Sulfatinib_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sulfatinib perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Sulfatinib_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.185517
ZCCHC7 zinc finger, CCHC domain containing 7 0.0934655
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.084465
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0757563
TPM3 tropomyosin 3 0.0710148
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0675176
CCNL1 cyclin L1 0.0639251
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0576373
TAS2R14 taste receptor, type 2, member 14 0.0567317
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0534856
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.052289
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0502339
COPA coatomer protein complex, subunit alpha 0.0483372
PUM2 pumilio RNA-binding family member 2 0.0467214
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0455105
WDR43 WD repeat domain 43 0.0452117
ANKRD36 ankyrin repeat domain 36 0.0425001
ENO1 enolase 1, (alpha) 0.0417479
FMNL2 formin-like 2 0.0413985
THSD4 thrombospondin, type I, domain containing 4 0.0412107
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.0401827
SRRM1 serine/arginine repetitive matrix 1 0.0391323
PTK2 protein tyrosine kinase 2 0.0379659
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.037892
RAD51B RAD51 paralog B 0.0377771
PDE10A phosphodiesterase 10A 0.0356904
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0356627
SAMD4A sterile alpha motif domain containing 4A 0.0355931
TRA2A transformer 2 alpha homolog (Drosophila) 0.0350158
TBC1D5 TBC1 domain family, member 5 0.0344873
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0344139
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.0341456
EXOC4 exocyst complex component 4 0.0339207
ZNF638 zinc finger protein 638 0.0335248
SMAD3 SMAD family member 3 0.0328765
RBM25 RNA binding motif protein 25 0.0326661
BABAM2 BRISC and BRCA1 A complex member 2 0.0326479
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.0325912
AFF3 AF4/FMR2 family, member 3 0.0325745
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase 0.0324487
FXR1 fragile X mental retardation, autosomal homolog 1 0.0317552
DENND1A DENN/MADD domain containing 1A 0.0315192
YBX1 Y box binding protein 1 0.0311537
CBX5 chromobox homolog 5 0.0307114
FAF1 Fas (TNFRSF6) associated factor 1 0.0305918
BRD4 bromodomain containing 4 0.0304646
ZNF148 zinc finger protein 148 0.0304037
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0300156
SRRM2 serine/arginine repetitive matrix 2 0.0299823
ATP13A3 ATPase type 13A3 0.0293121
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 0.0290676
CANX calnexin 0.0282959
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0281091
PNN pinin, desmosome associated protein 0.0279514
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0278292
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.027775
PTEN phosphatase and tensin homolog 0.0274245
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0269062
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0267702
UBE2H ubiquitin-conjugating enzyme E2H 0.0266899
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0265352
RSF1 remodeling and spacing factor 1 0.0263485
CUL3 cullin 3 0.0262153
PPIA peptidylprolyl isomerase A (cyclophilin A) 0.0259866
MARCHF7 membrane associated ring-CH-type finger 7 0.0258197
OGA O-GlcNAcase 0.0258121
HELZ helicase with zinc finger 0.0256761
PRELID2 PRELI domain containing 2 0.0256101
RBM33 RNA binding motif protein 33 0.0255214
HDGF hepatoma-derived growth factor 0.0254402
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0253373
ZMYM2 zinc finger, MYM-type 2 0.0252052
CSDE1 cold shock domain containing E1, RNA-binding 0.0251787
KMT2E lysine (K)-specific methyltransferase 2E 0.0249577
TBC1D15 TBC1 domain family, member 15 0.024705
IPO5 importin 5 0.0245776
PDIA6 protein disulfide isomerase family A, member 6 0.0245614
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) 0.024408
MSN moesin 0.0241891
FAM168A family with sequence similarity 168, member A 0.0238452
BIRC6 baculoviral IAP repeat containing 6 0.0236164
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0235941
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.0233717
TSR1 TSR1, 20S rRNA accumulation, homolog (S. cerevisiae) 0.0233281
SRSF1 serine/arginine-rich splicing factor 1 0.0231792
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0231352
EP400 E1A binding protein p400 0.0227656
NBAS neuroblastoma amplified sequence 0.0227418
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0226421
CAMTA1 calmodulin binding transcription activator 1 0.0226301
SFPQ splicing factor proline/glutamine-rich 0.0224747
BAZ2A bromodomain adjacent to zinc finger domain, 2A 0.0223458
ZBTB1 zinc finger and BTB domain containing 1 0.0221702
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0221649
SUPT16H suppressor of Ty 16 homolog (S. cerevisiae) 0.0221414
