Sunitinib_HS-578T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sunitinib perturbation in HS-578T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Sunitinib_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.23979
COL6A3 collagen, type VI, alpha 3 0.101097
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.100548
STC1 stanniocalcin 1 0.0716332
MYH9 myosin, heavy chain 9, non-muscle 0.0622805
TRIO trio Rho guanine nucleotide exchange factor 0.0540931
TM4SF1 transmembrane 4 L six family member 1 0.0529387
FBN1 fibrillin 1 0.0502964
IGFBP3 insulin-like growth factor binding protein 3 0.0434733
SOD2 superoxide dismutase 2, mitochondrial 0.0387878
COL1A1 collagen, type I, alpha 1 0.0387071
UBC ubiquitin C 0.0378891
COL5A1 collagen, type V, alpha 1 0.0347415
APP amyloid beta (A4) precursor protein 0.0313892
ERRFI1 ERBB receptor feedback inhibitor 1 0.030908
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.0304438
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.029531
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0280034
CLIC4 chloride intracellular channel 4 0.0278833
MTSS1 metastasis suppressor 1 0.0275914
CXCL8 chemokine (C-X-C motif) ligand 8 0.0265102
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0263741
ATP13A3 ATPase type 13A3 0.0260856
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 0.0259188
LTBP1 latent transforming growth factor beta binding protein 1 0.0254097
SLC39A14 solute carrier family 39 (zinc transporter), member 14 0.025001
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.024547
ECT2 epithelial cell transforming 2 0.0239681
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0238351
EXT1 exostosin glycosyltransferase 1 0.0236024
CALR calreticulin 0.0225585
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 0.0219739
SMAD3 SMAD family member 3 0.0219479
KDM3A lysine (K)-specific demethylase 3A 0.0218272
COL7A1 collagen, type VII, alpha 1 0.0217861
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.021732
TRAM2 translocation associated membrane protein 2 0.0208634
RND3 Rho family GTPase 3 0.0204737
FNDC3B fibronectin type III domain containing 3B 0.0203073
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0201375
HDLBP high density lipoprotein binding protein 0.0201149
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.0200374
HAS2 hyaluronan synthase 2 0.0194729
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.0193138
ICAM1 intercellular adhesion molecule 1 0.0185021
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0184899
SPAG9 sperm associated antigen 9 0.0181197
DPYSL3 dihydropyrimidinase-like 3 0.018112
STAT1 signal transducer and activator of transcription 1, 91kDa 0.017761
PICALM phosphatidylinositol binding clathrin assembly protein 0.0171061
TMEM263 transmembrane protein 263 0.0170166
NAMPT nicotinamide phosphoribosyltransferase 0.0170129
MAPK8 mitogen-activated protein kinase 8 0.0169379
CLTC clathrin, heavy chain (Hc) 0.0166834
RHEB Ras homolog enriched in brain 0.0165556
ANXA1 annexin A1 0.0165206
MYO9B myosin IXB 0.0165169
FAM20C family with sequence similarity 20, member C 0.0163892
COL4A1 collagen, type IV, alpha 1 0.0163779
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.0159145
SAFB2 scaffold attachment factor B2 0.0158063
KDM7A lysine (K)-specific demethylase 7A 0.0157459
CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 0.0152422
CTNND1 catenin (cadherin-associated protein), delta 1 0.0151763
CMIP c-Maf inducing protein 0.0151339
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 0.01511
RB1CC1 RB1-inducible coiled-coil 1 0.0150553
RASA3 RAS p21 protein activator 3 0.0147223
SEC31A SEC31 homolog A (S. cerevisiae) 0.0146301
SDC4 syndecan 4 0.0145921
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.014327
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0142758
BZW1 basic leucine zipper and W2 domains 1 0.0142312
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.014194
ANLN anillin, actin binding protein 0.0141641
EIF4A2 eukaryotic translation initiation factor 4A2 0.0141626
H1-0 H1.0 linker histone 0.0141298
VMP1 vacuole membrane protein 1 0.0137851
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0137441
IPO7 importin 7 0.0137209
NAV2 neuron navigator 2 0.0136439
TMEM39A transmembrane protein 39A 0.013538
CALU calumenin 0.0134648
DUSP6 dual specificity phosphatase 6 0.0134251
MYSM1 Myb-like, SWIRM and MPN domains 1 0.0133965
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 0.0133551
CNOT12 CCR4-NOT transcription complex subunit 12 0.0133549
MCL1 myeloid cell leukemia 1 0.0132973
CCDC9 coiled-coil domain containing 9 0.013222
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0132175
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0131491
IQGAP1 IQ motif containing GTPase activating protein 1 0.013013
SBNO1 strawberry notch homolog 1 (Drosophila) 0.0129392
HIPK1 homeodomain interacting protein kinase 1 0.0129388
