Sunitinib_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sunitinib perturbation in CHP-212 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Sunitinib_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
RPL23 ribosomal protein L23 0.0956921
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 0.0794864
PTMA prothymosin, alpha 0.0710428
SYT1 synaptotagmin I 0.0642803
LINGO2 leucine rich repeat and Ig domain containing 2 0.0640207
GPC5 glypican 5 0.0549255
VIM vimentin 0.0539806
AHR aryl hydrocarbon receptor 0.053033
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0526575
PSD3 pleckstrin and Sec7 domain containing 3 0.0489475
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0461036
RPL31 ribosomal protein L31 0.0457895
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.045424
LPIN1 lipin 1 0.0450421
ACTG1 actin gamma 1 0.0449791
RPL13A ribosomal protein L13a 0.0447655
DSCAM Down syndrome cell adhesion molecule 0.0439162
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0438123
RPL19 ribosomal protein L19 0.0435622
PKM pyruvate kinase, muscle 0.0427846
RPS3 ribosomal protein S3 0.0421984
TPST1 tyrosylprotein sulfotransferase 1 0.0406887
ZSWIM6 zinc finger, SWIM-type containing 6 0.0404404
RPL34 ribosomal protein L34 0.0388972
RPS27A ribosomal protein S27a 0.0388743
AUTS2 autism susceptibility candidate 2 0.0383805
CDK19 cyclin-dependent kinase 19 0.0378058
AEBP2 AE binding protein 2 0.0377153
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 0.0362204
RPS17 ribosomal protein S17 0.0356506
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0354422
RPS24 ribosomal protein S24 0.0353378
ZFC3H1 zinc finger, C3H1-type containing 0.0350362
RPS19 ribosomal protein S19 0.0344016
ZBTB20 zinc finger and BTB domain containing 20 0.0340009
RPS12 ribosomal protein S12 0.032783
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0324968
PDE4D phosphodiesterase 4D, cAMP-specific 0.0320168
ARHGAP5 Rho GTPase activating protein 5 0.0316606
RPL37A ribosomal protein L37a 0.0315464
EIF1 eukaryotic translation initiation factor 1 0.0302612
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0297349
TPT1 tumor protein, translationally-controlled 1 0.0296955
HMBOX1 homeobox containing 1 0.0291682
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 0.0287356
VCL vinculin 0.0286879
RPLP1 ribosomal protein, large, P1 0.0281688
RPS27 ribosomal protein S27 0.0281026
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0277199
RPLP0 ribosomal protein, large, P0 0.0277141
LOC112694756 uncharaterized LOC112694756 0.0272238
ENAH enabled homolog (Drosophila) 0.0271948
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 0.0270781
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 0.0268116
RACK1 receptor for activated C kinase 1 0.0268021
MBD5 methyl-CpG binding domain protein 5 0.0267871
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0266936
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0259935
DST dystonin 0.0259738
RPL27 ribosomal protein L27 0.0258498
RPL4 ribosomal protein L4 0.0257642
HSPA8 heat shock 70kDa protein 8 0.0257064
MAP1B microtubule-associated protein 1B 0.0256969
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0255713
NIPBL Nipped-B homolog (Drosophila) 0.025228
AHNAK AHNAK nucleoprotein 0.0250551
ITPRID2 ITPR interacting domain containing 2 0.0244297
RAD21 RAD21 homolog (S. pombe) 0.0244251
ATRNL1 attractin-like 1 0.0243592
EIF3B eukaryotic translation initiation factor 3, subunit B 0.0236254
ZMYM2 zinc finger, MYM-type 2 0.0235771
SOS1 son of sevenless homolog 1 (Drosophila) 0.023241
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related) 0.0228739
DISP1 dispatched homolog 1 (Drosophila) 0.0228524
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.0226633
CSDE1 cold shock domain containing E1, RNA-binding 0.022371
CCT8 chaperonin containing TCP1, subunit 8 (theta) 0.0223111
RPS6 ribosomal protein S6 0.02224
EZR ezrin 0.0220575
ZNF124 zinc finger protein 124 0.0218159
RPL18 ribosomal protein L18 0.0217273
PALS2 protein associated with LIN7 2, MAGUK p55 family member 0.0216626
ENO1 enolase 1, (alpha) 0.0216362
TBL1X transducin (beta)-like 1X-linked 0.0216323
NPLOC4 nuclear protein localization 4 homolog (S. cerevisiae) 0.0212987
RPL9 ribosomal protein L9 0.0212817
FOXK2 forkhead box K2 0.0212636
TBX2 T-box 2 0.0211812
RPL38 ribosomal protein L38 0.0211189
DLC1 DLC1 Rho GTPase activating protein 0.0209868
ARID5B AT rich interactive domain 5B (MRF1-like) 0.020848
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.020733
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 0.0206929
SIK2 salt-inducible kinase 2 0.0206404
RPS8 ribosomal protein S8 0.0203986
RPL12 ribosomal protein L12 0.0202451
PNISR PNN-interacting serine/arginine-rich protein 0.0202092
UQCRB ubiquinol-cytochrome c reductase binding protein 0.0199412
UBE2B ubiquitin-conjugating enzyme E2B 0.0198648
STK17A serine/threonine kinase 17a 0.0198239

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.218963
