| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/5920 |
| Similar Terms | |
| Downloads & Tools |
200 proteins with high or low expression in T3 relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HBA1 | hemoglobin, alpha 1 | 0.89 |
| SLC39A11 | solute carrier family 39, member 11 | 0.7 |
| GRHL1 | grainyhead-like 1 (Drosophila) | 0.62 |
| MYZAP | myocardial zonula adherens protein | 0.59 |
| TOR1AIP2 | torsin A interacting protein 2 | 0.48 |
| GATA2 | GATA binding protein 2 | 0.45 |
| HIST2H2AB | histone cluster 2, H2ab | 0.44 |
| PIP5K1C | phosphatidylinositol-4-phosphate 5-kinase, type I, gamma | 0.43 |
| GEMIN2 | gem (nuclear organelle) associated protein 2 | 0.43 |
| JPT1 | Jupiter microtubule associated homolog 1 | 0.43 |
| SIRT3 | sirtuin 3 | 0.41 |
| TACSTD2 | tumor-associated calcium signal transducer 2 | 0.39 |
| MCFD2 | multiple coagulation factor deficiency 2 | 0.39 |
| SSNA1 | Sjogren syndrome nuclear autoantigen 1 | 0.39 |
| KIAA1324L | KIAA1324-like | 0.38 |
| RPE | ribulose-5-phosphate-3-epimerase | 0.37 |
| CILP2 | cartilage intermediate layer protein 2 | 0.35 |
| TOB1 | transducer of ERBB2, 1 | 0.35 |
| CCND3 | cyclin D3 | 0.35 |
| AMACR | alpha-methylacyl-CoA racemase | 0.35 |
| PRKD3 | protein kinase D3 | 0.34 |
| TFR2 | transferrin receptor 2 | 0.34 |
| PSMC1 | proteasome (prosome, macropain) 26S subunit, ATPase, 1 | 0.33 |
| NAT14 | N-acetyltransferase 14 (GCN5-related, putative) | 0.33 |
| RPGR | retinitis pigmentosa GTPase regulator | 0.33 |
| ZNF430 | zinc finger protein 430 | 0.32 |
| PRSS8 | protease, serine, 8 | 0.32 |
| WDR47 | WD repeat domain 47 | 0.32 |
| AUNIP | aurora kinase A and ninein interacting protein | 0.32 |
| ATP13A3 | ATPase type 13A3 | 0.31 |
| PFKFB1 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 | 0.3 |
| ZNF444 | zinc finger protein 444 | 0.3 |
| SLC41A2 | solute carrier family 41 (magnesium transporter), member 2 | 0.3 |
| ZNF226 | zinc finger protein 226 | 0.3 |
| MARK4 | MAP/microtubule affinity-regulating kinase 4 | 0.29 |
| NUDT14 | nudix (nucleoside diphosphate linked moiety X)-type motif 14 | 0.29 |
| COA4 | cytochrome c oxidase assembly factor 4 homolog (S. cerevisiae) | 0.29 |
| GATA6 | GATA binding protein 6 | 0.29 |
| NACC2 | NACC family member 2, BEN and BTB (POZ) domain containing | 0.29 |
| ARSB | arylsulfatase B | 0.29 |
| CELSR3 | cadherin, EGF LAG seven-pass G-type receptor 3 | 0.29 |
| AAMDC | adipogenesis associated, Mth938 domain containing | 0.29 |
| TMEM51 | transmembrane protein 51 | 0.29 |
| ZC3H14 | zinc finger CCCH-type containing 14 | 0.29 |
| REEP1 | receptor accessory protein 1 | 0.29 |
| WDFY2 | WD repeat and FYVE domain containing 2 | 0.29 |
| LRRC20 | leucine rich repeat containing 20 | 0.29 |
| COMMD3 | COMM domain containing 3 | 0.28 |
| MUC16 | mucin 16, cell surface associated | 0.28 |
| CMC4 | C-x(9)-C motif containing 4 | 0.28 |
| ZNF711 | zinc finger protein 711 | 0.28 |
| SEMA4F | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4F | 0.28 |
| MSMO1 | methylsterol monooxygenase 1 | 0.27 |
| USP53 | ubiquitin specific peptidase 53 | 0.27 |
| ZNF761 | zinc finger protein 761 | 0.27 |
| MARVELD3 | MARVEL domain containing 3 | 0.27 |
| CELSR1 | cadherin, EGF LAG seven-pass G-type receptor 1 | 0.27 |
| RASGRP2 | RAS guanyl releasing protein 2 (calcium and DAG-regulated) | 0.26 |
| DOHH | deoxyhypusine hydroxylase/monooxygenase | 0.26 |
| BBS10 | Bardet-Biedl syndrome 10 | 0.26 |
| PYGM | phosphorylase, glycogen, muscle | 0.26 |
| VAMP4 | vesicle-associated membrane protein 4 | 0.26 |
| APOE | apolipoprotein E | 0.26 |
| MAGEE1 | melanoma antigen family E1 | 0.25 |
| SLC29A2 | solute carrier family 29 (equilibrative nucleoside transporter), member 2 | 0.25 |
