Sunitinib_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sunitinib perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Sunitinib_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AHNAK AHNAK nucleoprotein 0.105764
VCL vinculin 0.0723393
TPT1 tumor protein, translationally-controlled 1 0.0711873
PTMA prothymosin, alpha 0.0681213
TMSB4X thymosin beta 4, X-linked 0.0534871
PDE4D phosphodiesterase 4D, cAMP-specific 0.0520658
NAP1L1 nucleosome assembly protein 1-like 1 0.0453847
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0451522
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.038753
NBEA neurobeachin 0.0383376
RPL13A ribosomal protein L13a 0.0364103
RPL12 ribosomal protein L12 0.0349947
PYGB phosphorylase, glycogen; brain 0.0337643
RPS27A ribosomal protein S27a 0.0327559
PRELID2 PRELI domain containing 2 0.0322828
RPL37A ribosomal protein L37a 0.0307385
RPL26 ribosomal protein L26 0.0299831
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0293869
RPS3 ribosomal protein S3 0.0289657
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b 0.0289134
NAV2 neuron navigator 2 0.0276378
RPL9 ribosomal protein L9 0.0267282
SMYD3 SET and MYND domain containing 3 0.0267015
RSL1D1 ribosomal L1 domain containing 1 0.0259919
RPLP1 ribosomal protein, large, P1 0.0257009
RPL31 ribosomal protein L31 0.0253614
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0249442
FOXP1 forkhead box P1 0.0247343
RPS8 ribosomal protein S8 0.0241508
KLF3 Kruppel-like factor 3 (basic) 0.023933
RPL34 ribosomal protein L34 0.0237299
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0231237
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0227261
TMEM65 transmembrane protein 65 0.0225781
TM4SF1 transmembrane 4 L six family member 1 0.0224761
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0223734
PDGFC platelet derived growth factor C 0.022207
MYO5C myosin VC 0.0218516
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0218257
GLI3 GLI family zinc finger 3 0.0217623
RPS24 ribosomal protein S24 0.0216753
RPLP2 ribosomal protein, large, P2 0.0215713
TJP1 tight junction protein 1 0.021433
RPL18 ribosomal protein L18 0.0210837
UNC13A unc-13 homolog A (C. elegans) 0.0205985
KLF6 Kruppel-like factor 6 0.0205249
RPL23 ribosomal protein L23 0.0201794
TAS2R14 taste receptor, type 2, member 14 0.0200709
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0198563
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.0197399
CAMTA1 calmodulin binding transcription activator 1 0.0197089
DENND1A DENN/MADD domain containing 1A 0.0195582
MYL12B myosin, light chain 12B, regulatory 0.0195042
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0193772
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0190263
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.018988
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.01852
BZW1 basic leucine zipper and W2 domains 1 0.0185033
RPS29 ribosomal protein S29 0.0181746
TTC28 tetratricopeptide repeat domain 28 0.0181682
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) 0.0181364
BMP2K BMP2 inducible kinase 0.0181127
ARL4C ADP-ribosylation factor-like 4C 0.0180421
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0179022
MLIP muscular LMNA-interacting protein 0.0176086
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0174255
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0173275
IFI6 interferon, alpha-inducible protein 6 0.0172828
ALDH1A2 aldehyde dehydrogenase 1 family, member A2 0.0172561
IFI16 interferon, gamma-inducible protein 16 0.017233
DARS1 aspartyl-tRNA synthetase 1 0.0172264
TGFBR3 transforming growth factor, beta receptor III 0.0172194
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0170373
ACTG1 actin gamma 1 0.01699
AOPEP aminopeptidase O (putative) 0.0168916
ANKRD12 ankyrin repeat domain 12 0.0168265
HJURP Holliday junction recognition protein 0.0166268
SRP14 signal recognition particle 14kDa (homologous Alu RNA binding protein) 0.0163387
RPS19 ribosomal protein S19 0.0160439
RAD21 RAD21 homolog (S. pombe) 0.0160124
ABI1 abl-interactor 1 0.0158493
ANLN anillin, actin binding protein 0.0158013
CD47 CD47 molecule 0.0157253
EBNA1BP2 EBNA1 binding protein 2 0.0153033
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 0.015258
MKI67 marker of proliferation Ki-67 0.0152219
PARP4 poly (ADP-ribose) polymerase family, member 4 0.0150536
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0150443
SET SET nuclear proto-oncogene 0.0149213
PAN3 PAN3 poly(A) specific ribonuclease subunit 0.0148924
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A 0.0148427
EHBP1 EH domain binding protein 1 0.0148093
FMN1 formin 1 0.0146929
RPL35 ribosomal protein L35 0.0145398
NSD3 nuclear receptor binding SET domain protein 3 0.0145329
HMGB2 high mobility group box 2 0.0144387
YEATS2 YEATS domain containing 2 0.014429
ETV6 ets variant 6 0.0142283
ANKIB1 ankyrin repeat and IBR domain containing 1 0.0142203
CPED1 cadherin-like and PC-esterase domain containing 1 0.0141189

