Sulfatinib_HS-578T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sulfatinib perturbation in HS-578T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Sulfatinib_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
COL6A3 collagen, type VI, alpha 3 0.137583
TRIO trio Rho guanine nucleotide exchange factor 0.102858
CXCL8 chemokine (C-X-C motif) ligand 8 0.0976271
ATP13A3 ATPase type 13A3 0.089864
MYH9 myosin, heavy chain 9, non-muscle 0.0748945
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0666369
EXT1 exostosin glycosyltransferase 1 0.0641592
FNDC3B fibronectin type III domain containing 3B 0.0624575
DPYSL3 dihydropyrimidinase-like 3 0.0623512
ELL2 elongation factor, RNA polymerase II, 2 0.0562352
SMAD3 SMAD family member 3 0.0535331
PDE10A phosphodiesterase 10A 0.0534212
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0531377
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0436509
PRELID2 PRELI domain containing 2 0.043149
LOXL2 lysyl oxidase-like 2 0.0423285
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0405447
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0392072
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.037713
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0368001
MTSS1 metastasis suppressor 1 0.0359883
KMT2E lysine (K)-specific methyltransferase 2E 0.0358635
SPAG9 sperm associated antigen 9 0.0356219
DST dystonin 0.034792
NAV2 neuron navigator 2 0.034211
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0332145
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.033194
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0325216
ANTXR2 anthrax toxin receptor 2 0.0323949
CD44 CD44 molecule (Indian blood group) 0.0322952
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0321025
WWTR1 WW domain containing transcription regulator 1 0.0320631
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0317459
LTBP1 latent transforming growth factor beta binding protein 1 0.0316623
MACF1 microtubule-actin crosslinking factor 1 0.0315313
RASA2 RAS p21 protein activator 2 0.0312729
NAV1 neuron navigator 1 0.0312406
PICALM phosphatidylinositol binding clathrin assembly protein 0.0298866
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0291756
TNIP1 TNFAIP3 interacting protein 1 0.0290412
PAPPA pregnancy-associated plasma protein A, pappalysin 1 0.0280965
CENPF centromere protein F, 350/400kDa 0.0270381
AHNAK AHNAK nucleoprotein 0.0252268
TM4SF1 transmembrane 4 L six family member 1 0.0251753
ZNF292 zinc finger protein 292 0.0241814
VEGFC vascular endothelial growth factor C 0.0241072
JAK2 Janus kinase 2 0.0238175
NKAIN3 Na+/K+ transporting ATPase interacting 3 0.0237809
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0234192
SOD2 superoxide dismutase 2, mitochondrial 0.023147
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0230451
FN1 fibronectin 1 0.0229857
LPP LIM domain containing preferred translocation partner in lipoma 0.0228858
CLIC4 chloride intracellular channel 4 0.0228692
ARHGAP29 Rho GTPase activating protein 29 0.0228105
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0227856
HMGA2 high mobility group AT-hook 2 0.0227087
PTK2 protein tyrosine kinase 2 0.0225358
P3H2 prolyl 3-hydroxylase 2 0.0223833
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0219149
ANO6 anoctamin 6 0.0218109
KMT2C lysine (K)-specific methyltransferase 2C 0.0215399
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0214352
OGA O-GlcNAcase 0.0212221
ARRDC3 arrestin domain containing 3 0.0208722
ANKRD36 ankyrin repeat domain 36 0.0202909
NRIP1 nuclear receptor interacting protein 1 0.0198377
MSN moesin 0.0196004
TNS1 tensin 1 0.0195864
ERRFI1 ERBB receptor feedback inhibitor 1 0.0192719
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0189982
COL7A1 collagen, type VII, alpha 1 0.0189784
AGFG1 ArfGAP with FG repeats 1 0.0189434
APP amyloid beta (A4) precursor protein 0.0188401
RAI14 retinoic acid induced 14 0.0186213
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.0186138
ZEB1 zinc finger E-box binding homeobox 1 0.0183253
TPR translocated promoter region, nuclear basket protein 0.0182837
DOCK5 dedicator of cytokinesis 5 0.0182267
KDM7A lysine (K)-specific demethylase 7A 0.0182079
PLEC plectin 0.0181002
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0180931
DPYD dihydropyrimidine dehydrogenase 0.0180064
ANLN anillin, actin binding protein 0.0179687
AMPD3 adenosine monophosphate deaminase 3 0.0178131
GOLGA4 golgin A4 0.0177552
SHB Src homology 2 domain containing adaptor protein B 0.0176137
PTBP2 polypyrimidine tract binding protein 2 0.0176082
RIGI RNA sensor RIG-I 0.0175419
MED13L mediator complex subunit 13-like 0.0170974
JARID2 jumonji, AT rich interactive domain 2 0.0170278
CTNND1 catenin (cadherin-associated protein), delta 1 0.016997
ECT2 epithelial cell transforming 2 0.0168819
PSD3 pleckstrin and Sec7 domain containing 3 0.0166811
