Sulfatinib_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sulfatinib perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Sulfatinib_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
APOB apolipoprotein B 0.137448
LRMDA leucine rich melanocyte differentiation associated 0.0917661
FNDC3B fibronectin type III domain containing 3B 0.0799335
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0729678
ERRFI1 ERBB receptor feedback inhibitor 1 0.0662623
DSPP dentin sialophosphoprotein 0.0606028
SAMD4A sterile alpha motif domain containing 4A 0.0599639
EHBP1 EH domain binding protein 1 0.0556421
DST dystonin 0.0537306
NKD1 naked cuticle homolog 1 (Drosophila) 0.0513818
FN1 fibronectin 1 0.0494869
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0490081
TRIO trio Rho guanine nucleotide exchange factor 0.0484549
SESTD1 SEC14 and spectrin domains 1 0.0478409
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0471524
MYH9 myosin, heavy chain 9, non-muscle 0.0461881
SOD2 superoxide dismutase 2, mitochondrial 0.042793
ARHGAP9 Rho GTPase activating protein 9 0.0395955
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0391001
VCL vinculin 0.0387483
AFDN afadin, adherens junction formation factor 0.0362003
CNKSR3 CNKSR family member 3 0.0336866
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0329349
GPC6 glypican 6 0.0325896
PTPRM protein tyrosine phosphatase, receptor type, M 0.0325306
NPAS2 neuronal PAS domain protein 2 0.0316676
ATXN1 ataxin 1 0.0311464
SMAD3 SMAD family member 3 0.0311102
NRIP1 nuclear receptor interacting protein 1 0.0310105
ASPH aspartate beta-hydroxylase 0.0307715
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.03067
AKAP12 A kinase (PRKA) anchor protein 12 0.030645
GPAM glycerol-3-phosphate acyltransferase, mitochondrial 0.0304856
ELL2 elongation factor, RNA polymerase II, 2 0.0303375
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0301502
LPP LIM domain containing preferred translocation partner in lipoma 0.0291532
KIAA1217 KIAA1217 0.0290356
MAML2 mastermind-like 2 (Drosophila) 0.0287394
FRMD5 FERM domain containing 5 0.028478
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0283394
FMNL2 formin-like 2 0.027453
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0273619
RBM39 RNA binding motif protein 39 0.0271695
IGF1R insulin-like growth factor 1 receptor 0.0270676
BCL2L1 BCL2-like 1 0.0266667
PEG3 paternally expressed 3 0.026298
RUNX1 runt-related transcription factor 1 0.0261344
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) 0.0259668
FAT1 FAT atypical cadherin 1 0.0253932
GMDS GDP-mannose 4,6-dehydratase 0.0247924
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 0.0240165
DSCAM Down syndrome cell adhesion molecule 0.0239483
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.0236435
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 0.0233648
JMJD1C jumonji domain containing 1C 0.0230232
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0225827
PTPRK protein tyrosine phosphatase, receptor type, K 0.0225547
KIF5B kinesin family member 5B 0.022477
CEMIP2 cell migration inducing hyaluronidase 2 0.0220911
EXT1 exostosin glycosyltransferase 1 0.0219301
PHF3 PHD finger protein 3 0.0219086
DNAH17 dynein, axonemal, heavy chain 17 0.0217677
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5 0.0217344
PARD3 par-3 family cell polarity regulator 0.0217281
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 0.0217035
SOX5 SRY (sex determining region Y)-box 5 0.0216922
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0214986
RPL4 ribosomal protein L4 0.0214894
PDLIM5 PDZ and LIM domain 5 0.0214729
OSBPL10 oxysterol binding protein-like 10 0.0212251
KRT23 keratin 23, type I 0.0209925
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0208529
ANKRD11 ankyrin repeat domain 11 0.0208179
SVIL supervillin 0.0207442
AHR aryl hydrocarbon receptor 0.0206277
PRRC2B proline-rich coiled-coil 2B 0.02048
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0203299
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0200786
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0199326
ABTB3 ankyrin repeat and BTB domain containing 3 0.0195335
ANO6 anoctamin 6 0.0194956
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0193215
UGDH UDP-glucose 6-dehydrogenase 0.018971
PAWR PRKC, apoptosis, WT1, regulator 0.0189612
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0189425
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0188877
MTUS1 microtubule associated tumor suppressor 1 0.0188535
PTCHD4 patched domain containing 4 0.0188253
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0187466
DOCK5 dedicator of cytokinesis 5 0.0185802
FAM107B family with sequence similarity 107, member B 0.0185542
MALT1 MALT1 paracaspase 0.0183846
UTRN utrophin 0.0182263
ZMIZ1 zinc finger, MIZ-type containing 1 0.0180972
