Sulfatinib_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sulfatinib perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Sulfatinib_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LPIN1 lipin 1 0.0488859
NRG1 neuregulin 1 0.043608
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0400085
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0333292
PCDH9 protocadherin 9 0.0332123
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0325998
ACSL3 acyl-CoA synthetase long-chain family member 3 0.032464
SOS1 son of sevenless homolog 1 (Drosophila) 0.0314805
LSAMP limbic system-associated membrane protein 0.0301797
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0297067
SSBP2 single-stranded DNA binding protein 2 0.0287169
HELZ helicase with zinc finger 0.0282005
COL3A1 collagen, type III, alpha 1 0.0277995
MEF2A myocyte enhancer factor 2A 0.0260336
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog 0.0253579
RNF145 ring finger protein 145 0.0248678
SRSF1 serine/arginine-rich splicing factor 1 0.0247784
MEIS2 Meis homeobox 2 0.0242223
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 0.0233499
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related) 0.0231942
WAC WW domain containing adaptor with coiled-coil 0.0229349
DLC1 DLC1 Rho GTPase activating protein 0.0227209
RALYL RALY RNA binding protein-like 0.0223632
PTPRD protein tyrosine phosphatase, receptor type, D 0.022355
CD46 CD46 molecule, complement regulatory protein 0.0221396
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 0.0221347
ZMIZ1 zinc finger, MIZ-type containing 1 0.0215281
PLPP1 phospholipid phosphatase 1 0.0212307
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0211454
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2 0.0208157
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0207363
DSCAM Down syndrome cell adhesion molecule 0.0203998
KMT2C lysine (K)-specific methyltransferase 2C 0.0203052
BCLAF1 BCL2-associated transcription factor 1 0.0202754
USP9X ubiquitin specific peptidase 9, X-linked 0.0200478
CADM2 cell adhesion molecule 2 0.0192083
BIRC6 baculoviral IAP repeat containing 6 0.0189899
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0187469
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.018678
CDH10 cadherin 10, type 2 (T2-cadherin) 0.0186614
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.018605
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 0.0185215
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0185083
AFF4 AF4/FMR2 family, member 4 0.0184746
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.0184491
PRKD1 protein kinase D1 0.0182931
AHNAK AHNAK nucleoprotein 0.0182137
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0180217
CEP85L centrosomal protein 85kDa-like 0.0179634
NRIP1 nuclear receptor interacting protein 1 0.0176421
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0173341
AUH AU RNA binding protein/enoyl-CoA hydratase 0.0171183
ZNF292 zinc finger protein 292 0.0170977
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0170203
SLC35F3 solute carrier family 35, member F3 0.0169914
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.0168917
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0167721
SCAF4 SR-related CTD-associated factor 4 0.0166076
MYLK myosin light chain kinase 0.0164436
PSD3 pleckstrin and Sec7 domain containing 3 0.0163356
SLC35F5 solute carrier family 35, member F5 0.0162561
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0158723
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 0.01586
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0158345
DDR2 discoidin domain receptor tyrosine kinase 2 0.0156548
PDS5A PDS5 cohesin associated factor A 0.015597
TIAL1 TIA1 cytotoxic granule-associated RNA binding protein-like 1 0.0155612
NCAM2 neural cell adhesion molecule 2 0.0155004
SKIC3 SKI3 subunit of superkiller complex 0.0153924
IGF1R insulin-like growth factor 1 receptor 0.0153219
HNRNPK heterogeneous nuclear ribonucleoprotein K 0.0152382
WBP11 WW domain binding protein 11 0.0151888
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0151605
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0151138
FDXR ferredoxin reductase 0.015109
HOXD3 homeobox D3 0.0150938
CAMTA1 calmodulin binding transcription activator 1 0.0148677
LUC7L2 LUC7-like 2 (S. cerevisiae) 0.0148579
XPO1 exportin 1 0.0147409
CARD16 caspase recruitment domain family, member 16 0.0146463
ZFC3H1 zinc finger, C3H1-type containing 0.0145552
ANGPT1 angiopoietin 1 0.014465
MARCHF6 membrane associated ring-CH-type finger 6 0.0143829
UBQLN1 ubiquilin 1 0.014327
LRFN5 leucine rich repeat and fibronectin type III domain containing 5 0.0143239
SPPL3 signal peptide peptidase like 3 0.0142173
TRIM9 tripartite motif containing 9 0.014145
MED13L mediator complex subunit 13-like 0.0140565
TPP2 tripeptidyl peptidase II 0.0140283
RPL4 ribosomal protein L4 0.013958
OGA O-GlcNAcase 0.0139043
ANKRD28 ankyrin repeat domain 28 0.0138751
