Sulfisoxazole_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sulfisoxazole perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Sulfisoxazole_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
RPL4 ribosomal protein L4 0.0481112
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0324706
SMYD3 SET and MYND domain containing 3 0.0303834
SDK1 sidekick cell adhesion molecule 1 0.0270626
DHFR dihydrofolate reductase 0.0260306
RPS18 ribosomal protein S18 0.0259919
ENO2 enolase 2 (gamma, neuronal) 0.025579
ZBTB20 zinc finger and BTB domain containing 20 0.023003
NQO1 NAD(P)H dehydrogenase, quinone 1 0.0224719
HLA-B major histocompatibility complex, class I, B 0.0220796
IRS1 insulin receptor substrate 1 0.0200481
TXNRD1 thioredoxin reductase 1 0.0194246
RBM25 RNA binding motif protein 25 0.0189556
MT2A metallothionein 2A 0.0188532
MBD5 methyl-CpG binding domain protein 5 0.0188469
OSMR oncostatin M receptor 0.0187703
ANKRD36 ankyrin repeat domain 36 0.0184521
TBC1D5 TBC1 domain family, member 5 0.0179097
CEP112 centrosomal protein 112kDa 0.0177648
OFD1 oral-facial-digital syndrome 1 0.0160773
PRELID2 PRELI domain containing 2 0.0160645
ENOX1 ecto-NOX disulfide-thiol exchanger 1 0.0158806
HLA-A major histocompatibility complex, class I, A 0.0155094
VIM vimentin 0.0150746
GIGYF2 GRB10 interacting GYF protein 2 0.0150631
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0150473
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0147568
DOCK3 dedicator of cytokinesis 3 0.0145609
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 0.0142791
NUMA1 nuclear mitotic apparatus protein 1 0.0142401
PYGB phosphorylase, glycogen; brain 0.0140222
BAZ2B bromodomain adjacent to zinc finger domain, 2B 0.0138599
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0137925
LARP7 La ribonucleoprotein domain family, member 7 0.0135628
IGFBP3 insulin-like growth factor binding protein 3 0.01354
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0134465
PABPN1 poly(A) binding protein, nuclear 1 0.0132361
DOCK1 dedicator of cytokinesis 1 0.0131974
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0131034
NT5C2 5'-nucleotidase, cytosolic II 0.0128528
NR6A1 nuclear receptor subfamily 6, group A, member 1 0.0128279
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0127791
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.0127022
SCMH1 sex comb on midleg homolog 1 (Drosophila) 0.0126105
AHCYL2 adenosylhomocysteinase-like 2 0.0124493
NAV2 neuron navigator 2 0.0123736
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0123144
KMT2D lysine (K)-specific methyltransferase 2D 0.0121952
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0121353
GLIS3 GLIS family zinc finger 3 0.0121144
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0120941
RIGI RNA sensor RIG-I 0.0119686
RPS3 ribosomal protein S3 0.0119683
ZNFX1 zinc finger, NFX1-type containing 1 0.0118575
XKR6 XK, Kell blood group complex subunit-related family, member 6 0.0118129
ANKRD12 ankyrin repeat domain 12 0.0117556
RHBDD1 rhomboid domain containing 1 0.0117455
KIAA1328 KIAA1328 0.0116456
SPG7 spastic paraplegia 7 (pure and complicated autosomal recessive) 0.0116425
NBR1 neighbor of BRCA1 gene 1 0.0116153
KLC1 kinesin light chain 1 0.0115811
ANKRD26 ankyrin repeat domain 26 0.0115711
HIPK2 homeodomain interacting protein kinase 2 0.011536
TMSB10 thymosin beta 10 0.0115141
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0113333
PTPRG protein tyrosine phosphatase, receptor type, G 0.0113245
PRRC2C proline-rich coiled-coil 2C 0.0112141
MPRIP myosin phosphatase Rho interacting protein 0.0111931
FLNB filamin B, beta 0.0111192
BPTF bromodomain PHD finger transcription factor 0.0109037
CHD9 chromodomain helicase DNA binding protein 9 0.0108647
NALF1 NALCN channel auxiliary factor 1 0.0108047
NDUFA10 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa 0.0106989
EXOC6 exocyst complex component 6 0.0105712
RPS2 ribosomal protein S2 0.0104837
SEPTIN9 septin 9 0.0104341
BOD1L1 biorientation of chromosomes in cell division 1-like 1 0.0104288
METTL15 methyltransferase like 15 0.0104141
SUMF1 sulfatase modifying factor 1 0.0103947
DNAAF3 dynein, axonemal, assembly factor 3 0.0103179
BCL2L1 BCL2-like 1 0.0103017
TRIM25 tripartite motif containing 25 0.010271
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) 0.0102629
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) 0.0102567
SPG11 spastic paraplegia 11 (autosomal recessive) 0.0102563
SCLT1 sodium channel and clathrin linker 1 0.0102116
RILPL1 Rab interacting lysosomal protein-like 1 0.0101613
ZNF337 zinc finger protein 337 0.0101474
PCF11 PCF11 cleavage and polyadenylation factor subunit 0.0101274
PLSCR1 phospholipid scramblase 1 0.0100908
AUTS2 autism susceptibility candidate 2 0.0100521
FBXL4 F-box and leucine-rich repeat protein 4 0.0100283
FBXO34 F-box protein 34 0.00981749
PLXNA1 plexin A1 0.00976955
GCC2 GRIP and coiled-coil domain containing 2 0.00975291
FRMD8 FERM domain containing 8 0.00974754
RPS15A ribosomal protein S15a 0.0097141
NCOA5 nuclear receptor coactivator 5 0.00968917
