T98G Gene Set

Dataset Achilles Cell Line Gene Essentiality Profiles
Category disease or phenotype associations
Type cell line
Description A immortal human brain-derived cell line cell that has the characteristics: Human cell line derived from glioblastoma multiforme (Caucasian). Hyperpentaploid chromosome count. TKG0471(Deposited from Tohoku Univ.). (Cell Line Ontology, CLO_0050636)
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Genes

608 gene knockdowns changing fitness of T98G relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.

increased fitness

Symbol Name Standardized Value
MFNG MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 3.18312
P2RY13 purinergic receptor P2Y, G-protein coupled, 13 2.97138
HESX1 HESX homeobox 1 2.91838
ZNF200 zinc finger protein 200 2.8529
KIR2DL4 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4 2.63892
PSMB6 proteasome (prosome, macropain) subunit, beta type, 6 2.60145
CACNA2D4 calcium channel, voltage-dependent, alpha 2/delta subunit 4 2.53881
ECEL1 endothelin converting enzyme-like 1 2.52762
HOXA4 homeobox A4 2.4002
TRPV6 transient receptor potential cation channel, subfamily V, member 6 2.38861
UBE2H ubiquitin-conjugating enzyme E2H 2.36024
GADD45G growth arrest and DNA-damage-inducible, gamma 2.34778
SSH3 slingshot protein phosphatase 3 2.23034
LTBP4 latent transforming growth factor beta binding protein 4 2.22802
SLC35B1 solute carrier family 35, member B1 2.20309
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 2.14592
CIRH1A cirrhosis, autosomal recessive 1A (cirhin) 2.14202
NOXA1 NADPH oxidase activator 1 2.13993
TRIP13 thyroid hormone receptor interactor 13 2.07716
SYT11 synaptotagmin XI 2.05488
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide 2.03797
IVD isovaleryl-CoA dehydrogenase 2.03509
MAP3K14 mitogen-activated protein kinase kinase kinase 14 2.03355
BRSK1 BR serine/threonine kinase 1 2.03289
USP17L5 ubiquitin specific peptidase 17-like family member 5 2.01312
EHMT1 euchromatic histone-lysine N-methyltransferase 1 1.99074
S100A7A S100 calcium binding protein A7A 1.93808
HIST1H1C histone cluster 1, H1c 1.93247
TMPRSS4 transmembrane protease, serine 4 1.92933
LCK LCK proto-oncogene, Src family tyrosine kinase 1.91568
ADPRHL1 ADP-ribosylhydrolase like 1 1.9155
PRDX1 peroxiredoxin 1 1.90993
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14 1.90033
CRYBB2 crystallin, beta B2 1.89575
NEFL neurofilament, light polypeptide 1.8956
NHP2L1 NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae) 1.89131
SLC5A9 solute carrier family 5 (sodium/sugar cotransporter), member 9 1.8863
GSS glutathione synthetase 1.86905
SRRT serrate, RNA effector molecule 1.85808
CD151 CD151 molecule (Raph blood group) 1.81878
NUTF2 nuclear transport factor 2 1.80023
TCF19 transcription factor 19 1.77089
SORD sorbitol dehydrogenase 1.7595
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 1.7546
ST6GALNAC6 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 1.7529
MGAT3 mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase 1.7491
RBBP4 retinoblastoma binding protein 4 1.74852
ZCCHC3 zinc finger, CCHC domain containing 3 1.74614
UBQLNL ubiquilin-like 1.74342
DGCR2 DiGeorge syndrome critical region gene 2 1.74248
B3GAT2 beta-1,3-glucuronyltransferase 2 1.74004
ST7 suppression of tumorigenicity 7 1.73576
ZNF222 zinc finger protein 222 1.7327
