| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| Description | A pyrrole that has formula C22H27FN4O2. (Chemical Entities of Biological Interest Ontology, CHEBI_38940) |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/5329102 |
| Similar Terms | |
| Downloads & Tools |
200 proteins with high or low expression in Sunitinib relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TMEM59 | transmembrane protein 59 | 4.23 |
| APOB | apolipoprotein B | 4.2 |
| NDFIP1 | Nedd4 family interacting protein 1 | 4.12 |
| LRP10 | low density lipoprotein receptor-related protein 10 | 3.19 |
| NBR1 | neighbor of BRCA1 gene 1 | 2.9 |
| NDFIP2 | Nedd4 family interacting protein 2 | 2.85 |
| APOE | apolipoprotein E | 2.81 |
| ITM2C | integral membrane protein 2C | 2.78 |
| IFNGR1 | interferon gamma receptor 1 | 2.5 |
| TNFRSF10D | tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain | 2.5 |
| ITM2B | integral membrane protein 2B | 2.48 |
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | 2.47 |
| PDCD4 | programmed cell death 4 (neoplastic transformation inhibitor) | 2.34 |
| UNC80 | unc-80 homolog (C. elegans) | 2.3 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | 2.27 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 2.27 |
| CLK1 | CDC-like kinase 1 | 2.25 |
| SPINT2 | serine peptidase inhibitor, Kunitz type, 2 | 2.17 |
| RNF149 | ring finger protein 149 | 2.14 |
| PSAP | prosaposin | 2.04 |
| OPTN | optineurin | 1.99 |
| CCDC127 | coiled-coil domain containing 127 | 1.95 |
| SERINC3 | serine incorporator 3 | 1.94 |
| FDFT1 | farnesyl-diphosphate farnesyltransferase 1 | 1.93 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 1.89 |
| PLD3 | phospholipase D family, member 3 | 1.83 |
| ACVR1B | activin A receptor, type IB | 1.81 |
| TM7SF2 | transmembrane 7 superfamily member 2 | 1.8 |
| SLC38A2 | solute carrier family 38, member 2 | 1.8 |
| GRN | granulin | 1.78 |
| F5 | coagulation factor V (proaccelerin, labile factor) | 1.78 |
| FGFBP1 | fibroblast growth factor binding protein 1 | 1.77 |
| BMPR1B | bone morphogenetic protein receptor, type IB | 1.77 |
| MAP1LC3B2 | microtubule-associated protein 1 light chain 3 beta 2 | 1.71 |
| NCOA4 | nuclear receptor coactivator 4 | 1.7 |
| BTBD3 | BTB (POZ) domain containing 3 | 1.7 |
| TRIM2 | tripartite motif containing 2 | 1.65 |
| ACSS2 | acyl-CoA synthetase short-chain family member 2 | 1.63 |
| APP | amyloid beta (A4) precursor protein | 1.62 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 1.62 |
| SQLE | squalene epoxidase | 1.61 |
| MFGE8 | milk fat globule-EGF factor 8 protein | 1.59 |
| MSMO1 | methylsterol monooxygenase 1 | 1.58 |
| FBXL20 | F-box and leucine-rich repeat protein 20 | 1.55 |
| CCDC158 | coiled-coil domain containing 158 | 1.51 |
| PTPRS | protein tyrosine phosphatase, receptor type, S | 1.5 |
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 1.49 |
| SDCBP | syndecan binding protein (syntenin) | 1.47 |
| LSS | lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) | 1.45 |
| BMPR1A | bone morphogenetic protein receptor, type IA | 1.45 |
| BMERB1 | bMERB domain containing 1 | 1.43 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | 1.42 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | 1.37 |
| CALCOCO2 | calcium binding and coiled-coil domain 2 | 1.36 |
| IFRD1 | interferon-related developmental regulator 1 | 1.34 |
| IDI1 | isopentenyl-diphosphate delta isomerase 1 | 1.34 |
| CD63 | CD63 molecule | 1.33 |
| CLK4 | CDC-like kinase 4 | 1.32 |
| LMBRD1 | LMBR1 domain containing 1 | 1.31 |