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.0179549
CP ceruloplasmin (ferroxidase) 0.017915
JAK1 Janus kinase 1 0.0179138
PTK2 protein tyrosine kinase 2 0.0177888
TM4SF1 transmembrane 4 L six family member 1 0.0176173
ATP11A ATPase, class VI, type 11A 0.01761

decreased expression

Symbol Name Standardized Value
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -0.497233
IGF2 insulin-like growth factor 2 -0.347871
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.225694
MT2A metallothionein 2A -0.202848
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.103236
TIMP1 TIMP metallopeptidase inhibitor 1 -0.100509
FTL ferritin, light polypeptide -0.077931
C3 complement component 3 -0.076777
AHSG alpha-2-HS-glycoprotein -0.0670258
RPS6 ribosomal protein S6 -0.0643772
FBF1 Fas (TNFRSF6) binding factor 1 -0.0608106
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0546828
RPS12 ribosomal protein S12 -0.0513919
RPLP0 ribosomal protein, large, P0 -0.0510054
NDRG1 N-myc downstream regulated 1 -0.0506791
APOA2 apolipoprotein A-II -0.049182
CPE carboxypeptidase E -0.0462065
HMGA1 high mobility group AT-hook 1 -0.0453591
CCL20 chemokine (C-C motif) ligand 20 -0.0430599
LOC112694756 uncharaterized LOC112694756 -0.0428534
PLIN2 perilipin 2 -0.0413999
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0413689
DDIT4 DNA-damage-inducible transcript 4 -0.0395055
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0384052
RPLP1 ribosomal protein, large, P1 -0.0338953
PCBP2 poly(rC) binding protein 2 -0.0333186
RPL23 ribosomal protein L23 -0.0331382
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein -0.0329424
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.032821
RPL34 ribosomal protein L34 -0.0312073
RPS19 ribosomal protein S19 -0.0305072
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0286386
APOA1 apolipoprotein A-I -0.0286063
RPS14 ribosomal protein S14 -0.0283275
APOE apolipoprotein E -0.0282255
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0281206
S100A9 S100 calcium binding protein A9 -0.0280744
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0273747
RPS5 ribosomal protein S5 -0.0272977
MT1X metallothionein 1X -0.0272562
GOLGA4 golgin A4 -0.0270406
RPL37A ribosomal protein L37a -0.0266157
EEF2 eukaryotic translation elongation factor 2 -0.0261225
RPS8 ribosomal protein S8 -0.026108
PFN1 profilin 1 -0.0254957
GNAS GNAS complex locus -0.0251591
RPLP2 ribosomal protein, large, P2 -0.0250477
RPL8 ribosomal protein L8 -0.0248034
PDIA3 protein disulfide isomerase family A, member 3 -0.0241426
RPL9 ribosomal protein L9 -0.0239953
RPL35A ribosomal protein L35a -0.0237647
FAM162A family with sequence similarity 162, member A -0.0236828
RPL32 ribosomal protein L32 -0.0232103
ENO1 enolase 1, (alpha) -0.0231277
RPS29 ribosomal protein S29 -0.0229336
LDHA lactate dehydrogenase A -0.022772
VEGFA vascular endothelial growth factor A -0.0226013
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1 -0.0222465
WDR45B WD repeat domain 45B -0.021803
RPS3 ribosomal protein S3 -0.0214163
RPL12 ribosomal protein L12 -0.021278
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0204735
TMSB10 thymosin beta 10 -0.0201873
RACK1 receptor for activated C kinase 1 -0.0201746
TPT1 tumor protein, translationally-controlled 1 -0.0200446
APOH apolipoprotein H (beta-2-glycoprotein I) -0.0196469
RPS23 ribosomal protein S23 -0.0195738
PKM pyruvate kinase, muscle -0.0194734
RPS13 ribosomal protein S13 -0.0192014
RBM25 RNA binding motif protein 25 -0.0192001
RPL36 ribosomal protein L36 -0.0191959
CST3 cystatin C -0.0188976
RPL26 ribosomal protein L26 -0.0188718
PERP PERP, TP53 apoptosis effector -0.0188472
LYZ lysozyme -0.018602
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0184394
DHRS2 dehydrogenase/reductase (SDR family) member 2 -0.0183288
TSC22D2 TSC22 domain family, member 2 -0.0182644
RPL5 ribosomal protein L5 -0.0181794
NUP58 nucleoporin 58 -0.0179471
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0178771
RPS21 ribosomal protein S21 -0.0177192
EIF5B eukaryotic translation initiation factor 5B -0.0176811
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0176671
AMBP alpha-1-microglobulin/bikunin precursor -0.0173718
SEC62 SEC62 homolog (S. cerevisiae) -0.0173599
CYB5R3 cytochrome b5 reductase 3 -0.0173393
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0170521
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0168353
IL32 interleukin 32 -0.0168347
PDE8A phosphodiesterase 8A -0.0167991
RPL18 ribosomal protein L18 -0.0165549
RPS25 ribosomal protein S25 -0.0164963
RPL11 ribosomal protein L11 -0.0164819
RPL35 ribosomal protein L35 -0.0164503
RPL31 ribosomal protein L31 -0.0162575
RPS11 ribosomal protein S11 -0.0161577
RPL39 ribosomal protein L39 -0.0160419
RPL28 ribosomal protein L28 -0.016035
RPL27 ribosomal protein L27 -0.0160261