| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Sunitinib perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Sunitinib_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.168318 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0921548 |
| APOB | apolipoprotein B | 0.0800235 |
| DSPP | dentin sialophosphoprotein | 0.0625497 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0551281 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0533573 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0493022 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0446809 |
| SDC4 | syndecan 4 | 0.0420689 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0415575 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0414655 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0406345 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0392044 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0341691 |
| CANX | calnexin | 0.0334189 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0329091 |
| RBM39 | RNA binding motif protein 39 | 0.0298809 |
| INSIG2 | insulin induced gene 2 | 0.0286193 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0274531 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0272701 |
| ENO1 | enolase 1, (alpha) | 0.0266337 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0264151 |
| RPS2 | ribosomal protein S2 | 0.0242873 |
| DHRS2 | dehydrogenase/reductase (SDR family) member 2 | 0.0237455 |
| RPL7 | ribosomal protein L7 | 0.0231398 |
| JAK1 | Janus kinase 1 | 0.0229405 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0227413 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0226144 |
| GPC3 | glypican 3 | 0.0224867 |
| CFB | complement factor B | 0.0223848 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.022094 |
| CCL20 | chemokine (C-C motif) ligand 20 | 0.0220906 |
| SPAG9 | sperm associated antigen 9 | 0.0219941 |
| B2M | beta-2-microglobulin | 0.0219794 |
| MATR3 | matrin 3 | 0.0214063 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0212064 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0211858 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0211083 |
| RPS8 | ribosomal protein S8 | 0.0208781 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0204602 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.0203417 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0202559 |
| TMEM181 | transmembrane protein 181 | 0.0196181 |
| ARRDC3 | arrestin domain containing 3 | 0.0194891 |
| SFTPA2 | surfactant protein A2 | 0.0191986 |
| SERINC3 | serine incorporator 3 | 0.0191723 |
| NCKAP1 | NCK-associated protein 1 | 0.0191288 |
| PAPOLA | poly(A) polymerase alpha | 0.0191046 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0186178 |
| A2M | alpha-2-macroglobulin | 0.0185651 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0185384 |
| SERINC1 | serine incorporator 1 | 0.018251 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0180417 |
| ITIH2 | inter-alpha-trypsin inhibitor heavy chain 2 | 0.0179248 |
| SSR1 | signal sequence receptor, alpha | 0.0178304 |
| EIF3E | eukaryotic translation initiation factor 3, subunit E | 0.0173685 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0172414 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0171274 |
| RNASET2 | ribonuclease T2 | 0.0171232 |
| LRRC1 | leucine rich repeat containing 1 | 0.016881 |
| RPL11 | ribosomal protein L11 | 0.0168444 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0166074 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | 0.0163386 |
| CEP350 | centrosomal protein 350kDa | 0.0162038 |
| WDR45B | WD repeat domain 45B | 0.0160044 |
| EIF3L | eukaryotic translation initiation factor 3, subunit L | 0.0159836 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0157876 |
| DNAJC1 | DnaJ (Hsp40) homolog, subfamily C, member 1 | 0.0157753 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0157548 |
| TRIM26 | tripartite motif containing 26 | 0.0157145 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0155638 |
| RLF | rearranged L-myc fusion | 0.015379 |
| RPS18 | ribosomal protein S18 | 0.0152337 |
| KIF5B | kinesin family member 5B | 0.0151882 |
| SET | SET nuclear proto-oncogene | 0.0148085 |
| UBC | ubiquitin C | 0.0146923 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0146911 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0146616 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0146427 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.014471 |
| PTMA | prothymosin, alpha | 0.0144409 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0144222 |
| PCCA | propionyl CoA carboxylase, alpha polypeptide | 0.0144161 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.014353 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0143474 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | 0.0142512 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | 0.0142351 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0142172 |
| PDGFB | platelet-derived growth factor beta polypeptide | 0.0141802 |
| RPL7A | ribosomal protein L7a | 0.0140947 |
| IFNGR1 | interferon gamma receptor 1 | 0.0140485 |
| TF | transferrin | 0.0139035 |
| TIAL1 | TIA1 cytotoxic granule-associated RNA binding protein-like 1 | 0.0137871 |
| CHMP4B | charged multivesicular body protein 4B | 0.0137279 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | 0.0136621 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | 0.0135866 |
| APOE | apolipoprotein E | 0.0133896 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0133333 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0131902 |
