Sunitinib_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sunitinib perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Sunitinib_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CEMIP cell migration inducing protein, hyaluronan binding 0.0389603
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.0355177
PRELID2 PRELI domain containing 2 0.0341722
KIAA1217 KIAA1217 0.0294949
OGA O-GlcNAcase 0.0269616
ITCH itchy E3 ubiquitin protein ligase 0.0268082
LIFR leukemia inhibitory factor receptor alpha 0.0256952
CTNND1 catenin (cadherin-associated protein), delta 1 0.024987
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0246616
H1-0 H1.0 linker histone 0.0221303
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain 0.0213342
NPEPPS aminopeptidase puromycin sensitive 0.0212996
HYCC2 hyccin PI4KA lipid kinase complex subunit 2 0.0210683
NAMPT nicotinamide phosphoribosyltransferase 0.0209008
DSCAM Down syndrome cell adhesion molecule 0.020419
NCOA3 nuclear receptor coactivator 3 0.0203837
MEF2A myocyte enhancer factor 2A 0.0203057
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 0.0198589
FLOT1 flotillin 1 0.0197688
SBF2 SET binding factor 2 0.0196194
SLC45A4 solute carrier family 45, member 4 0.0193691
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0184664
CDK19 cyclin-dependent kinase 19 0.0181264
BRWD3 bromodomain and WD repeat domain containing 3 0.0175742
NT5C2 5'-nucleotidase, cytosolic II 0.0173152
PNISR PNN-interacting serine/arginine-rich protein 0.0171214
AOPEP aminopeptidase O (putative) 0.0168227
KDM3A lysine (K)-specific demethylase 3A 0.0164836
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0160803
ZNF292 zinc finger protein 292 0.0156319
CD46 CD46 molecule, complement regulatory protein 0.0154771
ABHD17C abhydrolase domain containing 17C 0.0153429
ANKRD10 ankyrin repeat domain 10 0.0153421
DLG1 discs, large homolog 1 (Drosophila) 0.0151532
ARHGAP29 Rho GTPase activating protein 29 0.0144778
ANKH ANKH inorganic pyrophosphate transport regulator 0.0144422
ANKRD33B ankyrin repeat domain 33B 0.0143608
HIP1 huntingtin interacting protein 1 0.01428
CD47 CD47 molecule 0.0135831
PLAT plasminogen activator, tissue 0.0134737
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0133374
DDB2 damage-specific DNA binding protein 2, 48kDa 0.0133196
YEATS2 YEATS domain containing 2 0.0132229
CEP95 centrosomal protein 95kDa 0.0131239
ANXA11 annexin A11 0.0128607
MARCHF6 membrane associated ring-CH-type finger 6 0.012815
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0127696
PARP4 poly (ADP-ribose) polymerase family, member 4 0.0122962
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.0120914
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0119716
RB1CC1 RB1-inducible coiled-coil 1 0.0115522
OTUD7B OTU deubiquitinase 7B 0.0114205
USP24 ubiquitin specific peptidase 24 0.011237
MNAT1 MNAT CDK-activating kinase assembly factor 1 0.0112294
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0110387
WDR26 WD repeat domain 26 0.0109342
ANXA4 annexin A4 0.0108645
KDM6A lysine (K)-specific demethylase 6A 0.0108097
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.0108082
CREBRF CREB3 regulatory factor 0.0107957
RIPK2 receptor-interacting serine-threonine kinase 2 0.0106893
OSBPL6 oxysterol binding protein-like 6 0.0106128
ARHGAP12 Rho GTPase activating protein 12 0.0106033
RNF145 ring finger protein 145 0.0104652
DNAJC13 DnaJ (Hsp40) homolog, subfamily C, member 13 0.0103998
UBE2H ubiquitin-conjugating enzyme E2H 0.0103623
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.010335
APOLD1 apolipoprotein L domain containing 1 0.0103054
PLAAT3 phospholipase A and acyltransferase 3 0.0102431
ELF2 E74-like factor 2 (ets domain transcription factor) 0.0102426
PDE8A phosphodiesterase 8A 0.0102332
LIN54 lin-54 DREAM MuvB core complex component 0.0102271
PLAC8 placenta-specific 8 0.0101806
CDC42SE2 CDC42 small effector 2 0.0101191
BIRC2 baculoviral IAP repeat containing 2 0.0100391
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0100011
SERINC1 serine incorporator 1 0.0100009
UVRAG UV radiation resistance associated 0.00991611
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5 0.00986368
PSMD5 proteasome (prosome, macropain) 26S subunit, non-ATPase, 5 0.00977632
ATP6V1H ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H 0.00976289
POU2F1 POU class 2 homeobox 1 0.00965811
DNAH5 dynein, axonemal, heavy chain 5 0.00961928
GATA6 GATA binding protein 6 0.00960408
GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase 0.00959944
ALDH1A3 aldehyde dehydrogenase 1 family, member A3 0.00958937
RNF19B ring finger protein 19B 0.00954396
TMEM41B transmembrane protein 41B 0.00953282
SLC41A2 solute carrier family 41 (magnesium transporter), member 2 0.00953263
OSBPL9 oxysterol binding protein-like 9 0.00948345
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 0.00943293
PSMF1 proteasome (prosome, macropain) inhibitor subunit 1 (PI31) 0.00938312
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.00936309
GPBP1L1 GC-rich promoter binding protein 1-like 1 0.00936007
