Sulfatinib_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sulfatinib perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Sulfatinib_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NAMPT nicotinamide phosphoribosyltransferase 0.229176
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.222022
CXCL8 chemokine (C-X-C motif) ligand 8 0.131218
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.123964
AHR aryl hydrocarbon receptor 0.0951366
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.083926
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0705286
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0684102
CANX calnexin 0.0674311
FNDC3B fibronectin type III domain containing 3B 0.0669994
TXNIP thioredoxin interacting protein 0.0642581
OGA O-GlcNAcase 0.0613757
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0605678
FTH1 ferritin, heavy polypeptide 1 0.0601364
NRIP1 nuclear receptor interacting protein 1 0.0561286
PRRC2C proline-rich coiled-coil 2C 0.0559366
GOLGA4 golgin A4 0.0551197
ZNF292 zinc finger protein 292 0.054001
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0534199
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0531008
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0529084
RUNX2 runt-related transcription factor 2 0.0518702
ELL2 elongation factor, RNA polymerase II, 2 0.0510168
ETNK1 ethanolamine kinase 1 0.0509006
RNF145 ring finger protein 145 0.050307
EREG epiregulin 0.0501063
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0490412
PTK2 protein tyrosine kinase 2 0.0488068
MCTP2 multiple C2 domains, transmembrane 2 0.0486836
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0486823
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0468141
TFG TRK-fused gene 0.046479
TENT2 terminal nucleotidyltransferase 2 0.046142
CAB39 calcium binding protein 39 0.0457539
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.0454732
TM9SF3 transmembrane 9 superfamily member 3 0.0452493
KMT2E lysine (K)-specific methyltransferase 2E 0.044962
ITGA1 integrin, alpha 1 0.0439845
SUCO SUN domain containing ossification factor 0.043441
CD109 CD109 molecule 0.0431613
ACBD3 acyl-CoA binding domain containing 3 0.042529
TPR translocated promoter region, nuclear basket protein 0.0418014
SOD2 superoxide dismutase 2, mitochondrial 0.0415983
COPA coatomer protein complex, subunit alpha 0.0412753
RICTOR RPTOR independent companion of MTOR, complex 2 0.0402957
OSMR oncostatin M receptor 0.0402642
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0401781
CENPF centromere protein F, 350/400kDa 0.0400634
EPS8 epidermal growth factor receptor pathway substrate 8 0.0400078
RBM39 RNA binding motif protein 39 0.0395437
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0394439
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0392895
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0380212
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0378901
RTN4 reticulon 4 0.0375932
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0373549
SPRED1 sprouty-related, EVH1 domain containing 1 0.0370565
HELZ helicase with zinc finger 0.036994
NEK7 NIMA-related kinase 7 0.0366631
SEC23A Sec23 homolog A (S. cerevisiae) 0.0363816
MYH9 myosin, heavy chain 9, non-muscle 0.035115
KMT2C lysine (K)-specific methyltransferase 2C 0.0350996
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0350981
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 0.0350754
MNAT1 MNAT CDK-activating kinase assembly factor 1 0.034833
RB1CC1 RB1-inducible coiled-coil 1 0.034791
WAC WW domain containing adaptor with coiled-coil 0.0346732
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0344604
JMJD1C jumonji domain containing 1C 0.034336
CTNND1 catenin (cadherin-associated protein), delta 1 0.0342151
KTN1 kinectin 1 (kinesin receptor) 0.0341975
LIFR leukemia inhibitory factor receptor alpha 0.034168
PELO pelota homolog (Drosophila) 0.0341497
COG5 component of oligomeric golgi complex 5 0.0340258
NUP58 nucleoporin 58 0.0338035
SLTM SAFB-like, transcription modulator 0.0335029
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.0332823
SMOX spermine oxidase 0.0331654
NRP1 neuropilin 1 0.0328763
SMAD3 SMAD family member 3 0.0325863
IL6ST interleukin 6 signal transducer 0.0324617
APP amyloid beta (A4) precursor protein 0.0324004
CDC73 cell division cycle 73 0.032214
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0321832
FAM13A family with sequence similarity 13, member A 0.0321478
PTBP3 polypyrimidine tract binding protein 3 0.032042
SFXN1 sideroflexin 1 0.0318789
ANKRD28 ankyrin repeat domain 28 0.0318435
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0317299
DST dystonin 0.0316995
USP12 ubiquitin specific peptidase 12 0.0314739
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0312189
APLP2 amyloid beta (A4) precursor-like protein 2 0.0310516
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0307695
ADAM17 ADAM metallopeptidase domain 17 0.0307417
IRAK3 interleukin-1 receptor-associated kinase 3 0.0307298
