| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| Description | A sulfonamide that consists of N,N-dimethyltryptamine bearing an additional (N-methylsulfamoyl)methyl substituent at position 5. Selective agonist for a vascular 5-HT1 receptor subtype (probably a member of the 5-HT1D family). (Chemical Entities of Biological Interest Ontology, CHEBI_10650) |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/5358 |
| Similar Terms | |
| Downloads & Tools |
198 proteins with high or low expression in Sumatriptan relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GREB1 | growth regulation by estrogen in breast cancer 1 | 2.44 |
| MYH8 | myosin, heavy chain 8, skeletal muscle, perinatal | 1.02 |
| FAN1 | FANCD2/FANCI-associated nuclease 1 | 0.76 |
| NABP2 | nucleic acid binding protein 2 | 0.54 |
| CD82 | CD82 molecule | 0.49 |
| ZFYVE9 | zinc finger, FYVE domain containing 9 | 0.49 |
| RNF126 | ring finger protein 126 | 0.48 |
| ZNF107 | zinc finger protein 107 | 0.47 |
| PAFAH1B2 | platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa) | 0.46 |
| PPP1R2 | protein phosphatase 1, regulatory (inhibitor) subunit 2 | 0.45 |
| RPGR | retinitis pigmentosa GTPase regulator | 0.42 |
| GJC1 | gap junction protein, gamma 1, 45kDa | 0.41 |
| ETNK2 | ethanolamine kinase 2 | 0.39 |
| RPS21 | ribosomal protein S21 | 0.38 |
| JMJD4 | jumonji domain containing 4 | 0.37 |
| IQCE | IQ motif containing E | 0.37 |
| GINS2 | GINS complex subunit 2 (Psf2 homolog) | 0.37 |
| FRS2 | fibroblast growth factor receptor substrate 2 | 0.36 |
| PAH | phenylalanine hydroxylase | 0.36 |
| CFD | complement factor D (adipsin) | 0.36 |
| RIPK4 | receptor-interacting serine-threonine kinase 4 | 0.36 |
| RGL2 | ral guanine nucleotide dissociation stimulator-like 2 | 0.36 |
| CLTA | clathrin, light chain A | 0.35 |
| ZDHHC12 | zinc finger, DHHC-type containing 12 | 0.35 |
| RASSF3 | Ras association (RalGDS/AF-6) domain family member 3 | 0.35 |
| FGF2 | fibroblast growth factor 2 (basic) | 0.34 |
| COA4 | cytochrome c oxidase assembly factor 4 homolog (S. cerevisiae) | 0.34 |
| DTL | denticleless E3 ubiquitin protein ligase homolog (Drosophila) | 0.34 |
| TESC | tescalcin | 0.34 |
| HRH1 | histamine receptor H1 | 0.34 |
| INO80B | INO80 complex subunit B | 0.34 |
| ACTBL2 | actin, beta-like 2 | 0.33 |
| CRPPA | CDP-L-ribitol pyrophosphorylase A | 0.33 |
| LSM10 | LSM10, U7 small nuclear RNA associated | 0.33 |
| NOLC1 | nucleolar and coiled-body phosphoprotein 1 | 0.33 |
| DNAAF2 | dynein, axonemal, assembly factor 2 | 0.33 |
| TMEM9B | TMEM9 domain family, member B | 0.33 |
| SF1 | splicing factor 1 | 0.33 |
| ZNF304 | zinc finger protein 304 | 0.33 |
| TMSB10 | thymosin beta 10 | 0.33 |
| NUDT16 | nudix (nucleoside diphosphate linked moiety X)-type motif 16 | 0.33 |
| RNF138 | ring finger protein 138, E3 ubiquitin protein ligase | 0.32 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | 0.32 |
| PTPN18 | protein tyrosine phosphatase, non-receptor type 18 (brain-derived) | 0.32 |
| CYB5A | cytochrome b5 type A (microsomal) | 0.32 |
| DGKH | diacylglycerol kinase, eta | 0.32 |
| ZNF14 | zinc finger protein 14 | 0.32 |
| BICRAL | BICRA like chromatin remodeling complex associated protein | 0.31 |
| TLE5 | TLE family member 5, transcriptional modulator | 0.31 |
| SLC35C1 | solute carrier family 35 (GDP-fucose transporter), member C1 | 0.31 |
| ZNF584 | zinc finger protein 584 | 0.3 |
| ALG8 | ALG8, alpha-1,3-glucosyltransferase | 0.3 |
| ENOX2 | ecto-NOX disulfide-thiol exchanger 2 | 0.3 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | 0.29 |
| BBS9 | Bardet-Biedl syndrome 9 | 0.29 |
| RBM3 | RNA binding motif (RNP1, RRM) protein 3 | 0.29 |
| ZNF316 | zinc finger protein 316 | 0.29 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.28 |
| NDUFAF6 | NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 | 0.28 |
