Sulfatinib_KATO III Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sulfatinib perturbation in KATO III cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Sulfatinib_KATO III drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FGFR2 fibroblast growth factor receptor 2 0.167959
FNDC3B fibronectin type III domain containing 3B 0.0768795
MAML2 mastermind-like 2 (Drosophila) 0.0524143
ATXN1 ataxin 1 0.0490499
ARHGAP32 Rho GTPase activating protein 32 0.0478801
MBNL2 muscleblind-like splicing regulator 2 0.0470721
DSCAM Down syndrome cell adhesion molecule 0.0451731
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0422068
GOLGA4 golgin A4 0.0420764
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0398266
GOLGB1 golgin B1 0.0396207
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0387896
MYH9 myosin, heavy chain 9, non-muscle 0.0371227
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0370796
EXT1 exostosin glycosyltransferase 1 0.0369939
CADPS2 Ca++-dependent secretion activator 2 0.0360807
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0358381
GMDS GDP-mannose 4,6-dehydratase 0.0341644
SAMD12 sterile alpha motif domain containing 12 0.0336857
PTPRK protein tyrosine phosphatase, receptor type, K 0.0327035
LPP LIM domain containing preferred translocation partner in lipoma 0.0324837
DSPP dentin sialophosphoprotein 0.0321743
HYOU1 hypoxia up-regulated 1 0.0321393
ZCCHC7 zinc finger, CCHC domain containing 7 0.031569
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0307449
EXOC4 exocyst complex component 4 0.0306952
TRIM2 tripartite motif containing 2 0.0297141
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.029449
PUM2 pumilio RNA-binding family member 2 0.0293391
IARS1 isoleucyl-tRNA synthetase 1 0.0291534
ARHGAP26 Rho GTPase activating protein 26 0.0286908
CDK13 cyclin-dependent kinase 13 0.0285344
RBM39 RNA binding motif protein 39 0.0285095
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0281673
CTNND1 catenin (cadherin-associated protein), delta 1 0.0279075
KMT2C lysine (K)-specific methyltransferase 2C 0.0278104
KLHL29 kelch-like family member 29 0.027803
COG5 component of oligomeric golgi complex 5 0.0271935
STK24 serine/threonine kinase 24 0.0271646
KDM6A lysine (K)-specific demethylase 6A 0.0270778
ANXA11 annexin A11 0.0266277
SEL1L sel-1 suppressor of lin-12-like (C. elegans) 0.0264469
MON2 MON2 homolog (S. cerevisiae) 0.0262518
FNIP1 folliculin interacting protein 1 0.0259292
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0257692
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0257282
ZFAND3 zinc finger, AN1-type domain 3 0.0256618
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0254288
ZNF292 zinc finger protein 292 0.0251987
PICALM phosphatidylinositol binding clathrin assembly protein 0.0250111
CLTC clathrin, heavy chain (Hc) 0.0248635
ESRP1 epithelial splicing regulatory protein 1 0.024814
PRELID2 PRELI domain containing 2 0.0242533
TMF1 TATA element modulatory factor 1 0.0238357
AHR aryl hydrocarbon receptor 0.023765
BIRC6 baculoviral IAP repeat containing 6 0.0237199
SNX13 sorting nexin 13 0.0236157
VMP1 vacuole membrane protein 1 0.0235481
SEC31A SEC31 homolog A (S. cerevisiae) 0.0233217
KIF16B kinesin family member 16B 0.0233134
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0230326
AHNAK AHNAK nucleoprotein 0.0227828
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0227087
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0222648
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.022263
CEP95 centrosomal protein 95kDa 0.0222479
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6 0.0221425
AKAP13 A kinase (PRKA) anchor protein 13 0.0219286
ALPK1 alpha-kinase 1 0.0219033
AFDN afadin, adherens junction formation factor 0.0218166
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0217774
HELZ helicase with zinc finger 0.0217717
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0216997
PMM2 phosphomannomutase 2 0.0216542
RAD51B RAD51 paralog B 0.0215983
FGD4 FYVE, RhoGEF and PH domain containing 4 0.0215459
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0214419
USP9X ubiquitin specific peptidase 9, X-linked 0.0214125
VEGFA vascular endothelial growth factor A 0.0211862
MYO5B myosin VB 0.0208569
CTBP2 C-terminal binding protein 2 0.0208258
ANKRD11 ankyrin repeat domain 11 0.020807
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0207146
KDM4C lysine (K)-specific demethylase 4C 0.0205926
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta 0.0205187
UMAD1 UBAP1-MVB12-associated (UMA) domain containing 1 0.0203281
SH3RF1 SH3 domain containing ring finger 1 0.0203006
SEPTIN9 septin 9 0.020294
ARCN1 archain 1 0.0201524
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0201216
MGAM2 maltase-glucoamylase 2 (putative) 0.0200304
BTBD9 BTB (POZ) domain containing 9 0.0197828
YAP1 Yes-associated protein 1 0.0196928
