Sulfatinib_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sulfatinib perturbation in SW 1271 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Sulfatinib_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0670841
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0531314
BIRC3 baculoviral IAP repeat containing 3 0.0529979
ANKRD36 ankyrin repeat domain 36 0.0506111
SPAG9 sperm associated antigen 9 0.0454212
NUP58 nucleoporin 58 0.0432224
ZNF292 zinc finger protein 292 0.040604
ECT2 epithelial cell transforming 2 0.0403376
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0382809
MSN moesin 0.0349644
KIAA1328 KIAA1328 0.0348771
PICALM phosphatidylinositol binding clathrin assembly protein 0.0348576
NUP153 nucleoporin 153kDa 0.0347633
DSCAM Down syndrome cell adhesion molecule 0.0344507
GOLGA4 golgin A4 0.0344148
AP2B1 adaptor-related protein complex 2, beta 1 subunit 0.0342696
PUM2 pumilio RNA-binding family member 2 0.0342645
USP9X ubiquitin specific peptidase 9, X-linked 0.0336728
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0330137
LCORL ligand dependent nuclear receptor corepressor-like 0.0327007
ZC3H13 zinc finger CCCH-type containing 13 0.032372
TNPO1 transportin 1 0.0318313
SNX14 sorting nexin 14 0.0307826
KIAA1958 KIAA1958 0.0306636
SAMD4A sterile alpha motif domain containing 4A 0.0304485
CHD1 chromodomain helicase DNA binding protein 1 0.0303286
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0301517
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.0301133
SET SET nuclear proto-oncogene 0.030064
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.029613
TAS2R14 taste receptor, type 2, member 14 0.0295376
KIF20B kinesin family member 20B 0.0293535
KIF4A kinesin family member 4A 0.0292545
TOP2B topoisomerase (DNA) II beta 180kDa 0.0288969
NBAS neuroblastoma amplified sequence 0.0287904
BIRC2 baculoviral IAP repeat containing 2 0.02797
TPX2 TPX2, microtubule-associated 0.0276499
TRA2A transformer 2 alpha homolog (Drosophila) 0.027159
HSPA8 heat shock 70kDa protein 8 0.0270254
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0269862
RPL4 ribosomal protein L4 0.0266818
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 0.0264838
SEC23A Sec23 homolog A (S. cerevisiae) 0.0261231
IARS1 isoleucyl-tRNA synthetase 1 0.0260325
PMM2 phosphomannomutase 2 0.0258419
CEP95 centrosomal protein 95kDa 0.0256244
TOP2A topoisomerase (DNA) II alpha 170kDa 0.025574
CTNNBL1 catenin, beta like 1 0.0255256
HMGB2 high mobility group box 2 0.0252939
CKAP5 cytoskeleton associated protein 5 0.0252862
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0252719
CLINT1 clathrin interactor 1 0.0251665
CEP70 centrosomal protein 70kDa 0.0250559
SPTBN1 spectrin, beta, non-erythrocytic 1 0.024975
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) 0.0249622
GOLT1B golgi transport 1B 0.0246223
CDK5RAP2 CDK5 regulatory subunit associated protein 2 0.0241526
PDE4D phosphodiesterase 4D, cAMP-specific 0.0234454
XPO1 exportin 1 0.0234388
CEP250 centrosomal protein 250kDa 0.0233963
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0230983
ARF4 ADP-ribosylation factor 4 0.0227326
TMEM263 transmembrane protein 263 0.0223254
SUCO SUN domain containing ossification factor 0.0222668
SPAG5 sperm associated antigen 5 0.0220168
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.021979
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.0219172
NAA35 N(alpha)-acetyltransferase 35, NatC auxiliary subunit 0.0218099
COG5 component of oligomeric golgi complex 5 0.021783
MARCHF7 membrane associated ring-CH-type finger 7 0.0217393
H1-4 H1.4 linker histone, cluster member 0.0216923
TBC1D5 TBC1 domain family, member 5 0.0216349
KIF23 kinesin family member 23 0.0216227
HMMR hyaluronan-mediated motility receptor (RHAMM) 0.021432
TMEM39A transmembrane protein 39A 0.0213791
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta 0.0213706
CENPF centromere protein F, 350/400kDa 0.0212933
BTN3A3 butyrophilin, subfamily 3, member A3 0.0210593
PANK3 pantothenate kinase 3 0.0210311
PEAK1 pseudopodium-enriched atypical kinase 1 0.0210299
CABIN1 calcineurin binding protein 1 0.0210198
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) 0.0210189
ANLN anillin, actin binding protein 0.0210185
RICTOR RPTOR independent companion of MTOR, complex 2 0.0209889
ZFAND6 zinc finger, AN1-type domain 6 0.020944
ORC4 origin recognition complex, subunit 4 0.0208803
NR1D2 nuclear receptor subfamily 1, group D, member 2 0.0208629
RBM22 RNA binding motif protein 22 0.0208596
ARCN1 archain 1 0.0207172
PREPL prolyl endopeptidase-like 0.0206904
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0206203
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 0.0204386
ALG9 ALG9, alpha-1,2-mannosyltransferase 0.0204321
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0203306
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 0.020309
FNIP1 folliculin interacting protein 1 0.0202231
HDLBP high density lipoprotein binding protein 0.020162
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae) 0.0201167
CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 0.0200719
