Sulfatinib_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sulfatinib perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Sulfatinib_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ASPH aspartate beta-hydroxylase 0.17258
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.164681
FNDC3B fibronectin type III domain containing 3B 0.126674
GRB10 growth factor receptor-bound protein 10 0.116439
FN1 fibronectin 1 0.0919867
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0864631
CANX calnexin 0.0789721
MYH9 myosin, heavy chain 9, non-muscle 0.0748525
IGFBP3 insulin-like growth factor binding protein 3 0.0739345
TOP1 topoisomerase (DNA) I 0.072044
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0698423
AHNAK AHNAK nucleoprotein 0.0677895
PGK1 phosphoglycerate kinase 1 0.0631916
LMO7 LIM domain 7 0.0617545
LPP LIM domain containing preferred translocation partner in lipoma 0.0616712
ENO1 enolase 1, (alpha) 0.0613477
LAMB3 laminin, beta 3 0.0559198
SAMD4A sterile alpha motif domain containing 4A 0.0552094
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0517825
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.050122
FAM13A family with sequence similarity 13, member A 0.048751
PTK2 protein tyrosine kinase 2 0.0477794
TM4SF1 transmembrane 4 L six family member 1 0.0466951
KRT8 keratin 8, type II 0.0459943
PLAU plasminogen activator, urokinase 0.0457842
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0439017
SDC4 syndecan 4 0.0425791
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0421513
CXCL8 chemokine (C-X-C motif) ligand 8 0.0418829
ADAM9 ADAM metallopeptidase domain 9 0.039817
LIMCH1 LIM and calponin homology domains 1 0.039494
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.038667
RAD21 RAD21 homolog (S. pombe) 0.038587
YBX1 Y box binding protein 1 0.0385437
APLP2 amyloid beta (A4) precursor-like protein 2 0.0384681
TFG TRK-fused gene 0.0377213
CLIP4 CAP-GLY domain containing linker protein family, member 4 0.037105
BZW1 basic leucine zipper and W2 domains 1 0.0368296
RPL4 ribosomal protein L4 0.0367903
CD109 CD109 molecule 0.036625
COPA coatomer protein complex, subunit alpha 0.0362183
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0351524
IRF6 interferon regulatory factor 6 0.0349543
EPCAM epithelial cell adhesion molecule 0.0347583
UBA6 ubiquitin-like modifier activating enzyme 6 0.0340968
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0336259
ANXA2 annexin A2 0.0335815
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked 0.0335192
MYOF myoferlin 0.0333762
KMT2E lysine (K)-specific methyltransferase 2E 0.0325371
IQGAP1 IQ motif containing GTPase activating protein 1 0.0323884
KRT7 keratin 7, type II 0.032286
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0316123
FXR1 fragile X mental retardation, autosomal homolog 1 0.0314548
RAI14 retinoic acid induced 14 0.030363
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0297113
TPM3 tropomyosin 3 0.0293851
RAD23B RAD23 homolog B (S. cerevisiae) 0.0292576
WASF2 WAS protein family, member 2 0.028964
DST dystonin 0.0285341
USP9X ubiquitin specific peptidase 9, X-linked 0.0285158
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0283685
KDM5B lysine (K)-specific demethylase 5B 0.0281637
PPARD peroxisome proliferator-activated receptor delta 0.0281493
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0279201
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0274263
PICALM phosphatidylinositol binding clathrin assembly protein 0.0274003
ANKRD11 ankyrin repeat domain 11 0.0273021
TMF1 TATA element modulatory factor 1 0.0271354
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0269769
GARS1 glycyl-tRNA synthetase 1 0.0267008
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0259215
SEC23A Sec23 homolog A (S. cerevisiae) 0.0256122
RPL14 ribosomal protein L14 0.0255797
BHLHE40 basic helix-loop-helix family, member e40 0.0255284
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0250179
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0247682
HELZ helicase with zinc finger 0.0247623
HMGN2 high mobility group nucleosomal binding domain 2 0.0246759
UBE2E1 ubiquitin-conjugating enzyme E2E 1 0.0246327
MACF1 microtubule-actin crosslinking factor 1 0.0243821
TNIP1 TNFAIP3 interacting protein 1 0.0243529
NPEPPS aminopeptidase puromycin sensitive 0.0243453
DSPP dentin sialophosphoprotein 0.0241738
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0241602
SET SET nuclear proto-oncogene 0.0240309
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0240029
TTC3 tetratricopeptide repeat domain 3 0.0238746
CCNL1 cyclin L1 0.0237009
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0234356
MSI2 musashi RNA-binding protein 2 0.0233826
UBAP2L ubiquitin associated protein 2-like 0.0233531
CD2AP CD2-associated protein 0.0232407
