Syndactyly Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores 2025
Category disease or phenotype associations
Type disease
Description A synostosis that results_in the fusion of two or more digits. (Human Disease Ontology, DOID_11193)
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Genes

689 genes co-occuring with the disease Syndactyly in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.

Symbol Name Standardized Value
HOXD13 homeobox D13 3.199
LMBR1 limb development membrane protein 1 3.022
FRAS1 Fraser extracellular matrix complex subunit 1 2.939
FREM2 FRAS1 related extracellular matrix protein 2 2.908
BHLHA9 basic helix-loop-helix family, member a9 2.885
FGFR2 fibroblast growth factor receptor 2 2.786
ZP2 zona pellucida glycoprotein 2 (sperm receptor) 2.761
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit 2.755
GLI3 GLI family zinc finger 3 2.739
SHH sonic hedgehog 2.646
DHCR7 7-dehydrocholesterol reductase 2.62
FREM1 FRAS1 related extracellular matrix 1 2.604
NOG noggin 2.564
HOXA13 homeobox A13 2.558
CCNQ cyclin Q 2.544
PORCN porcupine homolog (Drosophila) 2.495
GDF5 growth differentiation factor 5 2.493
GJA1 gap junction protein, alpha 1, 43kDa 2.431
IRF6 interferon regulatory factor 6 2.428
MSX2 msh homeobox 2 2.415
ADAMTS20 ADAM metallopeptidase with thrombospondin type 1 motif, 20 2.384
HOXD12 homeobox D12 2.379
IHH indian hedgehog 2.356
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2 2.351
OFD1 oral-facial-digital syndrome 1 2.347
FBN2 fibrillin 2 2.303
FGF8 fibroblast growth factor 8 (androgen-induced) 2.289
FGFR1 fibroblast growth factor receptor 1 2.273
FBLN1 fibulin 1 2.252
BMP4 bone morphogenetic protein 4 2.244
BBS10 Bardet-Biedl syndrome 10 2.238
HOXD11 homeobox D11 2.231
TP63 tumor protein p63 2.219
FBXW4 F-box and WD repeat domain containing 4 2.207
BBS1 Bardet-Biedl syndrome 1 2.206
DLX6 distal-less homeobox 6 2.19
DLX5 distal-less homeobox 5 2.169
SOST sclerostin 2.168
MSX1 msh homeobox 1 2.152
NECTIN4 nectin cell adhesion molecule 4 2.15
BBS2 Bardet-Biedl syndrome 2 2.14
EVX2 even-skipped homeobox 2 2.133
BBS9 Bardet-Biedl syndrome 9 2.125
BBS12 Bardet-Biedl syndrome 12 2.124
PTCH1 patched 1 2.116
FGFR3 fibroblast growth factor receptor 3 2.105
BBS7 Bardet-Biedl syndrome 7 2.092
BBS5 Bardet-Biedl syndrome 5 2.067
BMP7 bone morphogenetic protein 7 2.063
TTC8 tetratricopeptide repeat domain 8 2.052
NECTIN1 nectin cell adhesion molecule 1 2.031
RAB23 RAB23, member RAS oncogene family 2.01
YY1AP1 YY1 associated protein 1 1.994
NIPBL Nipped-B homolog (Drosophila) 1.985
GLI1 GLI family zinc finger 1 1.984
MKS1 Meckel syndrome, type 1 1.979
FBN1 fibrillin 1 1.963
WNT10B wingless-type MMTV integration site family, member 10B 1.953
BMPR1B bone morphogenetic protein receptor, type IB 1.943
WDPCP WD repeat containing planar cell polarity effector 1.943
FGF4 fibroblast growth factor 4 1.936
SOX9 SRY (sex determining region Y)-box 9 1.93
EVC2 Ellis van Creveld syndrome 2 1.93
GREM1 gremlin 1, DAN family BMP antagonist 1.928
BBIP1 BBSome interacting protein 1 1.926
EFNB1 ephrin-B1 1.926
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 1.918
FGF10 fibroblast growth factor 10 1.912
SMOC1 SPARC related modular calcium binding 1 1.912
RUNX2 runt-related transcription factor 2 1.911
FREM3 FRAS1 related extracellular matrix 3 1.91
TMEM216 transmembrane protein 216 1.907
BBS4 Bardet-Biedl syndrome 4 1.905
SALL1 spalt-like transcription factor 1 1.899
GRHL3 grainyhead-like 3 (Drosophila) 1.897
RNF32 ring finger protein 32 1.891
HOXD9 homeobox D9 1.886
LRP4 low density lipoprotein receptor-related protein 4 1.885
IQCE IQ motif containing E 1.876
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1 1.869
FGF16 fibroblast growth factor 16 1.869
HAND2 heart and neural crest derivatives expressed 2 1.866
