Sulfisoxazole_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sulfisoxazole perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Sulfisoxazole_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CAPRIN2 caprin family member 2 0.125039
EZR ezrin 0.107634
MT2A metallothionein 2A 0.0934051
DST dystonin 0.0889386
WWTR1 WW domain containing transcription regulator 1 0.080525
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0754671
JUN jun proto-oncogene 0.0735843
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0646706
SPAG9 sperm associated antigen 9 0.0604505
TMSB10 thymosin beta 10 0.0602789
RPS19 ribosomal protein S19 0.0593321
KMT2E lysine (K)-specific methyltransferase 2E 0.0568283
RPL36 ribosomal protein L36 0.0551943
EGR1 early growth response 1 0.0530279
BIRC3 baculoviral IAP repeat containing 3 0.0519819
JMJD1C jumonji domain containing 1C 0.0498591
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0495624
RPS12 ribosomal protein S12 0.0490325
TSC22D2 TSC22 domain family, member 2 0.0474961
RPL4 ribosomal protein L4 0.0467016
ERRFI1 ERBB receptor feedback inhibitor 1 0.0454854
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0452777
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0438331
SQSTM1 sequestosome 1 0.043361
MACF1 microtubule-actin crosslinking factor 1 0.0401714
RAI1 retinoic acid induced 1 0.0395564
VMP1 vacuole membrane protein 1 0.0392376
RBM39 RNA binding motif protein 39 0.0384077
RPL35 ribosomal protein L35 0.0380757
RPS18 ribosomal protein S18 0.0379712
ANGPTL4 angiopoietin-like 4 0.0365885
WSB1 WD repeat and SOCS box containing 1 0.0364841
AMPD3 adenosine monophosphate deaminase 3 0.0361871
TXNRD1 thioredoxin reductase 1 0.0361121
BCAR3 breast cancer anti-estrogen resistance 3 0.0350256
ENO2 enolase 2 (gamma, neuronal) 0.0343958
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.0337381
RPL18 ribosomal protein L18 0.0336309
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0335105
RPS27 ribosomal protein S27 0.0324673
TMEM41B transmembrane protein 41B 0.0323724
FTL ferritin, light polypeptide 0.0322951
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0322533
LOC102724023 ES1 protein homolog, mitochondrial 0.0320711
RPL26 ribosomal protein L26 0.0317911
FTH1 ferritin, heavy polypeptide 1 0.0311615
AREG amphiregulin 0.0311419
PRRC2B proline-rich coiled-coil 2B 0.0303702
RPS2 ribosomal protein S2 0.0298509
SMAD3 SMAD family member 3 0.0298348
TOP1 topoisomerase (DNA) I 0.0296813
BRD2 bromodomain containing 2 0.0296037
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0293776
MYH9 myosin, heavy chain 9, non-muscle 0.0293389
RPS17 ribosomal protein S17 0.0286502
NPEPPS aminopeptidase puromycin sensitive 0.0286377
FMNL2 formin-like 2 0.0281418
SDK1 sidekick cell adhesion molecule 1 0.0280633
KTN1 kinectin 1 (kinesin receptor) 0.0279893
SRRM2 serine/arginine repetitive matrix 2 0.0279811
USP36 ubiquitin specific peptidase 36 0.0277008
ANKRD12 ankyrin repeat domain 12 0.0276136
ZNF292 zinc finger protein 292 0.0272498
KDM3A lysine (K)-specific demethylase 3A 0.0270146
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0269972
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0268875
WDR26 WD repeat domain 26 0.0266382
PUM1 pumilio RNA-binding family member 1 0.0265858
SYAP1 synapse associated protein 1 0.0262902
CORO1C coronin, actin binding protein, 1C 0.0262233
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.02617
NUP58 nucleoporin 58 0.0261563
KIF1B kinesin family member 1B 0.0261477
ABI1 abl-interactor 1 0.0260254
WAC WW domain containing adaptor with coiled-coil 0.0259248
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB 0.0256697
SLCO4A1 solute carrier organic anion transporter family, member 4A1 0.0251982
ACTN1 actinin, alpha 1 0.0250256
FXR1 fragile X mental retardation, autosomal homolog 1 0.0248291
BHLHE40 basic helix-loop-helix family, member e40 0.0245548
DNTTIP1 deoxynucleotidyltransferase, terminal, interacting protein 1 0.0242053
RTN4 reticulon 4 0.0236862
CTNND1 catenin (cadherin-associated protein), delta 1 0.0233494
CSNK1A1 casein kinase 1, alpha 1 0.0231606
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0230732
SPRED2 sprouty-related, EVH1 domain containing 2 0.0228578
PDE4D phosphodiesterase 4D, cAMP-specific 0.0226852
AFF4 AF4/FMR2 family, member 4 0.0224729
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0224371
RPL37A ribosomal protein L37a 0.0223623
PRRC2C proline-rich coiled-coil 2C 0.0222474
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.0222051
GPAT3 glycerol-3-phosphate acyltransferase 3 0.0221636
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.0220554
OSBPL8 oxysterol binding protein-like 8 0.0215949
ANKRD11 ankyrin repeat domain 11 0.021434
SRSF11 serine/arginine-rich splicing factor 11 0.0212475
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.020764
RB1CC1 RB1-inducible coiled-coil 1 0.0207533
RPL3 ribosomal protein L3 0.0206572

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.334372
VIM vimentin -0.207822
