Sulfisoxazole_KATO III Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sulfisoxazole perturbation in KATO III cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Sulfisoxazole_KATO III drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LMO7 LIM domain 7 0.146159
EZR ezrin 0.0759944
TPT1 tumor protein, translationally-controlled 1 0.0757269
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0724036
EMP1 epithelial membrane protein 1 0.0690962
RBM39 RNA binding motif protein 39 0.0671168
RPS6 ribosomal protein S6 0.0606522
ANXA1 annexin A1 0.0561575
ASPH aspartate beta-hydroxylase 0.0505483
DOCK5 dedicator of cytokinesis 5 0.0476586
DSPP dentin sialophosphoprotein 0.0456161
PLEC plectin 0.0452017
FGFR2 fibroblast growth factor receptor 2 0.0446033
SMAD3 SMAD family member 3 0.0443016
AKAP13 A kinase (PRKA) anchor protein 13 0.043783
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) 0.0434308
PTMA prothymosin, alpha 0.0422853
MYH9 myosin, heavy chain 9, non-muscle 0.0409385
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.039613
RPL35A ribosomal protein L35a 0.0389092
ERRFI1 ERBB receptor feedback inhibitor 1 0.0373049
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0371774
NDRG1 N-myc downstream regulated 1 0.0363756
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.035233
KLF5 Kruppel-like factor 5 (intestinal) 0.0347527
MYOF myoferlin 0.0338785
DST dystonin 0.0333707
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0323908
AREG amphiregulin 0.0320453
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0319194
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0318063
MACF1 microtubule-actin crosslinking factor 1 0.0312279
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0305091
RPS8 ribosomal protein S8 0.0304693
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0302378
MBNL2 muscleblind-like splicing regulator 2 0.0302195
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0297272
AHNAK AHNAK nucleoprotein 0.0295971
OGA O-GlcNAcase 0.029591
MPRIP myosin phosphatase Rho interacting protein 0.0290347
BAIAP2L1 BAI1-associated protein 2-like 1 0.028928
SEPTIN9 septin 9 0.0288043
LMNA lamin A/C 0.0287369
EFNA5 ephrin-A5 0.0282912
ZSWIM6 zinc finger, SWIM-type containing 6 0.027823
FRMD5 FERM domain containing 5 0.0276713
ARHGAP29 Rho GTPase activating protein 29 0.0269898
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.0269805
ESYT2 extended synaptotagmin-like protein 2 0.0268736
RPL26 ribosomal protein L26 0.0259765
EXT1 exostosin glycosyltransferase 1 0.0257522
SOX4 SRY (sex determining region Y)-box 4 0.0255206
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0254489
PSD3 pleckstrin and Sec7 domain containing 3 0.0253294
KDM3A lysine (K)-specific demethylase 3A 0.0253018
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0252718
PARP4 poly (ADP-ribose) polymerase family, member 4 0.0250366
LAMB3 laminin, beta 3 0.0249636
TM4SF1 transmembrane 4 L six family member 1 0.0248119
PRELID2 PRELI domain containing 2 0.0247155
EIF1 eukaryotic translation initiation factor 1 0.0244649
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 0.0243569
AKAP9 A kinase (PRKA) anchor protein 9 0.0241919
SQSTM1 sequestosome 1 0.0240493
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0238603
EIF4H eukaryotic translation initiation factor 4H 0.0237605
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0229754
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.022898
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0227755
RPS19 ribosomal protein S19 0.0225835
RPL37A ribosomal protein L37a 0.0225753
LCN2 lipocalin 2 0.0224804
EGFR epidermal growth factor receptor 0.0224317
CTNND1 catenin (cadherin-associated protein), delta 1 0.0222321
FTL ferritin, light polypeptide 0.022209
USP53 ubiquitin specific peptidase 53 0.0219736
RPL23 ribosomal protein L23 0.0217359
NCEH1 neutral cholesterol ester hydrolase 1 0.0215937
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0215037
TXNRD1 thioredoxin reductase 1 0.021237
HMGB2 high mobility group box 2 0.021102
JMJD1C jumonji domain containing 1C 0.0210173
SNX9 sorting nexin 9 0.0207735
RASEF RAS and EF-hand domain containing 0.0206674
EPS8 epidermal growth factor receptor pathway substrate 8 0.0206522
HLA-A major histocompatibility complex, class I, A 0.0205304
AKAP12 A kinase (PRKA) anchor protein 12 0.0200651
PPL periplakin 0.0198221
RPS29 ribosomal protein S29 0.0198194
SPAG9 sperm associated antigen 9 0.0197556
TRIO trio Rho guanine nucleotide exchange factor 0.0195502
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0194976
LURAP1L leucine rich adaptor protein 1-like 0.0191313
FNIP1 folliculin interacting protein 1 0.0188127
WSB1 WD repeat and SOCS box containing 1 0.0188007
HKDC1 hexokinase domain containing 1 0.018745
ZBTB20 zinc finger and BTB domain containing 20 0.0186904
HMGN2 high mobility group nucleosomal binding domain 2 0.0185577
ALCAM activated leukocyte cell adhesion molecule 0.0185081
TMC5 transmembrane channel-like 5 0.0184319

decreased expression