| PBXIP1 | pre-B-cell leukemia homeobox interacting protein 1 | 1.31 |
| FBXL8 | F-box and leucine-rich repeat protein 8 | 1.31 |
| CALCOCO1 | calcium binding and coiled-coil domain 1 | 1.31 |
| GDF15 | growth differentiation factor 15 | 1.31 |
| HGFAC | HGF activator | 1.31 |
| SLFN5 | schlafen family member 5 | 1.28 |
| METTL7A | methyltransferase like 7A | 1.27 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 1.27 |
| ACSF2 | acyl-CoA synthetase family member 2 | 1.26 |
| LAMB2 | laminin, beta 2 (laminin S) | 1.26 |
| SQSTM1 | sequestosome 1 | 1.26 |
| AXL | AXL receptor tyrosine kinase | 1.25 |
| SERINC1 | serine incorporator 1 | 1.24 |
| CLDN3 | claudin 3 | 1.23 |
| LDLR | low density lipoprotein receptor | 1.22 |
| SPPL2B | signal peptide peptidase like 2B | 1.21 |
| SYTL1 | synaptotagmin-like 1 | 1.21 |
| PRSS8 | protease, serine, 8 | 1.21 |
| DDR1 | discoidin domain receptor tyrosine kinase 1 | 1.2 |
| PCK2 | phosphoenolpyruvate carboxykinase 2 (mitochondrial) | 1.2 |
| DHCR7 | 7-dehydrocholesterol reductase | 1.2 |
| VEZT | vezatin, adherens junctions transmembrane protein | 1.19 |
| MVK | mevalonate kinase | 1.19 |
| AREG | amphiregulin | 1.19 |
| COL14A1 | collagen, type XIV, alpha 1 | 1.18 |
| TGFBR1 | transforming growth factor, beta receptor 1 | 1.17 |
| OSMR | oncostatin M receptor | 1.17 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | 1.16 |
| LPIN1 | lipin 1 | 1.16 |
| HSD17B7 | hydroxysteroid (17-beta) dehydrogenase 7 | 1.16 |
| FN1 | fibronectin 1 | 1.15 |
| BRD9 | bromodomain containing 9 | 1.15 |
| NEO1 | neogenin 1 | 1.15 |
| H1FX | H1 histone family, member X | 1.15 |
| MTHFR | methylenetetrahydrofolate reductase (NAD(P)H) | 1.15 |
| HBA1 | hemoglobin, alpha 1 | 1.14 |
| ADIPOR1 | adiponectin receptor 1 | 1.13 |
| COQ8A | coenzyme Q8A | 1.13 |
| PTPRU | protein tyrosine phosphatase, receptor type, U | 1.11 |
| TPRG1L | tumor protein p63 regulated 1-like | 1.11 |
| FBRSL1 | fibrosin-like 1 | 1.1 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GMNN | geminin, DNA replication inhibitor | -2.92 |
| KIF18B | kinesin family member 18B | -2.8 |
| RRM2 | ribonucleotide reductase M2 | -2.73 |
| CDC20 | cell division cycle 20 | -2.54 |
| DUOX1 | dual oxidase 1 | -2.5 |
| CCNA2 | cyclin A2 | -2.43 |
| PCLAF | PCNA clamp associated factor | -2.33 |
| PTTG1 | pituitary tumor-transforming 1 | -2.29 |
| ARHGAP19 | Rho GTPase activating protein 19 | -2.27 |
| KLHL21 | kelch-like family member 21 | -2.13 |
| KIF22 | kinesin family member 22 | -2.1 |
| CCNB1 | cyclin B1 | -2.03 |
| MCM8 | minichromosome maintenance complex component 8 | -2.02 |
| ANLN | anillin, actin binding protein | -2.02 |
| DTL | denticleless E3 ubiquitin protein ligase homolog (Drosophila) | -2.01 |
| PIMREG | PICALM interacting mitotic regulator | -2.0 |
| LRRC58 | leucine rich repeat containing 58 | -1.99 |
| TK1 | thymidine kinase 1, soluble | -1.96 |
| BUB1 | BUB1 mitotic checkpoint serine/threonine kinase | -1.92 |
| CDCA5 | cell division cycle associated 5 | -1.89 |
| CLSPN | claspin | -1.89 |
| DEPDC1B | DEP domain containing 1B | -1.88 |
| GTSE1 | G-2 and S-phase expressed 1 | -1.88 |
| PLK1 | polo-like kinase 1 | -1.86 |
| DONSON | downstream neighbor of SON | -1.85 |
| UBE2T | ubiquitin-conjugating enzyme E2T | -1.81 |
| TPX2 | TPX2, microtubule-associated | -1.79 |
| DEPDC1 | DEP domain containing 1 | -1.78 |
| RPS6KA4 | ribosomal protein S6 kinase, 90kDa, polypeptide 4 | -1.76 |
| MCM10 | minichromosome maintenance complex component 10 | -1.74 |
| TACC3 | transforming, acidic coiled-coil containing protein 3 | -1.73 |
