T-Cell Lymphoma Gene Set

Dataset DisGeNET Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description A type of lymphoma that originates in T-cells. (Human Phenotype Ontology, HP_0012190)
External Link https://www.disgenet.org/browser/0/1/0/C0079772
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Genes

448 genes associated with the disease T-Cell Lymphoma in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
ACSBG1 acyl-CoA synthetase bubblegum family member 1
ACVRL1 activin A receptor type II-like 1
ADA adenosine deaminase
ADRM1 adhesion regulating molecule 1
AKAP13 A kinase (PRKA) anchor protein 13
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT2 v-akt murine thymoma viral oncogene homolog 2
ALK anaplastic lymphoma receptor tyrosine kinase
AQP4 aquaporin 4
AR androgen receptor
ARHGAP24 Rho GTPase activating protein 24
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7
ARID1A AT rich interactive domain 1A (SWI-like)
ARR3 arrestin 3, retinal (X-arrestin)
ASCC1 activating signal cointegrator 1 complex subunit 1
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASPG asparaginase
ASRGL1 asparaginase like 1
ASXL3 additional sex combs like transcriptional regulator 3
ATF2 activating transcription factor 2
ATM ATM serine/threonine kinase
ATR ATR serine/threonine kinase
ATXN2L ataxin 2-like
B2M beta-2-microglobulin
BAG3 BCL2-associated athanogene 3
BCL10 B-cell CLL/lymphoma 10
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BCL2 B-cell CLL/lymphoma 2
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BCL3 B-cell CLL/lymphoma 3
BCL6 B-cell CLL/lymphoma 6
BCR breakpoint cluster region
BECN1 beclin 1, autophagy related
BIRC3 baculoviral IAP repeat containing 3
BMI1 BMI1 proto-oncogene, polycomb ring finger
CA12 carbonic anhydrase XII
CADM1 cell adhesion molecule 1
CALCR calcitonin receptor
CALR calreticulin
CASP10 caspase 10, apoptosis-related cysteine peptidase
CASR calcium-sensing receptor
CASZ1 castor zinc finger 1
CAV1 caveolin 1, caveolae protein, 22kDa
CCK cholecystokinin
CCL17 chemokine (C-C motif) ligand 17
CCL3 chemokine (C-C motif) ligand 3
CCND1 cyclin D1
CCND2 cyclin D2
CCND3 cyclin D3
CCR1 chemokine (C-C motif) receptor 1
CCR4 chemokine (C-C motif) receptor 4
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CCR9 chemokine (C-C motif) receptor 9
CCRN4L CCR4 carbon catabolite repression 4-like (S. cerevisiae)
CD19 CD19 molecule
CD1D CD1d molecule
CD24 CD24 molecule
CD247 CD247 molecule
CD27 CD27 molecule
CD274 CD274 molecule
CD28 CD28 molecule
CD37 CD37 molecule
CD3E CD3e molecule, epsilon (CD3-TCR complex)
CD4 CD4 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CD40LG CD40 ligand
CD44 CD44 molecule (Indian blood group)
CD47 CD47 molecule
CD68 CD68 molecule
CD70 CD70 molecule
CD79A CD79a molecule, immunoglobulin-associated alpha
CDC25C cell division cycle 25C
CDK4 cyclin-dependent kinase 4
CDK6 cyclin-dependent kinase 6
CDK7 cyclin-dependent kinase 7
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
CEP55 centrosomal protein 55kDa
CHKA choline kinase alpha
CKAP4 cytoskeleton-associated protein 4
CLDN10 claudin 10
CLEC7A C-type lectin domain family 7, member A
CMA1 chymase 1, mast cell
COMMD3-BMI1 COMMD3-BMI1 readthrough
CR2 complement component (3d/Epstein Barr virus) receptor 2
CRTC2 CREB regulated transcription coactivator 2
CSF1R colony stimulating factor 1 receptor
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CUL1 cullin 1
CXADR coxsackie virus and adenovirus receptor
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL13 chemokine (C-X-C motif) ligand 13
CXCR3 chemokine (C-X-C motif) receptor 3
CXCR4 chemokine (C-X-C motif) receptor 4
CYBA cytochrome b-245, alpha polypeptide
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DAP death-associated protein
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
DERL2 derlin 2
DICER1 dicer 1, ribonuclease type III
DLEC1 deleted in lung and esophageal cancer 1
DLL1 delta-like 1 (Drosophila)
DLX5 distal-less homeobox 5
DLX6 distal-less homeobox 6