CPLANE1 ciliogenesis and planar polarity effector complex subunit 1 1.858
IFT27 intraflagellar transport 27 1.852
TWIST1 twist family bHLH transcription factor 1 1.851
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1 1.85
FGF9 fibroblast growth factor 9 1.848
ALX4 ALX homeobox 4 1.838
GLI2 GLI family zinc finger 2 1.831
TMEM67 transmembrane protein 67 1.829
TBX5 T-box 5 1.815
LRP5 low density lipoprotein receptor-related protein 5 1.815
BMP2 bone morphogenetic protein 2 1.812
GREM2 gremlin 2, DAN family BMP antagonist 1.807
CEP290 centrosomal protein 290kDa 1.804
RIPK4 receptor-interacting serine-threonine kinase 4 1.8
SMAD9 SMAD family member 9 1.79
LRP6 low density lipoprotein receptor-related protein 6 1.79
SDCCAG8 serologically defined colon cancer antigen 8 1.784
CHD7 chromodomain helicase DNA binding protein 7 1.78
KCNE1 potassium channel, voltage gated subfamily E regulatory beta subunit 1 1.779
VWA2 von Willebrand factor A domain containing 2 1.778
NPHP1 nephronophthisis 1 (juvenile) 1.778
SCN5A sodium channel, voltage gated, type V alpha subunit 1.776
DPCD deleted in primary ciliary dyskinesia homolog (mouse) 1.764
ZIC2 Zic family member 2 1.763
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2 1.763
CDK10 cyclin-dependent kinase 10 1.759
WNT6 wingless-type MMTV integration site family, member 6 1.75
FMN1 formin 1 1.743
MYO10 myosin X 1.743
FGF3 fibroblast growth factor 3 1.74
ANOS1 anosmin 1 1.736
FGF17 fibroblast growth factor 17 1.734
WNT7A wingless-type MMTV integration site family, member 7A 1.731
BMPR1A bone morphogenetic protein receptor, type IA 1.73
ARHGAP31 Rho GTPase activating protein 31 1.724
IFT80 intraflagellar transport 80 1.719
FGF7 fibroblast growth factor 7 1.717
IFT172 intraflagellar transport 172 1.714
FGF18 fibroblast growth factor 18 1.713
SMO smoothened, frizzled class receptor 1.709
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.706
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta) 1.702
FGF20 fibroblast growth factor 20 1.7
FGF22 fibroblast growth factor 22 1.695
FGF6 fibroblast growth factor 6 1.693
SMC1A structural maintenance of chromosomes 1A 1.692
TBX1 T-box 1 1.691
ALMS1 Alstrom syndrome protein 1 1.682
OTX2 orthodenticle homeobox 2 1.679
KIF7 kinesin family member 7 1.672
FGF5 fibroblast growth factor 5 1.671
SMC3 structural maintenance of chromosomes 3 1.67
LZTFL1 leucine zipper transcription factor-like 1 1.668
DLX2 distal-less homeobox 2 1.658
LAMA5 laminin, alpha 5 1.651
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit 1.647
TRIM8 tripartite motif containing 8 1.635
CHRD chordin 1.634
HOXD1 homeobox D1 1.631
CKAP2L cytoskeleton associated protein 2-like 1.627
KIAA0586 KIAA0586 1.614
SUFU suppressor of fused homolog (Drosophila) 1.609
FGF13 fibroblast growth factor 13 1.609
CDAN1 codanin 1 1.605
COL2A1 collagen, type II, alpha 1 1.604
TGFB1 transforming growth factor, beta 1 1.603
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2 1.603
DOCK6 dedicator of cytokinesis 6 1.601
MEGF8 multiple EGF-like-domains 8 1.601
CDH17 cadherin 17, LI cadherin (liver-intestine) 1.591
BCOR BCL6 corepressor 1.589
HOXA11 homeobox A11 1.588
CACNA1S calcium channel, voltage-dependent, L type, alpha 1S subunit 1.587
AKIRIN2 akirin 2 1.585
WDR35 WD repeat domain 35 1.581
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 1.581
GJC1 gap junction protein, gamma 1, 45kDa 1.579
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5 1.579
JAG2 jagged 2 1.578
EOGT EGF domain-specific O-linked N-acetylglucosamine (GlcNAc) transferase 1.577
SCLT1 sodium channel and clathrin linker 1 1.576
ALDH1A2 aldehyde dehydrogenase 1 family, member A2 1.576
GDF6 growth differentiation factor 6 1.571
TRDN triadin 1.57
PROKR2 prokineticin receptor 2 1.568
PITX1 paired-like homeodomain 1 1.558
FOXL2 forkhead box L2 1.557