| PFDN1 | prefoldin subunit 1 | 0.25 |
| KLF13 | Kruppel-like factor 13 | 0.25 |
| RAB30 | RAB30, member RAS oncogene family | 0.25 |
| KLK6 | kallikrein-related peptidase 6 | 0.25 |
| SLC25A30 | solute carrier family 25, member 30 | 0.25 |
| COMMD8 | COMM domain containing 8 | 0.24 |
| DYNLRB1 | dynein, light chain, roadblock-type 1 | 0.24 |
| ZNF22 | zinc finger protein 22 | 0.24 |
| LMF1 | lipase maturation factor 1 | 0.24 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.24 |
| COX5A | cytochrome c oxidase subunit Va | 0.24 |
| KLHL5 | kelch-like family member 5 | 0.24 |
| STAB1 | stabilin 1 | 0.24 |
| TCOF1 | Treacher Collins-Franceschetti syndrome 1 | 0.24 |
| ZNF354A | zinc finger protein 354A | 0.24 |
| LIPA | lipase A, lysosomal acid, cholesterol esterase | 0.24 |
| SARAF | store-operated calcium entry-associated regulatory factor | 0.24 |
| CNTNAP1 | contactin associated protein 1 | 0.23 |
| MRPS11 | mitochondrial ribosomal protein S11 | 0.23 |
| PROSER1 | proline and serine rich 1 | 0.23 |
| TBP | TATA box binding protein | 0.23 |
| GAS2L3 | growth arrest-specific 2 like 3 | 0.23 |
| PPCDC | phosphopantothenoylcysteine decarboxylase | 0.23 |
| SPPL3 | signal peptide peptidase like 3 | 0.23 |
| DNAL4 | dynein, axonemal, light chain 4 | 0.23 |
| PSMD4 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 | 0.23 |
| FURIN | furin (paired basic amino acid cleaving enzyme) | 0.23 |
| SHC4 | SHC (Src homology 2 domain containing) family, member 4 | 0.23 |
| LYST | lysosomal trafficking regulator | 0.23 |
| GAREM1 | GRB2 associated regulator of MAPK1 subtype 1 | 0.23 |
| ZBED6 | zinc finger, BED-type containing 6 | 0.23 |
| SVIP | small VCP/p97-interacting protein | 0.23 |
| CHST12 | carbohydrate (chondroitin 4) sulfotransferase 12 | 0.22 |
| ADIRF | adipogenesis regulatory factor | 0.22 |
| ACTN3 | actinin, alpha 3 (gene/pseudogene) | 0.22 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CKM | creatine kinase, muscle | -3.27 |
| KMT2B | lysine (K)-specific methyltransferase 2B | -1.96 |
| PTPRB | protein tyrosine phosphatase, receptor type, B | -1.39 |
| PLEKHH2 | pleckstrin homology domain containing, family H (with MyTH4 domain) member 2 | -1.31 |
| ZNF175 | zinc finger protein 175 | -1.26 |
| SET | SET nuclear proto-oncogene | -1.24 |
| NRP1 | neuropilin 1 | -1.24 |
| RPL26 | ribosomal protein L26 | -1.22 |
| SEPTIN4 | septin 4 | -1.18 |
| TEN1 | TEN1 CST complex subunit | -1.11 |
| NR1D2 | nuclear receptor subfamily 1, group D, member 2 | -0.94 |
| CFD | complement factor D (adipsin) | -0.84 |
| SUMO2 | small ubiquitin-like modifier 2 | -0.8 |
| CLTA | clathrin, light chain A | -0.78 |
| MYH13 | myosin, heavy chain 13, skeletal muscle | -0.77 |
| TNNI3 | troponin I type 3 (cardiac) | -0.69 |
| LMCD1 | LIM and cysteine-rich domains 1 | -0.63 |
| SLC16A3 | solute carrier family 16 (monocarboxylate transporter), member 3 | -0.61 |
| MNT | MAX network transcriptional repressor | -0.6 |
| TTLL4 | tubulin tyrosine ligase-like family member 4 | -0.51 |
| JUND | jun D proto-oncogene | -0.51 |
| ZNF823 | zinc finger protein 823 | -0.47 |
| DYNC2LI1 | dynein, cytoplasmic 2, light intermediate chain 1 | -0.46 |
| CEP104 | centrosomal protein 104kDa | -0.44 |
| DNPH1 | 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 | -0.43 |
| ANKRD46 | ankyrin repeat domain 46 | -0.42 |
| YBX3 | Y box binding protein 3 | -0.41 |
| RIBC2 | RIB43A domain with coiled-coils 2 | -0.41 |
| LCP1 | lymphocyte cytosolic protein 1 (L-plastin) | -0.39 |
| TMEM14C | transmembrane protein 14C | -0.39 |
| FZD7 | frizzled class receptor 7 | -0.39 |
| IER5 | immediate early response 5 | -0.39 |
| SGMS1 | sphingomyelin synthase 1 | -0.39 |
