regulatory (inhibitor) subunit 1B
PRKCE protein kinase C, epsilon
PRKCH protein kinase C, eta
PRPF4 pre-mRNA processing factor 4
QSOX1 quiescin Q6 sulfhydryl oxidase 1
RAD51B RAD51 paralog B
RGS17 regulator of G-protein signaling 17
RGS20 regulator of G-protein signaling 20
RHBDD3 rhomboid domain containing 3
SAMD4A sterile alpha motif domain containing 4A
SEMA6D sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SIGMAR1 sigma non-opioid intracellular receptor 1
SLC10A2 solute carrier family 10 (sodium/bile acid cotransporter), member 2
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2
SLC22A3 solute carrier family 22 (organic cation transporter), member 3
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13
SLC45A2 solute carrier family 45, member 2
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SLK STE20-like kinase
SYNE1 spectrin repeat containing, nuclear envelope 1
TENM2 teneurin transmembrane protein 2
THSD4 thrombospondin, type I, domain containing 4
TIAM2 T-cell lymphoma invasion and metastasis 2
TMPRSS7 transmembrane protease, serine 7
TTC12 tetratricopeptide repeat domain 12
TTC21B tetratricopeptide repeat domain 21B
WASF2 WAS protein family, member 2
WDR11 WD repeat domain 11
XKR4 XK, Kell blood group complex subunit-related family, member 4
XPO6 exportin 6
XYLT1 xylosyltransferase I
ZNF366 zinc finger protein 366
ZNF385D zinc finger protein 385D
ZNF606 zinc finger protein 606
ZNF804A zinc finger protein 804A