T47D Gene Set

Dataset DepMap CRISPR Gene Dependency
Category disease or phenotype associations
Type cell line
External Link https://depmap.org/portal/cell_line/ACH-000147
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Genes

286 gene knockdowns changing fitness of T47D relative to other cell lines from the DepMap CRISPR Gene Dependency Dataset.

Symbol Name Standardized Value
TRPS1 trichorhinophalangeal syndrome I 10.1932
MSX2 msh homeobox 2 9.51454
ESR1 estrogen receptor 1 8.79433
KIAA0232 KIAA0232 8.48391
SPDEF SAM pointed domain containing ETS transcription factor 7.02071
CYP21A2 cytochrome P450, family 21, subfamily A, polypeptide 2 6.79369
IRX5 iroquois homeobox 5 6.62831
SIAH2 siah E3 ubiquitin protein ligase 2 6.55659
MORN4 MORN repeat containing 4 6.38053
OXSR1 oxidative stress responsive 1 6.15287
STMND1 stathmin domain containing 1 5.81021
TCTEX1D2 Tctex1 domain containing 2 5.70041
AKT1 v-akt murine thymoma viral oncogene homolog 1 5.67385
FAM131A family with sequence similarity 131, member A 5.59421
HRG histidine-rich glycoprotein 5.02097
CLPP caseinolytic mitochondrial matrix peptidase proteolytic subunit 4.78653
C14ORF79 chromosome 14 open reading frame 79 4.75546
PHF19 PHD finger protein 19 4.70284
PSMC3IP PSMC3 interacting protein 4.54577
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 4.51397
GATA3 GATA binding protein 3 4.50086
ZDHHC11 zinc finger, DHHC-type containing 11 4.46067
KAT6A K(lysine) acetyltransferase 6A 4.45334
FOXA1 forkhead box A1 4.36409
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 4.22637
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) 4.21918
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 4.20949
TTC23L tetratricopeptide repeat domain 23-like 4.19529
SARDH sarcosine dehydrogenase 4.06844
SLC7A6 solute carrier family 7 (amino acid transporter light chain, y+L system), member 6 4.0586
MAP1LC3A microtubule-associated protein 1 light chain 3 alpha 4.03927
MB21D2 Mab-21 domain containing 2 3.97319
KRT86 keratin 86, type II 3.95933
SRGAP3 SLIT-ROBO Rho GTPase activating protein 3 3.92022
HOXC5 homeobox C5 3.9127
SLC38A8 solute carrier family 38, member 8 3.90457
NEK1 NIMA-related kinase 1 3.87904
C3 complement component 3 3.83053
IFI27 interferon, alpha-inducible protein 27 3.76278
GRHL2 grainyhead-like 2 (Drosophila) 3.69939
CFAP410 cilia and flagella associated protein 410 3.68986
RMND1 required for meiotic nuclear division 1 homolog (S. cerevisiae) 3.67204
ABCA2 ATP-binding cassette, sub-family A (ABC1), member 2 3.60608
PREX1 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 3.59443
TMEM261 transmembrane protein 261 3.55652
IRX3 iroquois homeobox 3 3.53586
ATL3 atlastin GTPase 3 3.53093
ELOVL3 ELOVL fatty acid elongase 3 3.52067
CLUH clustered mitochondria (cluA/CLU1) homolog 3.49704
EPHB3 EPH receptor B3 3.43315
THEM4 thioesterase superfamily member 4 3.43022
NCOA6 nuclear receptor coactivator 6 3.41376
BARX2 BARX homeobox 2 3.40064
LRRC15 leucine rich repeat containing 15 3.35512
LHX3 LIM homeobox 3 3.35291
ATAD1 ATPase family, AAA domain containing 1 3.35146
PSD pleckstrin and Sec7 domain containing 3.31171
STAG1 stromal antigen 1 3.3095
DVL3 dishevelled segment polarity protein 3 3.30762
THEM5 thioesterase superfamily member 5 3.30528
CEP170B centrosomal protein 170B 3.26613
HAX1 HCLS1 associated protein X-1 3.26589
TLCD3A TLC domain containing 3A 3.26031
PRAMEF14 PRAME family member 14 3.21046
HMHB1 histocompatibility (minor) HB-1 3.19919
JPT2 Jupiter microtubule associated homolog 2 3.17309
MRPL1 mitochondrial ribosomal protein L1 3.15617
TRIT1 tRNA isopentenyltransferase 1 3.14642
OR9G1 olfactory receptor, family 9, subfamily G, member 1 3.14622
TUT4 terminal uridylyl transferase 4 3.12935