| PIP | prolactin-induced protein | -0.38 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | -0.38 |
| N4BP3 | NEDD4 binding protein 3 | -0.38 |
| FABP6 | fatty acid binding protein 6, ileal | -0.38 |
| VMP1 | vacuole membrane protein 1 | -0.37 |
| ZNF766 | zinc finger protein 766 | -0.37 |
| FAM133A | family with sequence similarity 133, member A | -0.37 |
| MSX1 | msh homeobox 1 | -0.36 |
| ALG10B | ALG10B, alpha-1,2-glucosyltransferase | -0.36 |
| GPANK1 | G patch domain and ankyrin repeats 1 | -0.34 |
| ZFAT | zinc finger and AT hook domain containing | -0.34 |
| LIPT1 | lipoyltransferase 1 | -0.34 |
| PPP1R11 | protein phosphatase 1, regulatory (inhibitor) subunit 11 | -0.33 |
| KCTD5 | potassium channel tetramerization domain containing 5 | -0.33 |
| AFG1L | AFG1 like ATPase | -0.33 |
| MTIF3 | mitochondrial translational initiation factor 3 | -0.33 |
| VIM | vimentin | -0.33 |
| SARDH | sarcosine dehydrogenase | -0.33 |
| FLYWCH1 | FLYWCH-type zinc finger 1 | -0.32 |
| FANCM | Fanconi anemia, complementation group M | -0.32 |
| NDFIP2 | Nedd4 family interacting protein 2 | -0.32 |
| RASSF1 | Ras association (RalGDS/AF-6) domain family member 1 | -0.31 |
| ELOVL6 | ELOVL fatty acid elongase 6 | -0.31 |
| PPP3CB | protein phosphatase 3, catalytic subunit, beta isozyme | -0.31 |
| TMEM208 | transmembrane protein 208 | -0.31 |
| FLNA | filamin A, alpha | -0.31 |
| ANK2 | ankyrin 2, neuronal | -0.31 |
| PLEKHJ1 | pleckstrin homology domain containing, family J member 1 | -0.31 |
| HAL | histidine ammonia-lyase | -0.3 |
| PTPRU | protein tyrosine phosphatase, receptor type, U | -0.3 |
| DALRD3 | DALR anticodon binding domain containing 3 | -0.3 |
| RPL31 | ribosomal protein L31 | -0.3 |
| SMTN | smoothelin | -0.29 |
| ALG3 | ALG3, alpha-1,3- mannosyltransferase | -0.29 |
| IGFBP6 | insulin-like growth factor binding protein 6 | -0.29 |
| MEST | mesoderm specific transcript | -0.29 |
| FRMPD3 | FERM and PDZ domain containing 3 | -0.29 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.29 |
| ZNF511 | zinc finger protein 511 | -0.28 |
| TSPAN9 | tetraspanin 9 | -0.28 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.28 |
| GPATCH3 | G patch domain containing 3 | -0.28 |
| ABHD13 | abhydrolase domain containing 13 | -0.27 |
| MGLL | monoglyceride lipase | -0.27 |
| DCAF12 | DDB1 and CUL4 associated factor 12 | -0.27 |
| MAP3K21 | mitogen-activated protein kinase kinase kinase 21 | -0.27 |
| TAF4B | TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa | -0.27 |
| GTF3C6 | general transcription factor IIIC, polypeptide 6, alpha 35kDa | -0.27 |
| GGT2 | gamma-glutamyltransferase 2 | -0.26 |
| HDIP1 | HDAC and MIER1 interacting protein 1 | -0.26 |
| PTBP1 | polypyrimidine tract binding protein 1 | -0.26 |
| FAM126A | family with sequence similarity 126, member A | -0.26 |
| ANGPTL4 | angiopoietin-like 4 | -0.26 |
| TTC14 | tetratricopeptide repeat domain 14 | -0.26 |
| LRRC46 | leucine rich repeat containing 46 | -0.26 |
| PCTP | phosphatidylcholine transfer protein | -0.26 |
| LYSMD1 | LysM, putative peptidoglycan-binding, domain containing 1 | -0.26 |
| PIK3CD | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta | -0.26 |
| C15ORF41 | chromosome 15 open reading frame 41 | -0.25 |
| SERAC1 | serine active site containing 1 | -0.25 |
| UBC | ubiquitin C | -0.25 |
| ZNF296 | zinc finger protein 296 | -0.25 |
| CASP9 | caspase 9, apoptosis-related cysteine peptidase | -0.25 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.25 |
| EPB41L1 | erythrocyte membrane protein band 4.1-like 1 | -0.25 |
| SGTB | small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta | -0.25 |
| SLC15A4 | solute carrier family 15 (oligopeptide transporter), member 4 | -0.25 |
