Sulfisoxazole_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sulfisoxazole perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Sulfisoxazole_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.116257
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.100472
VIM vimentin 0.0995927
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0859567
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0828075
RBM25 RNA binding motif protein 25 0.0757178
KYNU kynureninase 0.0747577
ENO1 enolase 1, (alpha) 0.0718548
HMGA2 high mobility group AT-hook 2 0.068614
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0671547
CD44 CD44 molecule (Indian blood group) 0.0656287
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0646077
GOLGB1 golgin B1 0.0612481
RIGI RNA sensor RIG-I 0.0588685
ASPH aspartate beta-hydroxylase 0.058656
HLA-A major histocompatibility complex, class I, A 0.058148
SDC4 syndecan 4 0.0570056
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0558297
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0557668
TMSB10 thymosin beta 10 0.0555295
FNDC3A fibronectin type III domain containing 3A 0.0554736
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0548407
HLA-B major histocompatibility complex, class I, B 0.0543119
STC1 stanniocalcin 1 0.0531362
COL6A2 collagen, type VI, alpha 2 0.0524128
NCOR1 nuclear receptor corepressor 1 0.0513692
EFNA5 ephrin-A5 0.0508261
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0508227
HIP1 huntingtin interacting protein 1 0.0506521
BASP1 brain abundant, membrane attached signal protein 1 0.0493296
TM4SF1 transmembrane 4 L six family member 1 0.0490364
MACF1 microtubule-actin crosslinking factor 1 0.0478093
TGFBI transforming growth factor, beta-induced, 68kDa 0.047557
TFPI2 tissue factor pathway inhibitor 2 0.0475081
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0474082
FNDC3B fibronectin type III domain containing 3B 0.0468498
BACE2 beta-site APP-cleaving enzyme 2 0.0458547
EXT1 exostosin glycosyltransferase 1 0.044193
PTK2 protein tyrosine kinase 2 0.0440978
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0438048
LMO7 LIM domain 7 0.0436484
FTH1 ferritin, heavy polypeptide 1 0.0432763
FMNL2 formin-like 2 0.0422272
AKAP12 A kinase (PRKA) anchor protein 12 0.0415345
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0410248
MYH9 myosin, heavy chain 9, non-muscle 0.0409238
BIRC3 baculoviral IAP repeat containing 3 0.0407412
TLN1 talin 1 0.0392698
SAMD4A sterile alpha motif domain containing 4A 0.0392266
RPL28 ribosomal protein L28 0.0385875
TMEM158 transmembrane protein 158 (gene/pseudogene) 0.0385808
IFIH1 interferon induced with helicase C domain 1 0.0382537
CALR calreticulin 0.0381437
ERRFI1 ERBB receptor feedback inhibitor 1 0.0380954
TPR translocated promoter region, nuclear basket protein 0.0380338
PRSS23 protease, serine, 23 0.0380262
COL7A1 collagen, type VII, alpha 1 0.0379513
JUN jun proto-oncogene 0.0374181
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.0372834
RNF213 ring finger protein 213 0.0372464
MAP1B microtubule-associated protein 1B 0.0371788
RPL4 ribosomal protein L4 0.0370335
HIPK2 homeodomain interacting protein kinase 2 0.0367228
PRRC2C proline-rich coiled-coil 2C 0.0365303
BHLHE40 basic helix-loop-helix family, member e40 0.0364248
MAGED1 melanoma antigen family D1 0.0364031
EHBP1 EH domain binding protein 1 0.0358095
PLAUR plasminogen activator, urokinase receptor 0.0357057
EIF1 eukaryotic translation initiation factor 1 0.0355047
LAMB3 laminin, beta 3 0.0354864
WDFY2 WD repeat and FYVE domain containing 2 0.0346419
DSCAM Down syndrome cell adhesion molecule 0.0343415
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0342956
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0341963
VEGFC vascular endothelial growth factor C 0.034
MYO10 myosin X 0.0338835
SQSTM1 sequestosome 1 0.0337498
MYO1E myosin IE 0.0331179
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0331049
SMTN smoothelin 0.0330019
PARP4 poly (ADP-ribose) polymerase family, member 4 0.0325592
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.032553
SLC38A2 solute carrier family 38, member 2 0.0317839
SP100 SP100 nuclear antigen 0.0317323
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0316428
ALCAM activated leukocyte cell adhesion molecule 0.0315049
PTPRM protein tyrosine phosphatase, receptor type, M 0.0314577
NAP1L1 nucleosome assembly protein 1-like 1 0.0313944
CENPF centromere protein F, 350/400kDa 0.0313708
NAV2 neuron navigator 2 0.0312704
AMPD3 adenosine monophosphate deaminase 3 0.0311586
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2 0.031091
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0309422
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0306728
GOLGA3 golgin A3 0.0305045
RPL5 ribosomal protein L5 0.0304277
C1D C1D nuclear receptor corepressor 0.0302837
IRAK2 interleukin-1 receptor-associated kinase 2 0.030206
RPL37A ribosomal protein L37a 0.0301266
OPTN optineurin 0.0296974

