Sunitinib_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sunitinib perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Sunitinib_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.127874
COL6A3 collagen, type VI, alpha 3 0.0977924
MT2A metallothionein 2A 0.0816971
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0816471
COL1A1 collagen, type I, alpha 1 0.0777745
COL1A2 collagen, type I, alpha 2 0.0767635
TMSB10 thymosin beta 10 0.0750703
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0715867
PTMA prothymosin, alpha 0.0563992
FTL ferritin, light polypeptide 0.0543737
B2M beta-2-microglobulin 0.0538602
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0503682
NAMPT nicotinamide phosphoribosyltransferase 0.0415124
COL3A1 collagen, type III, alpha 1 0.0403769
ELL2 elongation factor, RNA polymerase II, 2 0.0374402
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0364254
MT1X metallothionein 1X 0.0357361
HLA-C major histocompatibility complex, class I, C 0.0352571
LGALS1 lectin, galactoside-binding, soluble, 1 0.0332491
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0324004
ARRDC3 arrestin domain containing 3 0.0321972
PTN pleiotrophin 0.0320685
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0304093
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 0.0301933
HMGB2 high mobility group box 2 0.030023
FAM13A family with sequence similarity 13, member A 0.0292911
HOOK2 hook microtubule-tethering protein 2 0.029149
ANXA2 annexin A2 0.0285185
RAB1A RAB1A, member RAS oncogene family 0.0282571
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.0281081
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0278795
DLG1 discs, large homolog 1 (Drosophila) 0.0276316
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 0.0276138
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0272749
H3-3B H3.3 histone B 0.0267731
RPS3 ribosomal protein S3 0.0263497
HLA-B major histocompatibility complex, class I, B 0.0263392
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0262777
GNAS GNAS complex locus 0.0261757
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0261624
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0260812
KDM3A lysine (K)-specific demethylase 3A 0.0258989
RPS8 ribosomal protein S8 0.0252059
RPS24 ribosomal protein S24 0.0248897
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0247487
EIF1 eukaryotic translation initiation factor 1 0.0244695
TXNRD1 thioredoxin reductase 1 0.023891
LAMA4 laminin, alpha 4 0.0236571
DDIT4 DNA-damage-inducible transcript 4 0.0231804
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0229454
S100A6 S100 calcium binding protein A6 0.0228346
PLCB4 phospholipase C, beta 4 0.0227174
TPM4 tropomyosin 4 0.0227002
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0226582
RPLP1 ribosomal protein, large, P1 0.022642
ACTG1 actin gamma 1 0.0225772
S100A9 S100 calcium binding protein A9 0.022499
PGK1 phosphoglycerate kinase 1 0.0223636
RLF rearranged L-myc fusion 0.0223253
MARCHF6 membrane associated ring-CH-type finger 6 0.0219695
ATP13A3 ATPase type 13A3 0.0218075
MMP14 matrix metallopeptidase 14 (membrane-inserted) 0.0216552
RPS19 ribosomal protein S19 0.0214678
GOLGA4 golgin A4 0.0211108
SH3BP5 SH3-domain binding protein 5 (BTK-associated) 0.021036
WSB1 WD repeat and SOCS box containing 1 0.0208348
RPL19 ribosomal protein L19 0.0207941
ZFHX3 zinc finger homeobox 3 0.020455
SYT1 synaptotagmin I 0.0202984
CALU calumenin 0.0202276
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0200615
PDIA4 protein disulfide isomerase family A, member 4 0.0198005
TPT1 tumor protein, translationally-controlled 1 0.0193408
MXI1 MAX interactor 1, dimerization protein 0.0193235
RPL7 ribosomal protein L7 0.0192355
BTN3A3 butyrophilin, subfamily 3, member A3 0.0191649
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 0.0190136
TMED9 transmembrane emp24 protein transport domain containing 9 0.0190015
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.0189735
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0188123
CAVIN1 caveolae associated protein 1 0.0186476
R3HDM1 R3H domain containing 1 0.0184038
TPI1 triosephosphate isomerase 1 0.0182138
SDC4 syndecan 4 0.018196
RPLP0 ribosomal protein, large, P0 0.0181773
TNPO1 transportin 1 0.0181658
SCARB2 scavenger receptor class B, member 2 0.0180665
BIRC2 baculoviral IAP repeat containing 2 0.0179293
IGFBP7 insulin-like growth factor binding protein 7 0.0178229
ACSL4 acyl-CoA synthetase long-chain family member 4 0.0177834
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.0176068
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0174375
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.0173516
CCNI cyclin I 0.0172867
TUBA1B tubulin, alpha 1b 0.0172458
LOC102724023 ES1 protein homolog, mitochondrial 0.0170531
PLAUR plasminogen activator, urokinase receptor 0.0169178
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 0.0168659
GOLGA2 golgin A2 0.0166042
NCOR1 nuclear receptor corepressor 1 0.0163995

decreased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 -0.205337
