Syphilis Gene Set

Dataset DisGeNET Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description A primary bacterial infectious disease that is a sexually transmitted systemic disease, has_material_basis_in Treponema pallidum subsp pallidum, which is transmitted_by sexual contact, transmitted_by blood product transfusion, transmitted_by congenital method from mother to fetus or transmitted_by contact with infectious lesions. If left untreated, produces chancres, rashes, and systemic lesions in a clinical course with three stages continued over many years. (Human Disease Ontology, DOID_4166)
External Link https://www.disgenet.org/browser/0/1/0/C0039128
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Genes

78 genes associated with the disease Syphilis in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

Symbol Name
ABCG4 ATP-binding cassette, sub-family G (WHITE), member 4
ACE angiotensin I converting enzyme
ACKR1 atypical chemokine receptor 1 (Duffy blood group)
AGRP agouti related neuropeptide
AHR aryl hydrocarbon receptor
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
APOC3 apolipoprotein C-III
APOH apolipoprotein H (beta-2-glycoprotein I)
ARFRP1 ADP-ribosylation factor related protein 1
ARSI arylsulfatase family, member I
ARTN artemin
ASF1A anti-silencing function 1A histone chaperone
CCL2 chemokine (C-C motif) ligand 2
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CD14 CD14 molecule
CD40LG CD40 ligand
CHP1 calcineurin-like EF-hand protein 1
COL17A1 collagen, type XVII, alpha 1
CRISP1 cysteine-rich secretory protein 1
CRP C-reactive protein, pentraxin-related
CRX cone-rod homeobox
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL8 chemokine (C-X-C motif) ligand 8
DCTN3 dynactin 3 (p22)
DDX41 DEAD (Asp-Glu-Ala-Asp) box polypeptide 41
DSPP dentin sialophosphoprotein
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1
EHD3 EH-domain containing 3
EXTL3 exostosin-like glycosyltransferase 3
F2 coagulation factor II (thrombin)
GEM GTP binding protein overexpressed in skeletal muscle
GYPC glycophorin C (Gerbich blood group)
HLA-A major histocompatibility complex, class I, A
HLA-C major histocompatibility complex, class I, C
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
IFNA1 interferon, alpha 1
IFNA13 interferon, alpha 13
IL10 interleukin 10
IL17A interleukin 17A
ITIH4 inter-alpha-trypsin inhibitor heavy chain family, member 4
KIR2DL3 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3
KIR2DS1 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1
KIR2DS4 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 4
KIR2DS5 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 5
KIR3DL1 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1
KIR3DL2 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2
KIR3DS1 killer cell immunoglobulin-like receptor, three domains, short cytoplasmic tail, 1
LAMC2 laminin, gamma 2
LRP1 low density lipoprotein receptor-related protein 1
MANF mesencephalic astrocyte-derived neurotrophic factor
MTA2 metastasis associated 1 family, member 2
NCOA5 nuclear receptor coactivator 5
NR4A3 nuclear receptor subfamily 4, group A, member 3
PDPN podoplanin
PHB2 prohibitin 2
PLAT plasminogen activator, tissue
PLG plasminogen
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit
POMC proopiomelanocortin
POR P450 (cytochrome) oxidoreductase
PTER phosphotriesterase related
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RERE arginine-glutamic acid dipeptide (RE) repeats
RNF112 ring finger protein 112
RPGR retinitis pigmentosa GTPase regulator
SAFB scaffold attachment factor B
SARS1 seryl-tRNA synthetase 1
SARS2 seryl-tRNA synthetase 2, mitochondrial
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1
SSB Sjogren syndrome antigen B (autoantigen La)
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
TLR1 toll-like receptor 1
TLR2 toll-like receptor 2
TLR6 toll-like receptor 6
TPR translocated promoter region, nuclear basket protein
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa