Sulfisoxazole_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sulfisoxazole perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Sulfisoxazole_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
BIRC3 baculoviral IAP repeat containing 3 0.0711623
AKAP12 A kinase (PRKA) anchor protein 12 0.0638375
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0633816
DST dystonin 0.0579294
ZSWIM6 zinc finger, SWIM-type containing 6 0.0546826
ENO2 enolase 2 (gamma, neuronal) 0.0535765
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0528903
CAPRIN2 caprin family member 2 0.0520415
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0504197
MYH9 myosin, heavy chain 9, non-muscle 0.0498279
ANGPTL4 angiopoietin-like 4 0.0496029
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0471668
EXT1 exostosin glycosyltransferase 1 0.0459376
LMO7 LIM domain 7 0.0458519
SLC38A2 solute carrier family 38, member 2 0.0422285
BASP1 brain abundant, membrane attached signal protein 1 0.0421152
BICD1 bicaudal D homolog 1 (Drosophila) 0.0416176
PRRC2C proline-rich coiled-coil 2C 0.041331
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0406582
PRKCA protein kinase C, alpha 0.0405274
HLA-A major histocompatibility complex, class I, A 0.0394098
DTNA dystrobrevin, alpha 0.0393269
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0388795
MACF1 microtubule-actin crosslinking factor 1 0.0386402
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0384382
FNDC3A fibronectin type III domain containing 3A 0.0384024
SQSTM1 sequestosome 1 0.0373128
HMGA2 high mobility group AT-hook 2 0.037067
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0362215
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0359014
PDE4D phosphodiesterase 4D, cAMP-specific 0.0343304
FLNA filamin A, alpha 0.03409
JAK1 Janus kinase 1 0.0335391
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0331679
FN1 fibronectin 1 0.033115
ZNF638 zinc finger protein 638 0.0330831
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0326715
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0306079
EGFR epidermal growth factor receptor 0.0305867
SH3KBP1 SH3-domain kinase binding protein 1 0.0302952
ZFP36L1 ZFP36 ring finger protein-like 1 0.028722
ESYT2 extended synaptotagmin-like protein 2 0.0283993
BCAR3 breast cancer anti-estrogen resistance 3 0.0283467
ITGB4 integrin, beta 4 0.02828
OGA O-GlcNAcase 0.0282668
FTH1 ferritin, heavy polypeptide 1 0.0281502
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0273499
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 0.0270511
DOCK9 dedicator of cytokinesis 9 0.0270326
NPAS2 neuronal PAS domain protein 2 0.0266147
JARID2 jumonji, AT rich interactive domain 2 0.026561
RBMS1 RNA binding motif, single stranded interacting protein 1 0.0263856
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0263651
KDM2A lysine (K)-specific demethylase 2A 0.0262392
SRRM2 serine/arginine repetitive matrix 2 0.0262217
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0261662
FMNL2 formin-like 2 0.0259567
PTMA prothymosin, alpha 0.0259029
NALF1 NALCN channel auxiliary factor 1 0.0258012
BAZ1A bromodomain adjacent to zinc finger domain, 1A 0.025746
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.025683
CPEB4 cytoplasmic polyadenylation element binding protein 4 0.0256126
WWOX WW domain containing oxidoreductase 0.0256009
INTS6 integrator complex subunit 6 0.0254404
SAMD4A sterile alpha motif domain containing 4A 0.0249322
NCOR2 nuclear receptor corepressor 2 0.0246895
ANO6 anoctamin 6 0.0245909
CLIC4 chloride intracellular channel 4 0.0241671
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 0.0241247
PRR16 proline rich 16 0.024068
KMT2C lysine (K)-specific methyltransferase 2C 0.0240406
AKAP9 A kinase (PRKA) anchor protein 9 0.0240012
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0239587
B2M beta-2-microglobulin 0.023951
EHBP1 EH domain binding protein 1 0.0236523
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.023558
TNRC18 trinucleotide repeat containing 18 0.0234576
ARHGAP26 Rho GTPase activating protein 26 0.0234261
MAML3 mastermind-like 3 (Drosophila) 0.0233892
MED13L mediator complex subunit 13-like 0.023213
RUNX1 runt-related transcription factor 1 0.0230782
ANKRD11 ankyrin repeat domain 11 0.023043
PDLIM5 PDZ and LIM domain 5 0.0227177
UBE3A ubiquitin protein ligase E3A 0.0226816
RBBP6 retinoblastoma binding protein 6 0.022497
ITPRID2 ITPR interacting domain containing 2 0.022421
RASAL2 RAS protein activator like 2 0.0223948
BAIAP2L1 BAI1-associated protein 2-like 1 0.0222996
CEMIP2 cell migration inducing hyaluronidase 2 0.0222606
OCIAD1 OCIA domain containing 1 0.0221587
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0219291
DOCK4 dedicator of cytokinesis 4 0.0218685
CAMSAP2 calmodulin regulated spectrin-associated protein family, member 2 0.0218603
TRIM56 tripartite motif containing 56 0.0212752
ITGAV integrin, alpha V 0.0211157
RABGAP1L RAB GTPase activating protein 1-like 0.0210597
GIGYF2 GRB10 interacting GYF protein 2 0.0209664
MEF2A myocyte enhancer factor 2A 0.0206013