RSRP1 arginine/serine-rich protein 1 0.00928978
SOS1 son of sevenless homolog 1 (Drosophila) 0.00925877
MRPS6 mitochondrial ribosomal protein S6 0.00922038
RNF149 ring finger protein 149 0.00920592
SCFD1 sec1 family domain containing 1 0.00918732
FAM168B family with sequence similarity 168, member B 0.00907718

decreased expression

Symbol Name Standardized Value
TIMP3 TIMP metallopeptidase inhibitor 3 -0.238236
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.231225
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.122636
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.120905
FLNB filamin B, beta -0.119989
POTEF POTE ankyrin domain family, member F -0.116284
ANXA1 annexin A1 -0.112942
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.10811
LMO7 LIM domain 7 -0.102755
LDHA lactate dehydrogenase A -0.0960612
ENO1 enolase 1, (alpha) -0.0924944
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0874923
NDRG1 N-myc downstream regulated 1 -0.0845085
SLC35F3 solute carrier family 35, member F3 -0.0810109
MTSS1 metastasis suppressor 1 -0.0801281
CD44 CD44 molecule (Indian blood group) -0.0795411
PODXL podocalyxin-like -0.0786842
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0783773
DPYD dihydropyrimidine dehydrogenase -0.07466
ALCAM activated leukocyte cell adhesion molecule -0.0732614
PGK1 phosphoglycerate kinase 1 -0.0717603
TMSB10 thymosin beta 10 -0.0691696
RPS6 ribosomal protein S6 -0.0676317
HSPG2 heparan sulfate proteoglycan 2 -0.0665196
RASAL2 RAS protein activator like 2 -0.0654307
PDLIM5 PDZ and LIM domain 5 -0.0631213
PTMA prothymosin, alpha -0.0631196
ITGA6 integrin, alpha 6 -0.0629911
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0602537
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0596712
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0595113
RPS8 ribosomal protein S8 -0.0591204
APLP2 amyloid beta (A4) precursor-like protein 2 -0.059033
LOC112694756 uncharaterized LOC112694756 -0.0578811
IFITM3 interferon induced transmembrane protein 3 -0.0552227
B2M beta-2-microglobulin -0.0543083
ANO1 anoctamin 1, calcium activated chloride channel -0.0527761
PLS3 plastin 3 -0.0525986
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0516769
CAV1 caveolin 1, caveolae protein, 22kDa -0.0505428
IFITM1 interferon induced transmembrane protein 1 -0.0492314
MT2A metallothionein 2A -0.0487621
ANXA2 annexin A2 -0.048534
RPS3 ribosomal protein S3 -0.0478114
EMP1 epithelial membrane protein 1 -0.0468609
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0466466
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 -0.0463364
S100A10 S100 calcium binding protein A10 -0.0459382
PSD3 pleckstrin and Sec7 domain containing 3 -0.0456865
RPL37 ribosomal protein L37 -0.0453493
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0449461
CDK6 cyclin-dependent kinase 6 -0.0447316
LAMC2 laminin, gamma 2 -0.0443421
TPM3 tropomyosin 3 -0.043824
EZR ezrin -0.0437553
HMGA2 high mobility group AT-hook 2 -0.0432558
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0432146
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0431731
SULF2 sulfatase 2 -0.0429627
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.0423413
SAMD9 sterile alpha motif domain containing 9 -0.0422247
ZSWIM6 zinc finger, SWIM-type containing 6 -0.04218
CALB1 calbindin 1, 28kDa -0.0421767
RACK1 receptor for activated C kinase 1 -0.0421456
PALLD palladin, cytoskeletal associated protein -0.0420432
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0420173
GRB10 growth factor receptor-bound protein 10 -0.0417157
RPL11 ribosomal protein L11 -0.0411941
HM13 histocompatibility (minor) 13 -0.041093
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 -0.0410512
TGM2 transglutaminase 2 -0.040718
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0405518
EEF2 eukaryotic translation elongation factor 2 -0.0403147
LMNA lamin A/C -0.0402524
RPL23 ribosomal protein L23 -0.0398028
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0395999
RIGI RNA sensor RIG-I -0.0390578
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0388099
PDE4D phosphodiesterase 4D, cAMP-specific -0.0387091
ACTN4 actinin, alpha 4 -0.0383531
MACF1 microtubule-actin crosslinking factor 1 -0.0382573
AKAP13 A kinase (PRKA) anchor protein 13 -0.0379808
INTS6 integrator complex subunit 6 -0.0373677
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0369591
KTN1 kinectin 1 (kinesin receptor) -0.0368962
MSN moesin -0.0363159
KLF5 Kruppel-like factor 5 (intestinal) -0.0354862
CALR calreticulin -0.0352489
F3 coagulation factor III (thromboplastin, tissue factor) -0.0351331
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.03495
YBX1 Y box binding protein 1 -0.0349168
GOLGB1 golgin B1 -0.0347366
TSC22D1 TSC22 domain family, member 1 -0.0344207
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0343996
RPS25 ribosomal protein S25 -0.0340338
RABGAP1L RAB GTPase activating protein 1-like -0.0338879
TAGLN2 transgelin 2 -0.0338286
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0336067
RPS19 ribosomal protein S19 -0.0334531
PKM pyruvate kinase, muscle -0.0330899