CBR3 carbonyl reductase 3 1.72309
RNF148 ring finger protein 148 1.72194
TRIM58 tripartite motif containing 58 1.70742
RWDD2A RWD domain containing 2A 1.70034
TRAF3 TNF receptor-associated factor 3 1.68441
CHDH choline dehydrogenase 1.6728
ZNF546 zinc finger protein 546 1.66334
TNS1 tensin 1 1.65939
CISH cytokine inducible SH2-containing protein 1.65672
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 1.65382
DHX38 DEAH (Asp-Glu-Ala-His) box polypeptide 38 1.64889
IL10 interleukin 10 1.6362
PPIE peptidylprolyl isomerase E (cyclophilin E) 1.62707
CAPN5 calpain 5 1.62061
MS4A2 membrane-spanning 4-domains, subfamily A, member 2 1.60835
CCR8 chemokine (C-C motif) receptor 8 1.60407
PAPPA2 pappalysin 2 1.59657
HTR1D 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled 1.59113
ZNF737 zinc finger protein 737 1.57756
VCP valosin containing protein 1.57201
FBXO17 F-box protein 17 1.568
PUF60 poly-U binding splicing factor 60KDa 1.55871
GCLM glutamate-cysteine ligase, modifier subunit 1.55603
MPG N-methylpurine-DNA glycosylase 1.55458
OSGEP O-sialoglycoprotein endopeptidase 1.55179
NAPA N-ethylmaleimide-sensitive factor attachment protein, alpha 1.55116
PPP4C protein phosphatase 4, catalytic subunit 1.54915
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 1.54799
C8A complement component 8, alpha polypeptide 1.5435
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase 1.53856
SOX4 SRY (sex determining region Y)-box 4 1.53805
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 1.53602
ARF5 ADP-ribosylation factor 5 1.53569
TPSG1 tryptase gamma 1 1.53383
SLC12A6 solute carrier family 12 (potassium/chloride transporter), member 6 1.53035
RBP5 retinol binding protein 5, cellular 1.52437
CCNDBP1 cyclin D-type binding-protein 1 1.52198
PCDHA6 protocadherin alpha 6 1.51825
PTPN12 protein tyrosine phosphatase, non-receptor type 12 1.51004
PPME1 protein phosphatase methylesterase 1 1.50648
IRS2 insulin receptor substrate 2 1.50158
GPR35 G protein-coupled receptor 35 1.49799
LAD1 ladinin 1 1.4966
BCKDHA branched chain keto acid dehydrogenase E1, alpha polypeptide 1.49642
STK3 serine/threonine kinase 3 1.49045
ZNF257 zinc finger protein 257 1.4837
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 1.47899
ADORA3 adenosine A3 receptor 1.47634
SUMO2 small ubiquitin-like modifier 2 1.47158
ATP6V0E2 ATPase, H+ transporting V0 subunit e2 1.46053
TPSD1 tryptase delta 1 1.46003
CASP6 caspase 6, apoptosis-related cysteine peptidase 1.44983
HIST1H2BJ histone cluster 1, H2bj 1.44543
LSM2 LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae) 1.44543
UBR1 ubiquitin protein ligase E3 component n-recognin 1 1.44254
WNT9B wingless-type MMTV integration site family, member 9B 1.44106
UBE2R2 ubiquitin-conjugating enzyme E2R 2 1.43568
ARG1 arginase 1 1.43064
HES6 hes family bHLH transcription factor 6 1.4263
EXOSC4 exosome component 4 1.42574
UBB ubiquitin B 1.42371
PPP2R5A protein phosphatase 2, regulatory subunit B', alpha 1.41865
DDX19B DEAD (Asp-Glu-Ala-Asp) box polypeptide 19B 1.41237
ZNF160 zinc finger protein 160 1.40792
ZNF584 zinc finger protein 584 1.4038
MYL7 myosin, light chain 7, regulatory 1.39868
OVOL1 ovo-like zinc finger 1 1.39111
RDH8 retinol dehydrogenase 8 (all-trans) 1.39099
LRRK2 leucine-rich repeat kinase 2 1.38869
WHSC1 Wolf-Hirschhorn syndrome candidate 1 1.38233
CLCNKB chloride channel, voltage-sensitive Kb 1.37592
