Sulfisoxazole_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sulfisoxazole perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Sulfisoxazole_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MEF2A myocyte enhancer factor 2A 0.064135
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0623492
MT2A metallothionein 2A 0.0593077
LMO7 LIM domain 7 0.0571445
PRRC2C proline-rich coiled-coil 2C 0.0563977
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0546513
OSMR oncostatin M receptor 0.0522992
SLK STE20-like kinase 0.0517706
PLAT plasminogen activator, tissue 0.0510557
BCL2L1 BCL2-like 1 0.0509128
RPL4 ribosomal protein L4 0.050036
TGM2 transglutaminase 2 0.0485952
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0463814
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.045258
ARHGAP21 Rho GTPase activating protein 21 0.0444231
KTN1 kinectin 1 (kinesin receptor) 0.0442
PDE4D phosphodiesterase 4D, cAMP-specific 0.0426303
B2M beta-2-microglobulin 0.0426003
BCAR3 breast cancer anti-estrogen resistance 3 0.0424566
TPM3 tropomyosin 3 0.0420411
HLA-B major histocompatibility complex, class I, B 0.0416547
CEMIP cell migration inducing protein, hyaluronan binding 0.0410381
KMT2E lysine (K)-specific methyltransferase 2E 0.0410089
ITGB4 integrin, beta 4 0.0396569
MYH9 myosin, heavy chain 9, non-muscle 0.038707
IFI44L interferon-induced protein 44-like 0.0385505
HLA-A major histocompatibility complex, class I, A 0.0380284
AKAP12 A kinase (PRKA) anchor protein 12 0.0373375
NCOR2 nuclear receptor corepressor 2 0.0365966
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0361734
EZR ezrin 0.0360287
YBX3 Y box binding protein 3 0.0359311
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0354338
ASPH aspartate beta-hydroxylase 0.0354243
APLP2 amyloid beta (A4) precursor-like protein 2 0.0347108
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0345217
PLEC plectin 0.0337378
PARP4 poly (ADP-ribose) polymerase family, member 4 0.0335494
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0335421
TXNIP thioredoxin interacting protein 0.0334774
DSPP dentin sialophosphoprotein 0.0334026
DOCK5 dedicator of cytokinesis 5 0.0326662
DHFR dihydrofolate reductase 0.0323043
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 0.0319237
IFI6 interferon, alpha-inducible protein 6 0.0318602
KRT17 keratin 17, type I 0.0317654
RPS2 ribosomal protein S2 0.0302642
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0302389
MACF1 microtubule-actin crosslinking factor 1 0.0300435
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0300045
SEPTIN9 septin 9 0.0300014
BARX2 BARX homeobox 2 0.029403
RBM39 RNA binding motif protein 39 0.0291797
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0284027
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0279639
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.0278157
ANXA11 annexin A11 0.0275354
IGFBP6 insulin-like growth factor binding protein 6 0.0274581
HMGN2 high mobility group nucleosomal binding domain 2 0.0274434
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0270203
LUZP1 leucine zipper protein 1 0.0269457
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0269341
ANGPTL4 angiopoietin-like 4 0.0269104
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.026752
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.026724
SRRM2 serine/arginine repetitive matrix 2 0.0264632
RIN2 Ras and Rab interactor 2 0.0264456
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0261232
ANKRD12 ankyrin repeat domain 12 0.0260556
PDLIM1 PDZ and LIM domain 1 0.025996
VIM vimentin 0.0259287
UGCG UDP-glucose ceramide glucosyltransferase 0.0259207
ESYT2 extended synaptotagmin-like protein 2 0.0257406
AKAP13 A kinase (PRKA) anchor protein 13 0.0254286
FOXP1 forkhead box P1 0.0253794
NAMPT nicotinamide phosphoribosyltransferase 0.0253224
TNS4 tensin 4 0.0252545
SLCO4A1 solute carrier organic anion transporter family, member 4A1 0.0252472
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0251947
TXNRD1 thioredoxin reductase 1 0.0250092
TMF1 TATA element modulatory factor 1 0.0249237
IFI44 interferon-induced protein 44 0.024751
OGA O-GlcNAcase 0.0246218
OPTN optineurin 0.0245147
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0243184
SPTBN1 spectrin, beta, non-erythrocytic 1 0.024244
DSCAM Down syndrome cell adhesion molecule 0.0239313
RPL26 ribosomal protein L26 0.0239179
RPS12 ribosomal protein S12 0.0238254
RB1CC1 RB1-inducible coiled-coil 1 0.0235665
AOPEP aminopeptidase O (putative) 0.0234481
RPS18 ribosomal protein S18 0.0232861
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0232706
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0231033
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0230713
IFITM1 interferon induced transmembrane protein 1 0.0229301
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0225726
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0224454
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0221356
