Sulfisoxazole_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sulfisoxazole perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Sulfisoxazole_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.138329
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.136256
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.122303
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.122032
MYH9 myosin, heavy chain 9, non-muscle 0.0961105
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0958901
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0940702
FTH1 ferritin, heavy polypeptide 1 0.085455
BHLHE40 basic helix-loop-helix family, member e40 0.0837358
DSPP dentin sialophosphoprotein 0.0823618
APLP2 amyloid beta (A4) precursor-like protein 2 0.0796104
RPL4 ribosomal protein L4 0.0740223
CALR calreticulin 0.0720701
ERRFI1 ERBB receptor feedback inhibitor 1 0.070078
PLEC plectin 0.0665404
IGFBP3 insulin-like growth factor binding protein 3 0.06562
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0589146
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0564572
ELL2 elongation factor, RNA polymerase II, 2 0.0558053
SAMD4A sterile alpha motif domain containing 4A 0.0556
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0525179
VEGFA vascular endothelial growth factor A 0.0521424
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0510542
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 0.0496167
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0474912
TPM3 tropomyosin 3 0.0471079
RPS12 ribosomal protein S12 0.0457725
ASPH aspartate beta-hydroxylase 0.0454331
LAMB3 laminin, beta 3 0.0446814
HSPA8 heat shock 70kDa protein 8 0.0439003
EEF2 eukaryotic translation elongation factor 2 0.0438256
SQSTM1 sequestosome 1 0.0436578
MSN moesin 0.0434562
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0430711
EZR ezrin 0.0423393
LAMC2 laminin, gamma 2 0.0417344
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0415585
HLA-A major histocompatibility complex, class I, A 0.0405352
RPS6 ribosomal protein S6 0.0400086
ZFP36L1 ZFP36 ring finger protein-like 1 0.0397257
ENO1 enolase 1, (alpha) 0.0383857
NAV2 neuron navigator 2 0.0381622
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0374498
EIF1 eukaryotic translation initiation factor 1 0.0373496
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0365159
MYO6 myosin VI 0.0361904
LOC112694756 uncharaterized LOC112694756 0.0361788
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0357217
HMGB2 high mobility group box 2 0.0347989
RPS3 ribosomal protein S3 0.0336401
TRIO trio Rho guanine nucleotide exchange factor 0.0335838
PPARD peroxisome proliferator-activated receptor delta 0.0333995
KTN1 kinectin 1 (kinesin receptor) 0.0332337
ANO6 anoctamin 6 0.0329553
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0323431
BRD2 bromodomain containing 2 0.0317805
RPS2 ribosomal protein S2 0.0314657
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0314279
GOLGA4 golgin A4 0.0313085
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0310631
HMGN2 high mobility group nucleosomal binding domain 2 0.0303618
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0301099
SDC4 syndecan 4 0.0299905
VMP1 vacuole membrane protein 1 0.029941
ANXA1 annexin A1 0.0295511
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.029144
JUP junction plakoglobin 0.0290991
PRRC2C proline-rich coiled-coil 2C 0.0290532
RPL3 ribosomal protein L3 0.0290348
SRRM2 serine/arginine repetitive matrix 2 0.0289458
RPS18 ribosomal protein S18 0.0282137
MYO5B myosin VB 0.0281136
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0279795
DTNA dystrobrevin, alpha 0.0277232
SET SET nuclear proto-oncogene 0.0276933
KIAA1217 KIAA1217 0.0276036
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0275454
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0274922
G0S2 G0/G1 switch 2 0.0274098
RPS17 ribosomal protein S17 0.0271506
TMF1 TATA element modulatory factor 1 0.0269214
GLS2 glutaminase 2 (liver, mitochondrial) 0.0268532
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0265656
RAP2B RAP2B, member of RAS oncogene family 0.0263315
MAP1B microtubule-associated protein 1B 0.0262144
CDCP1 CUB domain containing protein 1 0.0259921
ALCAM activated leukocyte cell adhesion molecule 0.0259234
FAM13A family with sequence similarity 13, member A 0.0259178
SEPTIN9 septin 9 0.0259107
RACK1 receptor for activated C kinase 1 0.0254452
EGR1 early growth response 1 0.0252387
MCTP2 multiple C2 domains, transmembrane 2 0.0248065
ICAM1 intercellular adhesion molecule 1 0.0247072
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0245979
MKI67 marker of proliferation Ki-67 0.0245912
ST14 suppression of tumorigenicity 14 (colon carcinoma) 0.0241455
YBX1 Y box binding protein 1 0.0240826
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0234562
AKAP13 A kinase (PRKA) anchor protein 13 0.0233944
DST dystonin 0.023262

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.131872
ACTG1 actin gamma 1 -0.0965942
