Sulfatinib_NCI-H661 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sulfatinib perturbation in NCI-H661 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Sulfatinib_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.112743
DST dystonin 0.081095
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0792738
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0779162
ZNF292 zinc finger protein 292 0.0729599
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0645878
TSC22D2 TSC22 domain family, member 2 0.0626887
THBS1 thrombospondin 1 0.0587063
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0566965
ADAM9 ADAM metallopeptidase domain 9 0.0562516
PUM2 pumilio RNA-binding family member 2 0.0529303
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0492324
NAMPT nicotinamide phosphoribosyltransferase 0.0474777
COL5A2 collagen, type V, alpha 2 0.0461912
XPO1 exportin 1 0.0461839
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0447523
H1-4 H1.4 linker histone, cluster member 0.0444287
HDAC9 histone deacetylase 9 0.0439135
USP3 ubiquitin specific peptidase 3 0.0431228
TFRC transferrin receptor 0.0424118
ZFAND3 zinc finger, AN1-type domain 3 0.0423725
TBC1D12 TBC1 domain family, member 12 0.0423351
TPM3 tropomyosin 3 0.0421593
KDM3A lysine (K)-specific demethylase 3A 0.0409297
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0401088
PDGFC platelet derived growth factor C 0.0396521
ITGAV integrin, alpha V 0.0384542
CALCR calcitonin receptor 0.0381272
CTNNA3 catenin (cadherin-associated protein), alpha 3 0.0379737
RHEB Ras homolog enriched in brain 0.0379171
UPP1 uridine phosphorylase 1 0.0373033
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0364286
FAM171B family with sequence similarity 171, member B 0.0362872
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0362786
SFPQ splicing factor proline/glutamine-rich 0.0354347
USP9X ubiquitin specific peptidase 9, X-linked 0.0338408
ANXA5 annexin A5 0.0338356
ANXA1 annexin A1 0.0337514
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0329512
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.032854
WDR43 WD repeat domain 43 0.0327501
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0323858
H1-0 H1.0 linker histone 0.0321121
ANKRD33B ankyrin repeat domain 33B 0.0319765
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0316306
CSDE1 cold shock domain containing E1, RNA-binding 0.0312668
SET SET nuclear proto-oncogene 0.0311458
DSCAM Down syndrome cell adhesion molecule 0.0309609
RBM33 RNA binding motif protein 33 0.030705
MB21D2 Mab-21 domain containing 2 0.0305745
ZEB2 zinc finger E-box binding homeobox 2 0.0303571
BCLAF1 BCL2-associated transcription factor 1 0.0302825
PPP1R12A protein phosphatase 1, regulatory subunit 12A 0.0302564
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0297618
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 0.0296868
NCKAP1 NCK-associated protein 1 0.0294677
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0294321
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) 0.0290295
YES1 YES proto-oncogene 1, Src family tyrosine kinase 0.0289597
CORO1C coronin, actin binding protein, 1C 0.0287922
ACSL3 acyl-CoA synthetase long-chain family member 3 0.028565
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0285308
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0283215
FUBP1 far upstream element (FUSE) binding protein 1 0.028204
CXADR coxsackie virus and adenovirus receptor 0.0281155
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.028
BUB1 BUB1 mitotic checkpoint serine/threonine kinase 0.0279993
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 0.0278697
ECT2 epithelial cell transforming 2 0.0278329
NEK7 NIMA-related kinase 7 0.0276716
CFL2 cofilin 2 (muscle) 0.0275808
YAP1 Yes-associated protein 1 0.027452
CDC73 cell division cycle 73 0.0274281
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 0.0272059
TNPO1 transportin 1 0.0270136
LRRN3 leucine rich repeat neuronal 3 0.0270078
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0268484
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.0266405
DMXL1 Dmx-like 1 0.0260672
RPL4 ribosomal protein L4 0.0260194
RTN4 reticulon 4 0.0257133
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0256595
MYH9 myosin, heavy chain 9, non-muscle 0.0255589
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0254386
OSBPL9 oxysterol binding protein-like 9 0.0254321
BZW1 basic leucine zipper and W2 domains 1 0.0249677
WASL Wiskott-Aldrich syndrome-like 0.0248808
KMT2C lysine (K)-specific methyltransferase 2C 0.0247005
SERTAD2 SERTA domain containing 2 0.024399
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) 0.024209
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0240908
PARD3 par-3 family cell polarity regulator 0.0238482
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1 0.0238422
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0237503
POU2F1 POU class 2 homeobox 1 0.0236745
