Syncope Gene Set

Dataset CTD Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description Syncope refers to a generalized weakness of muscles with loss of postural tone, inability to stand upright, and loss of consciousness. Once the patient is in a horizontal position, blood flow to the brain is no longer hindered by gravitation and consciousness is regained. Unconsciousness usually lasts for seconds to minutes. Headache and drowsiness (which usually follow seizures) do not follow a syncopal attack. Syncope results from a sudden impairment of brain metabolism usually due to a reduction in cerebral blood flow. (Human Phenotype Ontology, HP_0001279)
External Link http://ctdbase.org/detail.go?type=disease&acc=MESH:D013575
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Genes

305 genes/proteins associated with the disease Syncope from the curated CTD Gene-Disease Associations dataset.

Symbol Name Standardized Value
SLC22A2 solute carrier family 22 (organic cation transporter), member 2 2.47061
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2 2.46374
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 2.40215
TNF tumor necrosis factor 2.36899
FOS FBJ murine osteosarcoma viral oncogene homolog 2.34851
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 2.33829
REN renin 2.32291
CASP3 caspase 3, apoptosis-related cysteine peptidase 2.30861
BAX BCL2-associated X protein 2.29976
IL6 interleukin 6 2.24588
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 2.21123
MAPK3 mitogen-activated protein kinase 3 2.20112
BCL2 B-cell CLL/lymphoma 2 2.17897
MAPK1 mitogen-activated protein kinase 1 2.16256
NPPB natriuretic peptide B 2.15699
PRL prolactin 2.14223
NPPA natriuretic peptide A 2.14047
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 2.13502
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9 2.11518
VEGFA vascular endothelial growth factor A 2.11021
NOS2 nitric oxide synthase 2, inducible 2.0887
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 2.0478
NUPR1 nuclear protein, transcriptional regulator, 1 2.02334
CAT catalase 2.01869
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 2.01787
EDN1 endothelin 1 2.01567
TGFB1 transforming growth factor, beta 1 2.01308
DRD2 dopamine receptor D2 1.98582
INHBE inhibin, beta E 1.97714
BDNF brain-derived neurotrophic factor 1.96551
ADRB1 adrenoceptor beta 1 1.93506
NOS3 nitric oxide synthase 3 (endothelial cell) 1.93246
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.93137
SLC22A1 solute carrier family 22 (organic cation transporter), member 1 1.92375
NPY neuropeptide Y 1.90754
CREB1 cAMP responsive element binding protein 1 1.8996
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled 1.89796
NR0B2 nuclear receptor subfamily 0, group B, member 2 1.89568
MYH7 myosin, heavy chain 7, cardiac muscle, beta 1.88737
IL1B interleukin 1, beta 1.88042
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A 1.87759
SOD1 superoxide dismutase 1, soluble 1.87476
EGR1 early growth response 1 1.86462
CCL2 chemokine (C-C motif) ligand 2 1.85098
ADRB2 adrenoceptor beta 2, surface 1.83449
TH tyrosine hydroxylase 1.82937
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8 1.82726
AVP arginine vasopressin 1.82499
CASP7 caspase 7, apoptosis-related cysteine peptidase 1.79923
PENK proenkephalin 1.79541
GJA1 gap junction protein, alpha 1, 43kDa 1.79101
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3 1.77762
ASNS asparagine synthetase (glutamine-hydrolyzing) 1.77394
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 1.77316
INS insulin 1.76713
VCAM1 vascular cell adhesion molecule 1 1.76617
JUN jun proto-oncogene 1.76424
POMC proopiomelanocortin 1.76111
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 1.7568
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 1.7564
C10ORF10 chromosome 10 open reading frame 10 1.7564
GSK3B glycogen synthase kinase 3 beta 1.74661
GSTP1 glutathione S-transferase pi 1 1.74441