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DPP4 dipeptidyl-peptidase 4
ECSIT ECSIT signalling integrator
EGFR epidermal growth factor receptor
EGR1 early growth response 1
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EMCN endomucin
EP300 E1A binding protein p300
EPB41L3 erythrocyte membrane protein band 4.1-like 3
EPHA3 EPH receptor A3
ERCC2 excision repair cross-complementation group 2
ERCC5 excision repair cross-complementation group 5
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
ESR2 estrogen receptor 2 (ER beta)
ETV6 ets variant 6
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FBXO7 F-box protein 7
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FGFR1 fibroblast growth factor receptor 1
FGFR3 fibroblast growth factor receptor 3
FIP1L1 factor interacting with PAPOLA and CPSF1
FKBP4 FK506 binding protein 4, 59kDa
FN1 fibronectin 1
FOXP3 forkhead box P3
FOXQ1 forkhead box Q1
FRAT1 frequently rearranged in advanced T-cell lymphomas 1
FURIN furin (paired basic amino acid cleaving enzyme)
FUT4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
GADD45A growth arrest and DNA-damage-inducible, alpha
GAL galanin/GMAP prepropeptide
GATA3 GATA binding protein 3
GCFC2 GC-rich sequence DNA-binding factor 2
GDNF glial cell derived neurotrophic factor
GFI1B growth factor independent 1B transcription repressor
GLI1 GLI family zinc finger 1
GLIS2 GLIS family zinc finger 2
GNAQ guanine nucleotide binding protein (G protein), q polypeptide
GNG8 guanine nucleotide binding protein (G protein), gamma 8
GNLY granulysin
GTF2H4 general transcription factor IIH, polypeptide 4, 52kDa
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
GZMM granzyme M (lymphocyte met-ase 1)
HACE1 HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1
HAVCR2 hepatitis A virus cellular receptor 2
HDAC8 histone deacetylase 8
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HLA-DOA major histocompatibility complex, class II, DO alpha
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-G major histocompatibility complex, class I, G
HOXC5 homeobox C5
HPR haptoglobin-related protein
HRAS Harvey rat sarcoma viral oncogene homolog
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA4 heat shock 70kDa protein 4
ICAM3 intercellular adhesion molecule 3
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IFNA1 interferon, alpha 1
IFNA13 interferon, alpha 13
IFNG interferon, gamma
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1)
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF1R insulin-like growth factor 1 receptor
IGH immunoglobulin heavy locus
IGK immunoglobulin kappa locus
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IL10 interleukin 10
IL13 interleukin 13
IL13RA1 interleukin 13 receptor, alpha 1
IL15 interleukin 15
IL16 interleukin 16
IL18 interleukin 18
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL2 interleukin 2
IL23A interleukin 23, alpha subunit p19
IL2RA interleukin 2 receptor, alpha
IL2RB interleukin 2 receptor, beta
IL2RG interleukin 2 receptor, gamma
IL3 interleukin 3
IL4 interleukin 4
IL5 interleukin 5
IL6 interleukin 6
IL7 interleukin 7
IL7R interleukin 7 receptor
IL9 interleukin 9
IRF4 interferon regulatory factor 4
ISYNA1 inositol-3-phosphate synthase 1
ITGB7 integrin, beta 7
ITK IL2-inducible T-cell kinase
ITM2B integral membrane protein 2B
JAK1 Janus kinase 1
JAK2 Janus kinase 2
JAK3 Janus kinase 3
JUNB jun B proto-oncogene
KCNJ6 potassium channel, inwardly rectifying subfamily J, member 6
KDM1A lysine (K)-specific demethylase 1A
KDM2B lysine (K)-specific demethylase 2B
KDM4C lysine (K)-specific demethylase 4C
KDR kinase insert domain receptor
KIR3DL2 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KL klotho
KLRK1 killer cell lectin-like receptor subfamily K, member 1
KMT2A lysine (K)-specific methyltransferase 2A
KMT2C lysine (K)-specific methyltransferase 2C
KMT2D lysine (K)-specific methyltransferase 2D
KRAS Kirsten rat sarcoma viral oncogene homolog
KRT20 keratin 20, type I
LAG3 lymphocyte-activation gene 3