YEATS2 YEATS domain containing 2 0.00967165
BASP1 brain abundant, membrane attached signal protein 1 0.00964699

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.509644
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.140328
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.126143
AHNAK AHNAK nucleoprotein -0.119894
PTMA prothymosin, alpha -0.114274
CPED1 cadherin-like and PC-esterase domain containing 1 -0.107414
ACTG1 actin gamma 1 -0.106476
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0931728
SSBP2 single-stranded DNA binding protein 2 -0.0926767
TPT1 tumor protein, translationally-controlled 1 -0.090263
LDHA lactate dehydrogenase A -0.085553
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0825791
TMSB4X thymosin beta 4, X-linked -0.0816305
PKM pyruvate kinase, muscle -0.0795431
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0746726
PDE4B phosphodiesterase 4B, cAMP-specific -0.0744986
EML4 echinoderm microtubule associated protein like 4 -0.0739865
DLG1 discs, large homolog 1 (Drosophila) -0.0677225
TJP1 tight junction protein 1 -0.0674308
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0673404
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0655802
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b -0.0645621
CAMKMT calmodulin-lysine N-methyltransferase -0.061598
RHOA ras homolog family member A -0.0606065
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0598502
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0593463
RPS8 ribosomal protein S8 -0.0589945
ANXA1 annexin A1 -0.058786
SLC38A2 solute carrier family 38, member 2 -0.0587274
RPS6 ribosomal protein S6 -0.0552304
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0523964
BMP10 bone morphogenetic protein 10 -0.0523663
ZEB1 zinc finger E-box binding homeobox 1 -0.0510514
QKI QKI, KH domain containing, RNA binding -0.0509875
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.0500669
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0492904
SMNDC1 survival motor neuron domain containing 1 -0.0488883
ARL4C ADP-ribosylation factor-like 4C -0.0488819
RPS23 ribosomal protein S23 -0.0476981
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.045845
PGK1 phosphoglycerate kinase 1 -0.0454011
HSPH1 heat shock 105kDa/110kDa protein 1 -0.0451682
HSPB1 heat shock 27kDa protein 1 -0.0449352
ADAM10 ADAM metallopeptidase domain 10 -0.0445945
RPL7A ribosomal protein L7a -0.0439798
POTEF POTE ankyrin domain family, member F -0.0436184
RPLP1 ribosomal protein, large, P1 -0.043237
EVI5 ecotropic viral integration site 5 -0.0430125
RPL19 ribosomal protein L19 -0.0429541
EIF4A2 eukaryotic translation initiation factor 4A2 -0.0428347
NAP1L1 nucleosome assembly protein 1-like 1 -0.0421805
RPL34 ribosomal protein L34 -0.0420165
EEF2 eukaryotic translation elongation factor 2 -0.0419971
VCL vinculin -0.0418164
CANX calnexin -0.0416218
RPS19 ribosomal protein S19 -0.0410581
RPLP0 ribosomal protein, large, P0 -0.0407299
NFIA nuclear factor I/A -0.0389133
RPS25 ribosomal protein S25 -0.0387982
ZNF217 zinc finger protein 217 -0.0386105
S100A10 S100 calcium binding protein A10 -0.0385582
CYB5B cytochrome b5 type B (outer mitochondrial membrane) -0.0381042
ZFAND3 zinc finger, AN1-type domain 3 -0.038058
RTN4 reticulon 4 -0.0371981
ECT2 epithelial cell transforming 2 -0.0368631
TXNIP thioredoxin interacting protein -0.0364352
RPS24 ribosomal protein S24 -0.0363126
NBEA neurobeachin -0.0361782
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0361492
IARS1 isoleucyl-tRNA synthetase 1 -0.0360296
S100A6 S100 calcium binding protein A6 -0.0357306
LPP LIM domain containing preferred translocation partner in lipoma -0.0347417
GNAS GNAS complex locus -0.0345589
NAMPT nicotinamide phosphoribosyltransferase -0.0341941
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.0341675
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0331823
RPL7 ribosomal protein L7 -0.033115
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0329456
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0328719
LOC112694756 uncharaterized LOC112694756 -0.0328098
CCND1 cyclin D1 -0.0325646
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.032079
SEC24D SEC24 family member D -0.0320513
JMJD1C jumonji domain containing 1C -0.0318773
RPL27A ribosomal protein L27a -0.0316104
TPM4 tropomyosin 4 -0.0314532
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0314339
WAC WW domain containing adaptor with coiled-coil -0.0314019
UBC ubiquitin C -0.0313852
CDC73 cell division cycle 73 -0.0312948
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 -0.0310519
CACNB4 calcium channel, voltage-dependent, beta 4 subunit -0.0310497
KMT2E lysine (K)-specific methyltransferase 2E -0.0307342
RPL12 ribosomal protein L12 -0.0300454
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0300111
HEG1 heart development protein with EGF-like domains 1 -0.029836
SPATS2L spermatogenesis associated, serine-rich 2-like -0.0298288
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 -0.0298252
PDIA6 protein disulfide isomerase family A, member 6 -0.0294897
NF1 neurofibromin 1 -0.0293157