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 1.73008
SLC22A3 solute carrier family 22 (organic cation transporter), member 3 1.728
IL1A interleukin 1, alpha 1.72779
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 1.71399
FNDC4 fibronectin type III domain containing 4 1.70947
HPN hepsin 1.70595
MMP9 matrix metallopeptidase 9 1.69951
DUSP1 dual specificity phosphatase 1 1.6906
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 1.68761
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 1.68274
MMP2 matrix metallopeptidase 2 1.67933
IL10 interleukin 10 1.67868
CXCL8 chemokine (C-X-C motif) ligand 8 1.67029
DRD1 dopamine receptor D1 1.669
MAOA monoamine oxidase A 1.66684
IFNG interferon, gamma 1.65181
WIPI1 WD repeat domain, phosphoinositide interacting 1 1.65136
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1 1.63877
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 1.63721
IGF1 insulin-like growth factor 1 (somatomedin C) 1.63586
MAPK14 mitogen-activated protein kinase 14 1.63473
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 1.6287
SOD2 superoxide dismutase 2, mitochondrial 1.62401
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 1.6192
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 1.61342
IL4 interleukin 4 1.60664
FABP1 fatty acid binding protein 1, liver 1.6036
TP53 tumor protein p53 1.60151
GAD1 glutamate decarboxylase 1 (brain, 67kDa) 1.60105
HMOX1 heme oxygenase 1 1.60035
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.59241
CALCA calcitonin-related polypeptide alpha 1.57947
CASP9 caspase 9, apoptosis-related cysteine peptidase 1.56971
TAGLN transgelin 1.56899
FOSB FBJ murine osteosarcoma viral oncogene homolog B 1.56632
ARC activity-regulated cytoskeleton-associated protein 1.5619
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 1.55525
ADRA2A adrenoceptor alpha 2A 1.55182
BCL2L1 BCL2-like 1 1.54548
FGF2 fibroblast growth factor 2 (basic) 1.54159
NR1I2 nuclear receptor subfamily 1, group I, member 2 1.52767
ICAM1 intercellular adhesion molecule 1 1.52237
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 1.52061
GFAP glial fibrillary acidic protein 1.51734
MAPK8 mitogen-activated protein kinase 8 1.50979
FAS Fas cell surface death receptor 1.50423
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) 1.48684
CASP8 caspase 8, apoptosis-related cysteine peptidase 1.47864
CDK5 cyclin-dependent kinase 5 1.4727
JUNB jun B proto-oncogene 1.46727
GNAS GNAS complex locus 1.4633
G6PD glucose-6-phosphate dehydrogenase 1.46067
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 1.4591
GAL galanin/GMAP prepropeptide 1.4583
EGFR epidermal growth factor receptor 1.45141
ADORA1 adenosine A1 receptor 1.45063
BDKRB2 bradykinin receptor B2 1.44845
GRIK2 glutamate receptor, ionotropic, kainate 2 1.44708
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 1.43974
CAMK2A calcium/calmodulin-dependent protein kinase II alpha 1.42266
MAOB monoamine oxidase B 1.42156
LEP leptin 1.41829
TAC1 tachykinin, precursor 1 1.41694
CYBA cytochrome b-245, alpha polypeptide 1.41229
AP1S1 adaptor-related protein complex 1, sigma 1 subunit 1.4026
GH1 growth hormone 1 1.39869
MPO myeloperoxidase 1.39674
CRH corticotropin releasing hormone 1.39646
NEFH neurofilament, heavy polypeptide 1.3903
CCND3 cyclin D3 1.39002
DRD3 dopamine receptor D3 1.38185
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6 1.37504
COL1A1 collagen, type I, alpha 1 1.37018
NCF1 neutrophil cytosolic factor 1 1.36876
OXT oxytocin/neurophysin I prepropeptide 1.35763
SCN5A sodium channel, voltage gated, type V alpha subunit 1.35328
CYCS cytochrome c, somatic 1.35213
FASLG Fas ligand (TNF superfamily, member 6) 1.34983
HIGD1A HIG1 hypoxia inducible domain family, member 1A 1.34343
SREBF1 sterol regulatory element binding transcription factor 1 1.34343
HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4 1.34111
CCND1 cyclin D1 1.33553