FNDC3B fibronectin type III domain containing 3B -0.0765338
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0739135
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0702856
NRG1 neuregulin 1 -0.0679784
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.060413
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0587299
FAM13A family with sequence similarity 13, member A -0.057583
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0559874
CDH10 cadherin 10, type 2 (T2-cadherin) -0.0551092
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0536438
EPAS1 endothelial PAS domain protein 1 -0.0530246
NDRG1 N-myc downstream regulated 1 -0.0513003
CEMIP cell migration inducing protein, hyaluronan binding -0.0466815
DDIT4 DNA-damage-inducible transcript 4 -0.0411685
COPA coatomer protein complex, subunit alpha -0.0404349
MEF2A myocyte enhancer factor 2A -0.0401686
DTNA dystrobrevin, alpha -0.0400011
WDR45B WD repeat domain 45B -0.0399372
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0390894
HILPDA hypoxia inducible lipid droplet-associated -0.0357477
HELZ helicase with zinc finger -0.0355018
ERRFI1 ERBB receptor feedback inhibitor 1 -0.033174
MED13 mediator complex subunit 13 -0.0331437
NCOA7 nuclear receptor coactivator 7 -0.0325865
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0324346
FNIP1 folliculin interacting protein 1 -0.0322843
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0322442
BCAT1 branched chain amino-acid transaminase 1, cytosolic -0.0318174
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 -0.031547
SCARB1 scavenger receptor class B, member 1 -0.0315203
PHF21A PHD finger protein 21A -0.0299522
GOLGA4 golgin A4 -0.029445
ASPH aspartate beta-hydroxylase -0.028977
ADM adrenomedullin -0.028814
NAMPT nicotinamide phosphoribosyltransferase -0.0287977
SMAD3 SMAD family member 3 -0.02879
FNBP1 formin binding protein 1 -0.0283142
SEC31A SEC31 homolog A (S. cerevisiae) -0.0282953
SOX9 SRY (sex determining region Y)-box 9 -0.0278212
ARF4 ADP-ribosylation factor 4 -0.0276908
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0275491
RBM39 RNA binding motif protein 39 -0.0271941
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0271333
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.027099
NFIB nuclear factor I/B -0.0267285
TRA2A transformer 2 alpha homolog (Drosophila) -0.0266842
B2M beta-2-microglobulin -0.0265129
STC1 stanniocalcin 1 -0.0264419
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) -0.0258342
FHIT fragile histidine triad -0.0257782
ADNP activity-dependent neuroprotector homeobox -0.0256712
AKAP12 A kinase (PRKA) anchor protein 12 -0.025667
PPP1R15A protein phosphatase 1, regulatory subunit 15A -0.0255365
MEIS2 Meis homeobox 2 -0.0255308
FLT1 fms-related tyrosine kinase 1 -0.0255304
WDR43 WD repeat domain 43 -0.0255012
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase -0.0253597
MAML2 mastermind-like 2 (Drosophila) -0.0247899
ZNF638 zinc finger protein 638 -0.0246282
COL1A1 collagen, type I, alpha 1 -0.0244081
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0243289
CCDC88A coiled-coil domain containing 88A -0.0242843
CALD1 caldesmon 1 -0.0239391
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.023816
PHIP pleckstrin homology domain interacting protein -0.0234304
MX2 MX dynamin-like GTPase 2 -0.0232054
LSM14A LSM14A, SCD6 homolog A (S. cerevisiae) -0.0231309
COL4A2 collagen, type IV, alpha 2 -0.0228144
DLG1 discs, large homolog 1 (Drosophila) -0.0228075
TRPA1 transient receptor potential cation channel, subfamily A, member 1 -0.0225803
LDHA lactate dehydrogenase A -0.0224691
RB1CC1 RB1-inducible coiled-coil 1 -0.0223229
TPR translocated promoter region, nuclear basket protein -0.0222833
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0221527
AUH AU RNA binding protein/enoyl-CoA hydratase -0.0221431
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0221293
CDON cell adhesion associated, oncogene regulated -0.0220684
DHX40 DEAH (Asp-Glu-Ala-His) box polypeptide 40 -0.0219126
CENPF centromere protein F, 350/400kDa -0.0217248
CDH13 cadherin 13 -0.021593
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.021364
TFG TRK-fused gene -0.0212926
FUS FUS RNA binding protein -0.0210385
SCARB2 scavenger receptor class B, member 2 -0.0209238
ANGPTL4 angiopoietin-like 4 -0.0207391
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0207235
GPBP1 GC-rich promoter binding protein 1 -0.0206539
KDM3A lysine (K)-specific demethylase 3A -0.0205535
ADGRG6 adhesion G protein-coupled receptor G6 -0.0205113
ZEB1 zinc finger E-box binding homeobox 1 -0.0204757
VEGFA vascular endothelial growth factor A -0.0204096
PDIA3 protein disulfide isomerase family A, member 3 -0.0202355
LOX lysyl oxidase -0.0202347
RAB7A RAB7A, member RAS oncogene family -0.0201837
ANTXR1 anthrax toxin receptor 1 -0.0201079
EPC1 enhancer of polycomb homolog 1 (Drosophila) -0.0198601
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0197915
FMN1 formin 1 -0.0197889
ARHGAP32 Rho GTPase activating protein 32 -0.0197793