WNT9A wingless-type MMTV integration site family, member 9A 1.555
DLX1 distal-less homeobox 1 1.555
RPGRIP1L RPGRIP1-like 1.555
LBX1 ladybird homeobox 1 1.554
AGRN agrin 1.551
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 1.548
SP7 Sp7 transcription factor 1.547
RAD21 RAD21 homolog (S. pombe) 1.547
KIAA0825 KIAA0825 1.542
PAX6 paired box 6 1.542
ANKRD11 ankyrin repeat domain 11 1.541
IFT140 intraflagellar transport 140 1.539
AKT3 v-akt murine thymoma viral oncogene homolog 3 1.539
SIX3 SIX homeobox 3 1.538
SNTA1 syntrophin, alpha 1 1.537
WDR19 WD repeat domain 19 1.531
BGLAP bone gamma-carboxyglutamate (gla) protein 1.529
SFRP2 secreted frizzled-related protein 2 1.529
GRIP1 glutamate receptor interacting protein 1 1.528
FERMT1 fermitin family member 1 1.527
PAX2 paired box 2 1.524
DYNC1I1 dynein, cytoplasmic 1, intermediate chain 1 1.524
DONSON downstream neighbor of SON 1.519
CCDC28B coiled-coil domain containing 28B 1.517
ACAN aggrecan 1.515
GJA3 gap junction protein, alpha 3, 46kDa 1.507
FBN3 fibrillin 3 1.504
HSPG2 heparan sulfate proteoglycan 2 1.502
HOXD8 homeobox D8 1.501
WNT4 wingless-type MMTV integration site family, member 4 1.5
WLS wntless Wnt ligand secretion mediator 1.497
DKK1 dickkopf WNT signaling pathway inhibitor 1 1.496
TBX4 T-box 4 1.496
PABPN1 poly(A) binding protein, nuclear 1 1.496
IFT122 intraflagellar transport 122 1.496
TWIST2 twist family bHLH transcription factor 2 1.495
NAA10 N(alpha)-acetyltransferase 10, NatA catalytic subunit 1.494
EPHA4 EPH receptor A4 1.492
ARID1B AT rich interactive domain 1B (SWI1-like) 1.491
KDF1 keratinocyte differentiation factor 1 1.491
ADAMTS15 ADAM metallopeptidase with thrombospondin type 1 motif, 15 1.489
SOX3 SRY (sex determining region Y)-box 3 1.488
FGF2 fibroblast growth factor 2 (basic) 1.488
ZNF141 zinc finger protein 141 1.485
TBX22 T-box 22 1.48
CAV3 caveolin 3 1.476
STKLD1 serine/threonine kinase-like domain containing 1 1.469
PAX3 paired box 3 1.466
CC2D2A coiled-coil and C2 domain containing 2A 1.465
SHOX short stature homeobox 1.462
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog 1.462
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.455
SOSTDC1 sclerostin domain containing 1 1.453
HOXD10 homeobox D10 1.453
AFDN afadin, adherens junction formation factor 1.451
B3GLCT beta 3-glucosyltransferase 1.45
TTC21B tetratricopeptide repeat domain 21B 1.449
VPREB1 pre-B lymphocyte 1 1.448
SRY sex determining region Y 1.444
FLNA filamin A, alpha 1.443
GJB2 gap junction protein, beta 2, 26kDa 1.441
WNT5A wingless-type MMTV integration site family, member 5A 1.439
CHRNG cholinergic receptor, nicotinic, gamma (muscle) 1.438
TCTN2 tectonic family member 2 1.437
TBX6 T-box 6 1.437
TCTN3 tectonic family member 3 1.436
SIX2 SIX homeobox 2 1.434
KCNJ18 potassium channel, inwardly rectifying subfamily J, member 18 1.432
EN1 engrailed homeobox 1 1.431
TCF12 transcription factor 12 1.43
HOXD4 homeobox D4 1.428
LBR lamin B receptor 1.428
HMCN1 hemicentin 1 1.426
FMR1 fragile X mental retardation 1 1.423
AKIRIN1 akirin 1 1.423
TLX1 T-cell leukemia homeobox 1 1.421
EPHA7 EPH receptor A7 1.42
NSD1 nuclear receptor binding SET domain protein 1 1.42
EGF epidermal growth factor 1.418
ARL13B ADP-ribosylation factor-like 13B 1.418
WNT3A wingless-type MMTV integration site family, member 3A 1.415
TBC1D32 TBC1 domain family, member 32 1.415
EBP emopamil binding protein (sterol isomerase) 1.415
JAG1 jagged 1 1.415
ANKFN1 ankyrin-repeat and fibronectin type III domain containing 1 1.412
RARG retinoic acid receptor, gamma 1.41
SCN4B sodium channel, voltage gated, type IV beta subunit 1.407
GJA5 gap junction protein, alpha 5, 40kDa 1.406
PAX9 paired box 9 1.404
MECP2 methyl CpG binding protein 2 1.399
CALM3 calmodulin 3 (phosphorylase kinase, delta) 1.396
HDAC8 histone deacetylase 8 1.395
ESCO2 establishment of sister chromatid cohesion N-acetyltransferase 2 1.39
