Synovitis Gene Set

Dataset DisGeNET Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description A connective tissue disease that results_in inflammation located_in synovial membrane that lines a synovial joint which causes pain and swelling. (Human Disease Ontology, DOID_2703)
External Link https://www.disgenet.org/browser/0/1/0/C0039103
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Genes

194 genes associated with the disease Synovitis in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

Symbol Name
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ACCS 1-aminocyclopropane-1-carboxylate synthase homolog (Arabidopsis)(non-functional)
ACLY ATP citrate lyase
ACSS2 acyl-CoA synthetase short-chain family member 2
ADAM8 ADAM metallopeptidase domain 8
ADIPOQ adiponectin, C1Q and collagen domain containing
ADORA2A adenosine A2a receptor
AGER advanced glycosylation end product-specific receptor
AGTR2 angiotensin II receptor, type 2
AQP1 aquaporin 1 (Colton blood group)
AREG amphiregulin
BRAF B-Raf proto-oncogene, serine/threonine kinase
C4BPA complement component 4 binding protein, alpha
CAPG capping protein (actin filament), gelsolin-like
CARD14 caspase recruitment domain family, member 14
CCL2 chemokine (C-C motif) ligand 2
CCL5 chemokine (C-C motif) ligand 5
CCL8 chemokine (C-C motif) ligand 8
CCN2 cellular communication network factor 2
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CCR6 chemokine (C-C motif) receptor 6
CCR7 chemokine (C-C motif) receptor 7
CD14 CD14 molecule
CD163 CD163 molecule
CD274 CD274 molecule
CD44 CD44 molecule (Indian blood group)
CD46 CD46 molecule, complement regulatory protein
CD47 CD47 molecule
CD58 CD58 molecule
CD68 CD68 molecule
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CIP2A cellular inhibitor of PP2A
CISH cytokine inducible SH2-containing protein
CLU clusterin
CMC1 C-x(9)-C motif containing 1
COL2A1 collagen, type II, alpha 1
COMP cartilage oligomeric matrix protein
COX1
CPB1 carboxypeptidase B1 (tissue)
CPB2 carboxypeptidase B2 (plasma)
CRP C-reactive protein, pentraxin-related
CRYGD crystallin, gamma D
CSF1 colony stimulating factor 1 (macrophage)
CSF1R colony stimulating factor 1 receptor
CSTB cystatin B (stefin B)
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL8 chemokine (C-X-C motif) ligand 8
CXCL9 chemokine (C-X-C motif) ligand 9
DCXR dicarbonyl/L-xylulose reductase
DDR2 discoidin domain receptor tyrosine kinase 2
DHCR24 24-dehydrocholesterol reductase
DKK1 dickkopf WNT signaling pathway inhibitor 1
DOCK2 dedicator of cytokinesis 2
DPEP1 dipeptidase 1 (renal)
DPP4 dipeptidyl-peptidase 4
EDN1 endothelin 1
EFNA5 ephrin-A5
EGFR epidermal growth factor receptor
F2R coagulation factor II (thrombin) receptor
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAM188B family with sequence similarity 188, member B
FGFR3 fibroblast growth factor receptor 3
FLT4 fms-related tyrosine kinase 4
FN1 fibronectin 1
FOLR2 folate receptor 2 (fetal)
FZD5 frizzled class receptor 5
GADD45B growth arrest and DNA-damage-inducible, beta
GLI3 GLI family zinc finger 3
GNAQ guanine nucleotide binding protein (G protein), q polypeptide
GPBAR1 G protein-coupled bile acid receptor 1
GPI glucose-6-phosphate isomerase
HLA-B major histocompatibility complex, class I, B
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HMGB1 high mobility group box 1
HPN hepsin
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
ICAM1 intercellular adhesion molecule 1
IDO1 indoleamine 2,3-dioxygenase 1
IFNG interferon, gamma
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IL10 interleukin 10
