Sunitinib_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sunitinib perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Sunitinib_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CES1 carboxylesterase 1 0.0245135
FTH1 ferritin, heavy polypeptide 1 0.021506
CAMTA1 calmodulin binding transcription activator 1 0.0194119
GPATCH2L G patch domain containing 2-like 0.0179575
MKI67 marker of proliferation Ki-67 0.01772
NPC1 Niemann-Pick disease, type C1 0.015919
DTNA dystrobrevin, alpha 0.0155806
ADGRF1 adhesion G protein-coupled receptor F1 0.0151867
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0145436
FNIP1 folliculin interacting protein 1 0.0139262
WDR26 WD repeat domain 26 0.013739
AGO2 argonaute RISC catalytic component 2 0.0136392
RNF169 ring finger protein 169 0.0135926
KLRD1 killer cell lectin-like receptor subfamily D, member 1 0.0133704
WDR49 WD repeat domain 49 0.0124261
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0123222
RUNX1 runt-related transcription factor 1 0.0117032
NEK7 NIMA-related kinase 7 0.0116146
CAB39 calcium binding protein 39 0.0114466
MYO6 myosin VI 0.0110973
SS18 synovial sarcoma translocation, chromosome 18 0.0104021
OGA O-GlcNAcase 0.0103417
CDK19 cyclin-dependent kinase 19 0.0099548
PRELID2 PRELI domain containing 2 0.00987621
ESCO1 establishment of sister chromatid cohesion N-acetyltransferase 1 0.00955402
AGFG1 ArfGAP with FG repeats 1 0.00937328
KIAA1328 KIAA1328 0.00934345
HELB helicase (DNA) B 0.00929127
MYO1B myosin IB 0.00915738
GPAT3 glycerol-3-phosphate acyltransferase 3 0.00906254
GAK cyclin G associated kinase 0.00892725
N4BP1 NEDD4 binding protein 1 0.00860629
SLC35F5 solute carrier family 35, member F5 0.00858294
GIGYF2 GRB10 interacting GYF protein 2 0.00853373
DCUN1D2 DCN1, defective in cullin neddylation 1, domain containing 2 0.00852012
GCLM glutamate-cysteine ligase, modifier subunit 0.00826246
SREBF2 sterol regulatory element binding transcription factor 2 0.00823581
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 0.00817978
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.00807942
PHC3 polyhomeotic homolog 3 (Drosophila) 0.00807885
BLTP1 bridge-like lipid transfer protein family member 1 0.00804007
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.00802711
SMAD4 SMAD family member 4 0.00798981
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.00789138
CCNG2 cyclin G2 0.0078635
RTN4 reticulon 4 0.00784061
ZBTB1 zinc finger and BTB domain containing 1 0.0078321
MGST1 microsomal glutathione S-transferase 1 0.00780064
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.00779756
LYSMD3 LysM, putative peptidoglycan-binding, domain containing 3 0.00775002
ZBTB44 zinc finger and BTB domain containing 44 0.00770965
BET1 Bet1 golgi vesicular membrane trafficking protein 0.00762008
RAP2B RAP2B, member of RAS oncogene family 0.00759201
NFIB nuclear factor I/B 0.00758222
ZBTB20 zinc finger and BTB domain containing 20 0.0075779
SPRED2 sprouty-related, EVH1 domain containing 2 0.00754412
NFXL1 nuclear transcription factor, X-box binding-like 1 0.0075433
BSDC1 BSD domain containing 1 0.00748692
CHIC2 cysteine-rich hydrophobic domain 2 0.00742324
KLC1 kinesin light chain 1 0.00740397
METTL15 methyltransferase like 15 0.00735464
ZC3H11A zinc finger CCCH-type containing 11A 0.00735453
TBC1D22A TBC1 domain family, member 22A 0.00732118
COX16 COX16 cytochrome c oxidase assembly homolog (S. cerevisiae) 0.0073095
LVRN laeverin 0.00721257
RAB8B RAB8B, member RAS oncogene family 0.00712965
RUBCN rubicon autophagy regulator 0.00711294
RB1CC1 RB1-inducible coiled-coil 1 0.0070844
MAP2K4 mitogen-activated protein kinase kinase 4 0.00706405
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 0.00705173
PIGG phosphatidylinositol glycan anchor biosynthesis, class G 0.00698449
CPEB2 cytoplasmic polyadenylation element binding protein 2 0.00694125
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.00693164
SOS2 son of sevenless homolog 2 (Drosophila) 0.00692338
NIPA1 non imprinted in Prader-Willi/Angelman syndrome 1 0.00684563
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.00683953
CRTC3 CREB regulated transcription coactivator 3 0.0068261
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.00680125
ITGB5 integrin, beta 5 0.00675382
KDM2A lysine (K)-specific demethylase 2A 0.00674244
NGLY1 N-glycanase 1 0.00661818
APOLD1 apolipoprotein L domain containing 1 0.00655563
COPA coatomer protein complex, subunit alpha 0.00655271
STK4 serine/threonine kinase 4 0.00649829
PRMT9 protein arginine methyltransferase 9 0.00649286
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.00647833
ZFC3H1 zinc finger, C3H1-type containing 0.00645848
GAN gigaxonin 0.00643201
MAEA macrophage erythroblast attacher 0.00642482
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6 0.00639387
LPCAT2 lysophosphatidylcholine acyltransferase 2 0.00637434
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0063602
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 0.0063574
ARGLU1 arginine and glutamate rich 1 0.00632847