| TLL2 | tolloid-like 2 | 0.28 |
| XTBD1 | XRN2 binding domain containing 1 | 0.28 |
| ZNF267 | zinc finger protein 267 | 0.28 |
| SLC29A2 | solute carrier family 29 (equilibrative nucleoside transporter), member 2 | 0.28 |
| IPMK | inositol polyphosphate multikinase | 0.28 |
| ZBTB6 | zinc finger and BTB domain containing 6 | 0.27 |
| RALGAPA1 | Ral GTPase activating protein, alpha subunit 1 (catalytic) | 0.27 |
| CEP70 | centrosomal protein 70kDa | 0.27 |
| MRPL50 | mitochondrial ribosomal protein L50 | 0.27 |
| SPATA2 | spermatogenesis associated 2 | 0.26 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.26 |
| POLR2K | polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa | 0.26 |
| MAT1A | methionine adenosyltransferase I, alpha | 0.26 |
| PDP2 | pyruvate dehyrogenase phosphatase catalytic subunit 2 | 0.26 |
| MAGEA12 | melanoma antigen family A12 | 0.26 |
| HNRNPA0 | heterogeneous nuclear ribonucleoprotein A0 | 0.26 |
| HYPK | huntingtin interacting protein K | 0.26 |
| CDC26 | cell division cycle 26 | 0.26 |
| GABPB2 | GA binding protein transcription factor, beta subunit 2 | 0.26 |
| ZNF600 | zinc finger protein 600 | 0.25 |
| IFT43 | intraflagellar transport 43 | 0.25 |
| ALKBH5 | AlkB family member 5, RNA demethylase | 0.25 |
| TNNC2 | troponin C type 2 (fast) | 0.25 |
| ZDHHC23 | zinc finger, DHHC-type containing 23 | 0.25 |
| SS18L1 | synovial sarcoma translocation gene on chromosome 18-like 1 | 0.25 |
| MSANTD4 | Myb/SANT-like DNA-binding domain containing 4 with coiled-coils | 0.25 |
| NFU1 | NFU1 iron-sulfur cluster scaffold | 0.25 |
| MAST4 | microtubule associated serine/threonine kinase family member 4 | 0.25 |
| KLHL2 | kelch-like family member 2 | 0.25 |
| DEF8 | differentially expressed in FDCP 8 homolog (mouse) | 0.24 |
| HBA1 | hemoglobin, alpha 1 | 0.24 |
| GSKIP | GSK3B interacting protein | 0.24 |
| RSAD1 | radical S-adenosyl methionine domain containing 1 | 0.24 |
| AKT1S1 | AKT1 substrate 1 (proline-rich) | 0.24 |
| METAP1D | methionyl aminopeptidase type 1D (mitochondrial) | 0.24 |
| GRK5 | G protein-coupled receptor kinase 5 | 0.24 |
| KLF10 | Kruppel-like factor 10 | 0.24 |
| GPN3 | GPN-loop GTPase 3 | 0.24 |
| PDGFC | platelet derived growth factor C | 0.24 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CELSR3 | cadherin, EGF LAG seven-pass G-type receptor 3 | -1.91 |
| POF1B | premature ovarian failure, 1B | -1.84 |
| TAF1B | TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa | -1.4 |
| PDRG1 | p53 and DNA-damage regulated 1 | -0.79 |
| PIP | prolactin-induced protein | -0.77 |
| CLCN3 | chloride channel, voltage-sensitive 3 | -0.76 |
| ABCC9 | ATP-binding cassette, sub-family C (CFTR/MRP), member 9 | -0.7 |
| S100PBP | S100P binding protein | -0.69 |
| ZNF324 | zinc finger protein 324 | -0.65 |
| COL6A6 | collagen, type VI, alpha 6 | -0.56 |
| FRMPD1 | FERM and PDZ domain containing 1 | -0.56 |
| ABCB4 | ATP-binding cassette, sub-family B (MDR/TAP), member 4 | -0.55 |
| KMT2B | lysine (K)-specific methyltransferase 2B | -0.54 |
| TNKS2 | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 | -0.52 |
| ZXDB | zinc finger, X-linked, duplicated B | -0.47 |
| CAB39L | calcium binding protein 39-like | -0.44 |
| ADCY10 | adenylate cyclase 10 (soluble) | -0.44 |
| COL7A1 | collagen, type VII, alpha 1 | -0.42 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | -0.41 |
| MYO1G | myosin IG | -0.41 |
| LRP12 | low density lipoprotein receptor-related protein 12 | -0.4 |
| ATXN7L1 | ataxin 7-like 1 | -0.4 |
| ZNF91 | zinc finger protein 91 | -0.38 |
| MYPOP | Myb-related transcription factor, partner of profilin | -0.38 |
| ACIN1 | apoptotic chromatin condensation inducer 1 | -0.38 |
| TM7SF3 | transmembrane 7 superfamily member 3 | -0.37 |
| MAP3K1 | mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase | -0.37 |