CANX calnexin 0.019537
RABGAP1 RAB GTPase activating protein 1 0.0195298
TNRC18 trinucleotide repeat containing 18 0.0192963
COPA coatomer protein complex, subunit alpha 0.0191658
SND1 staphylococcal nuclease and tudor domain containing 1 0.0190839
NBAS neuroblastoma amplified sequence 0.0188403
PTEN phosphatase and tensin homolog 0.018828

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.241572
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.162767
TPT1 tumor protein, translationally-controlled 1 -0.126269
FTL ferritin, light polypeptide -0.113161
RPL35A ribosomal protein L35a -0.110899
PTMA prothymosin, alpha -0.103719
RPL23 ribosomal protein L23 -0.100009
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.095136
RPS19 ribosomal protein S19 -0.092027
RPLP1 ribosomal protein, large, P1 -0.089028
RPS6 ribosomal protein S6 -0.0878641
S100A10 S100 calcium binding protein A10 -0.0870448
B2M beta-2-microglobulin -0.0854636
S100A6 S100 calcium binding protein A6 -0.083036
EIF1 eukaryotic translation initiation factor 1 -0.0807134
EMP1 epithelial membrane protein 1 -0.0733412
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0729757
RPS25 ribosomal protein S25 -0.0694008
IFI27 interferon, alpha-inducible protein 27 -0.0666137
S100P S100 calcium binding protein P -0.065943
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0650778
S100A9 S100 calcium binding protein A9 -0.0649693
RPS3 ribosomal protein S3 -0.0641572
RPL19 ribosomal protein L19 -0.0598435
RPS8 ribosomal protein S8 -0.0586086
RPL12 ribosomal protein L12 -0.0558893
RPS21 ribosomal protein S21 -0.0553194
RPL26 ribosomal protein L26 -0.0504281
ACTG1 actin gamma 1 -0.0498731
KRT18 keratin 18, type I -0.0498423
RPL34 ribosomal protein L34 -0.0494078
HLA-A major histocompatibility complex, class I, A -0.0491643
S100A11 S100 calcium binding protein A11 -0.0479282
AGR2 anterior gradient 2 -0.0475659
RPL37A ribosomal protein L37a -0.0473272
RPL28 ribosomal protein L28 -0.0462964
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0460265
RPS16 ribosomal protein S16 -0.045187
LOC102724023 ES1 protein homolog, mitochondrial -0.0443683
RPS24 ribosomal protein S24 -0.0439461
RPL8 ribosomal protein L8 -0.0434971
LOC112694756 uncharaterized LOC112694756 -0.0424817
RPS29 ribosomal protein S29 -0.042371
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0413592
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0411064
GSTP1 glutathione S-transferase pi 1 -0.0406115
RPLP2 ribosomal protein, large, P2 -0.0405771
RPL38 ribosomal protein L38 -0.0404921
NDRG1 N-myc downstream regulated 1 -0.0403675
RPL36A ribosomal protein L36a -0.0400725
RPS12 ribosomal protein S12 -0.0398677
PKM pyruvate kinase, muscle -0.039406
RPL32 ribosomal protein L32 -0.0393487
KRT19 keratin 19, type I -0.0393297
RPL9 ribosomal protein L9 -0.0391349
RPL35 ribosomal protein L35 -0.0389441
RPL18 ribosomal protein L18 -0.0385244
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0383059
HMGA1 high mobility group AT-hook 1 -0.0380379
NDUFA4 NDUFA4, mitochondrial complex associated -0.037813
IFI6 interferon, alpha-inducible protein 6 -0.0377496
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0366844
RPS17 ribosomal protein S17 -0.0364393
RPL27 ribosomal protein L27 -0.0362601
RPS11 ribosomal protein S11 -0.0360324
RPS27 ribosomal protein S27 -0.0359779
AREG amphiregulin -0.0359434
LMNA lamin A/C -0.035748
RPS27A ribosomal protein S27a -0.0357054
RPL11 ribosomal protein L11 -0.0356329
IFITM3 interferon induced transmembrane protein 3 -0.0353035
RPL36 ribosomal protein L36 -0.0347129
MYL12B myosin, light chain 12B, regulatory -0.0346664
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0343476
HLA-B major histocompatibility complex, class I, B -0.0343336
RPL7A ribosomal protein L7a -0.0341357
ATF5 activating transcription factor 5 -0.0338332
CALR calreticulin -0.0335283
SEC61G Sec61 gamma subunit -0.0334469
EPCAM epithelial cell adhesion molecule -0.033284
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0330674
RPS20 ribosomal protein S20 -0.0323503
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0320418
SERF2 small EDRK-rich factor 2 -0.0320396
RPS5 ribosomal protein S5 -0.0316313
POTEF POTE ankyrin domain family, member F -0.0315317
TUBB4B tubulin, beta 4B class IVb -0.0313513
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0312846
PFN1 profilin 1 -0.0308674
RPS23 ribosomal protein S23 -0.0307793
H3-3B H3.3 histone B -0.0303365
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0302616
RPL31 ribosomal protein L31 -0.0296625
RPS14 ribosomal protein S14 -0.029629
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0295736
SLC38A1 solute carrier family 38, member 1 -0.0295356
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0294396
RPS13 ribosomal protein S13 -0.029153
RPL5 ribosomal protein L5 -0.0291341
HLA-E major histocompatibility complex, class I, E -0.0290725