DENND5A DENN/MADD domain containing 5A 0.0166671
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0166611
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0166593
ZFC3H1 zinc finger, C3H1-type containing 0.016608
KIAA1217 KIAA1217 0.0164967
USP24 ubiquitin specific peptidase 24 0.0164291

decreased expression

Symbol Name Standardized Value
NDRG1 N-myc downstream regulated 1 -0.281964
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.239456
VIM vimentin -0.236496
IGFBP3 insulin-like growth factor binding protein 3 -0.231465
MT2A metallothionein 2A -0.197076
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.155067
TMSB10 thymosin beta 10 -0.144854
COL1A1 collagen, type I, alpha 1 -0.107881
FTL ferritin, light polypeptide -0.102189
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0807995
TGFBI transforming growth factor, beta-induced, 68kDa -0.0801237
RPS8 ribosomal protein S8 -0.0800898
COL1A2 collagen, type I, alpha 2 -0.0779451
RPL35A ribosomal protein L35a -0.0717372
ACTG1 actin gamma 1 -0.0606382
RPS6 ribosomal protein S6 -0.0601695
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0585609
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0543331
RPS19 ribosomal protein S19 -0.0506565
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0506556
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.04934
RPL23 ribosomal protein L23 -0.0477479
EIF1 eukaryotic translation initiation factor 1 -0.0465564
IER3 immediate early response 3 -0.0465508
RPL28 ribosomal protein L28 -0.0445543
RPLP1 ribosomal protein, large, P1 -0.0433276
MT1X metallothionein 1X -0.0428115
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0418648
RPL8 ribosomal protein L8 -0.0417837
EEF2 eukaryotic translation elongation factor 2 -0.041347
HLA-B major histocompatibility complex, class I, B -0.0396944
TPM4 tropomyosin 4 -0.039648
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0396211
RPLP2 ribosomal protein, large, P2 -0.038466
RPL11 ribosomal protein L11 -0.0381162
EGR1 early growth response 1 -0.037502
RPL12 ribosomal protein L12 -0.0374059
B2M beta-2-microglobulin -0.0371682
MTDH metadherin -0.036906
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0368951
TPT1 tumor protein, translationally-controlled 1 -0.0366934
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0353035
PKM pyruvate kinase, muscle -0.035049
RPS14 ribosomal protein S14 -0.0341292
RPL19 ribosomal protein L19 -0.0341236
PTMA prothymosin, alpha -0.0339649
RPL36 ribosomal protein L36 -0.0339569
S100A10 S100 calcium binding protein A10 -0.0338655
CALR calreticulin -0.033759
LDHA lactate dehydrogenase A -0.0336339
ENO1 enolase 1, (alpha) -0.0335961
RACK1 receptor for activated C kinase 1 -0.0335651
RPLP0 ribosomal protein, large, P0 -0.032974
RPL5 ribosomal protein L5 -0.0328314
RPL7 ribosomal protein L7 -0.0327438
RPS3 ribosomal protein S3 -0.032115
RPS13 ribosomal protein S13 -0.0319366
RPS11 ribosomal protein S11 -0.0314417
PFN1 profilin 1 -0.0308774
IFITM3 interferon induced transmembrane protein 3 -0.0307213
S100A6 S100 calcium binding protein A6 -0.0303997
RPL30 ribosomal protein L30 -0.0303231
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0301819
RPS5 ribosomal protein S5 -0.0294847
RPL34 ribosomal protein L34 -0.0294673
RPS20 ribosomal protein S20 -0.0289191
RPS25 ribosomal protein S25 -0.0283954
LOX lysyl oxidase -0.0282567
RPL37A ribosomal protein L37a -0.0280831
FTH1 ferritin, heavy polypeptide 1 -0.0279417
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0278285
RPL37 ribosomal protein L37 -0.0277379
RPL31 ribosomal protein L31 -0.0275298
RPL26 ribosomal protein L26 -0.0273349
HLA-A major histocompatibility complex, class I, A -0.0273335
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0273253
IFI6 interferon, alpha-inducible protein 6 -0.0269628
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0268164
VDAC1 voltage-dependent anion channel 1 -0.0267064
RPS15 ribosomal protein S15 -0.0266436
CDH13 cadherin 13 -0.0265362
RPS16 ribosomal protein S16 -0.0263286
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 -0.0261968
RPS12 ribosomal protein S12 -0.026129
RPL9 ribosomal protein L9 -0.0261081
RPL32 ribosomal protein L32 -0.0260869
GNAS GNAS complex locus -0.0260138
CYB5R3 cytochrome b5 reductase 3 -0.0253421
F3 coagulation factor III (thromboplastin, tissue factor) -0.0251928
RPS23 ribosomal protein S23 -0.0250858
S100A9 S100 calcium binding protein A9 -0.024185
UBC ubiquitin C -0.0239861
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -0.023762
RPS24 ribosomal protein S24 -0.0235777
RPS21 ribosomal protein S21 -0.0235424
ATF4 activating transcription factor 4 -0.0228961
SPDYA speedy/RINGO cell cycle regulator family member A -0.022873
ZBTB20 zinc finger and BTB domain containing 20 -0.0227719
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0226117
LOC112694756 uncharaterized LOC112694756 -0.0221567