TPT1 tumor protein, translationally-controlled 1 -0.084519
FN1 fibronectin 1 -0.074325
LPP LIM domain containing preferred translocation partner in lipoma -0.0625791
TMSB10 thymosin beta 10 -0.0557966
FTL ferritin, light polypeptide -0.0444677
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0382138
ZFAND3 zinc finger, AN1-type domain 3 -0.0368786
TSC22D2 TSC22 domain family, member 2 -0.0364774
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0357257
POTEF POTE ankyrin domain family, member F -0.0352414
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0347778
RAB1A RAB1A, member RAS oncogene family -0.0342166
H3-3B H3.3 histone B -0.0339326
RPL35A ribosomal protein L35a -0.0333129
TMEM263 transmembrane protein 263 -0.0333001
IFI16 interferon, gamma-inducible protein 16 -0.0330017
ANXA2 annexin A2 -0.0326932
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.0312031
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0307243
KDM3A lysine (K)-specific demethylase 3A -0.0307196
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0305027
RHEB Ras homolog enriched in brain -0.0303628
RPS23 ribosomal protein S23 -0.0284258
USP3 ubiquitin specific peptidase 3 -0.0278345
NPEPPS aminopeptidase puromycin sensitive -0.027341
CD2AP CD2-associated protein -0.0268948
S100A10 S100 calcium binding protein A10 -0.0266263
RPLP0 ribosomal protein, large, P0 -0.0261882
CERT1 ceramide transporter 1 -0.0251134
KDM5B lysine (K)-specific demethylase 5B -0.0250714
PDLIM5 PDZ and LIM domain 5 -0.024909
VDAC1 voltage-dependent anion channel 1 -0.0247515
MX2 MX dynamin-like GTPase 2 -0.0238151
CTSD cathepsin D -0.0236077
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0233103
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0230343
RNF213 ring finger protein 213 -0.0229615
S100A6 S100 calcium binding protein A6 -0.0226806
TRA2B transformer 2 beta homolog (Drosophila) -0.0226027
OSBPL3 oxysterol binding protein-like 3 -0.0224886
RPL34 ribosomal protein L34 -0.0221727
GNAS GNAS complex locus -0.0220273
ECT2 epithelial cell transforming 2 -0.021794
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0217245
CTBP2 C-terminal binding protein 2 -0.0214871
ANKRD28 ankyrin repeat domain 28 -0.0214013
ISG15 ISG15 ubiquitin-like modifier -0.0213935
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0213185
WASF2 WAS protein family, member 2 -0.0209486
IARS1 isoleucyl-tRNA synthetase 1 -0.0209459
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0209447
STRN3 striatin, calmodulin binding protein 3 -0.0207062
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0206452
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0203658
HMGA1 high mobility group AT-hook 1 -0.0202174
MAML2 mastermind-like 2 (Drosophila) -0.020002
SEC24D SEC24 family member D -0.0199565
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0199133
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0199052
LMAN1 lectin, mannose-binding, 1 -0.0196074
CAVIN1 caveolae associated protein 1 -0.0195531
BLZF1 basic leucine zipper nuclear factor 1 -0.0194401
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 -0.0193032
RASA2 RAS p21 protein activator 2 -0.0190181
LY6E lymphocyte antigen 6 complex, locus E -0.0189858
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) -0.0188753
CDC50A cell division cycle 50 P4-ATPase accessory subunit A -0.0187975
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.0187333
RPL27A ribosomal protein L27a -0.0187304
MAP3K13 mitogen-activated protein kinase kinase kinase 13 -0.0187065
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.018526
WARS1 tryptophanyl-tRNA synthetase 1 -0.0183708
G2E3 G2/M-phase specific E3 ubiquitin protein ligase -0.0181795
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0180936
BZW1 basic leucine zipper and W2 domains 1 -0.0180046
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 -0.0179706
CCND1 cyclin D1 -0.0179362
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0179021
SEC31A SEC31 homolog A (S. cerevisiae) -0.017813
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0177769
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0175013
RPL38 ribosomal protein L38 -0.0174497
SPATS2L spermatogenesis associated, serine-rich 2-like -0.0173493
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0173195
RPS24 ribosomal protein S24 -0.0173034
MON2 MON2 homolog (S. cerevisiae) -0.0170375
NPC2 Niemann-Pick disease, type C2 -0.0169134
MAN2A1 mannosidase, alpha, class 2A, member 1 -0.0167418
COPB1 coatomer protein complex, subunit beta 1 -0.0166564
PTMA prothymosin, alpha -0.0166254
PPP2R3A protein phosphatase 2, regulatory subunit B'', alpha -0.0165824
MSI2 musashi RNA-binding protein 2 -0.0164204
RAB2A RAB2A, member RAS oncogene family -0.01635
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 -0.0162695
SPDYA speedy/RINGO cell cycle regulator family member A -0.016225
NIPBL Nipped-B homolog (Drosophila) -0.0160742
YY1 YY1 transcription factor -0.0160516
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0158637