SOX10 SRY (sex determining region Y)-box 10 1.389
SOX2 SRY (sex determining region Y)-box 2 1.384
FAT4 FAT atypical cadherin 4 1.382
NSDHL NAD(P) dependent steroid dehydrogenase-like 1.382
TECRL trans-2,3-enoyl-CoA reductase-like 1.381
VAX1 ventral anterior homeobox 1 1.38
NHEJ1 nonhomologous end-joining factor 1 1.38
CDH3 cadherin 3, type 1, P-cadherin (placental) 1.379
AKAP9 A kinase (PRKA) anchor protein 9 1.379
BMP5 bone morphogenetic protein 5 1.378
STRA6 stimulated by retinoic acid 6 1.378
KCNA3 potassium channel, voltage gated shaker related subfamily A, member 3 1.376
FAT1 FAT atypical cadherin 1 1.374
C17ORF67 chromosome 17 open reading frame 67 1.372
INVS inversin 1.372
ITGA8 integrin, alpha 8 1.371
RYR2 ryanodine receptor 2 (cardiac) 1.37
GJB6 gap junction protein, beta 6, 30kDa 1.367
ARX aristaless related homeobox 1.367
NECTIN3 nectin cell adhesion molecule 3 1.367
WNT1 wingless-type MMTV integration site family, member 1 1.367
FOXF1 forkhead box F1 1.364
EYA1 EYA transcriptional coactivator and phosphatase 1 1.364
CACNA1E calcium channel, voltage-dependent, R type, alpha 1E subunit 1.36
ACVR1 activin A receptor, type I 1.359
KRT14 keratin 14, type I 1.358
CREBBP CREB binding protein 1.357
IFT88 intraflagellar transport 88 1.355
GJB4 gap junction protein, beta 4, 30.3kDa 1.354
UBA2 ubiquitin-like modifier activating enzyme 2 1.353
DDX59 DEAD (Asp-Glu-Ala-Asp) box polypeptide 59 1.351
IQCB1 IQ motif containing B1 1.35
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 1.349
CASQ2 calsequestrin 2 (cardiac muscle) 1.349
SOX11 SRY (sex determining region Y)-box 11 1.348
LTBP1 latent transforming growth factor beta binding protein 1 1.347
CNTLN centlein, centrosomal protein 1.346
DUSP6 dual specificity phosphatase 6 1.342
GJC2 gap junction protein, gamma 2, 47kDa 1.342
GJB1 gap junction protein, beta 1, 32kDa 1.341
SLC12A6 solute carrier family 12 (potassium/chloride transporter), member 6 1.34
PTPN11 protein tyrosine phosphatase, non-receptor type 11 1.339
MAP3K20 mitogen-activated protein kinase kinase kinase 20 1.339
WNT9B wingless-type MMTV integration site family, member 9B 1.339
STPG3 sperm-tail PG-rich repeat containing 3 1.339
HOXC8 homeobox C8 1.337
GAPDH glyceraldehyde-3-phosphate dehydrogenase 1.337
COL7A1 collagen, type VII, alpha 1 1.336
PRRX1 paired related homeobox 1 1.335
CACNB2 calcium channel, voltage-dependent, beta 2 subunit 1.334
PTCH2 patched 2 1.333
GJA4 gap junction protein, alpha 4, 37kDa 1.332
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5 1.332
KAT6B K(lysine) acetyltransferase 6B 1.331
ROR2 receptor tyrosine kinase-like orphan receptor 2 1.329
EMX2 empty spiracles homeobox 2 1.329
LNPK lunapark, ER junction formation factor 1.327
GAS1 growth arrest-specific 1 1.326
HOXD3 homeobox D3 1.324
WNT10A wingless-type MMTV integration site family, member 10A 1.323
TCTN1 tectonic family member 1 1.323
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit 1.323
ADAMTSL2 ADAMTS-like 2 1.322
MTOR mechanistic target of rapamycin (serine/threonine kinase) 1.32
ADAMTS17 ADAM metallopeptidase with thrombospondin type 1 motif, 17 1.319
ZNF541 zinc finger protein 541 1.317
EFCAB7 EF-hand calcium binding domain 7 1.315
SHANK3 SH3 and multiple ankyrin repeat domains 3 1.315
KMT2D lysine (K)-specific methyltransferase 2D 1.314
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog 1.312
SNAP29 synaptosomal-associated protein, 29kDa 1.311
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) 1.31
DLL3 delta-like 3 (Drosophila) 1.31
DVL1 dishevelled segment polarity protein 1 1.309
GJB3 gap junction protein, beta 3, 31kDa 1.308
PTH parathyroid hormone 1.307
ANK2 ankyrin 2, neuronal 1.305
ZNF699 zinc finger protein 699 1.304
CDC42 cell division cycle 42 1.302
CEP19 centrosomal protein 19kDa 1.297
