Sunitinib_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sunitinib perturbation in LS 180 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Sunitinib_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0211823
DSCAM Down syndrome cell adhesion molecule 0.0207268
EREG epiregulin 0.0185566
RNF43 ring finger protein 43 0.0171186
ZFAND3 zinc finger, AN1-type domain 3 0.0158391
ZFC3H1 zinc finger, C3H1-type containing 0.0157814
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0157703
BTBD9 BTB (POZ) domain containing 9 0.0149495
ADAM17 ADAM metallopeptidase domain 17 0.0133896
USP34 ubiquitin specific peptidase 34 0.0130197
PICALM phosphatidylinositol binding clathrin assembly protein 0.0115905
PNISR PNN-interacting serine/arginine-rich protein 0.0110285
ACSS2 acyl-CoA synthetase short-chain family member 2 0.0108678
PTEN phosphatase and tensin homolog 0.0107316
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.010581
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.010448
PLAUR plasminogen activator, urokinase receptor 0.0103945
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0102549
RABGAP1 RAB GTPase activating protein 1 0.0101822
ESRP1 epithelial splicing regulatory protein 1 0.0101647
OGA O-GlcNAcase 0.00989065
MON2 MON2 homolog (S. cerevisiae) 0.00973629
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor 0.00967714
TMEM263 transmembrane protein 263 0.00945341
NEK7 NIMA-related kinase 7 0.00935055
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.00930433
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.00920236
DERA deoxyribose-phosphate aldolase (putative) 0.00917279
PTPRJ protein tyrosine phosphatase, receptor type, J 0.00915981
MINK1 misshapen-like kinase 1 0.00899826
DHFR dihydrofolate reductase 0.00894286
TUBE1 tubulin, epsilon 1 0.00893763
NKD1 naked cuticle homolog 1 (Drosophila) 0.00880148
AVL9 AVL9 homolog (S. cerevisiase) 0.00878525
FAM13A family with sequence similarity 13, member A 0.00876564
PHC3 polyhomeotic homolog 3 (Drosophila) 0.00863994
XRN1 5'-3' exoribonuclease 1 0.00857678
CCNG1 cyclin G1 0.00856533
ARL15 ADP-ribosylation factor-like 15 0.00833801
CASC3 cancer susceptibility candidate 3 0.00820199
CDPF1 cysteine-rich, DPF motif domain containing 1 0.00809745
NBAS neuroblastoma amplified sequence 0.00809502
ITFG1 integrin alpha FG-GAP repeat containing 1 0.00803503
CCPG1 cell cycle progression 1 0.00798098
RELCH RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing 0.00797639
INSIG1 insulin induced gene 1 0.00796296
WDR11 WD repeat domain 11 0.00795795
EXOC1 exocyst complex component 1 0.00784958
AUH AU RNA binding protein/enoyl-CoA hydratase 0.00783874
CARD16 caspase recruitment domain family, member 16 0.00776537
FUT3 fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group) 0.00773859
EP300 E1A binding protein p300 0.00769876
ASNS asparagine synthetase (glutamine-hydrolyzing) 0.00765325
NEBL nebulette 0.00761617
SRP54 signal recognition particle 54kDa 0.00756556
RNF145 ring finger protein 145 0.0075379
CDK19 cyclin-dependent kinase 19 0.00753434
GOSR1 golgi SNAP receptor complex member 1 0.00749959
ZNF160 zinc finger protein 160 0.00748808
TENT2 terminal nucleotidyltransferase 2 0.00737437
TOM1L1 target of myb1 (chicken)-like 1 0.00732076
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.00731429
MED13L mediator complex subunit 13-like 0.00730859
GAK cyclin G associated kinase 0.00715723
HBS1L HBS1-like translational GTPase 0.00714577
MBD5 methyl-CpG binding domain protein 5 0.0071215
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 0.00710491
TNS4 tensin 4 0.00710372
KDM4B lysine (K)-specific demethylase 4B 0.00707449
CRLS1 cardiolipin synthase 1 0.00703147
TMEM87B transmembrane protein 87B 0.00699234
COPA coatomer protein complex, subunit alpha 0.00693677
SHB Src homology 2 domain containing adaptor protein B 0.00688529
BNIP2 BCL2/adenovirus E1B 19kDa interacting protein 2 0.00687875
WASHC4 WASH complex subunit 4 0.00684222
ARFGAP1 ADP-ribosylation factor GTPase activating protein 1 0.00681298
KDM7A lysine (K)-specific demethylase 7A 0.00675833
HEATR5B HEAT repeat containing 5B 0.00673319
ZMYM2 zinc finger, MYM-type 2 0.00671446
SPRED1 sprouty-related, EVH1 domain containing 1 0.00669923
RSRP1 arginine/serine-rich protein 1 0.00664984
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.00663462
TBC1D22A TBC1 domain family, member 22A 0.00658193
VMP1 vacuole membrane protein 1 0.00658089
FNIP1 folliculin interacting protein 1 0.00646322
MLPH melanophilin 0.00646217
FDPS farnesyl diphosphate synthase 0.00644625
CARS1 cysteinyl-tRNA synthetase 1 0.00644506
EPC1 enhancer of polycomb homolog 1 (Drosophila) 0.00644311
CDK5RAP3 CDK5 regulatory subunit associated protein 3 0.00644307
FBXO42 F-box protein 42 0.0063748
TM9SF3 transmembrane 9 superfamily member 3 0.00632305
PTCH1 patched 1 0.00631781
AP2A2 adaptor-related protein complex 2, alpha 2 subunit 0.00628464
