Sunitinib_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sunitinib perturbation in COLO 205 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Sunitinib_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0506344
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0373862
RPL35A ribosomal protein L35a 0.0174445
NPEPPS aminopeptidase puromycin sensitive 0.0173763
CAB39 calcium binding protein 39 0.0167511
RPS6 ribosomal protein S6 0.0157488
C6ORF132 chromosome 6 open reading frame 132 0.0151178
BICRAL BICRA like chromatin remodeling complex associated protein 0.0151085
BSDC1 BSD domain containing 1 0.0141104
ARGLU1 arginine and glutamate rich 1 0.0136133
CTNND1 catenin (cadherin-associated protein), delta 1 0.0135803
RPL34 ribosomal protein L34 0.0132884
BCL2L1 BCL2-like 1 0.0119309
ANXA4 annexin A4 0.0117287
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0113809
FTL ferritin, light polypeptide 0.0105528
NIBAN2 niban apoptosis regulator 2 0.0104273
EPB41L1 erythrocyte membrane protein band 4.1-like 1 0.0102671
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0102502
NRIP1 nuclear receptor interacting protein 1 0.0102218
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0102041
MPHOSPH8 M-phase phosphoprotein 8 0.0101215
NACA nascent polypeptide-associated complex alpha subunit 0.0100323
RPL31 ribosomal protein L31 0.0100181
TSPAN15 tetraspanin 15 0.00959137
ZMYM2 zinc finger, MYM-type 2 0.00947911
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.00939665
SREBF2 sterol regulatory element binding transcription factor 2 0.00934992
GNAS GNAS complex locus 0.00933563
MYO1D myosin ID 0.00932842
NMU neuromedin U 0.00929725
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.00926047
LASP1 LIM and SH3 protein 1 0.00922481
RPLP1 ribosomal protein, large, P1 0.0091107
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein 0.00898604
RPL37A ribosomal protein L37a 0.00882607
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 0.00879395
PNPLA7 patatin-like phospholipase domain containing 7 0.00877569
EXOC1 exocyst complex component 1 0.00877189
RPL36AL ribosomal protein L36a-like 0.00869144
CAMTA1 calmodulin binding transcription activator 1 0.0086776
OGA O-GlcNAcase 0.00858694
ITGB4 integrin, beta 4 0.00854015
SH3RF1 SH3 domain containing ring finger 1 0.0085234
RPL26 ribosomal protein L26 0.00847122
MYO5B myosin VB 0.00834928
RPL9 ribosomal protein L9 0.00833391
CRYL1 crystallin, lambda 1 0.00830473
IL4R interleukin 4 receptor 0.00823503
TPTEP2-CSNK1E TPTEP2-CSNK1E readthrough 0.00811134
CLOCK clock circadian regulator 0.00787044
KTN1 kinectin 1 (kinesin receptor) 0.00786192
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.00784112
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric 0.0077031
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) 0.00765736
RNF13 ring finger protein 13 0.00759703
PLEKHA7 pleckstrin homology domain containing, family A member 7 0.00757646
HMGXB4 HMG box domain containing 4 0.00757096
USP12 ubiquitin specific peptidase 12 0.00748498
ERGIC3 ERGIC and golgi 3 0.00744638
MAPK8 mitogen-activated protein kinase 8 0.00743222
BAZ1B bromodomain adjacent to zinc finger domain, 1B 0.00739067
EIF5B eukaryotic translation initiation factor 5B 0.00736876
RPL37 ribosomal protein L37 0.00733213
ICA1 islet cell autoantigen 1, 69kDa 0.00731435
PADI1 peptidyl arginine deiminase, type I 0.00724839
SKIC3 SKI3 subunit of superkiller complex 0.00723347
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) 0.00721378
CAPN2 calpain 2, (m/II) large subunit 0.00720904
RNF130 ring finger protein 130 0.00718501
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.00716924
DOCK6 dedicator of cytokinesis 6 0.00713244
ESF1 ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) 0.00709614
SEPTIN10 septin 10 0.00708197
SECISBP2L SECIS binding protein 2-like 0.00704369
NUMB numb homolog (Drosophila) 0.00703612
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.00702596
TLCD2 TLC domain containing 2 0.00702491
SNX1 sorting nexin 1 0.00701475
DIAPH1 diaphanous-related formin 1 0.00697608
SUN1 Sad1 and UNC84 domain containing 1 0.0069686
SET SET nuclear proto-oncogene 0.00696507
RPS14 ribosomal protein S14 0.00695606
RPS17 ribosomal protein S17 0.00693056
SMAGP small cell adhesion glycoprotein 0.00691894
NPLOC4 nuclear protein localization 4 homolog (S. cerevisiae) 0.00691473
NCKAP1 NCK-associated protein 1 0.00682076
NEK7 NIMA-related kinase 7 0.00681012
ANXA11 annexin A11 0.00679074
TMEM165 transmembrane protein 165 0.00676754
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 0.00674315
KLHDC10 kelch domain containing 10 0.00669351
NKAP NFKB activating protein 0.00664873
RTN4 reticulon 4 0.0066371
RASA2 RAS p21 protein activator 2 0.00661144
CCDC82 coiled-coil domain containing 82 0.0065781
FNBP1L formin binding protein 1-like 0.00657505
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.00655684