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 1.33257
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 1.33228
JUND jun D proto-oncogene 1.32993
UCP1 uncoupling protein 1 (mitochondrial, proton carrier) 1.32935
ADRB3 adrenoceptor beta 3 1.32607
PARP1 poly (ADP-ribose) polymerase 1 1.32251
FOSL2 FOS-like antigen 2 1.31956
PRKCE protein kinase C, epsilon 1.31297
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 1.31237
PKM pyruvate kinase, muscle 1.31089
PPARG peroxisome proliferator-activated receptor gamma 1.31
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled 1.3085
NOS1 nitric oxide synthase 1 (neuronal) 1.30696
ACTA2 actin, alpha 2, smooth muscle, aorta 1.30421
MYC v-myc avian myelocytomatosis viral oncogene homolog 1.30269
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 1.30269
NR3C2 nuclear receptor subfamily 3, group C, member 2 1.29781
DDIT3 DNA-damage-inducible transcript 3 1.29657
ADRBK1 adrenergic, beta, receptor kinase 1 1.29164
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 1.28796
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 1.28518
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5 1.28272
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 1.27132
RELN reelin 1.26856
ADORA2A adenosine A2a receptor 1.26856
HOMER1 homer scaffolding protein 1 1.26856
TGFB2 transforming growth factor, beta 2 1.26825
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 1.26763
CD36 CD36 molecule (thrombospondin receptor) 1.26359
SREBF2 sterol regulatory element binding transcription factor 2 1.26083
HRH1 histamine receptor H1 1.25745
NOX4 NADPH oxidase 4 1.25745
FKBP1B FK506 binding protein 1B, 12.6 kDa 1.25525
CLU clusterin 1.24905
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 1.24655
PPM1B protein phosphatase, Mg2+/Mn2+ dependent, 1B 1.24401
ADCY5 adenylate cyclase 5 1.23868
MYBPC3 myosin binding protein C, cardiac 1.23328
IL2 interleukin 2 1.22948
RAPGEF4 Rap guanine nucleotide exchange factor (GEF) 4 1.22821
ACE angiotensin I converting enzyme 1.22632
EYA2 EYA transcriptional coactivator and phosphatase 2 1.22469
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled 1.22469
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) 1.22112
RGS4 regulator of G-protein signaling 4 1.22112
SQSTM1 sequestosome 1 1.22048
S100A9 S100 calcium binding protein A9 1.21631
LPL lipoprotein lipase 1.21501
CES2 carboxylesterase 2 1.21141
GRIA1 glutamate receptor, ionotropic, AMPA 1 1.20784
CYP3A cytochrome P450, family 3, subfamily A 1.2046
EFNB3 ephrin-B3 1.19999
EIF4E eukaryotic translation initiation factor 4E 1.19802
RGS2 regulator of G-protein signaling 2 1.19704
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) 1.19704
RAMP2 receptor (G protein-coupled) activity modifying protein 2 1.19345
CCL3 chemokine (C-C motif) ligand 3 1.19179
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled 1.18783
KDR kinase insert domain receptor 1.18751
NR1D1 nuclear receptor subfamily 1, group D, member 1 1.18521
ADRA2B adrenoceptor alpha 2B 1.18489
COMT catechol-O-methyltransferase 1.18424
TGFBR1 transforming growth factor, beta receptor 1 1.18226
CAMK4 calcium/calmodulin-dependent protein kinase IV 1.17993
ANGPT2 angiopoietin 2 1.1753
ACHE acetylcholinesterase (Yt blood group) 1.17366
ATF3 activating transcription factor 3 1.17101
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3 1.17067
GRIK5 glutamate receptor, ionotropic, kainate 5 1.16335
RGS8 regulator of G-protein signaling 8 1.16335
ARRB2 arrestin, beta 2 1.16236
ADRA1B adrenoceptor alpha 1B 1.16137
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) 1.1556
COL3A1 collagen, type III, alpha 1 1.15526
APP amyloid beta (A4) precursor protein 1.15425
GRIA2 glutamate receptor, ionotropic, AMPA 2 1.15391
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide 1.1529
APOA1 apolipoprotein A-I 1.15055
ALB albumin 1.1485
GPX1 glutathione peroxidase 1 1.14678
APOE apolipoprotein E 1.14575