LCK LCK proto-oncogene, Src family tyrosine kinase
LEF1 lymphoid enhancer-binding factor 1
LEP leptin
LEPR leptin receptor
LGALS1 lectin, galactoside-binding, soluble, 1
LMO4 LIM domain only 4
LOC102723407 putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8
LOC102724971 putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8
LONP1 lon peptidase 1, mitochondrial
LRP1 low density lipoprotein receptor-related protein 1
LTA lymphotoxin alpha
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MALT1 MALT1 paracaspase
MAP2K1 mitogen-activated protein kinase kinase 1
MAP3K20 mitogen-activated protein kinase kinase kinase 20
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MAPK8 mitogen-activated protein kinase 8
MARCKSL1 MARCKS-like 1
MATK megakaryocyte-associated tyrosine kinase
MBL2 mannose-binding lectin (protein C) 2, soluble
MCAT malonyl CoA:ACP acyltransferase (mitochondrial)
MCL1 myeloid cell leukemia 1
MCTS1 malignant T cell amplified sequence 1
MELK maternal embryonic leucine zipper kinase
MET MET proto-oncogene, receptor tyrosine kinase
MGA MGA, MAX dimerization protein
MKI67 marker of proliferation Ki-67
MLH1 mutL homolog 1
MME membrane metallo-endopeptidase
MRC1 mannose receptor, C type 1
MRPL28 mitochondrial ribosomal protein L28
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MSH6 mutS homolog 6
MSX1 msh homeobox 1
MTAP methylthioadenosine phosphorylase
MTDH metadherin
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase
MUC1 mucin 1, cell surface associated
MUM1 melanoma associated antigen (mutated) 1
MVP major vault protein
MYC v-myc avian myelocytomatosis viral oncogene homolog
MZF1 myeloid zinc finger 1
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NAV3 neuron navigator 3
NBN nibrin
NCAM1 neural cell adhesion molecule 1
NCR1 natural cytotoxicity triggering receptor 1
NDRG2 NDRG family member 2
NECTIN2 nectin cell adhesion molecule 2
NF1 neurofibromin 1
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NFE2L2 nuclear factor, erythroid 2-like 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NGF nerve growth factor (beta polypeptide)
NKAIN2 Na+/K+ transporting ATPase interacting 2
NLRP2 NLR family, pyrin domain containing 2
NME1 NME/NM23 nucleoside diphosphate kinase 1
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
NOS1 nitric oxide synthase 1 (neuronal)
NOS2 nitric oxide synthase 2, inducible
NOTCH1 notch 1
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NR0B2 nuclear receptor subfamily 0, group B, member 2
NR1I3 nuclear receptor subfamily 1, group I, member 3
NRP1 neuropilin 1
NUAK1 NUAK family, SNF1-like kinase, 1
NXT1 nuclear transport factor 2-like export factor 1
OPRM1 opioid receptor, mu 1
PAEP progestagen-associated endometrial protein
PARP2 poly (ADP-ribose) polymerase 2
PAX5 paired box 5
PCDH10 protocadherin 10
PDCD1 programmed cell death 1
PDCD1LG2 programmed cell death 1 ligand 2
PDCD2 programmed cell death 2
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDLIM7 PDZ and LIM domain 7 (enigma)
PHF6 PHD finger protein 6
PIAS2 protein inhibitor of activated STAT, 2
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLK1 polo-like kinase 1
PLK2 polo-like kinase 2
PNLIP pancreatic lipase
PON1 paraoxonase 1
POU2AF1 POU class 2 associating factor 1
PPARG peroxisome proliferator-activated receptor gamma
PRC1 protein regulator of cytokinesis 1
PRDM1 PR domain containing 1, with ZNF domain
PRG4 proteoglycan 4
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha
PRKCD protein kinase C, delta
PRKCQ protein kinase C, theta
PRNP prion protein
PSIP1 PC4 and SFRS1 interacting protein 1
PSMB6 proteasome (prosome, macropain) subunit, beta type, 6
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PTEN phosphatase and tensin homolog
PTPN2 protein tyrosine phosphatase, non-receptor type 2
PTPN6 protein tyrosine phosphatase, non-receptor type 6
PTPRA protein tyrosine phosphatase, receptor type, A
PTPRK protein tyrosine phosphatase, receptor type, K
RAG1 recombination activating gene 1
RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1
RARA retinoic acid receptor, alpha
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1
RASGRF2 Ras protein-specific guanine nucleotide-releasing factor 2
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RB1 retinoblastoma 1
RECQL4 RecQ protein-like 4
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RHOA ras homolog family member A
RHOJ ras homolog family member J
RPE65 retinal pigment epithelium-specific protein 65kDa
RPL17 ribosomal protein L17
RPL17-C18ORF32 RPL17-C18orf32 readthrough
RPL22 ribosomal protein L22
RPSA ribosomal protein SA
RRBP1 ribosome binding protein 1
RTEL1 regulator of telomere elongation helicase 1
RUNX3 runt-related transcription factor 3
S100A1 S100 calcium binding protein A1
S100A4 S100 calcium binding protein A4
S100B S100 calcium binding protein B
SAA1 serum amyloid A1
SAA2 serum amyloid A2
SATB1 SATB homeobox 1
SCT secretin
SEPT6 septin 6
SEPT9 septin 9
SESN2 sestrin 2
SIRT1 sirtuin 1
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLPI secretory leukocyte peptidase inhibitor
SMARCAL1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SOAT1 sterol O-acyltransferase 1
SOCS3 suppressor of cytokine signaling 3
SOS1 son of sevenless homolog 1 (Drosophila)
SOX11 SRY (sex determining region Y)-box 11
SOX4 SRY (sex determining region Y)-box 4
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPATA2 spermatogenesis associated 2
SPG7 spastic paraplegia 7 (pure and complicated autosomal recessive)
SPIB Spi-B transcription factor (Spi-1/PU.1 related)
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT5A signal transducer and activator of transcription 5A
STAT5B signal transducer and activator of transcription 5B
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
STK4 serine/threonine kinase 4
SUB1 SUB1 homolog (S. cerevisiae)
SUZ12 SUZ12 polycomb repressive complex 2 subunit
SYK spleen tyrosine kinase
TAL1 T-cell acute lymphocytic leukemia 1
TARP TCR gamma alternate reading frame protein
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TBX21 T-box 21
TCF3 transcription factor 3
TCL1A T-cell leukemia/lymphoma 1A
TCL1B T-cell leukemia/lymphoma 1B
TERT telomerase reverse transcriptase
TET2 tet methylcytosine dioxygenase 2
TF transferrin
TFRC transferrin receptor
TGFB1 transforming growth factor, beta 1
TIA1 TIA1 cytotoxic granule-associated RNA binding protein
TIAM1 T-cell lymphoma invasion and metastasis 1
TIGAR TP53 induced glycolysis regulatory phosphatase
TLR3 toll-like receptor 3
TLR7 toll-like receptor 7
TMEM132D transmembrane protein 132D
TMPRSS11D transmembrane protease, serine 11D
TNF tumor necrosis factor
TNFRSF13C tumor necrosis factor receptor superfamily, member 13C
TNFRSF17 tumor necrosis factor receptor superfamily, member 17
TNFRSF8 tumor necrosis factor receptor superfamily, member 8
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b
TP53 tumor protein p53
TP63 tumor protein p63
TP73 tumor protein p73
TPT1 tumor protein, translationally-controlled 1
TPX2 TPX2, microtubule-associated
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TRD T cell receptor delta locus
TRG T cell receptor gamma locus
TRIM13 tripartite motif containing 13
TSPYL2 TSPY-like 2
TWIST2 twist family bHLH transcription factor 2
TXN thioredoxin
TYMS thymidylate synthetase
UBL7 ubiquitin-like 7
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UCP1 uncoupling protein 1 (mitochondrial, proton carrier)
UVRAG UV radiation resistance associated
VAV1 vav 1 guanine nucleotide exchange factor
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A
WAS Wiskott-Aldrich syndrome
WIPF1 WAS/WASL interacting protein family, member 1
WLS wntless Wnt ligand secretion mediator
WRN Werner syndrome, RecQ helicase-like
WWOX WW domain containing oxidoreductase
YARS1 tyrosyl-tRNA synthetase 1
YY1 YY1 transcription factor
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa
ZBTB17 zinc finger and BTB domain containing 17
ZEB1 zinc finger E-box binding homeobox 1
ZMYM2 zinc finger, MYM-type 2