| LRFN3 | leucine rich repeat and fibronectin type III domain containing 3 | -0.37 |
| PRICKLE3 | prickle homolog 3 (Drosophila) | -0.36 |
| PLEKHA6 | pleckstrin homology domain containing, family A member 6 | -0.36 |
| TRAF5 | TNF receptor-associated factor 5 | -0.36 |
| TRABD | TraB domain containing | -0.36 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | -0.35 |
| MIIP | migration and invasion inhibitory protein | -0.35 |
| FSTL1 | follistatin-like 1 | -0.35 |
| PDGFA | platelet-derived growth factor alpha polypeptide | -0.34 |
| TMC6 | transmembrane channel-like 6 | -0.34 |
| DCHS1 | dachsous cadherin-related 1 | -0.34 |
| ZNF2 | zinc finger protein 2 | -0.34 |
| UFC1 | ubiquitin-fold modifier conjugating enzyme 1 | -0.33 |
| SLC49A4 | solute carrier family 49 member 4 | -0.33 |
| RCE1 | Ras converting CAAX endopeptidase 1 | -0.33 |
| SIPA1L2 | signal-induced proliferation-associated 1 like 2 | -0.33 |
| TDRD9 | tudor domain containing 9 | -0.33 |
| SPIRE2 | spire-type actin nucleation factor 2 | -0.32 |
| CEP112 | centrosomal protein 112kDa | -0.32 |
| BPTF | bromodomain PHD finger transcription factor | -0.32 |
| PTPRB | protein tyrosine phosphatase, receptor type, B | -0.31 |
| MFSD14B | major facilitator superfamily domain containing 14B | -0.31 |
| ZNF275 | zinc finger protein 275 | -0.31 |
| RPP25 | ribonuclease P/MRP 25kDa subunit | -0.31 |
| ECM1 | extracellular matrix protein 1 | -0.31 |
| ZNF525 | zinc finger protein 525 | -0.31 |
| PAQR4 | progestin and adipoQ receptor family member IV | -0.3 |
| BBS1 | Bardet-Biedl syndrome 1 | -0.3 |
| OLFM2 | olfactomedin 2 | -0.3 |
| TMEM219 | transmembrane protein 219 | -0.3 |
| MYL3 | myosin, light chain 3, alkali; ventricular, skeletal, slow | -0.3 |
| TPM4 | tropomyosin 4 | -0.29 |
| MYO18B | myosin XVIIIB | -0.29 |
| BAG1 | BCL2-associated athanogene | -0.29 |
| PXN | paxillin | -0.29 |
| COL13A1 | collagen, type XIII, alpha 1 | -0.29 |
| CDKN1B | cyclin-dependent kinase inhibitor 1B (p27, Kip1) | -0.29 |
| CAPZB | capping protein (actin filament) muscle Z-line, beta | -0.29 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | -0.29 |
| TMEM87B | transmembrane protein 87B | -0.28 |
| PGK2 | phosphoglycerate kinase 2 | -0.28 |
| DTNA | dystrobrevin, alpha | -0.28 |
| DOP1A | DOP1 leucine zipper like protein A | -0.28 |
| TPGS2 | tubulin polyglutamylase complex subunit 2 | -0.28 |
| ZNF587 | zinc finger protein 587 | -0.27 |
| GGT2 | gamma-glutamyltransferase 2 | -0.27 |
| CAV2 | caveolin 2 | -0.27 |
| SAV1 | salvador family WW domain containing protein 1 | -0.27 |
| ZNF551 | zinc finger protein 551 | -0.27 |
| PHLDB3 | pleckstrin homology-like domain, family B, member 3 | -0.27 |
| ADAMTS14 | ADAM metallopeptidase with thrombospondin type 1 motif, 14 | -0.27 |
| YAF2 | YY1 associated factor 2 | -0.26 |
| ENO1 | enolase 1, (alpha) | -0.26 |
| RAB40C | RAB40C, member RAS oncogene family | -0.26 |
| ANO8 | anoctamin 8 | -0.26 |
| FAM135B | family with sequence similarity 135, member B | -0.26 |
| PIM3 | Pim-3 proto-oncogene, serine/threonine kinase | -0.26 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.26 |
| TMEM51 | transmembrane protein 51 | -0.26 |
| ABCD4 | ATP-binding cassette, sub-family D (ALD), member 4 | -0.26 |
| SLC25A23 | solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23 | -0.26 |
| ZNF480 | zinc finger protein 480 | -0.26 |
| PTK6 | protein tyrosine kinase 6 | -0.26 |
| ABRACL | ABRA C-terminal like | -0.26 |
| HFE | hemochromatosis | -0.25 |
| CTSL | cathepsin L | -0.25 |
| MCFD2 | multiple coagulation factor deficiency 2 | -0.25 |
| FER1L5 | fer-1-like family member 5 | -0.25 |
| STK16 | serine/threonine kinase 16 | -0.25 |
| SDR16C5 | short chain dehydrogenase/reductase family 16C, member 5 | -0.25 |
| ARSG | arylsulfatase G | -0.24 |
| NLRC3 | NLR family, CARD domain containing 3 | -0.24 |
| CEBPZOS | CEBPZ opposite strand | -0.24 |