PDIA4 protein disulfide isomerase family A, member 4 0.0129257
DDB1 damage-specific DNA binding protein 1, 127kDa 0.0128414
IL6 interleukin 6 0.0128118
ELL2 elongation factor, RNA polymerase II, 2 0.0126663
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) 0.0126557
GRB10 growth factor receptor-bound protein 10 0.0126263

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.202803
MT2A metallothionein 2A -0.170536
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.151333
NDRG1 N-myc downstream regulated 1 -0.130762
TMSB10 thymosin beta 10 -0.121412
RPS6 ribosomal protein S6 -0.104385
FTL ferritin, light polypeptide -0.0979563
RPS8 ribosomal protein S8 -0.0942481
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0841334
RPS19 ribosomal protein S19 -0.0711333
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0676617
RPS3 ribosomal protein S3 -0.0594568
B2M beta-2-microglobulin -0.0587667
RPL35A ribosomal protein L35a -0.0584924
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0572078
RPL23 ribosomal protein L23 -0.0566445
ALCAM activated leukocyte cell adhesion molecule -0.056375
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.056253
ZBTB20 zinc finger and BTB domain containing 20 -0.0539541
RPS12 ribosomal protein S12 -0.0532882
RPL11 ribosomal protein L11 -0.0526537
RPL19 ribosomal protein L19 -0.0526064
PTMA prothymosin, alpha -0.0513614
RPLP1 ribosomal protein, large, P1 -0.0508853
RPL36 ribosomal protein L36 -0.0494452
DSTN destrin (actin depolymerizing factor) -0.0473283
RPL37A ribosomal protein L37a -0.0466979
RPL12 ribosomal protein L12 -0.0455581
TPM4 tropomyosin 4 -0.0453855
ENO1 enolase 1, (alpha) -0.0452852
RPL28 ribosomal protein L28 -0.0444318
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0443573
CYB5R3 cytochrome b5 reductase 3 -0.0435116
RPL26 ribosomal protein L26 -0.0430633
PFN1 profilin 1 -0.0427152
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0426143
RACK1 receptor for activated C kinase 1 -0.0424988
RPS14 ribosomal protein S14 -0.0423179
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0421767
RPL5 ribosomal protein L5 -0.0412923
YBX1 Y box binding protein 1 -0.0400701
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0396841
RPL8 ribosomal protein L8 -0.0393287
RPLP0 ribosomal protein, large, P0 -0.0380115
RPL7 ribosomal protein L7 -0.0380053
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0377945
TPM2 tropomyosin 2 (beta) -0.0372237
RPL18 ribosomal protein L18 -0.0363204
S100A9 S100 calcium binding protein A9 -0.0356615
HLA-B major histocompatibility complex, class I, B -0.034182
RPL31 ribosomal protein L31 -0.0341663
RPL9 ribosomal protein L9 -0.0327054
RPS16 ribosomal protein S16 -0.0326133
HMGA1 high mobility group AT-hook 1 -0.0324776
IGFBP7 insulin-like growth factor binding protein 7 -0.0323942
RPS17 ribosomal protein S17 -0.0323533
EIF1 eukaryotic translation initiation factor 1 -0.0320878
RPL30 ribosomal protein L30 -0.0317952
CADM1 cell adhesion molecule 1 -0.0316164
HLA-A major histocompatibility complex, class I, A -0.0309597
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0304971
IFITM3 interferon induced transmembrane protein 3 -0.0300373
RPL34 ribosomal protein L34 -0.0293342
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.028909
RPL13A ribosomal protein L13a -0.0288931
RPS25 ribosomal protein S25 -0.0287805
RPL32 ribosomal protein L32 -0.0276056
S100A6 S100 calcium binding protein A6 -0.0275563
DLG1 discs, large homolog 1 (Drosophila) -0.0273287
RPL37 ribosomal protein L37 -0.0272709
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0272166
GNAS GNAS complex locus -0.0268758
UGCG UDP-glucose ceramide glucosyltransferase -0.0267783
ARHGAP29 Rho GTPase activating protein 29 -0.0267045
TPI1 triosephosphate isomerase 1 -0.0266686
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0263117
CST3 cystatin C -0.0260177
MAP1B microtubule-associated protein 1B -0.025961
ACTG1 actin gamma 1 -0.0258651
RPS5 ribosomal protein S5 -0.0256821
ITGA11 integrin, alpha 11 -0.0253498
RPLP2 ribosomal protein, large, P2 -0.0252995
ASPH aspartate beta-hydroxylase -0.0250541
RPS11 ribosomal protein S11 -0.0249791
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0248046
EGFR epidermal growth factor receptor -0.0246629
MTDH metadherin -0.0245235
TGFBI transforming growth factor, beta-induced, 68kDa -0.0244826
TPM1 tropomyosin 1 (alpha) -0.0242924
EEF1G eukaryotic translation elongation factor 1 gamma -0.0242119
RPS13 ribosomal protein S13 -0.0239711
NALF1 NALCN channel auxiliary factor 1 -0.023753
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0236053
STC2 stanniocalcin 2 -0.0235933
EDIL3 EGF-like repeats and discoidin I-like domains 3 -0.0235731
RTN4 reticulon 4 -0.023556
RPS20 ribosomal protein S20 -0.0233622
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 -0.0232005
EEF2 eukaryotic translation elongation factor 2 -0.0223796
RPL35 ribosomal protein L35 -0.0221469