Sulfatinib_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sulfatinib perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Sulfatinib_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.263779
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.227566
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.117065
TXNIP thioredoxin interacting protein 0.110915
FAM13A family with sequence similarity 13, member A 0.110717
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0928615
FAT1 FAT atypical cadherin 1 0.086122
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0811072
AHNAK AHNAK nucleoprotein 0.0753505
MED13L mediator complex subunit 13-like 0.0728093
ANKRD11 ankyrin repeat domain 11 0.0720143
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0707075
LMO7 LIM domain 7 0.0671812
GOLGA4 golgin A4 0.0655393
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0651167
PRELID2 PRELI domain containing 2 0.0641294
CCNY cyclin Y 0.0629202
PGK1 phosphoglycerate kinase 1 0.0627134
FNDC3B fibronectin type III domain containing 3B 0.0613478
ZFAND3 zinc finger, AN1-type domain 3 0.0606673
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0586728
ESYT2 extended synaptotagmin-like protein 2 0.058291
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0575323
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0575067
RBM39 RNA binding motif protein 39 0.057309
ITGA6 integrin, alpha 6 0.0562585
GRB10 growth factor receptor-bound protein 10 0.0550454
CALR calreticulin 0.0547006
MBNL2 muscleblind-like splicing regulator 2 0.0536191
ZNF292 zinc finger protein 292 0.0520153
EREG epiregulin 0.0519465
WAC WW domain containing adaptor with coiled-coil 0.0515437
DSCAM Down syndrome cell adhesion molecule 0.0514459
RNF145 ring finger protein 145 0.0502945
KDM3A lysine (K)-specific demethylase 3A 0.0488096
COPA coatomer protein complex, subunit alpha 0.0476948
OGA O-GlcNAcase 0.0465306
CANX calnexin 0.0459882
PUM2 pumilio RNA-binding family member 2 0.0459691
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0458093
MYO5B myosin VB 0.045781
RAB1A RAB1A, member RAS oncogene family 0.0453616
ENO1 enolase 1, (alpha) 0.0452825
KMT2E lysine (K)-specific methyltransferase 2E 0.0452382
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0450583
UBA6 ubiquitin-like modifier activating enzyme 6 0.044385
PARD3 par-3 family cell polarity regulator 0.0442439
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0441302
DSPP dentin sialophosphoprotein 0.0439408
EHF ets homologous factor 0.0437621
KRT8 keratin 8, type II 0.0429497
WDR45B WD repeat domain 45B 0.0426346
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0419504
JMJD1C jumonji domain containing 1C 0.0417773
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) 0.0414521
SEC31A SEC31 homolog A (S. cerevisiae) 0.0411978
H1-0 H1.0 linker histone 0.040876
LDHA lactate dehydrogenase A 0.0405864
RREB1 ras responsive element binding protein 1 0.0402254
EPS8 epidermal growth factor receptor pathway substrate 8 0.0401886
HELZ helicase with zinc finger 0.0398229
FNBP1L formin binding protein 1-like 0.0397017
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0394551
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0393007
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0387687
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0386433
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0385312
TTC3 tetratricopeptide repeat domain 3 0.038274
KDM6A lysine (K)-specific demethylase 6A 0.0382022
CTBP2 C-terminal binding protein 2 0.0376754
CEMIP2 cell migration inducing hyaluronidase 2 0.0373726
TM9SF3 transmembrane 9 superfamily member 3 0.0371981
TFG TRK-fused gene 0.0371854
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0371288
BTBD9 BTB (POZ) domain containing 9 0.0367667
LRRC1 leucine rich repeat containing 1 0.0366853
KDM2A lysine (K)-specific demethylase 2A 0.0361842
SRRM2 serine/arginine repetitive matrix 2 0.0361199
PIGR polymeric immunoglobulin receptor 0.0358143
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.035809
USP3 ubiquitin specific peptidase 3 0.0352815
PDIA6 protein disulfide isomerase family A, member 6 0.0352607
PPARG peroxisome proliferator-activated receptor gamma 0.0348286
MCTP2 multiple C2 domains, transmembrane 2 0.0347811
EZR ezrin 0.0347618
TRIO trio Rho guanine nucleotide exchange factor 0.0346297
NDRG1 N-myc downstream regulated 1 0.0344182
ADD3 adducin 3 (gamma) 0.0343661
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2 0.0342088
PDIA4 protein disulfide isomerase family A, member 4 0.0341856
SUCO SUN domain containing ossification factor 0.034078
IARS1 isoleucyl-tRNA synthetase 1 0.0340371
MACF1 microtubule-actin crosslinking factor 1 0.0335314
GARS1 glycyl-tRNA synthetase 1 0.0334461