| OPTN | optineurin | 0.0131743 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGF2 | insulin-like growth factor 2 | -0.280176 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | -0.264631 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | -0.131085 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0970399 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.085892 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0818374 |
| GPC6 | glypican 6 | -0.0787971 |
| FN1 | fibronectin 1 | -0.0782495 |
| ITGAV | integrin, alpha V | -0.0762558 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.0699633 |
| MT2A | metallothionein 2A | -0.067968 |
| VCL | vinculin | -0.0669849 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0650889 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0605696 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0577412 |
| DST | dystonin | -0.0557562 |
| PTCHD4 | patched domain containing 4 | -0.0553191 |
| EGR1 | early growth response 1 | -0.0498507 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0495471 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.049341 |
| EHBP1 | EH domain binding protein 1 | -0.0473296 |
| FBF1 | Fas (TNFRSF6) binding factor 1 | -0.0466123 |
| ANKRD1 | ankyrin repeat domain 1 (cardiac muscle) | -0.044914 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0436436 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0426128 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0414652 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.04063 |
| LRMDA | leucine rich melanocyte differentiation associated | -0.0404576 |
| FARP1 | FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) | -0.0395761 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0375251 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.0372453 |
| DNAH17 | dynein, axonemal, heavy chain 17 | -0.0371098 |
| ZNF644 | zinc finger protein 644 | -0.0361918 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0360282 |
| PAWR | PRKC, apoptosis, WT1, regulator | -0.0360228 |
| STK17A | serine/threonine kinase 17a | -0.0352915 |
| LMCD1 | LIM and cysteine-rich domains 1 | -0.0352798 |
| GPAM | glycerol-3-phosphate acyltransferase, mitochondrial | -0.0350657 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0341371 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0325241 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.0323868 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0306379 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.0301025 |
| ATP1A4 | ATPase, Na+/K+ transporting, alpha 4 polypeptide | -0.0299456 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.029434 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.028435 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | -0.0281102 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | -0.0269211 |
| AHR | aryl hydrocarbon receptor | -0.0262519 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0258095 |
| MALRD1 | MAM and LDL receptor class A domain containing 1 | -0.0254547 |
| CDH2 | cadherin 2, type 1, N-cadherin (neuronal) | -0.0250623 |
| RPL35A | ribosomal protein L35a | -0.0246751 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0245655 |
| FAT1 | FAT atypical cadherin 1 | -0.0244008 |
| ATXN1 | ataxin 1 | -0.0241001 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0234562 |
| BCL2L1 | BCL2-like 1 | -0.0233822 |
| CYB5R3 | cytochrome b5 reductase 3 | -0.0230852 |
| FILIP1L | filamin A interacting protein 1-like | -0.023068 |
| PARD3 | par-3 family cell polarity regulator | -0.0228384 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | -0.0228215 |
| CMIP | c-Maf inducing protein | -0.0227442 |
| NRIP1 | nuclear receptor interacting protein 1 | -0.0222543 |
| FOXP1 | forkhead box P1 | -0.0222163 |
| TPM1 | tropomyosin 1 (alpha) | -0.0217615 |
| CADM1 | cell adhesion molecule 1 | -0.0217431 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | -0.0216255 |
| RBM25 | RNA binding motif protein 25 | -0.0216084 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.021248 |
| MYO1E | myosin IE | -0.0211557 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | -0.0210487 |
| SCN9A | sodium channel, voltage gated, type IX alpha subunit | -0.0209283 |
| SEC62 | SEC62 homolog (S. cerevisiae) | -0.02037 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0199259 |
| CCN2 | cellular communication network factor 2 | -0.0199197 |
| LYZ | lysozyme | -0.0199107 |
| SRRM2 | serine/arginine repetitive matrix 2 | -0.0197486 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | -0.0196446 |
| HMGA1 | high mobility group AT-hook 1 | -0.0196297 |
| RUNX1 | runt-related transcription factor 1 | -0.0195054 |
| LCOR | ligand dependent nuclear receptor corepressor | -0.0193562 |
| MBNL2 | muscleblind-like splicing regulator 2 | -0.0193375 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | -0.0192857 |
| COBLL1 | cordon-bleu WH2 repeat protein-like 1 | -0.0192243 |
| FAM107B | family with sequence similarity 107, member B | -0.01906 |
| CNKSR3 | CNKSR family member 3 | -0.0186676 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0185262 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0184123 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0183018 |
| RAB7A | RAB7A, member RAS oncogene family | -0.018146 |
| SYNJ2 | synaptojanin 2 | -0.0180109 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0178443 |
| APOA1 | apolipoprotein A-I | -0.0176887 |
| PPP1R9A | protein phosphatase 1, regulatory subunit 9A | -0.0176632 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | -0.0175665 |
| VEGFA | vascular endothelial growth factor A | -0.0173259 |
| ESF1 | ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) | -0.0172083 |
| NABP1 | nucleic acid binding protein 1 | -0.0170637 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0169318 |