LMNA lamin A/C 1.296
RIPPLY2 ripply transcriptional repressor 2 1.295
AHI1 Abelson helper integration site 1 1.295
EVC Ellis van Creveld protein 1.294
AXIN2 axin 2 1.294
NPNT nephronectin 1.293
TRARG1 trafficking regulator of GLUT4 (SLC2A4) 1 1.292
IFT74 intraflagellar transport 74 1.291
MUSK muscle, skeletal, receptor tyrosine kinase 1.29
SPRY3 sprouty homolog 3 (Drosophila) 1.29
GJA8 gap junction protein, alpha 8, 50kDa 1.287
TRIM32 tripartite motif containing 32 1.286
NOTCH1 notch 1 1.286
SBF1 SET binding factor 1 1.285
GATA4 GATA binding protein 4 1.284
NID1 nidogen 1 1.283
DCHS1 dachsous cadherin-related 1 1.282
CDON cell adhesion associated, oncogene regulated 1.279
VPS13B vacuolar protein sorting 13 homolog B (yeast) 1.278
ACTB actin, beta 1.275
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11 1.273
ZIC3 Zic family member 3 1.272
RARB retinoic acid receptor, beta 1.269
VSX2 visual system homeobox 2 1.268
SNX14 sorting nexin 14 1.266
ATXN10 ataxin 10 1.264
IGF1 insulin-like growth factor 1 (somatomedin C) 1.263
ZNF385B zinc finger protein 385B 1.262
TGFB3 transforming growth factor, beta 3 1.26
RABL2B RAB, member of RAS oncogene family-like 2B 1.259
FAM20B family with sequence similarity 20, member B 1.258
MYH3 myosin, heavy chain 3, skeletal muscle, embryonic 1.257
NBN nibrin 1.257
TMEM11 transmembrane protein 11 1.256
CEP164 centrosomal protein 164kDa 1.256
CALML6 calmodulin-like 6 1.256
PHIP pleckstrin homology domain interacting protein 1.255
DISP1 dispatched homolog 1 (Drosophila) 1.254
RASA1 RAS p21 protein activator (GTPase activating protein) 1 1.254
PHF6 PHD finger protein 6 1.252
ADAMTS19 ADAM metallopeptidase with thrombospondin type 1 motif, 19 1.251
NEK1 NIMA-related kinase 1 1.25
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 1.25
TACR3 tachykinin receptor 3 1.249
FRZB frizzled-related protein 1.248
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) 1.247
HOXC13 homeobox C13 1.246
CALML4 calmodulin-like 4 1.246
SCAPER S-phase cyclin A-associated protein in the ER 1.245
SPECC1L sperm antigen with calponin homology and coiled-coil domains 1-like 1.244
RTTN rotatin 1.244
TP53 tumor protein p53 1.244
CALML3 calmodulin-like 3 1.243
CALML5 calmodulin-like 5 1.243
PITX2 paired-like homeodomain 2 1.241
SPRY4 sprouty homolog 4 (Drosophila) 1.241
POLL polymerase (DNA directed), lambda 1.24
SCN4A sodium channel, voltage gated, type IV alpha subunit 1.237
CTCF CCCTC-binding factor (zinc finger protein) 1.234
DEMA1 DPM1 ER membrane anchor 1 1.233
HOXA9 homeobox A9 1.233
EFTUD2 elongation factor Tu GTP binding domain containing 2 1.232
SALL4 spalt-like transcription factor 4 1.23
RAB39B RAB39B, member RAS oncogene family 1.229
EP300 E1A binding protein p300 1.227
COL1A1 collagen, type I, alpha 1 1.227
VWC2L von Willebrand factor C domain containing protein 2-like 1.226
FGF1 fibroblast growth factor 1 (acidic) 1.224
SPRY2 sprouty homolog 2 (Drosophila) 1.223
PHOX2B paired-like homeobox 2b 1.223
TCOF1 Treacher Collins-Franceschetti syndrome 1 1.222
SIX1 SIX homeobox 1 1.221
CACNA1F calcium channel, voltage-dependent, L type, alpha 1F subunit 1.221
MEIS3 Meis homeobox 3 1.221
FN1 fibronectin 1 1.219
HOXA2 homeobox A2 1.215
SMAD4 SMAD family member 4 1.213
RYR1 ryanodine receptor 1 (skeletal) 1.213
PTHLH parathyroid hormone-like hormone 1.209
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2) 1.209
DNAH8 dynein, axonemal, heavy chain 8 1.207
WNT16 wingless-type MMTV integration site family, member 16 1.206
PHEX phosphate regulating endopeptidase homolog, X-linked 1.206
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b 1.202
IRX3 iroquois homeobox 3 1.202
NOTCH2 notch 2 1.201
SMAD5 SMAD family member 5 1.201
SLC26A2 solute carrier family 26 (anion exchanger), member 2 1.201
DHH desert hedgehog 1.2
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 1.198