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0205155
FOXO3 forkhead box O3 0.020508

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.450861
LDHA lactate dehydrogenase A -0.132016
VIM vimentin -0.130461
DSCAM Down syndrome cell adhesion molecule -0.0815845
ANXA2 annexin A2 -0.0725418
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0698869
DEK DEK proto-oncogene -0.0576218
RAB1A RAB1A, member RAS oncogene family -0.057113
SMC4 structural maintenance of chromosomes 4 -0.0540494
IARS1 isoleucyl-tRNA synthetase 1 -0.053156
CANX calnexin -0.0503631
ANKRD28 ankyrin repeat domain 28 -0.0486021
TPT1 tumor protein, translationally-controlled 1 -0.0484925
GNAS GNAS complex locus -0.0477302
ECT2 epithelial cell transforming 2 -0.0468217
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0463313
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme -0.0451174
TPM4 tropomyosin 4 -0.0440935
NIPBL Nipped-B homolog (Drosophila) -0.0431895
BIRC6 baculoviral IAP repeat containing 6 -0.042182
DNER delta/notch-like EGF repeat containing -0.0415505
ETF1 eukaryotic translation termination factor 1 -0.0414281
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0412252
NAMPT nicotinamide phosphoribosyltransferase -0.0412219
TMSB10 thymosin beta 10 -0.0409919
BIRC2 baculoviral IAP repeat containing 2 -0.0408889
TRIO trio Rho guanine nucleotide exchange factor -0.0408308
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0407637
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0404988
NCAPD2 non-SMC condensin I complex, subunit D2 -0.0402835
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0401575
COPB1 coatomer protein complex, subunit beta 1 -0.0394245
RPLP1 ribosomal protein, large, P1 -0.0386704
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0379105
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0376449
FAF2 Fas associated factor family member 2 -0.0373304
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 -0.0372558
KMT2A lysine (K)-specific methyltransferase 2A -0.0372136
TMEM123 transmembrane protein 123 -0.0359786
PRRC1 proline-rich coiled-coil 1 -0.0357317
BSG basigin (Ok blood group) -0.0353721
HNRNPK heterogeneous nuclear ribonucleoprotein K -0.0353677
ZNF609 zinc finger protein 609 -0.0346803
RPLP0 ribosomal protein, large, P0 -0.0346015
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0344678
LOC112694756 uncharaterized LOC112694756 -0.0341004
TBC1D5 TBC1 domain family, member 5 -0.0340876
NCEH1 neutral cholesterol ester hydrolase 1 -0.0338985
H3-3B H3.3 histone B -0.0332577
TM4SF1 transmembrane 4 L six family member 1 -0.0325389
RPL35A ribosomal protein L35a -0.0325151
BTG1 B-cell translocation gene 1, anti-proliferative -0.0324939
SEPTIN7 septin 7 -0.0323731
RPS15 ribosomal protein S15 -0.0323254
SMYD3 SET and MYND domain containing 3 -0.0321877
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0321075
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0320028
RPL27A ribosomal protein L27a -0.0317692
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0317475
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0315692
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) -0.0315253
CLASP2 cytoplasmic linker associated protein 2 -0.0314654
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0308191
AHCTF1 AT hook containing transcription factor 1 -0.0307226
ATF7IP activating transcription factor 7 interacting protein -0.0306645
WDR45B WD repeat domain 45B -0.0306544
PAPOLA poly(A) polymerase alpha -0.030304
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 -0.0302173
ZC3H11A zinc finger CCCH-type containing 11A -0.0298977
NUP58 nucleoporin 58 -0.0297213
ATP13A3 ATPase type 13A3 -0.0295474
KIAA1958 KIAA1958 -0.0292709
TTC3 tetratricopeptide repeat domain 3 -0.0284585
LCORL ligand dependent nuclear receptor corepressor-like -0.0283767
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0283628
ZFR zinc finger RNA binding protein -0.0282992
NOP58 NOP58 ribonucleoprotein -0.0281208
ETNK1 ethanolamine kinase 1 -0.0280862
KIF4A kinesin family member 4A -0.0280659
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1 -0.0280423
TXNRD1 thioredoxin reductase 1 -0.0280043
MAPKAP1 mitogen-activated protein kinase associated protein 1 -0.0279042
YY1 YY1 transcription factor -0.0278279
PDS5A PDS5 cohesin associated factor A -0.0277971
CLTC clathrin, heavy chain (Hc) -0.0277201
WAC WW domain containing adaptor with coiled-coil -0.0275526
UBB ubiquitin B -0.0274395
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.0273062
GNAQ guanine nucleotide binding protein (G protein), q polypeptide -0.0271403
RPL30 ribosomal protein L30 -0.0271391
TPX2 TPX2, microtubule-associated -0.027048
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0268981
MARCHF6 membrane associated ring-CH-type finger 6 -0.0267168
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0267095
ZC3H6 zinc finger CCCH-type containing 6 -0.0265993
SNX14 sorting nexin 14 -0.0264069
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0261129
RAD21 RAD21 homolog (S. pombe) -0.0260807
RAD51B RAD51 paralog B -0.0260464
XPO1 exportin 1 -0.0260335