TGFBI transforming growth factor, beta-induced, 68kDa -0.126305
CXCL8 chemokine (C-X-C motif) ligand 8 -0.086347
IL6 interleukin 6 -0.0831243
FN1 fibronectin 1 -0.0768962
F3 coagulation factor III (thromboplastin, tissue factor) -0.0752238
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0737958
VEGFA vascular endothelial growth factor A -0.0717898
HMGA2 high mobility group AT-hook 2 -0.067024
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0606145
CDH13 cadherin 13 -0.0564975
NAV1 neuron navigator 1 -0.0554202
MACF1 microtubule-actin crosslinking factor 1 -0.0548808
TNS3 tensin 3 -0.0545265
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0531452
PSD3 pleckstrin and Sec7 domain containing 3 -0.0524146
PRELID2 PRELI domain containing 2 -0.051806
NRXN3 neurexin 3 -0.0517446
FNIP1 folliculin interacting protein 1 -0.0512748
COL5A1 collagen, type V, alpha 1 -0.050843
EGFR epidermal growth factor receptor -0.0508303
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0491357
SND1 staphylococcal nuclease and tudor domain containing 1 -0.0479974
VCL vinculin -0.0476003
SOD2 superoxide dismutase 2, mitochondrial -0.0474111
KYNU kynureninase -0.0469438
VEGFC vascular endothelial growth factor C -0.0462316
CD44 CD44 molecule (Indian blood group) -0.045702
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0449724
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0442982
FNDC3B fibronectin type III domain containing 3B -0.0435409
MYO1E myosin IE -0.0413049
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0407344
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.040288
RUNX1 runt-related transcription factor 1 -0.039497
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0394663
DNAH11 dynein, axonemal, heavy chain 11 -0.0390213
PRSS23 protease, serine, 23 -0.0373994
PDLIM5 PDZ and LIM domain 5 -0.0365747
GLS2 glutaminase 2 (liver, mitochondrial) -0.0364535
FTH1 ferritin, heavy polypeptide 1 -0.0359783
DPYD dihydropyrimidine dehydrogenase -0.0356416
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0350773
INTS6 integrator complex subunit 6 -0.0347188
KAZN kazrin, periplakin interacting protein -0.0347171
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0340805
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0340759
SEC24A SEC24 family member A -0.0339593
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0329958
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0325863
RND3 Rho family GTPase 3 -0.0318252
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0310949
AKAP9 A kinase (PRKA) anchor protein 9 -0.0310773
TAOK1 TAO kinase 1 -0.0306415
FBXL7 F-box and leucine-rich repeat protein 7 -0.030536
SEC31A SEC31 homolog A (S. cerevisiae) -0.0304804
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.030343
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0300475
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0298106
ATXN1 ataxin 1 -0.02964
GLIS3 GLIS family zinc finger 3 -0.0292445
SOX5 SRY (sex determining region Y)-box 5 -0.02879
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.0282166
POTEF POTE ankyrin domain family, member F -0.0276465
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0269783
KMT2C lysine (K)-specific methyltransferase 2C -0.026529
LPP LIM domain containing preferred translocation partner in lipoma -0.0264442
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0263387
CCDC88A coiled-coil domain containing 88A -0.0262845
RBMS1 RNA binding motif, single stranded interacting protein 1 -0.0261823
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0260868
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0260775
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.025653
ALK anaplastic lymphoma receptor tyrosine kinase -0.025601
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.0255731
ANXA5 annexin A5 -0.025473
CADM1 cell adhesion molecule 1 -0.0253967
GLG1 golgi glycoprotein 1 -0.025001
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0248952
SRRM2 serine/arginine repetitive matrix 2 -0.024836
MED13L mediator complex subunit 13-like -0.024662
PLOD1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 -0.0245311
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.02444
EPAS1 endothelial PAS domain protein 1 -0.0243238
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0242063
TNIP1 TNFAIP3 interacting protein 1 -0.024124
FLNA filamin A, alpha -0.0235379
CDK13 cyclin-dependent kinase 13 -0.0234638
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0233478
COL7A1 collagen, type VII, alpha 1 -0.0231751
SLC39A14 solute carrier family 39 (zinc transporter), member 14 -0.0231533
AFF4 AF4/FMR2 family, member 4 -0.0230525
OSBPL8 oxysterol binding protein-like 8 -0.023007
AFF3 AF4/FMR2 family, member 3 -0.0229926
PTK2 protein tyrosine kinase 2 -0.022838
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0226063
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0224869
CCND1 cyclin D1 -0.022387
GOLGB1 golgin B1 -0.0221521
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0219092