RBM33 RNA binding motif protein 33 1.198
LHX4 LIM homeobox 4 1.198
NPHP4 nephronophthisis 4 1.196
DYNC2LI1 dynein, cytoplasmic 2, light intermediate chain 1 1.193
TMEM231 transmembrane protein 231 1.191
POR P450 (cytochrome) oxidoreductase 1.188
KCTD1 potassium channel tetramerization domain containing 1 1.188
ADAMTS2 ADAM metallopeptidase with thrombospondin type 1 motif, 2 1.186
HESX1 HESX homeobox 1 1.185
LMX1B LIM homeobox transcription factor 1, beta 1.185
ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif, 4 1.183
IFT43 intraflagellar transport 43 1.182
LIG4 ligase IV, DNA, ATP-dependent 1.179
GNRHR gonadotropin-releasing hormone receptor 1.179
MYC v-myc avian myelocytomatosis viral oncogene homolog 1.179
TGFB2 transforming growth factor, beta 2 1.178
MEIS1 Meis homeobox 1 1.177
DHX34 DEAH (Asp-Glu-Ala-His) box polypeptide 34 1.177
HCCS holocytochrome c synthase 1.175
TSC2 tuberous sclerosis 2 1.174
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1 1.173
SLC25A21 solute carrier family 25 (mitochondrial oxoadipate carrier), member 21 1.172
H3-5 H3.5 histone 1.167
COL9A1 collagen, type IX, alpha 1 1.167
SOS1 son of sevenless homolog 1 (Drosophila) 1.167
H3-4 H3.4 histone, cluster member 1.166
H3C13 H3 clustered histone 13 1.166
FRS2 fibroblast growth factor receptor substrate 2 1.162
WNT3 wingless-type MMTV integration site family, member 3 1.161
KIF3A kinesin family member 3A 1.161
TGFBR1 transforming growth factor, beta receptor 1 1.161
SRRT serrate, RNA effector molecule 1.16
RABL2A RAB, member of RAS oncogene family-like 2A 1.157
CHSY1 chondroitin sulfate synthase 1 1.157
PCNT pericentrin 1.156
H3-3B H3.3 histone B 1.156
FST follistatin 1.156
PKP2 plakophilin 2 1.155
H3C12 H3 clustered histone 12 1.155
MEIS2 Meis homeobox 2 1.154
SCN1B sodium channel, voltage gated, type I beta subunit 1.153
PPP2R5D protein phosphatase 2, regulatory subunit B', delta 1.153
B9D1 B9 protein domain 1 1.151
SP8 Sp8 transcription factor 1.151
PKHD1 polycystic kidney and hepatic disease 1 (autosomal recessive) 1.151
PTEN phosphatase and tensin homolog 1.15
ATRNL1 attractin-like 1 1.15
RHOA ras homolog family member A 1.15
EPG5 ectopic P-granules autophagy protein 5 homolog (C. elegans) 1.149
RAB8A RAB8A, member RAS oncogene family 1.148
LAMA4 laminin, alpha 4 1.148
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma 1.146
NPAS1 neuronal PAS domain protein 1 1.146
INS insulin 1.146
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase 1.145
SHOX2 short stature homeobox 2 1.144
IFT57 intraflagellar transport 57 1.143
SC5D sterol-C5-desaturase 1.143
LTBP4 latent transforming growth factor beta binding protein 4 1.14
GMNN geminin, DNA replication inhibitor 1.14
DSG4 desmoglein 4 1.139
MEF2C myocyte enhancer factor 2C 1.139
MED12 mediator complex subunit 12 1.135
KCNJ8 potassium channel, inwardly rectifying subfamily J, member 8 1.134
NR0B1 nuclear receptor subfamily 0, group B, member 1 1.133
DSP desmoplakin 1.133
SMAD2 SMAD family member 2 1.133
IBSP integrin-binding sialoprotein 1.131
CEP120 centrosomal protein 120kDa 1.131
NF1 neurofibromin 1 1.13
FGFR4 fibroblast growth factor receptor 4 1.13
ADAMTS10 ADAM metallopeptidase with thrombospondin type 1 motif, 10 1.13
ETV5 ets variant 5 1.13
DVL3 dishevelled segment polarity protein 3 1.13
LHX1 LIM homeobox 1 1.13
PRKACG protein kinase, cAMP-dependent, catalytic, gamma 1.13
LAMA3 laminin, alpha 3 1.13
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta 1.129
TBP TATA box binding protein 1.128
SFRP4 secreted frizzled-related protein 4 1.128
FOXE1 forkhead box E1 1.126
SPATA4 spermatogenesis associated 4 1.125
LAMB3 laminin, beta 3 1.124
SOX6 SRY (sex determining region Y)-box 6 1.123
KCNE3 potassium channel, voltage gated subfamily E regulatory beta subunit 3 1.122
TAC3 tachykinin 3 1.121