AKAP9 A kinase (PRKA) anchor protein 9 0.0219575

decreased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.238104
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.205878
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.139666
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.12721
INTS6 integrator complex subunit 6 -0.114124
DPYD dihydropyrimidine dehydrogenase -0.10399
AHNAK AHNAK nucleoprotein -0.0968135
TRIO trio Rho guanine nucleotide exchange factor -0.0956876
SULF1 sulfatase 1 -0.0882014
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 -0.0866891
POTEF POTE ankyrin domain family, member F -0.0844898
TPT1 tumor protein, translationally-controlled 1 -0.0771685
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0705403
CAV1 caveolin 1, caveolae protein, 22kDa -0.0685843
S100A10 S100 calcium binding protein A10 -0.0681398
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0677198
LDHA lactate dehydrogenase A -0.0668472
HM13 histocompatibility (minor) 13 -0.0649941
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0638803
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0614686
PDLIM5 PDZ and LIM domain 5 -0.0599044
IARS1 isoleucyl-tRNA synthetase 1 -0.0561077
GNAS GNAS complex locus -0.0507429
MORF4L2 mortality factor 4 like 2 -0.0499153
CANX calnexin -0.0498625
NDRG1 N-myc downstream regulated 1 -0.049812
PDIA3 protein disulfide isomerase family A, member 3 -0.0495652
RPS24 ribosomal protein S24 -0.0495485
SQSTM1 sequestosome 1 -0.0486295
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.047452
RPS25 ribosomal protein S25 -0.0469316
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0467832
ANXA2 annexin A2 -0.0438898
STC1 stanniocalcin 1 -0.0421832
RPS23 ribosomal protein S23 -0.0417567
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0404335
SEC31A SEC31 homolog A (S. cerevisiae) -0.0402912
RPS13 ribosomal protein S13 -0.0394809
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0392386
COPB1 coatomer protein complex, subunit beta 1 -0.0374937
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0366095
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0360518
ALCAM activated leukocyte cell adhesion molecule -0.035931
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0356949
PLTP phospholipid transfer protein -0.0355768
SDCBP syndecan binding protein (syntenin) -0.0354549
S100A2 S100 calcium binding protein A2 -0.0350079
ARF1 ADP-ribosylation factor 1 -0.0349422
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0347657
UFM1 ubiquitin-fold modifier 1 -0.0347591
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -0.0344642
RPS21 ribosomal protein S21 -0.03444
PGK1 phosphoglycerate kinase 1 -0.0343302
ABI3BP ABI family, member 3 (NESH) binding protein -0.033992
WASF2 WAS protein family, member 2 -0.0329669
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0329267
VDAC1 voltage-dependent anion channel 1 -0.0328226
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0325827
FLNB filamin B, beta -0.0321078
RPL11 ribosomal protein L11 -0.0318312
ACTG1 actin gamma 1 -0.0316666
RPL27A ribosomal protein L27a -0.0314998
RPL19 ribosomal protein L19 -0.0310908
RPS29 ribosomal protein S29 -0.0310675
TTC3 tetratricopeptide repeat domain 3 -0.0310562
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0308361
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 -0.0306694
RALY RALY heterogeneous nuclear ribonucleoprotein -0.0302786
DENND1A DENN/MADD domain containing 1A -0.0300999
TNS3 tensin 3 -0.0300874
SEC24D SEC24 family member D -0.0300485
CLIC4 chloride intracellular channel 4 -0.0299575
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa -0.0299216
EMP1 epithelial membrane protein 1 -0.0292226
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0291227
DLG1 discs, large homolog 1 (Drosophila) -0.0290925
RUNX1 runt-related transcription factor 1 -0.0289855
CAVIN1 caveolae associated protein 1 -0.0288242
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0284533
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.0284216
ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa -0.0282562
KRT6A keratin 6A, type II -0.0281111
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0280547
CNOT1 CCR4-NOT transcription complex, subunit 1 -0.0275698
MBNL2 muscleblind-like splicing regulator 2 -0.0275455
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -0.0273955
RAB1A RAB1A, member RAS oncogene family -0.0273438
DGKH diacylglycerol kinase, eta -0.0271999
ANXA1 annexin A1 -0.0270326
PPIB peptidylprolyl isomerase B (cyclophilin B) -0.0268543
MECOM MDS1 and EVI1 complex locus -0.0267414
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0265284
PLS3 plastin 3 -0.0260542
PRSS23 protease, serine, 23 -0.0260131
ZNF217 zinc finger protein 217 -0.0258276
CRACDL CRACD like -0.0257886
FSCN1 fascin actin-bundling protein 1 -0.0253965
LMAN1 lectin, mannose-binding, 1 -0.0251357
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0250011
ATP5F1B ATP synthase F1 subunit beta -0.0247364