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0307272
WDR26 WD repeat domain 26 0.0306546
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0306055
WDR45B WD repeat domain 45B 0.0299648

decreased expression

Symbol Name Standardized Value
NRG1 neuregulin 1 -0.248979
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.129772
HMGA2 high mobility group AT-hook 2 -0.110722
TMSB10 thymosin beta 10 -0.097525
EFNA5 ephrin-A5 -0.0826284
FN1 fibronectin 1 -0.0774397
NDRG1 N-myc downstream regulated 1 -0.0766773
IFI27 interferon, alpha-inducible protein 27 -0.0738562
ACTG1 actin gamma 1 -0.0702238
VCL vinculin -0.0679823
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0650276
MRPS6 mitochondrial ribosomal protein S6 -0.0643944
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.063922
STC2 stanniocalcin 2 -0.0604858
SOX4 SRY (sex determining region Y)-box 4 -0.0583553
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0579489
AEBP2 AE binding protein 2 -0.0571684
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0561119
S100A6 S100 calcium binding protein A6 -0.055935
INTS6 integrator complex subunit 6 -0.0529961
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0525598
LOC102724023 ES1 protein homolog, mitochondrial -0.0523719
PTMA prothymosin, alpha -0.0503137
TPT1 tumor protein, translationally-controlled 1 -0.0494031
LIMCH1 LIM and calponin homology domains 1 -0.0462581
GRB10 growth factor receptor-bound protein 10 -0.0451433
SYT1 synaptotagmin I -0.0413208
TRIO trio Rho guanine nucleotide exchange factor -0.0389294
PALLD palladin, cytoskeletal associated protein -0.0386664
S100A10 S100 calcium binding protein A10 -0.0385413
POTEF POTE ankyrin domain family, member F -0.0381957
VIM vimentin -0.0380482
RASAL2 RAS protein activator like 2 -0.0375897
SLC35F3 solute carrier family 35, member F3 -0.0375552
SFRP1 secreted frizzled-related protein 1 -0.0375492
EGR1 early growth response 1 -0.0375481
FTL ferritin, light polypeptide -0.0369979
CADM1 cell adhesion molecule 1 -0.0369015
DNAH5 dynein, axonemal, heavy chain 5 -0.0352684
MCL1 myeloid cell leukemia 1 -0.0350317
SOX5 SRY (sex determining region Y)-box 5 -0.0349776
HMGA1 high mobility group AT-hook 1 -0.0338994
LMNA lamin A/C -0.0337577
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0336096
TMSB4X thymosin beta 4, X-linked -0.0332138
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0329756
HLA-B major histocompatibility complex, class I, B -0.0326054
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0321538
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.031744
PRKCA protein kinase C, alpha -0.0314444
NTN4 netrin 4 -0.0307232
TENM4 teneurin transmembrane protein 4 -0.0303394
LRRC23 leucine rich repeat containing 23 -0.0303104
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0299619
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0297867
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.02958
ABR active BCR-related -0.0292826
EXT1 exostosin glycosyltransferase 1 -0.0292745
DUSP6 dual specificity phosphatase 6 -0.029263
SLC38A2 solute carrier family 38, member 2 -0.0289193
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0286843
LY6E lymphocyte antigen 6 complex, locus E -0.0284173
FLNB filamin B, beta -0.0282298
TSHZ2 teashirt zinc finger homeobox 2 -0.0279794
EGFR epidermal growth factor receptor -0.0276196
TM4SF1 transmembrane 4 L six family member 1 -0.0275985
ASPH aspartate beta-hydroxylase -0.0273623
IGFBP3 insulin-like growth factor binding protein 3 -0.0271426
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0270715
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.02699
CTBP2 C-terminal binding protein 2 -0.0269594
RPL35A ribosomal protein L35a -0.0268458
IFI6 interferon, alpha-inducible protein 6 -0.0267777
WSB1 WD repeat and SOCS box containing 1 -0.0266307
MYOF myoferlin -0.0264456
UBASH3B ubiquitin associated and SH3 domain containing B -0.0262074
IER3 immediate early response 3 -0.0260717
AKAP12 A kinase (PRKA) anchor protein 12 -0.0258864
TGFB1 transforming growth factor, beta 1 -0.0257018
RANBP17 RAN binding protein 17 -0.0252434
RAI14 retinoic acid induced 14 -0.0252329
JUN jun proto-oncogene -0.0247855
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0241437
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0240096
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.0239547
MT2A metallothionein 2A -0.0238549
IGFBP5 insulin-like growth factor binding protein 5 -0.0238309
GNAS GNAS complex locus -0.0237915
CCND1 cyclin D1 -0.0237542
LOXL2 lysyl oxidase-like 2 -0.0235895
RPL9 ribosomal protein L9 -0.0232368
TNS3 tensin 3 -0.0230398
SAMD4A sterile alpha motif domain containing 4A -0.0226457
PLIN2 perilipin 2 -0.0226236
SHC3 SHC (Src homology 2 domain containing) transforming protein 3 -0.0217488
MLPH melanophilin -0.0216866
RPS24 ribosomal protein S24 -0.0214458
CTSD cathepsin D -0.0213583
FBXO11 F-box protein 11 -0.0213302
MX2 MX dynamin-like GTPase 2 -0.0210536