Sunitinib_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sunitinib perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Sunitinib_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PM20D1 peptidase M20 domain containing 1 0.0766265
FGB fibrinogen beta chain 0.0531634
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0510045
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0403566
ERRFI1 ERBB receptor feedback inhibitor 1 0.0331061
USP3 ubiquitin specific peptidase 3 0.0265878
CALR calreticulin 0.0222622
FAM168A family with sequence similarity 168, member A 0.0218494
PTP4A1 protein tyrosine phosphatase type IVA, member 1 0.0212973
RRM2 ribonucleotide reductase M2 0.0208506
TFG TRK-fused gene 0.020529
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0204211
PKM pyruvate kinase, muscle 0.020141
POTEF POTE ankyrin domain family, member F 0.0199469
PRPF8 pre-mRNA processing factor 8 0.0195121
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0189883
CCNL1 cyclin L1 0.0182971
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0182817
FGG fibrinogen gamma chain 0.01771
LAPTM4A lysosomal protein transmembrane 4 alpha 0.0176744
KHDC4 KH domain containing 4, pre-mRNA splicing factor 0.0174023
EIF4A1 eukaryotic translation initiation factor 4A1 0.0168962
TPM3 tropomyosin 3 0.0166593
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 0.0165885
TRA2A transformer 2 alpha homolog (Drosophila) 0.0161928
EIF4A2 eukaryotic translation initiation factor 4A2 0.0157931
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0157279
RHEB Ras homolog enriched in brain 0.0156542
HSPA8 heat shock 70kDa protein 8 0.0150348
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3 0.0148376
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0148109
MORF4L1 mortality factor 4 like 1 0.0147045
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0144594
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0142562
RBM27 RNA binding motif protein 27 0.0141834
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.014172
EIF4A3 eukaryotic translation initiation factor 4A3 0.0139853
ANXA5 annexin A5 0.0139586
SRRM1 serine/arginine repetitive matrix 1 0.0137846
NAMPT nicotinamide phosphoribosyltransferase 0.0135265
TFRC transferrin receptor 0.0134277
TPX2 TPX2, microtubule-associated 0.0133513
NOLC1 nucleolar and coiled-body phosphoprotein 1 0.0132167
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0131189
DCAF5 DDB1 and CUL4 associated factor 5 0.0131091
PDIA6 protein disulfide isomerase family A, member 6 0.0129611
HBS1L HBS1-like translational GTPase 0.0128653
PSMC6 proteasome (prosome, macropain) 26S subunit, ATPase, 6 0.0127979
CYRIB CYFIP related Rac1 interactor B 0.012692
BRD2 bromodomain containing 2 0.0126792
NR4A2 nuclear receptor subfamily 4, group A, member 2 0.0126781
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.0124811
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0120701
JAK1 Janus kinase 1 0.0120129
RYBP RING1 and YY1 binding protein 0.0119647
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A 0.0117777
CALU calumenin 0.011751
SRSF7 serine/arginine-rich splicing factor 7 0.0117428
ILF2 interleukin enhancer binding factor 2 0.0116901
ZNF292 zinc finger protein 292 0.0115904
YBX1 Y box binding protein 1 0.0115621
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0115474
RNF145 ring finger protein 145 0.0115099
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.0114935
FGA fibrinogen alpha chain 0.0114786
CASC3 cancer susceptibility candidate 3 0.0114634
MTF2 metal response element binding transcription factor 2 0.011348
ATP5F1B ATP synthase F1 subunit beta 0.0110237
BUD23 BUD23 rRNA methyltransferase and ribosome maturation factor 0.0110099
TMEM123 transmembrane protein 123 0.0109522
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0108627
YBX3 Y box binding protein 3 0.0108591
AP2B1 adaptor-related protein complex 2, beta 1 subunit 0.0107723
CCL2 chemokine (C-C motif) ligand 2 0.0107104
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) 0.010665
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0106525
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.0106003
EWSR1 EWS RNA-binding protein 1 0.0105821
NUP58 nucleoporin 58 0.0105662
PRRC1 proline-rich coiled-coil 1 0.0103854
OSBPL9 oxysterol binding protein-like 9 0.0103713
NXF1 nuclear RNA export factor 1 0.010366
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0102675
RNF121 ring finger protein 121 0.0102122
EIF4E eukaryotic translation initiation factor 4E 0.0101694
RPS4Y1 ribosomal protein S4, Y-linked 1 0.0101502
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 0.0101295
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0100274
RSRC2 arginine/serine-rich coiled-coil 2 0.0100152
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0099044
BCLAF1 BCL2-associated transcription factor 1 0.00989515
YME1L1 YME1-like 1 ATPase 0.0098929
CABIN1 calcineurin binding protein 1 0.00981455
SPOPL speckle-type POZ protein-like 0.0097017
HBP1 HMG-box transcription factor 1 0.00968091