CABLES1 Cdk5 and Abl enzyme substrate 1 0.0235512
RAD23B RAD23 homolog B (S. cerevisiae) 0.0234218
FGFR1OP2 FGFR1 oncogene partner 2 0.0233572
CYTH3 cytohesin 3 0.0231195
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.0230648

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.146096
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.117268
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.103025
TMSB10 thymosin beta 10 -0.0921023
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0832991
CADM2 cell adhesion molecule 2 -0.0718647
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 -0.0650516
GPC3 glypican 3 -0.0648676
RPL35A ribosomal protein L35a -0.0608864
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0585759
PCLO piccolo presynaptic cytomatrix protein -0.0578496
PTMA prothymosin, alpha -0.0566719
RPS16 ribosomal protein S16 -0.0543821
RPL23 ribosomal protein L23 -0.0527137
NCAM2 neural cell adhesion molecule 2 -0.0508232
RPLP1 ribosomal protein, large, P1 -0.0492067
PFN1 profilin 1 -0.0475873
HS3ST5 heparan sulfate (glucosamine) 3-O-sulfotransferase 5 -0.0455266
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0447796
RPL19 ribosomal protein L19 -0.0431303
MDK midkine (neurite growth-promoting factor 2) -0.0426151
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0424261
GNAS GNAS complex locus -0.0419525
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0417407
RPL37A ribosomal protein L37a -0.0414626
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 -0.0406924
TPT1 tumor protein, translationally-controlled 1 -0.040172
RPS6 ribosomal protein S6 -0.0382605
TAS2R14 taste receptor, type 2, member 14 -0.036912
PEG10 paternally expressed 10 -0.036376
RPLP2 ribosomal protein, large, P2 -0.0363041
HSPB1 heat shock 27kDa protein 1 -0.0361692
MED13L mediator complex subunit 13-like -0.0360054
ACTG1 actin gamma 1 -0.036003
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0356352
RAD51B RAD51 paralog B -0.0354601
RPS4X ribosomal protein S4, X-linked -0.0324907
GOLGA4 golgin A4 -0.032407
CNRIP1 cannabinoid receptor interacting protein 1 -0.0313717
NRG1 neuregulin 1 -0.0311861
RPL36 ribosomal protein L36 -0.0311282
RPS19 ribosomal protein S19 -0.0307782
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.030657
ARHGAP15 Rho GTPase activating protein 15 -0.0300685
ADGRL3 adhesion G protein-coupled receptor L3 -0.029848
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0297107
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0295458
SOX5 SRY (sex determining region Y)-box 5 -0.0295197
GALNTL6 polypeptide N-acetylgalactosaminyltransferase-like 6 -0.0295101
RPL12 ribosomal protein L12 -0.029419
SHROOM3 shroom family member 3 -0.0290181
UBE2K ubiquitin-conjugating enzyme E2K -0.0283703
LRRC4C leucine rich repeat containing 4C -0.0282598
CALU calumenin -0.027803
BPTF bromodomain PHD finger transcription factor -0.0277776
RPL34 ribosomal protein L34 -0.0273517
CUX1 cut-like homeobox 1 -0.0270435
MEIS2 Meis homeobox 2 -0.0265283
LHFPL6 LHFPL tetraspan subfamily member 6 -0.0264639
FTL ferritin, light polypeptide -0.0263728
RPS8 ribosomal protein S8 -0.0262678
FMNL2 formin-like 2 -0.0261405
MAML2 mastermind-like 2 (Drosophila) -0.0259642
DLG1 discs, large homolog 1 (Drosophila) -0.0254525
NBEAL1 neurobeachin-like 1 -0.0253749
PCDH9 protocadherin 9 -0.0253589
TUBA1B tubulin, alpha 1b -0.0251596
LYST lysosomal trafficking regulator -0.0250238
TENM2 teneurin transmembrane protein 2 -0.0248978
TTC3 tetratricopeptide repeat domain 3 -0.0248844
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0248815
RPS13 ribosomal protein S13 -0.0248429
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0247815
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0244658
UBB ubiquitin B -0.0241372
BRWD1 bromodomain and WD repeat domain containing 1 -0.024016
HMGB1 high mobility group box 1 -0.0239693
KIAA1328 KIAA1328 -0.0236322
RPL32 ribosomal protein L32 -0.0235769
RPS27A ribosomal protein S27a -0.0235658
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0233344
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0231957
RPL30 ribosomal protein L30 -0.023112
FAM177A1 family with sequence similarity 177, member A1 -0.0229853
S100A9 S100 calcium binding protein A9 -0.0229756
RPS12 ribosomal protein S12 -0.0229633
ZFPM2 zinc finger protein, FOG family member 2 -0.0229611
SQSTM1 sequestosome 1 -0.0228536
PHACTR4 phosphatase and actin regulator 4 -0.0227963
DYNC1I2 dynein, cytoplasmic 1, intermediate chain 2 -0.0227848
RPL11 ribosomal protein L11 -0.0223197
RPL36A ribosomal protein L36a -0.022253
RPS27 ribosomal protein S27 -0.0219389
RPL27A ribosomal protein L27a -0.0218978
RPS3 ribosomal protein S3 -0.0217148
RPL28 ribosomal protein L28 -0.0216895
YY1 YY1 transcription factor -0.0216426
PACS1 phosphofurin acidic cluster sorting protein 1 -0.0215978
SRP54 signal recognition particle 54kDa -0.0214585
DENND5B DENN/MADD domain containing 5B -0.0213692