ANKIB1 ankyrin repeat and IBR domain containing 1 0.0231737
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A 0.0231455
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.023139
TRIO trio Rho guanine nucleotide exchange factor 0.0230942
OSBPL3 oxysterol binding protein-like 3 0.0225084
CCND1 cyclin D1 0.0224976
PUM2 pumilio RNA-binding family member 2 0.0223547

decreased expression

Symbol Name Standardized Value
NDRG1 N-myc downstream regulated 1 -0.274757
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.253254
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.121368
FTL ferritin, light polypeptide -0.120328
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.10214
S100A6 S100 calcium binding protein A6 -0.0892187
ACTG1 actin gamma 1 -0.0876375
MT2A metallothionein 2A -0.0826791
HMGA1 high mobility group AT-hook 1 -0.0725594
POTEF POTE ankyrin domain family, member F -0.072048
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0709643
TMSB10 thymosin beta 10 -0.068561
S100A10 S100 calcium binding protein A10 -0.0672508
TPT1 tumor protein, translationally-controlled 1 -0.0551533
RPLP1 ribosomal protein, large, P1 -0.0546893
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0517804
RPLP2 ribosomal protein, large, P2 -0.0515998
RPS23 ribosomal protein S23 -0.0494237
RPL8 ribosomal protein L8 -0.0493092
RPS2 ribosomal protein S2 -0.0469057
TSC22D2 TSC22 domain family, member 2 -0.0466051
RPS13 ribosomal protein S13 -0.0463399
SLC38A1 solute carrier family 38, member 1 -0.0458656
RYBP RING1 and YY1 binding protein -0.0451954
RPL35A ribosomal protein L35a -0.0440039
RPS19 ribosomal protein S19 -0.0435787
LAMC2 laminin, gamma 2 -0.043278
IFI27 interferon, alpha-inducible protein 27 -0.0418483
EIF1 eukaryotic translation initiation factor 1 -0.0416732
RPL15 ribosomal protein L15 -0.0414766
ISG15 ISG15 ubiquitin-like modifier -0.041269
ELL2 elongation factor, RNA polymerase II, 2 -0.0408535
RPL7 ribosomal protein L7 -0.0403054
RPL9 ribosomal protein L9 -0.0400552
RPS29 ribosomal protein S29 -0.0395269
LOC112694756 uncharaterized LOC112694756 -0.0392569
RPL38 ribosomal protein L38 -0.0389768
RPL32 ribosomal protein L32 -0.0378097
RPL37A ribosomal protein L37a -0.0370923
RPS25 ribosomal protein S25 -0.0367906
TUBB4B tubulin, beta 4B class IVb -0.0363319
DTNA dystrobrevin, alpha -0.0356236
RPL23 ribosomal protein L23 -0.0352225
RPL36A ribosomal protein L36a -0.0351704
S100A9 S100 calcium binding protein A9 -0.0350229
RPS14 ribosomal protein S14 -0.0345313
RPL19 ribosomal protein L19 -0.034031
RPS6 ribosomal protein S6 -0.0336335
EXT1 exostosin glycosyltransferase 1 -0.033357
GOLGA4 golgin A4 -0.0329109
HSPA8 heat shock 70kDa protein 8 -0.0323923
RPS16 ribosomal protein S16 -0.0320325
UPP1 uridine phosphorylase 1 -0.0320322
RPL34 ribosomal protein L34 -0.0319035
DDIT4 DNA-damage-inducible transcript 4 -0.031835
RPL12 ribosomal protein L12 -0.0310989
RPS5 ribosomal protein S5 -0.0298424
RPL28 ribosomal protein L28 -0.0294722
RPS27 ribosomal protein S27 -0.0287489
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.028469
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.02841
RPL27A ribosomal protein L27a -0.0279263
BRD2 bromodomain containing 2 -0.0275872
RPS17 ribosomal protein S17 -0.0270517
RPS20 ribosomal protein S20 -0.0268071
MYO10 myosin X -0.0267459
ANKRD37 ankyrin repeat domain 37 -0.0265226
RPLP0 ribosomal protein, large, P0 -0.0264685
FBXO32 F-box protein 32 -0.0259703
CCNI cyclin I -0.0256983
WSB1 WD repeat and SOCS box containing 1 -0.025603
RPS8 ribosomal protein S8 -0.0255446
H3-3B H3.3 histone B -0.0252943
IFITM3 interferon induced transmembrane protein 3 -0.0248812
RPL5 ribosomal protein L5 -0.0246292
UGCG UDP-glucose ceramide glucosyltransferase -0.0242867
RPL37 ribosomal protein L37 -0.0242698
GPX4 glutathione peroxidase 4 -0.0239134
CNBP CCHC-type zinc finger, nucleic acid binding protein -0.0238021
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0236384
RPL30 ribosomal protein L30 -0.0233455
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0232181
NPC2 Niemann-Pick disease, type C2 -0.0228992
PRRC2C proline-rich coiled-coil 2C -0.0226914
RPL7A ribosomal protein L7a -0.022659
UGDH UDP-glucose 6-dehydrogenase -0.0224644
H2AZ1 H2A.Z variant histone 1 -0.0224595
RPS12 ribosomal protein S12 -0.022319
IFI6 interferon, alpha-inducible protein 6 -0.0221256
RPS27A ribosomal protein S27a -0.0217725
STARD4 StAR-related lipid transfer (START) domain containing 4 -0.0216778
RPL31 ribosomal protein L31 -0.021652
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.0207433
ANO6 anoctamin 6 -0.0204493
CDCP1 CUB domain containing protein 1 -0.0203788
RPL26 ribosomal protein L26 -0.0203782
PTMA prothymosin, alpha -0.0203332
CD44 CD44 molecule (Indian blood group) -0.0203099
RPS18 ribosomal protein S18 -0.0202377
BBX bobby sox homolog (Drosophila) -0.0198459