Sulindac Gene Set

Dataset HMDB Metabolites of Enzymes
Category physical interactions
Type metabolite
Description A monocarboxylic acid that is 1-benzylidene-1H-indene which is substituted at positions 2, 3, and 5 by methyl, carboxymethyl, and fluorine respectively, and in which the phenyl group of the benzylidene moiety is substituted at the para position by a methylsulfinyl group. It is a prodrug for the corresponding sulfide, a non-steroidal anti-inflammatory drug, used particularly in the treatment of acute and chronic inflammatory conditions. (Chemical Entities of Biological Interest Ontology, CHEBI_9352)
External Link http://www.hmdb.ca/metabolites/HMDB14743
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Genes

9 interacting proteins for the Sulindac metabolite from the curated HMDB Metabolites of Enzymes dataset.

Symbol Name
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2
MAPK3 mitogen-activated protein kinase 3
PPARD peroxisome proliferator-activated receptor delta
PTGDR2 prostaglandin D2 receptor 2
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
SLC22A6 solute carrier family 22 (organic anion transporter), member 6