Sunitinib_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sunitinib perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

169 genes differentially expressed following the Sunitinib_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VIM vimentin 0.195706
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.172613
LDHA lactate dehydrogenase A 0.134447
FLNB filamin B, beta 0.125843
ZNF292 zinc finger protein 292 0.113359
TMSB10 thymosin beta 10 0.112332
LMNA lamin A/C 0.107595
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.101497
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0997071
STC1 stanniocalcin 1 0.0987281
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0984152
PKM pyruvate kinase, muscle 0.0972031
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0969374
PSD3 pleckstrin and Sec7 domain containing 3 0.0955332
FN1 fibronectin 1 0.0889526
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0868933
WDFY2 WD repeat and FYVE domain containing 2 0.085605
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0838524
ETNK1 ethanolamine kinase 1 0.0833779
NKD1 naked cuticle homolog 1 (Drosophila) 0.08234
ACTG1 actin gamma 1 0.0807718
EFNA5 ephrin-A5 0.0806309
PTMA prothymosin, alpha 0.0803248
CTNND1 catenin (cadherin-associated protein), delta 1 0.0799584
TIMP3 TIMP metallopeptidase inhibitor 3 0.0793914
GMDS GDP-mannose 4,6-dehydratase 0.0769936
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0744108
SEPTIN7 septin 7 0.0737871
P4HB prolyl 4-hydroxylase, beta polypeptide 0.073462
KDM2A lysine (K)-specific demethylase 2A 0.0728719
B2M beta-2-microglobulin 0.0727733
OGA O-GlcNAcase 0.0714112
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0680344
MATR3 matrin 3 0.0670689
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.0659155
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0652712
IQGAP1 IQ motif containing GTPase activating protein 1 0.0643343
NIPBL Nipped-B homolog (Drosophila) 0.0641934
RAP1B RAP1B, member of RAS oncogene family 0.0625872
MAP4 microtubule-associated protein 4 0.0619444
TRIP12 thyroid hormone receptor interactor 12 0.0562076
SLC38A1 solute carrier family 38, member 1 0.0561106
NDRG1 N-myc downstream regulated 1 0.0538817
RPS6 ribosomal protein S6 0.0496647
VCL vinculin 0.0491281
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0484472
HELZ helicase with zinc finger 0.0475756
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0453966
FNDC3A fibronectin type III domain containing 3A 0.0436515
MYH9 myosin, heavy chain 9, non-muscle 0.039009
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0386138
PGK1 phosphoglycerate kinase 1 0.0380139
BIRC6 baculoviral IAP repeat containing 6 0.035024
TRIO trio Rho guanine nucleotide exchange factor 0.0330886
CANX calnexin 0.0326611
RPS8 ribosomal protein S8 0.0319153
EXT1 exostosin glycosyltransferase 1 0.0271829
KDM3A lysine (K)-specific demethylase 3A 0.0270593
FNBP1 formin binding protein 1 0.0268199
SRSF11 serine/arginine-rich splicing factor 11 0.0266679
EEF2 eukaryotic translation elongation factor 2 0.0265153
AKAP12 A kinase (PRKA) anchor protein 12 0.0265072
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0211427
ALCAM activated leukocyte cell adhesion molecule 0.0205125
ASPH aspartate beta-hydroxylase 0.0203576
PRRC2C proline-rich coiled-coil 2C 0.0202608
DOCK4 dedicator of cytokinesis 4 0.0201046
MORF4L2 mortality factor 4 like 2 0.0197755
ANXA2 annexin A2 0.0179042
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0172734
TBC1D5 TBC1 domain family, member 5 0.0166886
HDAC4 histone deacetylase 4 0.0139531
RPS4X ribosomal protein S4, X-linked 0.0130908
POTEF POTE ankyrin domain family, member F 0.0117453
MACF1 microtubule-actin crosslinking factor 1 0.0111957
SRPK2 SRSF protein kinase 2 0.00702646
WDR45B WD repeat domain 45B 0.00701833
AFDN afadin, adherens junction formation factor 0.00629581
RICTOR RPTOR independent companion of MTOR, complex 2 0.0047409
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.00362646
ZFAND3 zinc finger, AN1-type domain 3 0.00293492
TNRC6B trinucleotide repeat containing 6B 0.00266183
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.00201001
TPM4 tropomyosin 4 6.03526E-5