TRA2B transformer 2 beta homolog (Drosophila) 0.00966643
PATL1 protein associated with topoisomerase II homolog 1 (yeast) 0.00963318
KDM3A lysine (K)-specific demethylase 3A 0.00953658
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.00948561
PLS3 plastin 3 0.00945986

decreased expression

Symbol Name Standardized Value
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.198149
MT2A metallothionein 2A -0.128001
THSD4 thrombospondin, type I, domain containing 4 -0.123747
TMSB10 thymosin beta 10 -0.12307
PDE4D phosphodiesterase 4D, cAMP-specific -0.0932792
VIM vimentin -0.0926217
AKAP12 A kinase (PRKA) anchor protein 12 -0.0773575
RPL23 ribosomal protein L23 -0.0703182
DOCK4 dedicator of cytokinesis 4 -0.0658339
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0617858
SAMD4A sterile alpha motif domain containing 4A -0.0611477
ANKRD11 ankyrin repeat domain 11 -0.0610444
PARD3 par-3 family cell polarity regulator -0.05861
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0574941
CMIP c-Maf inducing protein -0.0572202
RPL19 ribosomal protein L19 -0.0569683
SVIL supervillin -0.0563458
FNDC3B fibronectin type III domain containing 3B -0.0559057
TRIO trio Rho guanine nucleotide exchange factor -0.0546821
EGFR epidermal growth factor receptor -0.0543553
DST dystonin -0.0501601
TXNRD1 thioredoxin reductase 1 -0.0490418
RPL37A ribosomal protein L37a -0.043892
FMNL2 formin-like 2 -0.0435477
FTL ferritin, light polypeptide -0.0435303
EIF1 eukaryotic translation initiation factor 1 -0.0433302
DOCK5 dedicator of cytokinesis 5 -0.0423462
NRG1 neuregulin 1 -0.0407635
KTN1 kinectin 1 (kinesin receptor) -0.0407577
MAML3 mastermind-like 3 (Drosophila) -0.0406626
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0406517
IER3 immediate early response 3 -0.0404766
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0400243
FLNB filamin B, beta -0.0398257
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0387713
LPP LIM domain containing preferred translocation partner in lipoma -0.0385786
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0384281
NTN4 netrin 4 -0.0381153
RPS12 ribosomal protein S12 -0.0376842
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0363581
RPS8 ribosomal protein S8 -0.0362855
ACTG1 actin gamma 1 -0.035705
RPS6 ribosomal protein S6 -0.0348854
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0346632
RPLP1 ribosomal protein, large, P1 -0.0346492
IGFBP3 insulin-like growth factor binding protein 3 -0.0345789
PYGL phosphorylase, glycogen, liver -0.0344895
RPL36 ribosomal protein L36 -0.0344736
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0340685
AHNAK AHNAK nucleoprotein -0.0330383
ZFAND3 zinc finger, AN1-type domain 3 -0.0327161
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.032668
EFNA5 ephrin-A5 -0.0322932
EXT1 exostosin glycosyltransferase 1 -0.0322452
GLIS3 GLIS family zinc finger 3 -0.0319531
ASPH aspartate beta-hydroxylase -0.0316973
EHBP1 EH domain binding protein 1 -0.0315596
ARHGAP26 Rho GTPase activating protein 26 -0.0314811
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0313266
NAV3 neuron navigator 3 -0.0312199
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0310876
AGO2 argonaute RISC catalytic component 2 -0.0310282
BIRC6 baculoviral IAP repeat containing 6 -0.0306544
TPT1 tumor protein, translationally-controlled 1 -0.030477
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0303201
RPS19 ribosomal protein S19 -0.030183
ZBTB20 zinc finger and BTB domain containing 20 -0.0299823
RPS27A ribosomal protein S27a -0.0299688
RPL31 ribosomal protein L31 -0.0298272
SLC35F3 solute carrier family 35, member F3 -0.0293369
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 -0.029239
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0290784
RPL36AL ribosomal protein L36a-like -0.028688
RPS27 ribosomal protein S27 -0.0284954
USP34 ubiquitin specific peptidase 34 -0.0284067
RPL26 ribosomal protein L26 -0.0284061
PTK2 protein tyrosine kinase 2 -0.0281753
ANKRD12 ankyrin repeat domain 12 -0.0279363
CUX1 cut-like homeobox 1 -0.0276807
RPL37 ribosomal protein L37 -0.0274049
ACTN1 actinin, alpha 1 -0.0270187
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0264876
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0263806
PATJ PATJ crumbs cell polarity complex component -0.0262112
RAD51B RAD51 paralog B -0.0261234
WAC WW domain containing adaptor with coiled-coil -0.0258052
MYOF myoferlin -0.0256436
NIPBL Nipped-B homolog (Drosophila) -0.0254668
RPL9 ribosomal protein L9 -0.0252441
RPLP0 ribosomal protein, large, P0 -0.0249135
RPL18 ribosomal protein L18 -0.024654
CFLAR CASP8 and FADD-like apoptosis regulator -0.0246325
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0245442
MAP1B microtubule-associated protein 1B -0.0245275
SMOC1 SPARC related modular calcium binding 1 -0.0245128
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0240878
UBASH3B ubiquitin associated and SH3 domain containing B -0.0240793
EXOC6B exocyst complex component 6B -0.0239972
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0232979
KYNU kynureninase -0.0231735