Sulfatinib_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sulfatinib perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

179 genes differentially expressed following the Sulfatinib_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.153067
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.125834
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0963367
FTL ferritin, light polypeptide 0.0782692
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0697297
GOLGA4 golgin A4 0.0642297
NDRG1 N-myc downstream regulated 1 0.0632484
RORA RAR-related orphan receptor A 0.0615133
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0603919
CALR calreticulin 0.0563108
NAMPT nicotinamide phosphoribosyltransferase 0.0557265
KTN1 kinectin 1 (kinesin receptor) 0.054742
SPAG9 sperm associated antigen 9 0.0546298
SEC31A SEC31 homolog A (S. cerevisiae) 0.0537978
DSTN destrin (actin depolymerizing factor) 0.0526881
PUM2 pumilio RNA-binding family member 2 0.0502553
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0470663
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0450734
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0448395
RTN4 reticulon 4 0.0442999
COPA coatomer protein complex, subunit alpha 0.0429378
ZNF292 zinc finger protein 292 0.0423981
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.041021
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0396511
RPL31 ribosomal protein L31 0.0386094
CLTC clathrin, heavy chain (Hc) 0.0379313
TRPS1 trichorhinophalangeal syndrome I 0.0374898
ANKRD12 ankyrin repeat domain 12 0.0364296
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0358073
RSF1 remodeling and spacing factor 1 0.0334837
SYAP1 synapse associated protein 1 0.0325724
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0325118
DST dystonin 0.0321546
NBAS neuroblastoma amplified sequence 0.0320916
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0315529
ERRFI1 ERBB receptor feedback inhibitor 1 0.031507
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0311696
RAB7A RAB7A, member RAS oncogene family 0.0311085
PTK2 protein tyrosine kinase 2 0.0309146
RAP1B RAP1B, member of RAS oncogene family 0.0307329
RPS8 ribosomal protein S8 0.0305842
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.0290374
WAC WW domain containing adaptor with coiled-coil 0.0289112
COG5 component of oligomeric golgi complex 5 0.028205
AFDN afadin, adherens junction formation factor 0.0279337
CANX calnexin 0.0274563
TXNRD1 thioredoxin reductase 1 0.0264159
RPS19 ribosomal protein S19 0.0252208
PGK1 phosphoglycerate kinase 1 0.0251277
SEC63 SEC63 homolog (S. cerevisiae) 0.0247306
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0241409
ZC3H11A zinc finger CCCH-type containing 11A 0.0239284
PDIA3 protein disulfide isomerase family A, member 3 0.0227975
RBM39 RNA binding motif protein 39 0.0226451
RPLP2 ribosomal protein, large, P2 0.0213249
RICTOR RPTOR independent companion of MTOR, complex 2 0.0200228
RPLP0 ribosomal protein, large, P0 0.019987
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0199155
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0195545
MT2A metallothionein 2A 0.0191219
VIM vimentin 0.0190663
PAN3 PAN3 poly(A) specific ribonuclease subunit 0.0189806
MORF4L2 mortality factor 4 like 2 0.0181596
FNIP1 folliculin interacting protein 1 0.0170419
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0169481
SRP54 signal recognition particle 54kDa 0.0165476
IGFBP3 insulin-like growth factor binding protein 3 0.0155226
ZCCHC7 zinc finger, CCHC domain containing 7 0.0150493
BIRC6 baculoviral IAP repeat containing 6 0.0150337
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0142465
EIF1 eukaryotic translation initiation factor 1 0.0130167
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.012478
KMT2E lysine (K)-specific methyltransferase 2E 0.0118039
B2M beta-2-microglobulin 0.0118023
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0111355
PDIA4 protein disulfide isomerase family A, member 4 0.00991054
MED13L mediator complex subunit 13-like 0.00983872
CTNND1 catenin (cadherin-associated protein), delta 1 0.00974269
UBE2B ubiquitin-conjugating enzyme E2B 0.00944874
MAML3 mastermind-like 3 (Drosophila) 0.00942312
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.00916215
HM13 histocompatibility (minor) 13 0.00881969
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.00862332
AFTPH aftiphilin 0.0083543
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.00807606
HILPDA hypoxia inducible lipid droplet-associated 0.00741934
PTGES3 prostaglandin E synthase 3 (cytosolic) 0.00731773
ANKRD11 ankyrin repeat domain 11 0.00672281
RERE arginine-glutamic acid dipeptide (RE) repeats 0.00586373
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.00488868
ARHGAP5 Rho GTPase activating protein 5 0.00413311
NALF1 NALCN channel auxiliary factor 1 0.00400073
RPL11 ribosomal protein L11 0.00352853
SBF2 SET binding factor 2 0.00342906
DDB1 damage-specific DNA binding protein 1, 127kDa 0.00251954
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.00242569
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0023626
FNDC3B fibronectin type III domain containing 3B 0.00216026
RPL12 ribosomal protein L12 7.17353E-4
STC1 stanniocalcin 1 5.13169E-4