Symbol Name Standardized Value
NPSR1 neuropeptide S receptor 1 -0.209414
GMDS GDP-mannose 4,6-dehydratase -0.196639
PDIA3 protein disulfide isomerase family A, member 3 -0.108594
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0994998
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 -0.0882757
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0714601
POTEF POTE ankyrin domain family, member F -0.068753
MUC17 mucin 17, cell surface associated -0.0611727
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0567858
CDK6 cyclin-dependent kinase 6 -0.0553438
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.0521613
CD46 CD46 molecule, complement regulatory protein -0.0509825
TNIK TRAF2 and NCK interacting kinase -0.0505752
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0499327
MAML2 mastermind-like 2 (Drosophila) -0.0498712
SAMD12 sterile alpha motif domain containing 12 -0.049503
ANXA2 annexin A2 -0.0438675
TMEM123 transmembrane protein 123 -0.0423455
INSIG1 insulin induced gene 1 -0.0417723
LOC112694756 uncharaterized LOC112694756 -0.0417195
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0410847
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0408745
CEMIP cell migration inducing protein, hyaluronan binding -0.0402263
ACACA acetyl-CoA carboxylase alpha -0.0399071
S100A6 S100 calcium binding protein A6 -0.0388111
GPX2 glutathione peroxidase 2 -0.0383216
LYZ lysozyme -0.0361174
C6ORF132 chromosome 6 open reading frame 132 -0.0359258
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -0.035006
LPP LIM domain containing preferred translocation partner in lipoma -0.034427
YAP1 Yes-associated protein 1 -0.034316
TRPS1 trichorhinophalangeal syndrome I -0.0343029
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0337432
PRSS3 protease, serine, 3 -0.0331005
HMGA1 high mobility group AT-hook 1 -0.0329384
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0327903
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 -0.0326204
WARS1 tryptophanyl-tRNA synthetase 1 -0.0323793
RUNX1 runt-related transcription factor 1 -0.0323652
TCF12 transcription factor 12 -0.0322233
FAT1 FAT atypical cadherin 1 -0.0317756
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0314998
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0312967
MCU mitochondrial calcium uniporter -0.0310131
FASN fatty acid synthase -0.0305448
RAB7A RAB7A, member RAS oncogene family -0.0293071
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0286966
PDIA6 protein disulfide isomerase family A, member 6 -0.0286944
PLSCR1 phospholipid scramblase 1 -0.0285283
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase -0.0283201
SULF2 sulfatase 2 -0.0278975
IARS1 isoleucyl-tRNA synthetase 1 -0.0278412
CCNL1 cyclin L1 -0.0274
PKM pyruvate kinase, muscle -0.0271308
ABHD2 abhydrolase domain containing 2 -0.0270925
SH3RF1 SH3 domain containing ring finger 1 -0.0268064
ARHGAP6 Rho GTPase activating protein 6 -0.0267321
CNOT1 CCR4-NOT transcription complex, subunit 1 -0.0263915
B2M beta-2-microglobulin -0.0263803
TMBIM6 transmembrane BAX inhibitor motif containing 6 -0.0263167
VEGFA vascular endothelial growth factor A -0.0262061
APOL6 apolipoprotein L, 6 -0.0261543
EHBP1 EH domain binding protein 1 -0.0259045
SPINT2 serine peptidase inhibitor, Kunitz type, 2 -0.0257296
TAPBP TAP binding protein (tapasin) -0.0251215
ACSS2 acyl-CoA synthetase short-chain family member 2 -0.0247967
FTH1 ferritin, heavy polypeptide 1 -0.0247567
MECOM MDS1 and EVI1 complex locus -0.0246249
CAMKMT calmodulin-lysine N-methyltransferase -0.0245841
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0244278
ETNK1 ethanolamine kinase 1 -0.0243463
CLDN7 claudin 7 -0.0242438
IRF1 interferon regulatory factor 1 -0.0241717
EGR1 early growth response 1 -0.024081
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 -0.0239848
MSMO1 methylsterol monooxygenase 1 -0.0238473
TNRC18 trinucleotide repeat containing 18 -0.0236499
MUC1 mucin 1, cell surface associated -0.0233631
DLG1 discs, large homolog 1 (Drosophila) -0.023013
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.022997
EPSTI1 epithelial stromal interaction 1 (breast) -0.0228791
ZFP36L2 ZFP36 ring finger protein-like 2 -0.0225676
DSTN destrin (actin depolymerizing factor) -0.0224993
ARHGAP32 Rho GTPase activating protein 32 -0.022487
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.022354
AVL9 AVL9 homolog (S. cerevisiase) -0.0223453
TTYH3 tweety family member 3 -0.022329
TPM4 tropomyosin 4 -0.0217979
PKP4 plakophilin 4 -0.0217963
MX1 MX dynamin-like GTPase 1 -0.0215281
CTSE cathepsin E -0.0213465
HYOU1 hypoxia up-regulated 1 -0.0213015
TFRC transferrin receptor -0.0210411
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0210119
ATF7IP2 activating transcription factor 7 interacting protein 2 -0.0210046
WWC1 WW and C2 domain containing 1 -0.0207169
DPY19L1 dpy-19-like 1 (C. elegans) -0.0206581
XKR6 XK, Kell blood group complex subunit-related family, member 6 -0.020321
LDHA lactate dehydrogenase A -0.0202843
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0201816