| SKP2 | S-phase kinase-associated protein 2, E3 ubiquitin protein ligase | -1.72 |
| CDC7 | cell division cycle 7 | -1.71 |
| UBE2C | ubiquitin-conjugating enzyme E2C | -1.7 |
| BUB1B | BUB1 mitotic checkpoint serine/threonine kinase B | -1.68 |
| RAD51 | RAD51 recombinase | -1.67 |
| STIL | SCL/TAL1 interrupting locus | -1.67 |
| CDCA2 | cell division cycle associated 2 | -1.66 |
| SLBP | stem-loop binding protein | -1.66 |
| MELK | maternal embryonic leucine zipper kinase | -1.65 |
| ZMYND19 | zinc finger, MYND-type containing 19 | -1.64 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -1.64 |
| EXO1 | exonuclease 1 | -1.63 |
| AURKA | aurora kinase A | -1.62 |
| KNSTRN | kinetochore-localized astrin/SPAG5 binding protein | -1.61 |
| UBE2S | ubiquitin-conjugating enzyme E2S | -1.59 |
| DLGAP5 | discs, large (Drosophila) homolog-associated protein 5 | -1.57 |
| BARD1 | BRCA1 associated RING domain 1 | -1.56 |
| CCNB2 | cyclin B2 | -1.56 |
| HMMR | hyaluronan-mediated motility receptor (RHAMM) | -1.56 |
| CDC6 | cell division cycle 6 | -1.56 |
| SACK1D | scaffolding CK1 anchoring protein D | -1.55 |
| TYMS | thymidylate synthetase | -1.55 |
| KNL1 | kinetochore scaffold 1 | -1.53 |
| KIF11 | kinesin family member 11 | -1.53 |
| RAD54B | RAD54 homolog B (S. cerevisiae) | -1.53 |
| ZWINT | ZW10 interacting kinetochore protein | -1.52 |
| CENPP | centromere protein P | -1.52 |
| SPDL1 | spindle apparatus coiled-coil protein 1 | -1.52 |
| OBI1 | ORC ubiquitin ligase 1 | -1.51 |
| PMS1 | PMS1 postmeiotic segregation increased 1 (S. cerevisiae) | -1.51 |
| MLPH | melanophilin | -1.5 |
| SASS6 | spindle assembly 6 homolog (C. elegans) | -1.5 |
| USP37 | ubiquitin specific peptidase 37 | -1.49 |
| SGO2 | shugoshin 2 | -1.47 |
| AMD1 | adenosylmethionine decarboxylase 1 | -1.47 |
| CDCA7 | cell division cycle associated 7 | -1.47 |
| SYTL3 | synaptotagmin-like 3 | -1.46 |
| GCH1 | GTP cyclohydrolase 1 | -1.46 |
| SMTN | smoothelin | -1.46 |
| TTK | TTK protein kinase | -1.45 |
| ECT2 | epithelial cell transforming 2 | -1.45 |
| PPRC1 | peroxisome proliferator-activated receptor gamma, coactivator-related 1 | -1.45 |
| ATAD2 | ATPase family, AAA domain containing 2 | -1.45 |
| SAPCD2 | suppressor APC domain containing 2 | -1.44 |
| KIF20B | kinesin family member 20B | -1.43 |
| CDKN3 | cyclin-dependent kinase inhibitor 3 | -1.42 |
| FBXO5 | F-box protein 5 | -1.42 |
| RAD51AP1 | RAD51 associated protein 1 | -1.42 |
| SHCBP1 | SHC SH2-domain binding protein 1 | -1.42 |
| UCK2 | uridine-cytidine kinase 2 | -1.41 |
| NET1 | neuroepithelial cell transforming 1 | -1.4 |
| UHRF1 | ubiquitin-like with PHD and ring finger domains 1 | -1.39 |
| STARD7 | StAR-related lipid transfer (START) domain containing 7 | -1.38 |
| CHEK1 | checkpoint kinase 1 | -1.38 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -1.37 |
| DEPDC7 | DEP domain containing 7 | -1.37 |
| TCF3 | transcription factor 3 | -1.37 |
| MAP3K9 | mitogen-activated protein kinase kinase kinase 9 | -1.36 |
| H1-4 | H1.4 linker histone, cluster member | -1.36 |
| PRELID3B | PRELI domain containing 3B | -1.35 |
| KIFC1 | kinesin family member C1 | -1.34 |
| SKA2 | spindle and kinetochore associated complex subunit 2 | -1.34 |
| CDC123 | cell division cycle 123 | -1.34 |
| PRICKLE3 | prickle homolog 3 (Drosophila) | -1.34 |
| TPGS1 | tubulin polyglutamylase complex subunit 1 | -1.34 |
| ZCCHC2 | zinc finger, CCHC domain containing 2 | -1.33 |
| CENPJ | centromere protein J | -1.31 |
| ODC1 | ornithine decarboxylase 1 | -1.31 |
| HELLS | helicase, lymphoid-specific | -1.29 |