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.00632671
MARF1 meiosis regulator and mRNA stability factor 1 0.00629066
GRK3 G protein-coupled receptor kinase 3 0.00626142
PNISR PNN-interacting serine/arginine-rich protein 0.006241
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.00624094
FBXL5 F-box and leucine-rich repeat protein 5 0.00612691

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.299145
TMSB10 thymosin beta 10 -0.183182
EGFR epidermal growth factor receptor -0.150475
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.145707
ASPH aspartate beta-hydroxylase -0.136484
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.128142
THSD4 thrombospondin, type I, domain containing 4 -0.116878
PTPRM protein tyrosine phosphatase, receptor type, M -0.112701
PTMA prothymosin, alpha -0.110881
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0905017
ANXA2 annexin A2 -0.0882585
CAV1 caveolin 1, caveolae protein, 22kDa -0.0879541
PKM pyruvate kinase, muscle -0.0872632
ACTG1 actin gamma 1 -0.0861928
LDHA lactate dehydrogenase A -0.0789879
FNDC3B fibronectin type III domain containing 3B -0.0755992
FTL ferritin, light polypeptide -0.0726798
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0720067
S100A10 S100 calcium binding protein A10 -0.0717172
ENO1 enolase 1, (alpha) -0.0663918
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0648135
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0643136
GRAMD1B GRAM domain containing 1B -0.0594871
LMO7 LIM domain 7 -0.0557513
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0556373
EGR1 early growth response 1 -0.0548438
KRT18 keratin 18, type I -0.0539355
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0535602
RPS3 ribosomal protein S3 -0.0534186
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0526478
LOC112694756 uncharaterized LOC112694756 -0.0519065
SEC61G Sec61 gamma subunit -0.0516964
PDE4D phosphodiesterase 4D, cAMP-specific -0.0491422
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0474929
STC1 stanniocalcin 1 -0.0470767
KRT7 keratin 7, type II -0.0457951
CST3 cystatin C -0.0445837
NDRG1 N-myc downstream regulated 1 -0.0442716
INTS6 integrator complex subunit 6 -0.043875
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0416151
IGFBP5 insulin-like growth factor binding protein 5 -0.0415718
MT2A metallothionein 2A -0.0399894
CCND1 cyclin D1 -0.0374681
RPLP1 ribosomal protein, large, P1 -0.0369483
DSPP dentin sialophosphoprotein -0.0365132
H1-0 H1.0 linker histone -0.0363916
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0363882
FAM13A family with sequence similarity 13, member A -0.0361181
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0359053
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0358842
RPL35A ribosomal protein L35a -0.0355418
SCEL sciellin -0.03545
TPT1 tumor protein, translationally-controlled 1 -0.0354067
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0351466
RPL37A ribosomal protein L37a -0.0350147
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0347968
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0347856
EGLN3 egl-9 family hypoxia-inducible factor 3 -0.034647
TPM4 tropomyosin 4 -0.0342977
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0342685
BZW1 basic leucine zipper and W2 domains 1 -0.0340079
PGK1 phosphoglycerate kinase 1 -0.0336111
MYOF myoferlin -0.0335632
AKAP12 A kinase (PRKA) anchor protein 12 -0.0334787
RPS25 ribosomal protein S25 -0.0332621
LPP LIM domain containing preferred translocation partner in lipoma -0.033237
SLC38A2 solute carrier family 38, member 2 -0.0330062
SLC38A1 solute carrier family 38, member 1 -0.0329252
MYO1E myosin IE -0.0328028
RNF213 ring finger protein 213 -0.0327212
AHNAK AHNAK nucleoprotein -0.0326739
MORF4L2 mortality factor 4 like 2 -0.0326314
IFI6 interferon, alpha-inducible protein 6 -0.0325197
PDLIM5 PDZ and LIM domain 5 -0.0320411
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0319474
HDLBP high density lipoprotein binding protein -0.0317871
LAMC2 laminin, gamma 2 -0.0315958
B2M beta-2-microglobulin -0.0314263
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0314216
TPD52 tumor protein D52 -0.0311133
RPS24 ribosomal protein S24 -0.0302773
EMP1 epithelial membrane protein 1 -0.0302771
MACF1 microtubule-actin crosslinking factor 1 -0.0302482
RPS12 ribosomal protein S12 -0.0300291
RPS8 ribosomal protein S8 -0.0298383
GNAS GNAS complex locus -0.0298178
RPL19 ribosomal protein L19 -0.0293866
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0288355
SLTM SAFB-like, transcription modulator -0.0288085
RPL31 ribosomal protein L31 -0.0287657
CANX calnexin -0.0286448
PARD3 par-3 family cell polarity regulator -0.028581
IGFBP3 insulin-like growth factor binding protein 3 -0.0283423
IER3 immediate early response 3 -0.0282464
EFNA5 ephrin-A5 -0.0279752
CPE carboxypeptidase E -0.0278662
RPL11 ribosomal protein L11 -0.0276785
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0274536
S100P S100 calcium binding protein P -0.0274343
S100A6 S100 calcium binding protein A6 -0.027353