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.127109
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.123857
DLG1 discs, large homolog 1 (Drosophila) -0.109128
CD44 CD44 molecule (Indian blood group) -0.105827
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0930691
LDHA lactate dehydrogenase A -0.0785511
CADM2 cell adhesion molecule 2 -0.0749756
POTEF POTE ankyrin domain family, member F -0.0716568
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0709427
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0689262
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0639378
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0627766
TSC22D1 TSC22 domain family, member 1 -0.0608409
EHBP1 EH domain binding protein 1 -0.0586683
EXOC4 exocyst complex component 4 -0.0577863
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0576148
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0571587
TPT1 tumor protein, translationally-controlled 1 -0.0558286
RIGI RNA sensor RIG-I -0.0555766
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0551448
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0529258
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0509036
ZDHHC14 zinc finger, DHHC-type containing 14 -0.0500436
AHNAK AHNAK nucleoprotein -0.0493258
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0493249
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0491008
RPLP0 ribosomal protein, large, P0 -0.0487889
ADGRG6 adhesion G protein-coupled receptor G6 -0.0473101
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0467824
VDAC1 voltage-dependent anion channel 1 -0.0464173
TNS3 tensin 3 -0.0461281
DPYD dihydropyrimidine dehydrogenase -0.0453048
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.045
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0427312
HMGA1 high mobility group AT-hook 1 -0.0419871
CANX calnexin -0.041966
TP63 tumor protein p63 -0.0404669
EPHA4 EPH receptor A4 -0.0399297
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0396682
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0389822
ACTG1 actin gamma 1 -0.0383079
RPS23 ribosomal protein S23 -0.0376047
PDIA3 protein disulfide isomerase family A, member 3 -0.0368278
MBNL2 muscleblind-like splicing regulator 2 -0.0368225
ZMYND8 zinc finger, MYND-type containing 8 -0.0367452
CENPF centromere protein F, 350/400kDa -0.0365144
EFNA5 ephrin-A5 -0.0365138
RPS24 ribosomal protein S24 -0.0364759
PGK1 phosphoglycerate kinase 1 -0.0359784
EIF3M eukaryotic translation initiation factor 3, subunit M -0.0348865
RNF213 ring finger protein 213 -0.0344082
WARS1 tryptophanyl-tRNA synthetase 1 -0.0342554
COL5A2 collagen, type V, alpha 2 -0.0330577
IFIH1 interferon induced with helicase C domain 1 -0.0329042
CFAP299 cilia and flagella associated protein 299 -0.0325262
PNPT1 polyribonucleotide nucleotidyltransferase 1 -0.0324921
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0323866
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0323444
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0322175
GCLM glutamate-cysteine ligase, modifier subunit -0.0318873
SOD2 superoxide dismutase 2, mitochondrial -0.0315184
ZNF217 zinc finger protein 217 -0.0314188
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0308602
ADAR adenosine deaminase, RNA-specific -0.0308124
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa -0.0306148
CDK6 cyclin-dependent kinase 6 -0.0304528
SRGN serglycin -0.0303886
USP34 ubiquitin specific peptidase 34 -0.0301828
TTC28 tetratricopeptide repeat domain 28 -0.0300974
TMEM123 transmembrane protein 123 -0.0298755
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0293034
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0290356
DOCK11 dedicator of cytokinesis 11 -0.028995
DENND1A DENN/MADD domain containing 1A -0.0279233
CSDE1 cold shock domain containing E1, RNA-binding -0.0277901
HNRNPK heterogeneous nuclear ribonucleoprotein K -0.0277621
PLSCR1 phospholipid scramblase 1 -0.0276357
IFI6 interferon, alpha-inducible protein 6 -0.0276052
ANKRD17 ankyrin repeat domain 17 -0.0274995
SMC4 structural maintenance of chromosomes 4 -0.0273074
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0272604
CDK12 cyclin-dependent kinase 12 -0.0272109
TUBB tubulin, beta class I -0.0268559
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3 -0.0265288
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0263579
STXBP5 syntaxin binding protein 5 (tomosyn) -0.0263517
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0262522
RPL7A ribosomal protein L7a -0.0261939
PSD3 pleckstrin and Sec7 domain containing 3 -0.0261767
ANXA1 annexin A1 -0.0255489
BRWD1 bromodomain and WD repeat domain containing 1 -0.0252933
FBXO11 F-box protein 11 -0.0252248
TASOR2 transcription activation suppressor family member 2 -0.0251001
TMSB4X thymosin beta 4, X-linked -0.0250863
APP amyloid beta (A4) precursor protein -0.0250216
DPH6 diphthamine biosynthesis 6 -0.0249742
ARHGAP5 Rho GTPase activating protein 5 -0.0247648
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0245803