decreased expression

Symbol Name Standardized Value
ENO1 enolase 1, (alpha) -0.148812
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.141768
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.121456
LPP LIM domain containing preferred translocation partner in lipoma -0.117449
PDE10A phosphodiesterase 10A -0.115708
KMT2C lysine (K)-specific methyltransferase 2C -0.115405
CXCL8 chemokine (C-X-C motif) ligand 8 -0.113625
EGFR epidermal growth factor receptor -0.112767
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.11101
TBC1D22A TBC1 domain family, member 22A -0.110544
MYO1E myosin IE -0.0964554
KTN1 kinectin 1 (kinesin receptor) -0.0847863
ELL2 elongation factor, RNA polymerase II, 2 -0.079879
KANSL1 KAT8 regulatory NSL complex subunit 1 -0.0763721
EPB41L2 erythrocyte membrane protein band 4.1-like 2 -0.0761355
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) -0.074894
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0743622
SPAG9 sperm associated antigen 9 -0.0735827
PDE8A phosphodiesterase 8A -0.0715402
FMN1 formin 1 -0.0703256
ARRDC3 arrestin domain containing 3 -0.0701093
SBF2 SET binding factor 2 -0.0696638
RUNX1 runt-related transcription factor 1 -0.0660268
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0656835
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.063783
TXNRD1 thioredoxin reductase 1 -0.0624771
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0605528
USP34 ubiquitin specific peptidase 34 -0.0604235
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0592087
EIF1 eukaryotic translation initiation factor 1 -0.0589857
DSCAM Down syndrome cell adhesion molecule -0.0565045
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -0.0560332
SOD2 superoxide dismutase 2, mitochondrial -0.0560212
MCL1 myeloid cell leukemia 1 -0.0557265
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0522377
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.0506547
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0483521
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0478943
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0461679
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0450574
ITCH itchy E3 ubiquitin protein ligase -0.0444464
HDAC9 histone deacetylase 9 -0.0423146
GPC6 glypican 6 -0.0405393
GOLGA4 golgin A4 -0.0400846
RPS3 ribosomal protein S3 -0.038287
CD44 CD44 molecule (Indian blood group) -0.0380204
PTK2 protein tyrosine kinase 2 -0.036812
RPLP1 ribosomal protein, large, P1 -0.0354093
RAB7A RAB7A, member RAS oncogene family -0.0346549
SLTM SAFB-like, transcription modulator -0.0333066
NAMPT nicotinamide phosphoribosyltransferase -0.0317992
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0307514
DST dystonin -0.0303845
FMNL2 formin-like 2 -0.029585
NKTR natural killer cell triggering receptor -0.0294774
PIAS1 protein inhibitor of activated STAT, 1 -0.0264988
RPL31 ribosomal protein L31 -0.026387
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0262711
YBX3 Y box binding protein 3 -0.0262081
FTH1 ferritin, heavy polypeptide 1 -0.0249214
MYO6 myosin VI -0.0230502
DLG1 discs, large homolog 1 (Drosophila) -0.0220469
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0219014
SMYD3 SET and MYND domain containing 3 -0.018646
IGF2 insulin-like growth factor 2 -0.0139438
MYOF myoferlin -0.0136886
HLA-B major histocompatibility complex, class I, B -0.0131878
RTN4 reticulon 4 -0.0102616
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0097263
TOP1 topoisomerase (DNA) I -0.00863263
VMP1 vacuole membrane protein 1 -0.00823595
CORO1C coronin, actin binding protein, 1C -0.00769977
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.00718078
SUCO SUN domain containing ossification factor -0.00687904
NCKAP1 NCK-associated protein 1 -0.00668866
WAC WW domain containing adaptor with coiled-coil -0.00559098
RPL19 ribosomal protein L19 -0.00521929
TPT1 tumor protein, translationally-controlled 1 -0.00439271
PDE4D phosphodiesterase 4D, cAMP-specific -0.00389652
HLA-A major histocompatibility complex, class I, A -0.00282447
FNDC3B fibronectin type III domain containing 3B -0.00277585
TLK2 tousled-like kinase 2 -0.00209296
MT2A metallothionein 2A -0.00197733
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -6.85243E-4
FTL ferritin, light polypeptide -2.1217E-4