IL15 interleukin 15
IL17A interleukin 17A
IL18 interleukin 18
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL1RN interleukin 1 receptor antagonist
IL23A interleukin 23, alpha subunit p19
IL23R interleukin 23 receptor
IL34 interleukin 34
IL37 interleukin 37
IL4 interleukin 4
IL5 interleukin 5
IL6 interleukin 6
LARS1 leucyl-tRNA synthetase 1
LGALS3 lectin, galactoside-binding, soluble, 3
LOC102724428 serine/threonine-protein kinase SIK1
LPIN2 lipin 2
MAOB monoamine oxidase B
MAP2K1 mitogen-activated protein kinase kinase 1
MARCO macrophage receptor with collagenous structure
MC3R melanocortin 3 receptor
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MFAP4 microfibrillar-associated protein 4
MMP13 matrix metallopeptidase 13
MMP3 matrix metallopeptidase 3
MMP9 matrix metallopeptidase 9
MOK MOK protein kinase
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MUC19 mucin 19, oligomeric
MYH2 myosin, heavy chain 2, skeletal muscle, adult
NGF nerve growth factor (beta polypeptide)
NMT1 N-myristoyltransferase 1
NOD2 nucleotide-binding oligomerization domain containing 2
NR1I2 nuclear receptor subfamily 1, group I, member 2
PAPPA pregnancy-associated plasma protein A, pappalysin 1
PDCD1 programmed cell death 1
PF4 platelet factor 4
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PIP prolactin-induced protein
PKD2L1 polycystic kidney disease 2-like 1
PLA2G15 phospholipase A2, group XV
PLAU plasminogen activator, urokinase
PLG plasminogen
POLR3A polymerase (RNA) III (DNA directed) polypeptide A, 155kDa
POMC proopiomelanocortin
PRAP1 proline-rich acidic protein 1
PRDX2 peroxiredoxin 2
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit
PRNP prion protein
PRSS2 protease, serine, 2 (trypsin 2)
PRTN3 proteinase 3
PSTPIP2 proline-serine-threonine phosphatase interacting protein 2
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
RETN resistin
RPS23 ribosomal protein S23
S100A8 S100 calcium binding protein A8
SAAL1 serum amyloid A-like 1
SDC4 syndecan 4
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFRP1 secreted frizzled-related protein 1
SIK1 salt-inducible kinase 1
SLC40A1 solute carrier family 40 (iron-regulated transporter), member 1
SLC52A2 solute carrier family 52 (riboflavin transporter), member 2
SLC5A12 solute carrier family 5 (sodium/monocarboxylate cotransporter), member 12
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1
SOAT1 sterol O-acyltransferase 1
SOCS3 suppressor of cytokine signaling 3
SPHK2 sphingosine kinase 2
SPP1 secreted phosphoprotein 1
SRM spermidine synthase
SRMS src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT4 signal transducer and activator of transcription 4
TAC1 tachykinin, precursor 1
TGFA transforming growth factor, alpha
TGFBI transforming growth factor, beta-induced, 68kDa
TGM2 transglutaminase 2
THBS1 thrombospondin 1
TIMP1 TIMP metallopeptidase inhibitor 1
TLR2 toll-like receptor 2
TLR4 toll-like receptor 4
TMEM60 transmembrane protein 60
TNC tenascin C
TNF tumor necrosis factor
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B
TNFRSF8 tumor necrosis factor receptor superfamily, member 8
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b
TP53 tumor protein p53
TRAF1 TNF receptor-associated factor 1
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TRAP triiodothyronine receptor auxiliary protein
TRPC5 transient receptor potential cation channel, subfamily C, member 5
TTR transthyretin
TYMP thymidine phosphorylase
VCAM1 vascular cell adhesion molecule 1
VEGFA vascular endothelial growth factor A
VEGFC vascular endothelial growth factor C
XCL1 chemokine (C motif) ligand 1