Sunitinib_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sunitinib perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Sunitinib_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.320052
NRG1 neuregulin 1 0.157574
FN1 fibronectin 1 0.128738
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.0992503
PTMA prothymosin, alpha 0.0958109
HMGA2 high mobility group AT-hook 2 0.0848159
TMSB10 thymosin beta 10 0.0826285
SQSTM1 sequestosome 1 0.0728586
ASPH aspartate beta-hydroxylase 0.0656545
MT2A metallothionein 2A 0.0633391
HLA-B major histocompatibility complex, class I, B 0.0623873
STC2 stanniocalcin 2 0.0593476
FTL ferritin, light polypeptide 0.0548801
IFI27 interferon, alpha-inducible protein 27 0.0546493
TMSB4X thymosin beta 4, X-linked 0.0497628
S100A6 S100 calcium binding protein A6 0.0488256
ITGA1 integrin, alpha 1 0.0477139
SYT1 synaptotagmin I 0.0472541
HIPK2 homeodomain interacting protein kinase 2 0.0470109
B2M beta-2-microglobulin 0.0449017
EXT1 exostosin glycosyltransferase 1 0.0445161
TPT1 tumor protein, translationally-controlled 1 0.0432355
LOC102724023 ES1 protein homolog, mitochondrial 0.0419581
VCL vinculin 0.0418088
AKAP12 A kinase (PRKA) anchor protein 12 0.0415105
RAI14 retinoic acid induced 14 0.0409
SOX4 SRY (sex determining region Y)-box 4 0.0400653
ACTG1 actin gamma 1 0.0386756
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0380452
AEBP2 AE binding protein 2 0.0361212
VIM vimentin 0.035786
AHRR aryl-hydrocarbon receptor repressor 0.0356633
SFTPA2 surfactant protein A2 0.0328173
ARHGAP35 Rho GTPase activating protein 35 0.0320054
ENO1 enolase 1, (alpha) 0.031939
PDE4D phosphodiesterase 4D, cAMP-specific 0.0319041
CANX calnexin 0.0316135
ZFP36L1 ZFP36 ring finger protein-like 1 0.0310756
TMEM156 transmembrane protein 156 0.0309992
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0306967
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0304008
NTN4 netrin 4 0.0295714
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0293147
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0289937
RPL31 ribosomal protein L31 0.0289866
LMNA lamin A/C 0.0282976
EFNA5 ephrin-A5 0.0265155
FBN1 fibrillin 1 0.0264161
RACK1 receptor for activated C kinase 1 0.0258073
GLIS3 GLIS family zinc finger 3 0.0249397
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.023228
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0226963
ENO2 enolase 2 (gamma, neuronal) 0.0226557
DNAH5 dynein, axonemal, heavy chain 5 0.0225763
HLA-A major histocompatibility complex, class I, A 0.0225649
PLIN2 perilipin 2 0.0223729
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0220198
IFI16 interferon, gamma-inducible protein 16 0.0220025
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0218917
KLHL5 kelch-like family member 5 0.0217481
SOS1 son of sevenless homolog 1 (Drosophila) 0.0216685
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.021605
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0215176
RPL37A ribosomal protein L37a 0.0211925
ZBTB20 zinc finger and BTB domain containing 20 0.0211792
TPI1 triosephosphate isomerase 1 0.0211481
ETV1 ets variant 1 0.0209645
SLC35F3 solute carrier family 35, member F3 0.020843
RPS3 ribosomal protein S3 0.0205326
RPS6 ribosomal protein S6 0.0204237
ERRFI1 ERBB receptor feedback inhibitor 1 0.0204077
IFI6 interferon, alpha-inducible protein 6 0.0203348
TMED9 transmembrane emp24 protein transport domain containing 9 0.0202046
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0201191
MRPS6 mitochondrial ribosomal protein S6 0.0200127
TNS3 tensin 3 0.0199341
AHNAK AHNAK nucleoprotein 0.0199114
RPL9 ribosomal protein L9 0.0197973
FAM20C family with sequence similarity 20, member C 0.0194454
CD63 CD63 molecule 0.0193718
RPL34 ribosomal protein L34 0.0191841
NRP1 neuropilin 1 0.018661
RPL35A ribosomal protein L35a 0.0186177
RPS27 ribosomal protein S27 0.0184947
RPL23 ribosomal protein L23 0.0184652
SSH1 slingshot protein phosphatase 1 0.0179697
SLC38A2 solute carrier family 38, member 2 0.0177273
RPS8 ribosomal protein S8 0.0175802
AHNAK2 AHNAK nucleoprotein 2 0.0175199
PALLD palladin, cytoskeletal associated protein 0.0174202
BPTF bromodomain PHD finger transcription factor 0.0173397
RANBP17 RAN binding protein 17 0.0172869
TAS2R14 taste receptor, type 2, member 14 0.0172074
INTS6 integrator complex subunit 6 0.0172064
H1-0 H1.0 linker histone 0.016635
BZW1 basic leucine zipper and W2 domains 1 0.016609
EIF1 eukaryotic translation initiation factor 1 0.0164146
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0163241
SKAP2 src kinase associated phosphoprotein 2 0.0163228
NBEA neurobeachin 0.0162147

decreased expression

Symbol Name Standardized Value
FNDC3B fibronectin type III domain containing 3B -0.0436865
NAMPT nicotinamide phosphoribosyltransferase -0.0403397
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0331613
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0327229
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0312676
RNF145 ring finger protein 145 -0.0302623
FTH1 ferritin, heavy polypeptide 1 -0.0297351
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0261238
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.0241587
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0241002
TFG TRK-fused gene -0.0224323
PTK2 protein tyrosine kinase 2 -0.0223018
FAM13A family with sequence similarity 13, member A -0.0212077
NUP58 nucleoporin 58 -0.0211907
NEK7 NIMA-related kinase 7 -0.0207412
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0202743
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0188447
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.018788
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0187502
ZNF292 zinc finger protein 292 -0.0186115
SUCO SUN domain containing ossification factor -0.0180878
HELZ helicase with zinc finger -0.018004
RAB8B RAB8B, member RAS oncogene family -0.0176639
VEGFA vascular endothelial growth factor A -0.0172826
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 -0.0172617
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0167235
FAT1 FAT atypical cadherin 1 -0.016079
FOSL1 FOS-like antigen 1 -0.0154691
MAP3K5 mitogen-activated protein kinase kinase kinase 5 -0.0152498
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0150982
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0149084
KMT2E lysine (K)-specific methyltransferase 2E -0.0146946
XPO1 exportin 1 -0.0143497
TENT2 terminal nucleotidyltransferase 2 -0.0141702
RYBP RING1 and YY1 binding protein -0.0139494
BHLHE40 basic helix-loop-helix family, member e40 -0.0138026
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -0.0136039
YAP1 Yes-associated protein 1 -0.0135672
SPAG9 sperm associated antigen 9 -0.0135646
EGLN1 egl-9 family hypoxia-inducible factor 1 -0.0134176
ARRDC3 arrestin domain containing 3 -0.013393
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0131833
FOXO3 forkhead box O3 -0.0130417
SOD2 superoxide dismutase 2, mitochondrial -0.0130308
RTN4 reticulon 4 -0.0129614
ELL2 elongation factor, RNA polymerase II, 2 -0.0128582
RIOK3 RIO kinase 3 -0.0128433
TSC22D2 TSC22 domain family, member 2 -0.0128086
PPP1R15B protein phosphatase 1, regulatory subunit 15B -0.0125808
GLS2 glutaminase 2 (liver, mitochondrial) -0.0125735
PSME4 proteasome (prosome, macropain) activator subunit 4 -0.0125618
PRPF8 pre-mRNA processing factor 8 -0.0125023
ANXA5 annexin A5 -0.012438
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -0.0122266
ETNK1 ethanolamine kinase 1 -0.0122004
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0121408
ADAM9 ADAM metallopeptidase domain 9 -0.0121252
ADAM17 ADAM metallopeptidase domain 17 -0.0120973
WAC WW domain containing adaptor with coiled-coil -0.0119137
PCBP2 poly(rC) binding protein 2 -0.011886
CCNL1 cyclin L1 -0.0118474
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 -0.0117557
PICALM phosphatidylinositol binding clathrin assembly protein -0.011699
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.011514
MYO1B myosin IB -0.0114917
YME1L1 YME1-like 1 ATPase -0.0114716
RAB18 RAB18, member RAS oncogene family -0.0113887
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 -0.0112991
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme -0.0112854
ANKRD28 ankyrin repeat domain 28 -0.0111587
PELI1 pellino E3 ubiquitin protein ligase 1 -0.0111075
TRA2A transformer 2 alpha homolog (Drosophila) -0.0110707
WDR43 WD repeat domain 43 -0.0110443
COG5 component of oligomeric golgi complex 5 -0.0109404
USP12 ubiquitin specific peptidase 12 -0.0108251
MNAT1 MNAT CDK-activating kinase assembly factor 1 -0.0108086
FOXJ3 forkhead box J3 -0.0108062
KDM6A lysine (K)-specific demethylase 6A -0.0108034
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha -0.0107553
MIDEAS mitotic deacetylase associated SANT domain protein -0.0105378
CNOT4 CCR4-NOT transcription complex, subunit 4 -0.0104277
RUNX1 runt-related transcription factor 1 -0.0104269
GOLGA4 golgin A4 -0.0103136
ATP13A3 ATPase type 13A3 -0.010303
FXR1 fragile X mental retardation, autosomal homolog 1 -0.0101561
USP3 ubiquitin specific peptidase 3 -0.0101179
LCORL ligand dependent nuclear receptor corepressor-like -0.0100968
CNOT1 CCR4-NOT transcription complex, subunit 1 -0.0100651
WDR45B WD repeat domain 45B -0.0100213
ACTR3 ARP3 actin-related protein 3 homolog (yeast) -0.00997804
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.00994509
NBAS neuroblastoma amplified sequence -0.00989598
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.00981576
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.00971649
HILPDA hypoxia inducible lipid droplet-associated -0.00971157
ABI1 abl-interactor 1 -0.0096611
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -0.00953681
MIS18BP1 MIS18 binding protein 1 -0.00947176
TFRC transferrin receptor -0.00946657
QKI QKI, KH domain containing, RNA binding -0.00946325