TRIM50 tripartite motif containing 50 3.08265
ATG9A autophagy related 9A 3.08103
SMG9 SMG9 nonsense mediated mRNA decay factor 3.06711
DPY19L1 dpy-19-like 1 (C. elegans) 3.06117
RFX5 regulatory factor X, 5 (influences HLA class II expression) 3.05557
TBC1D12 TBC1 domain family, member 12 3.0539
RABEPK Rab9 effector protein with kelch motifs 3.05178
GFRA4 GDNF family receptor alpha 4 3.0303
CPN2 carboxypeptidase N, polypeptide 2 3.01373
CIDEC cell death-inducing DFFA-like effector c 3.0014
MTX1 metaxin 1 2.98436
ZBTB7B zinc finger and BTB domain containing 7B 2.97229
ZBTB3 zinc finger and BTB domain containing 3 2.95677
MTO1 mitochondrial tRNA translation optimization 1 2.95552
CCT8L2 chaperonin containing TCP1, subunit 8 (theta)-like 2 2.95437
SPIRE2 spire-type actin nucleation factor 2 2.95243
UNC5C unc-5 homolog C (C. elegans) 2.94685
SETD4 SET domain containing 4 2.92477
FAM168A family with sequence similarity 168, member A 2.92464
NUDT14 nudix (nucleoside diphosphate linked moiety X)-type motif 14 2.90448
ELF5 E74-like factor 5 (ets domain transcription factor) 2.89199
FCRL3 Fc receptor-like 3 2.88955
RRNAD1 ribosomal RNA adenine dimethylase domain containing 1 2.88001
CRY2 cryptochrome circadian clock 2 2.8719
BRPF1 bromodomain and PHD finger containing, 1 2.81955
MTERF4 mitochondrial transcription termination factor 4 2.81305
NABP2 nucleic acid binding protein 2 2.80665
DAZAP2 DAZ associated protein 2 2.8065
TPCN2 two pore segment channel 2 2.80466
EFCAB11 EF-hand calcium binding domain 11 2.80444
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) 2.79338
AEBP1 AE binding protein 1 2.79238
ITPK1 inositol-tetrakisphosphate 1-kinase 2.78419
PPP1R14D protein phosphatase 1, regulatory (inhibitor) subunit 14D 2.78365
ZNF707 zinc finger protein 707 2.78115
ARID1B AT rich interactive domain 1B (SWI1-like) 2.77678
SLC25A51 solute carrier family 25, member 51 2.77238
BCL6 B-cell CLL/lymphoma 6 2.7655
GLIPR1L1 GLI pathogenesis-related 1 like 1 2.75838
KDM6A lysine (K)-specific demethylase 6A 2.75457
NPL N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase) 2.74446
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial 2.74123
CCDC153 coiled-coil domain containing 153 2.74082
C11ORF86 chromosome 11 open reading frame 86 2.71918
GAPVD1 GTPase activating protein and VPS9 domains 1 2.71258
NDUFB2 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDa 2.71201
ACP2 acid phosphatase 2, lysosomal 2.70056
ATP10B ATPase, class V, type 10B 2.69672
TSPOAP1 TSPO associated protein 1 2.64688
DNAJC30 DnaJ (Hsp40) homolog, subfamily C, member 30 2.64478
GRSF1 G-rich RNA sequence binding factor 1 2.64149
RTN4IP1 reticulon 4 interacting protein 1 2.63115
HP1BP3 heterochromatin protein 1, binding protein 3 2.62975
ADNP activity-dependent neuroprotector homeobox 2.62902
A3GALT2 alpha 1,3-galactosyltransferase 2 2.62366
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa 2.62016
CFC1 cripto, FRL-1, cryptic family 1 2.61543
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 2.61228
RUBCN rubicon autophagy regulator 2.61
CCDC117 coiled-coil domain containing 117 2.60825
NDUFA3 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa 2.60296
CEP43 centrosomal protein 43 2.60001
METRNL meteorin, glial cell differentiation regulator-like 2.59737
CLCF1 cardiotrophin-like cytokine factor 1 2.59679
LIN54 lin-54 DREAM MuvB core complex component 2.58628
AP1G1 adaptor-related protein complex 1, gamma 1 subunit 2.58546
POU6F1 POU class 6 homeobox 1 2.57819
ATXN7L3 ataxin 7-like 3 2.57744
CHCHD3 coiled-coil-helix-coiled-coil-helix domain containing 3 2.57583
HECTD1 HECT domain containing E3 ubiquitin protein ligase 1 2.57079
RPUSD3 RNA pseudouridylate synthase domain containing 3 2.56947