GNA13 guanine nucleotide binding protein (G protein), alpha 13 0.00625522
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.00624904
RIC1 RAB6A GEF complex partner 1 0.00621904
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.00618585
RASSF3 Ras association (RalGDS/AF-6) domain family member 3 0.00617356
MYSM1 Myb-like, SWIRM and MPN domains 1 0.00616847

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.296175
TMSB10 thymosin beta 10 -0.162362
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.141414
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.139553
RPS6 ribosomal protein S6 -0.120869
NPSR1 neuropeptide S receptor 1 -0.0945146
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0866589
KRT18 keratin 18, type I -0.083846
RPS8 ribosomal protein S8 -0.0791246
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0681602
RPL23 ribosomal protein L23 -0.0651846
LDHA lactate dehydrogenase A -0.0648036
RPS19 ribosomal protein S19 -0.064518
TPT1 tumor protein, translationally-controlled 1 -0.0640491
RPLP1 ribosomal protein, large, P1 -0.0636708
ALCAM activated leukocyte cell adhesion molecule -0.0634905
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0625861
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0618036
EZR ezrin -0.0599538
RPL37A ribosomal protein L37a -0.0591372
ACTG1 actin gamma 1 -0.0558805
RPS3 ribosomal protein S3 -0.0557493
ENO1 enolase 1, (alpha) -0.0531258
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0528111
RPL12 ribosomal protein L12 -0.0526032
RPS12 ribosomal protein S12 -0.0523157
ITGA6 integrin, alpha 6 -0.0520825
RPL36 ribosomal protein L36 -0.051623
FTL ferritin, light polypeptide -0.0514901
RPL26 ribosomal protein L26 -0.0489411
RPL35A ribosomal protein L35a -0.0472869
GMDS GDP-mannose 4,6-dehydratase -0.0470588
S100A6 S100 calcium binding protein A6 -0.0459402
TPM4 tropomyosin 4 -0.0452045
NALF1 NALCN channel auxiliary factor 1 -0.0437614
RPL34 ribosomal protein L34 -0.0434734
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0429144
MUC6 mucin 6, oligomeric mucus/gel-forming -0.0427267
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0427034
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0426735
KRT8 keratin 8, type II -0.0421014
MT2A metallothionein 2A -0.0420257
LOC102724023 ES1 protein homolog, mitochondrial -0.0419888
RPL11 ribosomal protein L11 -0.0418047
PGK1 phosphoglycerate kinase 1 -0.0412194
LMNA lamin A/C -0.0402301
RPL19 ribosomal protein L19 -0.0397355
RPL5 ribosomal protein L5 -0.0396186
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B -0.0386701
POTEF POTE ankyrin domain family, member F -0.0378973
RPL18 ribosomal protein L18 -0.0371546
RPL13A ribosomal protein L13a -0.0363027
RPLP2 ribosomal protein, large, P2 -0.0359438
RPS17 ribosomal protein S17 -0.035473
RPL7 ribosomal protein L7 -0.0354352
RPL9 ribosomal protein L9 -0.0354259
LMO7 LIM domain 7 -0.0350337
TPI1 triosephosphate isomerase 1 -0.0349403
RPL31 ribosomal protein L31 -0.0347738
KRT19 keratin 19, type I -0.0343743
MUC5AC mucin 5AC, oligomeric mucus/gel-forming -0.0343568
ASPH aspartate beta-hydroxylase -0.0341962
LOC112694756 uncharaterized LOC112694756 -0.0341929
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.033596
PKM pyruvate kinase, muscle -0.0335959
AHNAK AHNAK nucleoprotein -0.033484
ANXA1 annexin A1 -0.0333062
NAP1L1 nucleosome assembly protein 1-like 1 -0.0331077
LGALS3 lectin, galactoside-binding, soluble, 3 -0.0325122
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 -0.0323828
RACK1 receptor for activated C kinase 1 -0.0318411
MYO1E myosin IE -0.0317329
RPS23 ribosomal protein S23 -0.031525
PTPRK protein tyrosine phosphatase, receptor type, K -0.0313443
YBX1 Y box binding protein 1 -0.0311705
PDE4D phosphodiesterase 4D, cAMP-specific -0.0310432
SERBP1 SERPINE1 mRNA binding protein 1 -0.030148
HMGA1 high mobility group AT-hook 1 -0.0301148
CALR calreticulin -0.029832
GREB1L growth regulation by estrogen in breast cancer-like -0.0296015
EEF2 eukaryotic translation elongation factor 2 -0.0295652
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.029459
RPS29 ribosomal protein S29 -0.0290062
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0288125
FAT1 FAT atypical cadherin 1 -0.0286573
RPL32 ribosomal protein L32 -0.0285385
RPS24 ribosomal protein S24 -0.028409
RPS27 ribosomal protein S27 -0.0282287
RPS27A ribosomal protein S27a -0.0281087
S100A10 S100 calcium binding protein A10 -0.0279767
RPLP0 ribosomal protein, large, P0 -0.0273752
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0273454
RPS25 ribosomal protein S25 -0.0272707
HMGB1 high mobility group box 1 -0.0272646
EMP1 epithelial membrane protein 1 -0.0270474
TUBB4B tubulin, beta 4B class IVb -0.0265527
RPL37 ribosomal protein L37 -0.0264812
CANX calnexin -0.0263829
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0263134
DSPP dentin sialophosphoprotein -0.0262719