CDK17 cyclin-dependent kinase 17 0.0136356
TRMT11 tRNA methyltransferase 11 homolog (S. cerevisiae) 0.0135626
FNDC3B fibronectin type III domain containing 3B 0.0134729
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D 0.0134019
ATL2 atlastin GTPase 2 0.0133544
RPL3 ribosomal protein L3 0.0132802
GPC5 glypican 5 0.0132771
CSDE1 cold shock domain containing E1, RNA-binding 0.0132623

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.30661
IGF2 insulin-like growth factor 2 -0.275522
VIM vimentin -0.0916973
RPS6 ribosomal protein S6 -0.0858954
AKAP12 A kinase (PRKA) anchor protein 12 -0.0843742
PLAT plasminogen activator, tissue -0.0816223
RPL23 ribosomal protein L23 -0.0742716
PTMA prothymosin, alpha -0.0719753
RPLP1 ribosomal protein, large, P1 -0.0621557
RPL38 ribosomal protein L38 -0.0619854
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.056437
EIF1 eukaryotic translation initiation factor 1 -0.05634
B2M beta-2-microglobulin -0.0526658
BPTF bromodomain PHD finger transcription factor -0.0514226
RPL35A ribosomal protein L35a -0.0497845
RPL19 ribosomal protein L19 -0.0494597
NDRG1 N-myc downstream regulated 1 -0.0475439
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0474885
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0469914
ACTG1 actin gamma 1 -0.0449846
EXT1 exostosin glycosyltransferase 1 -0.0445398
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0443069
RPS19 ribosomal protein S19 -0.0434728
FTL ferritin, light polypeptide -0.0428138
FMN1 formin 1 -0.0415662
TMSB10 thymosin beta 10 -0.0414825
RPL12 ribosomal protein L12 -0.0404345
VCL vinculin -0.039725
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0380849
TPT1 tumor protein, translationally-controlled 1 -0.0379016
P4HB prolyl 4-hydroxylase, beta polypeptide -0.037728
RPS12 ribosomal protein S12 -0.0371868
VMP1 vacuole membrane protein 1 -0.0356069
RPS24 ribosomal protein S24 -0.0354996
RPS2 ribosomal protein S2 -0.0352002
GLG1 golgi glycoprotein 1 -0.034536
STC1 stanniocalcin 1 -0.0342524
EGR1 early growth response 1 -0.0332203
HILPDA hypoxia inducible lipid droplet-associated -0.0325858
RPL37A ribosomal protein L37a -0.0322464
RPS17 ribosomal protein S17 -0.0309712
RPL34 ribosomal protein L34 -0.0304928
RPL7A ribosomal protein L7a -0.0300912
RPL37 ribosomal protein L37 -0.0299878
RPL31 ribosomal protein L31 -0.0299143
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0297788
RPL26 ribosomal protein L26 -0.0296698
EPAS1 endothelial PAS domain protein 1 -0.0295167
S100A9 S100 calcium binding protein A9 -0.029096
EEF2 eukaryotic translation elongation factor 2 -0.0289071
GNAS GNAS complex locus -0.0288962
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0283159
RPL18 ribosomal protein L18 -0.027852
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0274167
PCBP2 poly(rC) binding protein 2 -0.0272415
IER3 immediate early response 3 -0.0271609
BCAS3 breast carcinoma amplified sequence 3 -0.0268334
RACK1 receptor for activated C kinase 1 -0.0266734
RPS3 ribosomal protein S3 -0.0265411
RPL36 ribosomal protein L36 -0.0264451
RPS11 ribosomal protein S11 -0.0260532
RPS5 ribosomal protein S5 -0.025998
RPL32 ribosomal protein L32 -0.0259563
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -0.0259403
RPS8 ribosomal protein S8 -0.02577
RPL8 ribosomal protein L8 -0.0256253
S100A6 S100 calcium binding protein A6 -0.0254359
PKM pyruvate kinase, muscle -0.0253374
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0253013
RPS25 ribosomal protein S25 -0.025266
RPS14 ribosomal protein S14 -0.0246248
TPM4 tropomyosin 4 -0.0245921
BICD1 bicaudal D homolog 1 (Drosophila) -0.0245816
IFI16 interferon, gamma-inducible protein 16 -0.0242649
RTN4 reticulon 4 -0.0239063
NAP1L1 nucleosome assembly protein 1-like 1 -0.0237069
H3-3B H3.3 histone B -0.0236847
DNMBP dynamin binding protein -0.0236707
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0236192
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.0235843
DCAF7 DDB1 and CUL4 associated factor 7 -0.0235037
RPS27 ribosomal protein S27 -0.02344
RBM25 RNA binding motif protein 25 -0.0233665
PHF21A PHD finger protein 21A -0.0232952
TPST1 tyrosylprotein sulfotransferase 1 -0.0231813
MCL1 myeloid cell leukemia 1 -0.0230178
RPLP0 ribosomal protein, large, P0 -0.0227172
PRRC2C proline-rich coiled-coil 2C -0.022576
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0221916
TPM1 tropomyosin 1 (alpha) -0.0220334
RSL1D1 ribosomal L1 domain containing 1 -0.0220139
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0219931
RPS10 ribosomal protein S10 -0.0217294
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0216139
RPS23 ribosomal protein S23 -0.0215215
RPL28 ribosomal protein L28 -0.0214979
LPP LIM domain containing preferred translocation partner in lipoma -0.0214677
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0214
GREM2 gremlin 2, DAN family BMP antagonist -0.0211715
RPL9 ribosomal protein L9 -0.0210737