OGA O-GlcNAcase 2.56443
ATF1 activating transcription factor 1 2.53584
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5 2.53116
IL6R interleukin 6 receptor 2.52769
CNIH4 cornichon family AMPA receptor auxiliary protein 4 2.5269
FOXK1 forkhead box K1 2.52281
FAM13C family with sequence similarity 13, member C 2.50546
NCOA1 nuclear receptor coactivator 1 2.49698
SEMA4G sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G 2.48622
OR1L6 olfactory receptor, family 1, subfamily L, member 6 2.48263
SIX4 SIX homeobox 4 2.47513
MRPL44 mitochondrial ribosomal protein L44 2.47277
CDK5RAP1 CDK5 regulatory subunit associated protein 1 2.47007
LCN6 lipocalin 6 2.469
TIMMDC1 translocase of inner mitochondrial membrane domain containing 1 2.45514
PEAR1 platelet endothelial aggregation receptor 1 2.44479
NDUFA1 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa 2.43667
CTSK cathepsin K 2.43176
KLHL3 kelch-like family member 3 2.42973
SNCG synuclein, gamma (breast cancer-specific protein 1) 2.41753
TLX1 T-cell leukemia homeobox 1 2.41579
NDUFA5 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5 2.40561
NDUFA9 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa 2.40187
KDSR 3-ketodihydrosphingosine reductase 2.39885
SNURF SNRPN upstream reading frame 2.38841
KLF7 Kruppel-like factor 7 (ubiquitous) 2.38473
ZNF397 zinc finger protein 397 2.38311
MUC20 mucin 20, cell surface associated 2.37797
NDUFAF7 NADH dehydrogenase (ubiquinone) complex I, assembly factor 7 2.37761
LYPD5 LY6/PLAUR domain containing 5 2.37481
ACAD8 acyl-CoA dehydrogenase family, member 8 2.37281
NR1H4 nuclear receptor subfamily 1, group H, member 4 2.37252
NDUFC1 NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1, 6kDa 2.37183
XXYLT1 xyloside xylosyltransferase 1 2.36754
NOA1 nitric oxide associated 1 2.3601
LIN28A lin-28 homolog A (C. elegans) 2.35907
PCDHGB7 protocadherin gamma subfamily B, 7 2.35631
MRPL51 mitochondrial ribosomal protein L51 2.34928
EHF ets homologous factor 2.34709
DBNL drebrin-like 2.34488
CARS2 cysteinyl-tRNA synthetase 2, mitochondrial (putative) 2.34026
SLC22A14 solute carrier family 22, member 14 2.33633
KIF13A kinesin family member 13A 2.33521
CSDE1 cold shock domain containing E1, RNA-binding 2.3329
TMEM120B transmembrane protein 120B 2.32724
SPG7 spastic paraplegia 7 (pure and complicated autosomal recessive) 2.32701
MRPS18C mitochondrial ribosomal protein S18C 2.31933
PET117 PET117 homolog (S. cerevisiae) 2.31889
LGALS7B lectin, galactoside-binding, soluble, 7B 2.31642
APC adenomatous polyposis coli 2.31378
HSPA6 heat shock 70kDa protein 6 (HSP70B') 2.30975
KIFC2 kinesin family member C2 2.30969
UBAP2L ubiquitin associated protein 2-like 2.30905
CDCA3 cell division cycle associated 3 2.30614
WRAP53 WD repeat containing, antisense to TP53 2.30599
NRN1L neuritin 1-like 2.30153
EML5 echinoderm microtubule associated protein like 5 2.30096
PGLS 6-phosphogluconolactonase 2.29935
YME1L1 YME1-like 1 ATPase 2.29222
DEF8 differentially expressed in FDCP 8 homolog (mouse) 2.28381
GOLGA2 golgin A2 2.28248
GNG11 guanine nucleotide binding protein (G protein), gamma 11 2.28208
TRIP10 thyroid hormone receptor interactor 10 2.28004
PTP4A2 protein tyrosine phosphatase type IVA, member 2 2.2792
ILRUN inflammation and lipid regulator with UBA-like and NBR1-like domains 2.27646
KCTD16 potassium channel tetramerization domain containing 16 2.27189
KHDC1L KH homology domain containing 1-like 2.27169
GPR68 G protein-coupled receptor 68 2.26809
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1 2.26352
ELAVL3 ELAV like neuron-specific RNA binding protein 3 2.26317
ELF2 E74-like factor 2 (ets domain transcription factor) 2.25639
BEGAIN brain-enriched guanylate kinase-associated 2.24897