decreased expression

Symbol Name Standardized Value
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0974699
EGFR epidermal growth factor receptor -0.0856827
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0778312
CFLAR CASP8 and FADD-like apoptosis regulator -0.0730681
VMP1 vacuole membrane protein 1 -0.0726625
FTH1 ferritin, heavy polypeptide 1 -0.0700947
SLC38A1 solute carrier family 38, member 1 -0.0642209
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme -0.0641222
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0579896
MYOF myoferlin -0.0575936
KMT2C lysine (K)-specific methyltransferase 2C -0.0566665
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0538526
INHBA inhibin, beta A -0.053774
ZBTB20 zinc finger and BTB domain containing 20 -0.0518375
LIMCH1 LIM and calponin homology domains 1 -0.0484555
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.047451
RPS6 ribosomal protein S6 -0.0467043
PDE8A phosphodiesterase 8A -0.0451204
TMSB10 thymosin beta 10 -0.0442497
ACTG1 actin gamma 1 -0.0421977
FN1 fibronectin 1 -0.0398289
SEPTIN9 septin 9 -0.0387917
LMO7 LIM domain 7 -0.037741
RUNX1 runt-related transcription factor 1 -0.0370015
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0348803
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0347904
FLNB filamin B, beta -0.0319624
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase -0.0312988
HELZ helicase with zinc finger -0.028987
ANXA2 annexin A2 -0.0286846
EEF2 eukaryotic translation elongation factor 2 -0.0281798
TRIO trio Rho guanine nucleotide exchange factor -0.0281384
NCOR1 nuclear receptor corepressor 1 -0.0260943
HMGA2 high mobility group AT-hook 2 -0.0250202
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0246477
CCNH cyclin H -0.0242823
CCDC88A coiled-coil domain containing 88A -0.0239515
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0232921
MTREX Mtr4 exosome RNA helicase -0.0231786
EXT1 exostosin glycosyltransferase 1 -0.0220571
PDE10A phosphodiesterase 10A -0.0195945
SLTM SAFB-like, transcription modulator -0.0195875
RPL35A ribosomal protein L35a -0.0195462
EPAS1 endothelial PAS domain protein 1 -0.018784
USP34 ubiquitin specific peptidase 34 -0.0184433
RNF213 ring finger protein 213 -0.0182351
TM9SF3 transmembrane 9 superfamily member 3 -0.0182137
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0167642
RPLP1 ribosomal protein, large, P1 -0.0163322
ENO1 enolase 1, (alpha) -0.0161294
RACK1 receptor for activated C kinase 1 -0.0159668
JMJD1C jumonji domain containing 1C -0.0155484
NAP1L1 nucleosome assembly protein 1-like 1 -0.0127356
NFIA nuclear factor I/A -0.0126403
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.012336
TRAM1 translocation associated membrane protein 1 -0.0121227
EFNA5 ephrin-A5 -0.0119684
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.0116867
LRP1B low density lipoprotein receptor-related protein 1B -0.011411
DSCAM Down syndrome cell adhesion molecule -0.0112251
ASPH aspartate beta-hydroxylase -0.011127
WDFY2 WD repeat and FYVE domain containing 2 -0.0106515
ETNK1 ethanolamine kinase 1 -0.00968984
FBXO11 F-box protein 11 -0.00963652
AKAP12 A kinase (PRKA) anchor protein 12 -0.00698843
NIPBL Nipped-B homolog (Drosophila) -0.00678916
ERP44 endoplasmic reticulum protein 44 -0.00589551
PTMA prothymosin, alpha -0.00495354
KIF5B kinesin family member 5B -0.004619
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.00404281
FAM13A family with sequence similarity 13, member A -0.00395517
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.00287651
ELL2 elongation factor, RNA polymerase II, 2 -0.0026727
PRRC2C proline-rich coiled-coil 2C -0.00205687
PDE4D phosphodiesterase 4D, cAMP-specific -0.0015606
SRRM2 serine/arginine repetitive matrix 2 -7.47565E-4
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa -5.56435E-4
KDM2A lysine (K)-specific demethylase 2A -3.61509E-4
TPT1 tumor protein, translationally-controlled 1 -1.91586E-4