TLK1 tousled-like kinase 1 0.0219603
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0219565
ADAR adenosine deaminase, RNA-specific 0.0219023
WRN Werner syndrome, RecQ helicase-like 0.0218565
ZNF644 zinc finger protein 644 0.0218212

decreased expression

Symbol Name Standardized Value
TFPI2 tissue factor pathway inhibitor 2 -0.264597
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.169691
TMSB10 thymosin beta 10 -0.119382
VIM vimentin -0.0930101
ACTG1 actin gamma 1 -0.0804805
RPL38 ribosomal protein L38 -0.071563
YBX3 Y box binding protein 3 -0.0666463
RPL37 ribosomal protein L37 -0.0641389
MT2A metallothionein 2A -0.0626777
TPT1 tumor protein, translationally-controlled 1 -0.0609629
MYL12B myosin, light chain 12B, regulatory -0.0608266
TPI1 triosephosphate isomerase 1 -0.0576782
PTMA prothymosin, alpha -0.0551805
EGR1 early growth response 1 -0.0512992
RPS8 ribosomal protein S8 -0.0509455
RPLP1 ribosomal protein, large, P1 -0.0505248
RPS21 ribosomal protein S21 -0.0502693
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0500388
RPL26 ribosomal protein L26 -0.0488629
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0486857
RPL35A ribosomal protein L35a -0.0473191
AKAP12 A kinase (PRKA) anchor protein 12 -0.0470017
RPL23 ribosomal protein L23 -0.0467764
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0431507
RPS29 ribosomal protein S29 -0.0429807
TM4SF1 transmembrane 4 L six family member 1 -0.042977
ANKRD12 ankyrin repeat domain 12 -0.0428451
OSMR oncostatin M receptor -0.041434
STC1 stanniocalcin 1 -0.0408118
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.040174
RPL12 ribosomal protein L12 -0.0395244
ELL2 elongation factor, RNA polymerase II, 2 -0.0391908
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0386116
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.037993
NCAPD2 non-SMC condensin I complex, subunit D2 -0.0374895
H3-3B H3.3 histone B -0.0373845
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0370335
CAVIN1 caveolae associated protein 1 -0.0363216
RPL9 ribosomal protein L9 -0.0361899
SEPTIN7 septin 7 -0.0353914
GRAMD1B GRAM domain containing 1B -0.0351095
RPS15 ribosomal protein S15 -0.0343168
HLA-B major histocompatibility complex, class I, B -0.0339124
VDAC1 voltage-dependent anion channel 1 -0.0337221
TUBA1B tubulin, alpha 1b -0.0336169
BPTF bromodomain PHD finger transcription factor -0.0335693
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0335571
RPS4X ribosomal protein S4, X-linked -0.033523
RPL34 ribosomal protein L34 -0.0329071
RPL19 ribosomal protein L19 -0.0326767
STK4 serine/threonine kinase 4 -0.0326255
CTTNBP2NL CTTNBP2 N-terminal like -0.0325516
RPS27A ribosomal protein S27a -0.0324216
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0317611
RIMS2 regulating synaptic membrane exocytosis 2 -0.0315801
NAP1L1 nucleosome assembly protein 1-like 1 -0.0314914
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0311919
IGF1R insulin-like growth factor 1 receptor -0.0305442
MCL1 myeloid cell leukemia 1 -0.0304011
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 -0.0303822
RPS27 ribosomal protein S27 -0.0302858
S100A10 S100 calcium binding protein A10 -0.0301587
RPS6 ribosomal protein S6 -0.0295175
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0295152
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) -0.0292583
RPS20 ribosomal protein S20 -0.0290509
WSB1 WD repeat and SOCS box containing 1 -0.0290443
UBB ubiquitin B -0.0288894
SMYD3 SET and MYND domain containing 3 -0.0284696
TUBB4B tubulin, beta 4B class IVb -0.0283304
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0281681
GNAS GNAS complex locus -0.0277421
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0277332
IGF2 insulin-like growth factor 2 -0.0277091
RPS19 ribosomal protein S19 -0.0274957
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0274861
RPS3 ribosomal protein S3 -0.0274835
ICAM1 intercellular adhesion molecule 1 -0.0273944
HMGA1 high mobility group AT-hook 1 -0.0272813
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0271389
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0270061
TGIF1 TGFB-induced factor homeobox 1 -0.0267608
RPS10 ribosomal protein S10 -0.0266776
RPL31 ribosomal protein L31 -0.0265151
NIPBL Nipped-B homolog (Drosophila) -0.0264956
KDM4B lysine (K)-specific demethylase 4B -0.0264826
S100A6 S100 calcium binding protein A6 -0.0264382
RPL5 ribosomal protein L5 -0.0262854
RPL36 ribosomal protein L36 -0.0262681
IER3 immediate early response 3 -0.026235
BSG basigin (Ok blood group) -0.0260244
RACK1 receptor for activated C kinase 1 -0.0259855
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0259292
RPL30 ribosomal protein L30 -0.0257721
RPS25 ribosomal protein S25 -0.0257127
RPL8 ribosomal protein L8 -0.0255821
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0254543
RPL32 ribosomal protein L32 -0.0254192
RTN4 reticulon 4 -0.0251403
RPS2 ribosomal protein S2 -0.0248698