HDLBP high density lipoprotein binding protein 0.0334294
ADAM17 ADAM metallopeptidase domain 17 0.033003
ARHGAP32 Rho GTPase activating protein 32 0.0329224
CLTC clathrin, heavy chain (Hc) 0.0326539
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0325214
ARHGAP26 Rho GTPase activating protein 26 0.0322341

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0809208
TMSB10 thymosin beta 10 -0.0765656
RPLP1 ribosomal protein, large, P1 -0.0639546
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0558113
VCL vinculin -0.053391
MYO1E myosin IE -0.0524011
TPT1 tumor protein, translationally-controlled 1 -0.0507459
RPL35A ribosomal protein L35a -0.0457425
TNS4 tensin 4 -0.045581
RPS19 ribosomal protein S19 -0.0453251
RPS6 ribosomal protein S6 -0.0440361
RPL23 ribosomal protein L23 -0.042919
RPLP2 ribosomal protein, large, P2 -0.0427877
EGR1 early growth response 1 -0.0404044
RPL12 ribosomal protein L12 -0.0389128
RPS12 ribosomal protein S12 -0.0384602
LAMA4 laminin, alpha 4 -0.0351744
LOC102724023 ES1 protein homolog, mitochondrial -0.0343927
RPS8 ribosomal protein S8 -0.0338145
NALF1 NALCN channel auxiliary factor 1 -0.0322349
RPS23 ribosomal protein S23 -0.0321172
RPL34 ribosomal protein L34 -0.0319372
RPL9 ribosomal protein L9 -0.0314354
RPS13 ribosomal protein S13 -0.0304342
NPSR1 neuropeptide S receptor 1 -0.0300512
RPLP0 ribosomal protein, large, P0 -0.0296527
RPS25 ribosomal protein S25 -0.0292466
FTL ferritin, light polypeptide -0.0280219
RPL5 ribosomal protein L5 -0.0279716
PDLIM5 PDZ and LIM domain 5 -0.0279192
ACTG1 actin gamma 1 -0.0267612
RPS27A ribosomal protein S27a -0.0266113
RPL36 ribosomal protein L36 -0.0257364
RPL31 ribosomal protein L31 -0.0246303
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.024529
RPS24 ribosomal protein S24 -0.0243318
S100A6 S100 calcium binding protein A6 -0.0240466
HMGA1 high mobility group AT-hook 1 -0.0239918
CADPS Ca++-dependent secretion activator -0.0239396
PTPRG protein tyrosine phosphatase, receptor type, G -0.0233415
RPS29 ribosomal protein S29 -0.0229664
MT2A metallothionein 2A -0.0226297
RPL37A ribosomal protein L37a -0.0226067
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0225808
ONECUT3 one cut homeobox 3 -0.0225587
RPL19 ribosomal protein L19 -0.0223656
RPL28 ribosomal protein L28 -0.0223072
RPS14 ribosomal protein S14 -0.0219346
S100A9 S100 calcium binding protein A9 -0.0215234
RPS27 ribosomal protein S27 -0.0214034
RPS10 ribosomal protein S10 -0.0212839
RPL37 ribosomal protein L37 -0.0204594
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0203016
RPS11 ribosomal protein S11 -0.0202203
RPL26 ribosomal protein L26 -0.0201301
IGFL2 IGF-like family member 2 -0.0198753
RPL35 ribosomal protein L35 -0.0186241
SOX9 SRY (sex determining region Y)-box 9 -0.0185744
RPL32 ribosomal protein L32 -0.0185273
RPL11 ribosomal protein L11 -0.0184536
AREG amphiregulin -0.018123
RPL18 ribosomal protein L18 -0.0179266
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0177424
NCEH1 neutral cholesterol ester hydrolase 1 -0.017723
RPL7A ribosomal protein L7a -0.0173997
ERGIC1 endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 -0.0173258
RPS21 ribosomal protein S21 -0.0167559
B4GALNT3 beta-1,4-N-acetyl-galactosaminyl transferase 3 -0.0167238
MT1E metallothionein 1E -0.0166788
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme -0.0166143
RPS15 ribosomal protein S15 -0.0165066
RPL8 ribosomal protein L8 -0.0164727
S100P S100 calcium binding protein P -0.0157857
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0157717
RPS3 ribosomal protein S3 -0.0156256
PFN1 profilin 1 -0.0154825
RPS20 ribosomal protein S20 -0.0154822
POTEF POTE ankyrin domain family, member F -0.0154799
RPL27A ribosomal protein L27a -0.0154612
RPL36A ribosomal protein L36a -0.0151919
RPS5 ribosomal protein S5 -0.0151725
IER3 immediate early response 3 -0.0151021
LURAP1L leucine rich adaptor protein 1-like -0.0149062
RPL27 ribosomal protein L27 -0.0146477
RAB10 RAB10, member RAS oncogene family -0.0145409
S100A10 S100 calcium binding protein A10 -0.0145401
NOSTRIN nitric oxide synthase trafficking -0.0145358
GPHN gephyrin -0.0143676
BPTF bromodomain PHD finger transcription factor -0.0143404
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0143075
RPL36AL ribosomal protein L36a-like -0.0140745
ASTN2 astrotactin 2 -0.0137881
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -0.0137103
MYL12B myosin, light chain 12B, regulatory -0.0136701
PERP PERP, TP53 apoptosis effector -0.0136444
UQCRQ ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa -0.0135603
VDAC1 voltage-dependent anion channel 1 -0.0135271
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 -0.0134494
ZBTB20 zinc finger and BTB domain containing 20 -0.0134438
COX5A cytochrome c oxidase subunit Va -0.0132847