TSHB thyroid stimulating hormone, beta 1.14438
NPTX2 neuronal pentraxin II 1.1437
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 1.13793
HTR1D 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled 1.13724
F3 coagulation factor III (thromboplastin, tissue factor) 1.13449
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme 1.13415
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4 1.13415
GRIA3 glutamate receptor, ionotropic, AMPA 3 1.13007
NCAN neurocan 1.12838
HEXA hexosaminidase A (alpha polypeptide) 1.12495
THRA thyroid hormone receptor, alpha 1.12288
ADIPOQ adiponectin, C1Q and collagen domain containing 1.12082
ODC1 ornithine decarboxylase 1 1.11945
STAR steroidogenic acute regulatory protein 1.11775
PLP1 proteolipid protein 1 1.1136
MYH6 myosin, heavy chain 6, cardiac muscle, alpha 1.10803
ATP6V1B2 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2 1.10769
NR4A2 nuclear receptor subfamily 4, group A, member 2 1.10769
FASN fatty acid synthase 1.10734
PPARA peroxisome proliferator-activated receptor alpha 1.10317
SYN2 synapsin II 1.10211
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 1.09751
EGR2 early growth response 2 1.09541
PDK4 pyruvate dehydrogenase kinase, isozyme 4 1.09541
NREP neuronal regeneration related protein 1.09401
TJP1 tight junction protein 1 1.09297
GATA4 GATA binding protein 4 1.08726
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 1.0869
MAPK9 mitogen-activated protein kinase 9 1.08584
ADCY7 adenylate cyclase 7 1.08091
HPCAL1 hippocalcin-like 1 1.08091
CASP2 caspase 2, apoptosis-related cysteine peptidase 1.08091
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha 1.0784
PTGDS prostaglandin D2 synthase 21kDa (brain) 1.07732
EFNA1 ephrin-A1 1.07732
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 1.07199
HSPD1 heat shock 60kDa protein 1 (chaperonin) 1.07163
MAP2 microtubule-associated protein 2 1.07093
SYK spleen tyrosine kinase 1.07093
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal) 1.06952
GSR glutathione reductase 1.06808
PECAM1 platelet/endothelial cell adhesion molecule 1 1.06771
PRKCB protein kinase C, beta 1.06734
DUSP8 dual specificity phosphatase 8 1.06625
HSPB6 heat shock protein, alpha-crystallin-related, B6 1.06588
LDLR low density lipoprotein receptor 1.06479
EPO erythropoietin 1.06261
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor 1.06116
MGEA5 meningioma expressed antigen 5 (hyaluronidase) 1.0608
GSTM1 glutathione S-transferase mu 1 1.06008
ADRA1A adrenoceptor alpha 1A 1.05828
PTHLH parathyroid hormone-like hormone 1.05828
CALM2 calmodulin 2 (phosphorylase kinase, delta) 1.05648
CYBB cytochrome b-245, beta polypeptide 1.0561
DCT dopachrome tautomerase 1.0561
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 1.05312
INHA inhibin, alpha 1.05163
SCD stearoyl-CoA desaturase (delta-9-desaturase) 1.05163
LDHB lactate dehydrogenase B 1.04904
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 1.04794
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit 1.04721
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1 1.04721
MAS1 MAS1 proto-oncogene, G protein-coupled receptor 1.04465
SYT4 synaptotagmin IV 1.04427
LIN7B lin-7 homolog B (C. elegans) 1.04427
CTGF connective tissue growth factor 1.04276
CFLAR CASP8 and FADD-like apoptosis regulator 1.04276
PALLD palladin, cytoskeletal associated protein 1.04239
AGPAT9 1-acylglycerol-3-phosphate O-acyltransferase 9 1.04201
MAP3K5 mitogen-activated protein kinase kinase kinase 5 1.03382
HSPA4 heat shock 70kDa protein 4 1.03382
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial 1.03345
PPP1R15A protein phosphatase 1, regulatory subunit 15A 1.03009
EFNA5 ephrin-A5 1.02151
DRD4 dopamine receptor D4 1.0204
TFRC transferrin receptor 1.01739
KCNA1 potassium channel, voltage gated shaker related subfamily A, member 1 1.01437
EIF1AX eukaryotic translation initiation factor 1A, X-linked 1.01399
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 1.01212