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.257629
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.11458
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.100037
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.0876066
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0734107
POTEF POTE ankyrin domain family, member F -0.072269
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0673715
PKM pyruvate kinase, muscle -0.0652104
SSBP2 single-stranded DNA binding protein 2 -0.0620458
KMT2E lysine (K)-specific methyltransferase 2E -0.0581322
ENO2 enolase 2 (gamma, neuronal) -0.0558855
EZR ezrin -0.054428
RHOA ras homolog family member A -0.0529306
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0528768
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0526705
GOLGA4 golgin A4 -0.0515331
NUP58 nucleoporin 58 -0.0479155
HDAC9 histone deacetylase 9 -0.0476787
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 -0.0475885
IARS1 isoleucyl-tRNA synthetase 1 -0.0458611
RNF145 ring finger protein 145 -0.0450047
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0444357
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0443368
NAMPT nicotinamide phosphoribosyltransferase -0.043599
QKI QKI, KH domain containing, RNA binding -0.0431331
PFN1 profilin 1 -0.0425898
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0421102
EEF2 eukaryotic translation elongation factor 2 -0.0417065
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0415751
CCNL1 cyclin L1 -0.0415674
USP3 ubiquitin specific peptidase 3 -0.0414854
PCBP2 poly(rC) binding protein 2 -0.0388143
ECT2 epithelial cell transforming 2 -0.0383858
ZNF207 zinc finger protein 207 -0.037802
COG6 component of oligomeric golgi complex 6 -0.0374434
HMGA1 high mobility group AT-hook 1 -0.0368468
GARS1 glycyl-tRNA synthetase 1 -0.0362617
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.0359741
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -0.0352089
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0349264
PDE4B phosphodiesterase 4B, cAMP-specific -0.0346936
TFG TRK-fused gene -0.0345024
PDIA3 protein disulfide isomerase family A, member 3 -0.0343683
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0342797
WDR43 WD repeat domain 43 -0.03404
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.0337636
SEC31A SEC31 homolog A (S. cerevisiae) -0.032665
FBXO11 F-box protein 11 -0.0325167
ELOVL5 ELOVL fatty acid elongase 5 -0.0319465
ZFAND3 zinc finger, AN1-type domain 3 -0.0316664
MATR3 matrin 3 -0.0314943
EVI5 ecotropic viral integration site 5 -0.0314287
COPA coatomer protein complex, subunit alpha -0.0311677
ZNF292 zinc finger protein 292 -0.0311515
RNASE3 ribonuclease, RNase A family, 3 -0.0310067
TXNIP thioredoxin interacting protein -0.0306448
CALR calreticulin -0.0304597
SPATS2L spermatogenesis associated, serine-rich 2-like -0.0304086
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 -0.0304076
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0303658
SESN2 sestrin 2 -0.0301678
CCND1 cyclin D1 -0.0300249
RTN4 reticulon 4 -0.0296389
WAC WW domain containing adaptor with coiled-coil -0.0295449
CNOT6L CCR4-NOT transcription complex, subunit 6-like -0.0293481
LOC112694756 uncharaterized LOC112694756 -0.0291966
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.028929
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.028364
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0278954
TMEM41B transmembrane protein 41B -0.027508
RPS2 ribosomal protein S2 -0.0271575
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0269595
MSI2 musashi RNA-binding protein 2 -0.0269008
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0263506
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0261062
SETD5 SET domain containing 5 -0.025613
NBAS neuroblastoma amplified sequence -0.0254345
FXR1 fragile X mental retardation, autosomal homolog 1 -0.0252599
MED13 mediator complex subunit 13 -0.025177
CDC73 cell division cycle 73 -0.0250568
AKAP9 A kinase (PRKA) anchor protein 9 -0.0249807
RAB6A RAB6A, member RAS oncogene family -0.0247729
DSTN destrin (actin depolymerizing factor) -0.0247708
SRRM2 serine/arginine repetitive matrix 2 -0.0246932
DLG1 discs, large homolog 1 (Drosophila) -0.0246303
ADAM9 ADAM metallopeptidase domain 9 -0.0240188
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0240099
SMC3 structural maintenance of chromosomes 3 -0.0237061
B2M beta-2-microglobulin -0.0233851
ATOSA atos homolog A -0.0233762
TSC22D2 TSC22 domain family, member 2 -0.0233708
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0232999
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase -0.0229538
RPL3 ribosomal protein L3 -0.0227975
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0226213
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 -0.0225828
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0225594
NCOR1 nuclear receptor corepressor 1 -0.0225058
CRY1 cryptochrome circadian clock 1 -0.0222373
CNOT4 CCR4-NOT transcription complex, subunit 4 -0.022182