PRKACB protein kinase, cAMP-dependent, catalytic, beta 1.12
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta 1.12
EHMT1 euchromatic histone-lysine N-methyltransferase 1 1.119
SMAD6 SMAD family member 6 1.118
MESP2 mesoderm posterior basic helix-loop-helix transcription factor 2 1.118
NSMF NMDA receptor synaptonuclear signaling and neuronal migration factor 1.118
EIF2B2 eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa 1.117
TBX3 T-box 3 1.115
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12 1.114
FLNB filamin B, beta 1.114
VANGL2 VANGL planar cell polarity protein 2 1.113
RAI1 retinoic acid induced 1 1.112
WNT11 wingless-type MMTV integration site family, member 11 1.112
PRKACA protein kinase, cAMP-dependent, catalytic, alpha 1.111
AXIN1 axin 1 1.109
SIX6 SIX homeobox 6 1.106
RBPJ recombination signal binding protein for immunoglobulin kappa J region 1.105
DSPP dentin sialophosphoprotein 1.104
CSTB cystatin B (stefin B) 1.104
ESX1 ESX homeobox 1 1.103
BGN biglycan 1.103
GPC5 glypican 5 1.103
PTDSS1 phosphatidylserine synthase 1 1.103
NKX3-2 NK3 homeobox 2 1.103
DSC3 desmocollin 3 1.1
ZFPM2 zinc finger protein, FOG family member 2 1.1
DLX3 distal-less homeobox 3 1.1
TBX2 T-box 2 1.098
ACVR2B activin A receptor, type IIB 1.097
IGF2 insulin-like growth factor 2 1.096
HS6ST1 heparan sulfate 6-O-sulfotransferase 1 1.095
TWNK twinkle mtDNA helicase 1.095
MAPK3 mitogen-activated protein kinase 3 1.095
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 1.094
OR8J1 olfactory receptor, family 8, subfamily J, member 1 1.094
GPC3 glypican 3 1.093
CDH15 cadherin 15, type 1, M-cadherin (myotubule) 1.092
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 1.092
DACT1 dishevelled-binding antagonist of beta-catenin 1 1.091
STK36 serine/threonine kinase 36 1.09
ALB albumin 1.09
RBM10 RNA binding motif protein 10 1.089
PROK2 prokineticin 2 1.089
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 1.088
ZNF585B zinc finger protein 585B 1.088
DHCR24 24-dehydrocholesterol reductase 1.087
HOXC10 homeobox C10 1.086
LEF1 lymphoid enhancer-binding factor 1 1.086
KRT1 keratin 1, type II 1.084
ADAMTS18 ADAM metallopeptidase with thrombospondin type 1 motif, 18 1.084
PDS5A PDS5 cohesin associated factor A 1.083
FAT2 FAT atypical cadherin 2 1.083
TSHZ1 teashirt zinc finger homeobox 1 1.082
PVR poliovirus receptor 1.082
IRX6 iroquois homeobox 6 1.082
ELN elastin 1.079
PHGDH phosphoglycerate dehydrogenase 1.079
CKB creatine kinase, brain 1.079
CKM creatine kinase, muscle 1.078
IFT38 intraflagellar transport 38 1.077
MTHFSD methenyltetrahydrofolate synthetase domain containing 1.076
DLL4 delta-like 4 (Drosophila) 1.076
TLE6 transducin-like enhancer of split 6 1.075
SHOC2 soc-2 suppressor of clear homolog (C. elegans) 1.074
HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4 1.074
KAT6A K(lysine) acetyltransferase 6A 1.074
CKMT2 creatine kinase, mitochondrial 2 (sarcomeric) 1.072
CKMT1B creatine kinase, mitochondrial 1B 1.071
WT1 Wilms tumor 1 1.071
RECQL4 RecQ protein-like 4 1.07
EMX1 empty spiracles homeobox 1 1.07
HOXB1 homeobox B1 1.069
SCARF2 scavenger receptor class F, member 2 1.069
SALL3 spalt-like transcription factor 3 1.069
EXT2 exostosin glycosyltransferase 2 1.068
DKK2 dickkopf WNT signaling pathway inhibitor 2 1.067
CCND2 cyclin D2 1.066
CACNA1B calcium channel, voltage-dependent, N type, alpha 1B subunit 1.066
MYH14 myosin, heavy chain 14, non-muscle 1.065
DAAM1 dishevelled associated activator of morphogenesis 1 1.064
EDARADD EDAR-associated death domain 1.064
OSR2 odd-skipped related transciption factor 2 1.063
XYLT1 xylosyltransferase I 1.062
CACNA1G calcium channel, voltage-dependent, T type, alpha 1G subunit 1.061
FURIN furin (paired basic amino acid cleaving enzyme) 1.058
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 1.057