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.237642
COL6A3 collagen, type VI, alpha 3 -0.190259
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.105806
COL1A2 collagen, type I, alpha 2 -0.0842591
COL6A1 collagen, type VI, alpha 1 -0.0794471
PDIA3 protein disulfide isomerase family A, member 3 -0.0698104
CALD1 caldesmon 1 -0.0651966
NDRG1 N-myc downstream regulated 1 -0.0634765
POTEF POTE ankyrin domain family, member F -0.0609668
LOXL2 lysyl oxidase-like 2 -0.0605754
ANKRD17 ankyrin repeat domain 17 -0.0581158
SEC24D SEC24 family member D -0.0564586
DPYD dihydropyrimidine dehydrogenase -0.0560711
IGFBP3 insulin-like growth factor binding protein 3 -0.0555441
SSBP2 single-stranded DNA binding protein 2 -0.0521546
IARS1 isoleucyl-tRNA synthetase 1 -0.050706
SETD5 SET domain containing 5 -0.0497708
LDHA lactate dehydrogenase A -0.0465297
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0454166
GARS1 glycyl-tRNA synthetase 1 -0.0449734
VCL vinculin -0.0446177
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.043841
EDIL3 EGF-like repeats and discoidin I-like domains 3 -0.0435754
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0431008
AUTS2 autism susceptibility candidate 2 -0.0429319
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0426513
RPL11 ribosomal protein L11 -0.0424875
CAMTA1 calmodulin binding transcription activator 1 -0.0424417
TMEM263 transmembrane protein 263 -0.0414226
H3-3B H3.3 histone B -0.0411115
VEGFA vascular endothelial growth factor A -0.0390961
TRA2A transformer 2 alpha homolog (Drosophila) -0.0385615
CAV1 caveolin 1, caveolae protein, 22kDa -0.0383464
FN1 fibronectin 1 -0.037394
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.037292
NAV1 neuron navigator 1 -0.0367803
COL5A1 collagen, type V, alpha 1 -0.035949
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0357319
LCOR ligand dependent nuclear receptor corepressor -0.0353178
CTSB cathepsin B -0.0351575
ANKRD28 ankyrin repeat domain 28 -0.0346606
NBAS neuroblastoma amplified sequence -0.034506
FTL ferritin, light polypeptide -0.034093
FAM13A family with sequence similarity 13, member A -0.0334036
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0332707
HOOK2 hook microtubule-tethering protein 2 -0.0329786
ESYT2 extended synaptotagmin-like protein 2 -0.032965
DST dystonin -0.0328209
MBNL1 muscleblind-like splicing regulator 1 -0.0319875
MYSM1 Myb-like, SWIRM and MPN domains 1 -0.0319694
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0319279
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0319118
KAZN kazrin, periplakin interacting protein -0.031795
AP3S1 adaptor-related protein complex 3, sigma 1 subunit -0.0317588
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0317017
ZNF395 zinc finger protein 395 -0.0316449
RNF24 ring finger protein 24 -0.0316393
NDFIP1 Nedd4 family interacting protein 1 -0.0316283
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0310563
LMAN1 lectin, mannose-binding, 1 -0.0309815
RAD51B RAD51 paralog B -0.0309007
UBC ubiquitin C -0.0303955
BRAF B-Raf proto-oncogene, serine/threonine kinase -0.0301521
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0297228
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0296519
RBM6 RNA binding motif protein 6 -0.0295612
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2 -0.029344
GOLPH3L golgi phosphoprotein 3-like -0.0292434
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -0.0290793
EPB41 erythrocyte membrane protein band 4.1 -0.0290489
TRPS1 trichorhinophalangeal syndrome I -0.0289374
PPME1 protein phosphatase methylesterase 1 -0.028882
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 -0.0286655
NRXN3 neurexin 3 -0.0286146
CALU calumenin -0.0285518
ACTG1 actin gamma 1 -0.0284477
NALF1 NALCN channel auxiliary factor 1 -0.028296
PCCA propionyl CoA carboxylase, alpha polypeptide -0.0279532
DKK3 dickkopf WNT signaling pathway inhibitor 3 -0.0278678
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0277891
TMEM59 transmembrane protein 59 -0.0277362
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.027732
CABIN1 calcineurin binding protein 1 -0.0277217
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.0276895
PGK1 phosphoglycerate kinase 1 -0.027648
PHF21A PHD finger protein 21A -0.0273992
RPS24 ribosomal protein S24 -0.0272987
CD109 CD109 molecule -0.0272882
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.0272676
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0272523
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) -0.0271438
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0269407
PDPK1 3-phosphoinositide dependent protein kinase 1 -0.026835
RNF111 ring finger protein 111 -0.026784
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0266716
HNRNPR heterogeneous nuclear ribonucleoprotein R -0.026632
BIRC6 baculoviral IAP repeat containing 6 -0.0265912
USP8 ubiquitin specific peptidase 8 -0.0263337
GGNBP2 gametogenetin binding protein 2 -0.0263293
TENT5A terminal nucleotidyltransferase 5A -0.0261911