PRKACG protein kinase, cAMP-dependent, catalytic, gamma 1.3754
PRPF38A pre-mRNA processing factor 38A 1.37004
QRFPR pyroglutamylated RFamide peptide receptor 1.36722
TNFRSF14 tumor necrosis factor receptor superfamily, member 14 1.36665
IFNAR1 interferon (alpha, beta and omega) receptor 1 1.36365
LSM3 LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae) 1.3624
PGD phosphogluconate dehydrogenase 1.36226
CYLD cylindromatosis (turban tumor syndrome) 1.35935
DDX46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 1.35845
PTPRM protein tyrosine phosphatase, receptor type, M 1.35483
RNF113A ring finger protein 113A 1.35342
SLC10A4 solute carrier family 10, member 4 1.35255
TK1 thymidine kinase 1, soluble 1.35255
RANBP2 RAN binding protein 2 1.34614
NRIP3 nuclear receptor interacting protein 3 1.34499
HSPA8 heat shock 70kDa protein 8 1.3417
CHD2 chromodomain helicase DNA binding protein 2 1.33638
NECAB2 N-terminal EF-hand calcium binding protein 2 1.33591
LPPR2 lipid phosphate phosphatase-related protein type 2 1.3344
CD1C CD1c molecule 1.32178
MTHFR methylenetetrahydrofolate reductase (NAD(P)H) 1.31844
TGFB1 transforming growth factor, beta 1 1.31799
CHI3L2 chitinase 3-like 2 1.31691
SF3B3 splicing factor 3b, subunit 3, 130kDa 1.31396
NOTCH2 notch 2 1.31304
EIF2B3 eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa 1.30793
PQBP1 polyglutamine binding protein 1 1.30289
NUMBL numb homolog (Drosophila)-like 1.30249
LRP6 low density lipoprotein receptor-related protein 6 1.30172
RNF24 ring finger protein 24 1.2951
GBX2 gastrulation brain homeobox 2 1.29498
ADAR adenosine deaminase, RNA-specific 1.29304
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 1.29249
CDK18 cyclin-dependent kinase 18 1.29165
TMED7 transmembrane emp24 protein transport domain containing 7 1.29128
FBXO27 F-box protein 27 1.29036
TAS2R50 taste receptor, type 2, member 50 1.2884
POLR2F polymerase (RNA) II (DNA directed) polypeptide F 1.28827
ILF3 interleukin enhancer binding factor 3, 90kDa 1.28619
ERH enhancer of rudimentary homolog (Drosophila) 1.28559
AKR1A1 aldo-keto reductase family 1, member A1 (aldehyde reductase) 1.28469
SNRPC small nuclear ribonucleoprotein polypeptide C 1.28455
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 1.28329
ATF7 activating transcription factor 7 1.27902
SECISBP2L SECIS binding protein 2-like 1.27513
PCDHA11 protocadherin alpha 11 1.27325
CALN1 calneuron 1 1.27324
SLC23A1 solute carrier family 23 (ascorbic acid transporter), member 1 1.27195
ALG1 ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase 1.26425
GPS1 G protein pathway suppressor 1 1.26186
IL25 interleukin 25 1.2576
ZP2 zona pellucida glycoprotein 2 (sperm receptor) 1.25602
TMEM241 transmembrane protein 241 1.25442
POLN polymerase (DNA directed) nu 1.25415
AQP12A aquaporin 12A 1.25403
PCBP1 poly(rC) binding protein 1 1.25388
SCUBE3 signal peptide, CUB domain, EGF-like 3 1.25341
RPL34 ribosomal protein L34 1.25207
METRN meteorin, glial cell differentiation regulator 1.25195
SF3B4 splicing factor 3b, subunit 4, 49kDa 1.25006
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3 1.24908
SEPHS1 selenophosphate synthetase 1 1.24896
CD109 CD109 molecule 1.23799
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 1.23569
FHIT fragile histidine triad 1.23526
SRSF8 serine/arginine-rich splicing factor 8 1.22744