SOX5 SRY (sex determining region Y)-box 5 1.056
ZNF181 zinc finger protein 181 1.056
FBLN2 fibulin 2 1.055
CATIP ciliogenesis associated TTC17 interacting protein 1.055
HNF4A hepatocyte nuclear factor 4, alpha 1.055
DCAF17 DDB1 and CUL4 associated factor 17 1.054
POTEF POTE ankyrin domain family, member F 1.053
SF3B4 splicing factor 3b, subunit 4, 49kDa 1.053
TLCD3A TLC domain containing 3A 1.052
ZNF697 zinc finger protein 697 1.051
ARL6 ADP-ribosylation factor-like 6 1.051
ERI1 exoribonuclease 1 1.05
DRGX dorsal root ganglia homeobox 1.048
ACVR2A activin A receptor, type IIA 1.047
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 1.046
NPHP3 nephronophthisis 3 (adolescent) 1.045
AMH anti-Mullerian hormone 1.045
RAPSN receptor-associated protein of the synapse 1.044
DSC2 desmocollin 2 1.044
HOXB9 homeobox B9 1.043
SCN1A sodium channel, voltage gated, type I alpha subunit 1.041
KATNB1 katanin p80 (WD repeat containing) subunit B 1 1.041
ACSM1 acyl-CoA synthetase medium-chain family member 1 1.04
UPK3A uroplakin 3A 1.04
BOC BOC cell adhesion associated, oncogene regulated 1.039
KCNH1 potassium channel, voltage gated eag related subfamily H, member 1 1.038
CPNE9 copine family member IX 1.038
BRD4 bromodomain containing 4 1.038
SCN3B sodium channel, voltage gated, type III beta subunit 1.037
KDM6A lysine (K)-specific demethylase 6A 1.036
PDE6D phosphodiesterase 6D, cGMP-specific, rod, delta 1.036
SMAD3 SMAD family member 3 1.036
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 1.036
SBDS Shwachman-Bodian-Diamond syndrome 1.035
ASPH aspartate beta-hydroxylase 1.035
HRAS Harvey rat sarcoma viral oncogene homolog 1.034
AGGF1 angiogenic factor with G patch and FHA domains 1 1.034
CIAO3 cytosolic iron-sulfur assembly component 3 1.033
PKN2 protein kinase N2 1.032
GRAMD4 GRAM domain containing 4 1.032
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 1.032
WDR17 WD repeat domain 17 1.03
FOXC1 forkhead box C1 1.029
FOXG1 forkhead box G1 1.029
WAPL WAPL cohesin release factor 1.028
ZNF30 zinc finger protein 30 1.027
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit 1.026
C5ORF52 chromosome 5 open reading frame 52 1.026
ISOC1 isochorismatase domain containing 1 1.026
DOK7 docking protein 7 1.026
TXNDC15 thioredoxin domain containing 15 1.025
POMC proopiomelanocortin 1.025
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit 1.023
SIM1 single-minded family bHLH transcription factor 1 1.023
SNRPN small nuclear ribonucleoprotein polypeptide N 1.023
FGD1 FYVE, RhoGEF and PH domain containing 1 1.022
EPS15L1 epidermal growth factor receptor pathway substrate 15-like 1 1.021
UBE3A ubiquitin protein ligase E3A 1.021
AMMECR1 Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1 1.021
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 1.02
TMEM107 transmembrane protein 107 1.019
C2CD3 C2 calcium-dependent domain containing 3 1.018
ZNF569 zinc finger protein 569 1.017
ATXN1 ataxin 1 1.017
DSG2 desmoglein 2 1.016
PRICKLE1 prickle homolog 1 (Drosophila) 1.015
FOXC2 forkhead box C2 1.014
RPS19 ribosomal protein S19 1.013
SATB2 SATB homeobox 2 1.011
LTBP2 latent transforming growth factor beta binding protein 2 1.01
MIPOL1 mirror-image polydactyly 1 1.01
DVL2 dishevelled segment polarity protein 2 1.01
GDNF glial cell derived neurotrophic factor 1.008
MYO15A myosin XVA 1.005
LZTR1 leucine-zipper-like transcription regulator 1 1.005
CHUK conserved helix-loop-helix ubiquitous kinase 1.003
KCNJ6 potassium channel, inwardly rectifying subfamily J, member 6 1.003
PRG4 proteoglycan 4 1.002
BANF1 barrier to autointegration factor 1 1.002
CCP110 centriolar coiled coil protein 110kDa 1.001
TBL1X transducin (beta)-like 1X-linked 1.001
CUL4B cullin 4B 1.0
SLC8A2 solute carrier family 8 (sodium/calcium exchanger), member 2 1.0
CEP55 centrosomal protein 55kDa 1.0
GNAS GNAS complex locus 1.0