FANCI Fanconi anemia, complementation group I 0.0200611

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.254487
VIM vimentin -0.145193
FNDC3B fibronectin type III domain containing 3B -0.141846
TMSB10 thymosin beta 10 -0.136716
IGFBP3 insulin-like growth factor binding protein 3 -0.122817
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.102951
PRKCA protein kinase C, alpha -0.0973602
LDHA lactate dehydrogenase A -0.0797563
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0794834
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0778265
HMGA2 high mobility group AT-hook 2 -0.0767065
CD44 CD44 molecule (Indian blood group) -0.0692626
ZBTB20 zinc finger and BTB domain containing 20 -0.0678757
NDRG1 N-myc downstream regulated 1 -0.0660134
ANGPTL4 angiopoietin-like 4 -0.065557
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0635226
FLNB filamin B, beta -0.059854
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0595686
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0581436
BASP1 brain abundant, membrane attached signal protein 1 -0.0580962
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0572051
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0559196
ZNF609 zinc finger protein 609 -0.0536434
IGF2 insulin-like growth factor 2 -0.0533808
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0532108
FMN1 formin 1 -0.0532076
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0529354
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0525002
PKM pyruvate kinase, muscle -0.0514862
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0511538
ATM ATM serine/threonine kinase -0.0506924
TPT1 tumor protein, translationally-controlled 1 -0.0505931
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.049554
NT5E 5'-nucleotidase, ecto (CD73) -0.0468629
SH3KBP1 SH3-domain kinase binding protein 1 -0.0466549
GPC6 glypican 6 -0.0463802
DST dystonin -0.0440207
MAP1B microtubule-associated protein 1B -0.0431674
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase -0.0431401
LOC112694756 uncharaterized LOC112694756 -0.0430375
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0418506
MT2A metallothionein 2A -0.0418124
PTMA prothymosin, alpha -0.041735
ZMYND8 zinc finger, MYND-type containing 8 -0.041317
EGR1 early growth response 1 -0.0412064
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0403967
AHNAK AHNAK nucleoprotein -0.0402484
MYO9B myosin IXB -0.0402337
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.039949
VCL vinculin -0.0395105
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0391745
PYGL phosphorylase, glycogen, liver -0.0386131
RNF213 ring finger protein 213 -0.0385592
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0385382
IL1RAP interleukin 1 receptor accessory protein -0.0384302
PTK2 protein tyrosine kinase 2 -0.0379595
RPL35A ribosomal protein L35a -0.0376294
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0375039
FTH1 ferritin, heavy polypeptide 1 -0.0368795
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0365506
SLC38A2 solute carrier family 38, member 2 -0.035376
MBNL1 muscleblind-like splicing regulator 1 -0.0349782
CDCP1 CUB domain containing protein 1 -0.0348018
EFNA5 ephrin-A5 -0.0347566
AKAP12 A kinase (PRKA) anchor protein 12 -0.0345843
VMP1 vacuole membrane protein 1 -0.0343517
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0341671
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0340709
HLA-B major histocompatibility complex, class I, B -0.0338053
CLIP1 CAP-GLY domain containing linker protein 1 -0.0336423
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.033243
CEMIP2 cell migration inducing hyaluronidase 2 -0.0327646
EGFR epidermal growth factor receptor -0.0327036
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0325854
KMT2C lysine (K)-specific methyltransferase 2C -0.0324445
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.0319949
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0318992
DENND5B DENN/MADD domain containing 5B -0.0318555
CAVIN1 caveolae associated protein 1 -0.0316946
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 -0.0316902
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.0313631
DNER delta/notch-like EGF repeat containing -0.031307
WWTR1 WW domain containing transcription regulator 1 -0.0303382
BHLHE40 basic helix-loop-helix family, member e40 -0.030324
ENO2 enolase 2 (gamma, neuronal) -0.0301159
ERCC6L2 excision repair cross-complementation group 6-like 2 -0.0298779
SVIL supervillin -0.0297795
PLEK2 pleckstrin 2 -0.0296151
ANO6 anoctamin 6 -0.0293226
IER3 immediate early response 3 -0.0291048
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 -0.0287111
RGS17 regulator of G-protein signaling 17 -0.0284867
HDAC9 histone deacetylase 9 -0.0284413
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0283693
RIN2 Ras and Rab interactor 2 -0.0282386
EPAS1 endothelial PAS domain protein 1 -0.0280397
DLGAP4 discs, large (Drosophila) homolog-associated protein 4 -0.0279756
RBMS1 RNA binding motif, single stranded interacting protein 1 -0.0279354
IFITM3 interferon induced transmembrane protein 3 -0.0277141
RPS13 ribosomal protein S13 -0.0273508