CSRNP2 cysteine-serine-rich nuclear protein 2 2.23944
FCN1 ficolin (collagen/fibrinogen domain containing) 1 2.23713
HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit 2.22948
MRM3 mitochondrial rRNA methyltransferase 3 2.22781
TFEC transcription factor EC 2.22731
TMEM14B transmembrane protein 14B 2.22447
GADD45GIP1 growth arrest and DNA-damage-inducible, gamma interacting protein 1 2.22434
DLD dihydrolipoamide dehydrogenase 2.2218
SSX3 synovial sarcoma, X breakpoint 3 2.21788
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2 2.20895
RP1 retinitis pigmentosa 1 (autosomal dominant) 2.20848
TSPAN5 tetraspanin 5 2.20012
LAMC3 laminin, gamma 3 2.19713
C12ORF65 chromosome 12 open reading frame 65 2.19432
GPRIN2 G protein regulated inducer of neurite outgrowth 2 2.18991
MEAF6 MYST/Esa1-associated factor 6 2.18911
HEXIM2 hexamethylene bis-acetamide inducible 2 2.18849
PAQR6 progestin and adipoQ receptor family member VI 2.17766
NDUFB11 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3kDa 2.16967
TSPAN14 tetraspanin 14 2.16353
BAD BCL2-associated agonist of cell death 2.14724
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 2.14697
NET1 neuroepithelial cell transforming 1 2.14294
POLL polymerase (DNA directed), lambda 2.13835
GLT6D1 glycosyltransferase 6 domain containing 1 2.13562
DPF3 D4, zinc and double PHD fingers, family 3 2.13027
RHOD ras homolog family member D 2.11947
BAG5 BCL2-associated athanogene 5 2.10792
NUDT8 nudix (nucleoside diphosphate linked moiety X)-type motif 8 2.10362
MEN1 multiple endocrine neoplasia I 2.10055
LCN15 lipocalin 15 2.0985
IL15 interleukin 15 2.09529
GPRC5B G protein-coupled receptor, class C, group 5, member B 2.09498
S100P S100 calcium binding protein P 2.09061
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 2.08976
MFN1 mitofusin 1 2.08847
TCF25 transcription factor 25 (basic helix-loop-helix) 2.08434
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1 2.07928
NDUFAF4 NADH dehydrogenase (ubiquinone) complex I, assembly factor 4 2.07926
ADD1 adducin 1 (alpha) 2.07736
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) 2.07734
S100A12 S100 calcium binding protein A12 2.07585
CA5A carbonic anhydrase VA, mitochondrial 2.07339
CDKN2AIP CDKN2A interacting protein 2.07089
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 2.06953
ANO8 anoctamin 8 2.06894
FANCD2 Fanconi anemia, complementation group D2 2.06492
BCL2L10 BCL2-like 10 (apoptosis facilitator) 2.06478
SSX5 synovial sarcoma, X breakpoint 5 2.05987
FAM222B family with sequence similarity 222, member B 2.05402
CPNE1 copine I 2.05157
KRT33A keratin 33A, type I 2.05045
MPV17L2 MPV17 mitochondrial membrane protein-like 2 2.04535
NDUFAF3 NADH dehydrogenase (ubiquinone) complex I, assembly factor 3 2.04533
GABRP gamma-aminobutyric acid (GABA) A receptor, pi 2.04429
MRPL48 mitochondrial ribosomal protein L48 2.04076
IBA57 IBA57, iron-sulfur cluster assembly homolog (S. cerevisiae) 2.03885
KRT83 keratin 83, type II 2.03851
FOXK2 forkhead box K2 2.03735
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2 2.03583
MRM2 mitochondrial rRNA methyltransferase 2 2.02788
KLHL2 kelch-like family member 2 2.02684
AHRR aryl-hydrocarbon receptor repressor 2.02476
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 2.01661
ARAF A-Raf proto-oncogene, serine/threonine kinase 2.01603
HIST3H2BB histone cluster 3, H2bb 2.01531
RPIA ribose 5-phosphate isomerase A 2.0152
LHCGR luteinizing hormone/choriogonadotropin receptor 2.01069
FOXRED1 FAD-dependent oxidoreductase domain containing 1 2.01007
TDP2 tyrosyl-DNA phosphodiesterase 2 2.00661
CS citrate synthase 2.00502
MTRF1L mitochondrial translational release factor 1-like 2.00351
BIRC6 baculoviral IAP repeat containing 6 2.00024