RPS8 ribosomal protein S8 0.00652874
ZC3H13 zinc finger CCCH-type containing 13 0.0065211

decreased expression

Symbol Name Standardized Value
EPSTI1 epithelial stromal interaction 1 (breast) -0.101745
LMO7 LIM domain 7 -0.097912
EGR1 early growth response 1 -0.0949976
GMDS GDP-mannose 4,6-dehydratase -0.0810595
EZR ezrin -0.079196
MBNL2 muscleblind-like splicing regulator 2 -0.0789154
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.075484
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0725153
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0716489
ANXA2 annexin A2 -0.0700337
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0692062
ZMYND8 zinc finger, MYND-type containing 8 -0.0604669
B2M beta-2-microglobulin -0.0587939
MACC1 metastasis associated in colon cancer 1 -0.0559871
PRKCA protein kinase C, alpha -0.0551198
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0543982
EGLN3 egl-9 family hypoxia-inducible factor 3 -0.05429
ARHGAP26 Rho GTPase activating protein 26 -0.0532624
JUN jun proto-oncogene -0.0532579
SQSTM1 sequestosome 1 -0.0526371
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0511533
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0456929
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -0.0454029
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0448973
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 -0.0448343
PLSCR1 phospholipid scramblase 1 -0.0430898
GOLGB1 golgin B1 -0.0430256
MX2 MX dynamin-like GTPase 2 -0.0428961
CCNL1 cyclin L1 -0.0422292
MYO1E myosin IE -0.0422223
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0420639
VMP1 vacuole membrane protein 1 -0.0418815
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0406086
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0390591
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0386724
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0384642
SEC31A SEC31 homolog A (S. cerevisiae) -0.0381819
RNF213 ring finger protein 213 -0.0379731
ITGA6 integrin, alpha 6 -0.0371815
H1-0 H1.0 linker histone -0.0366848
MSI2 musashi RNA-binding protein 2 -0.0362115
IRF1 interferon regulatory factor 1 -0.0355061
SP100 SP100 nuclear antigen -0.035467
RBM39 RNA binding motif protein 39 -0.0348114
BCLAF1 BCL2-associated transcription factor 1 -0.0343864
FNDC3B fibronectin type III domain containing 3B -0.0336716
NDRG1 N-myc downstream regulated 1 -0.033313
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0331423
RIGI RNA sensor RIG-I -0.0331127
RAB7A RAB7A, member RAS oncogene family -0.0325058
PTMA prothymosin, alpha -0.0323764
LYZ lysozyme -0.0322303
FNDC3A fibronectin type III domain containing 3A -0.0319389
DSCAM Down syndrome cell adhesion molecule -0.0318916
ENO1 enolase 1, (alpha) -0.0315141
PKM pyruvate kinase, muscle -0.0313357
INTS6 integrator complex subunit 6 -0.0309768
LCN2 lipocalin 2 -0.0308128
RUNX1 runt-related transcription factor 1 -0.0305791
GCLC glutamate-cysteine ligase, catalytic subunit -0.0302357
CANX calnexin -0.0300177
MEIS2 Meis homeobox 2 -0.0299598
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0295174
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.0295147
SPATA13 spermatogenesis associated 13 -0.0294223
XAF1 XIAP associated factor 1 -0.0293379
SPAG9 sperm associated antigen 9 -0.0291258
ABLIM1 actin binding LIM protein 1 -0.0290447
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38 -0.0290224
RABGAP1L RAB GTPase activating protein 1-like -0.0286497
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 -0.0286166
VCL vinculin -0.0285814
BTBD9 BTB (POZ) domain containing 9 -0.0284496
AHI1 Abelson helper integration site 1 -0.0280538
MX1 MX dynamin-like GTPase 1 -0.0279533
MORF4L2 mortality factor 4 like 2 -0.0278813
LDHA lactate dehydrogenase A -0.0277712
TRIM2 tripartite motif containing 2 -0.027734
FOXP1 forkhead box P1 -0.0271952
EPHB2 EPH receptor B2 -0.0271469
ANXA1 annexin A1 -0.0270128
LOC102724023 ES1 protein homolog, mitochondrial -0.0266842
HLA-E major histocompatibility complex, class I, E -0.0266198
ATXN1 ataxin 1 -0.0262229
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.0260435
TMC5 transmembrane channel-like 5 -0.0259668
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.0259003
MAML2 mastermind-like 2 (Drosophila) -0.0257712
ABHD2 abhydrolase domain containing 2 -0.0256588
ZNF292 zinc finger protein 292 -0.0252891
ERN1 endoplasmic reticulum to nucleus signaling 1 -0.0252453
NKD1 naked cuticle homolog 1 (Drosophila) -0.0248602
RAD51B RAD51 paralog B -0.024757
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0245064
PGK1 phosphoglycerate kinase 1 -0.0243332
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.024322
PDIA3 protein disulfide isomerase family A, member 3 -0.0242116
CALR calreticulin -0.0242054
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0241578
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0240897