OR2L13 olfactory receptor, family 2, subfamily L, member 13 1.2272
ALG6 ALG6, alpha-1,3-glucosyltransferase 1.22458
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal) 1.21737
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase 1.21365
APOA2 apolipoprotein A-II 1.21336
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 1.20952
USP17L3 ubiquitin specific peptidase 17-like family member 3 1.20677
TCF4 transcription factor 4 1.20533
CIB4 calcium and integrin binding family member 4 1.20519
MMP13 matrix metallopeptidase 13 1.20444
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) 1.19359
HOXA9 homeobox A9 1.19316
SLC35A4 solute carrier family 35, member A4 1.19025
COPA coatomer protein complex, subunit alpha 1.18725
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 1.18448
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A 1.18021
GAK cyclin G associated kinase 1.17213
ABCB7 ATP-binding cassette, sub-family B (MDR/TAP), member 7 1.17121
CSE1L CSE1 chromosome segregation 1-like (yeast) 1.1686
AMY2B amylase, alpha 2B (pancreatic) 1.16563
SOD3 superoxide dismutase 3, extracellular 1.1648
HOMEZ homeobox and leucine zipper encoding 1.16371
ZNF689 zinc finger protein 689 1.16246
SRSF7 serine/arginine-rich splicing factor 7 1.16065
ULBP3 UL16 binding protein 3 1.16009
CKM creatine kinase, muscle 1.1584
OGFR opioid growth factor receptor 1.15813
BBS4 Bardet-Biedl syndrome 4 1.15681
HNRNPA1L2 heterogeneous nuclear ribonucleoprotein A1-like 2 1.15642
WNT4 wingless-type MMTV integration site family, member 4 1.1545
EPHA5 EPH receptor A5 1.15303
ACTR6 ARP6 actin-related protein 6 homolog (yeast) 1.15299
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog 1.15139
MAN1A1 mannosidase, alpha, class 1A, member 1 1.15092
SMAD5 SMAD family member 5 1.15022
DLX3 distal-less homeobox 3 1.15016
CAND1 cullin-associated and neddylation-dissociated 1 1.1471
EXO1 exonuclease 1 1.14554
KRT17 keratin 17, type I 1.14457
ACTL6A actin-like 6A 1.14351
LMNB1 lamin B1 1.14116
PLXND1 plexin D1 1.13981
MARK3 MAP/microtubule affinity-regulating kinase 3 1.13872
AHCY adenosylhomocysteinase 1.13599
SSTR2 somatostatin receptor 2 1.13179
ZNF781 zinc finger protein 781 1.12453
COPS2 COP9 signalosome subunit 2 1.12169
REPIN1 replication initiator 1 1.11955
MKRN3 makorin ring finger protein 3 1.11859
SCN5A sodium channel, voltage gated, type V alpha subunit 1.11688
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 1.11432
ARCN1 archain 1 1.11264
SLC16A14 solute carrier family 16, member 14 1.10775
CXCL6 chemokine (C-X-C motif) ligand 6 1.10694
SAR1B secretion associated, Ras related GTPase 1B 1.10454
HIATL1 hippocampus abundant transcript-like 1 1.10337
RPS4X ribosomal protein S4, X-linked 1.1031
OSR1 odd-skipped related transciption factor 1 1.10146
SEPT3 septin 3 1.10108
GPR151 G protein-coupled receptor 151 1.10051
NOP16 NOP16 nucleolar protein 1.1
EMX2 empty spiracles homeobox 2 1.09707
APOC3 apolipoprotein C-III 1.09612
PCDHA2 protocadherin alpha 2 1.09508
ACR acrosin 1.09359
HRH2 histamine receptor H2 1.0933
AES amino-terminal enhancer of split 1.09243
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase 1.092
NDUFB3 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa 1.09163
TMEM130 transmembrane protein 130 1.0893
ZC3H13 zinc finger CCCH-type containing 13 1.08799
SLC6A16 solute carrier family 6, member 16 1.08526
IL4R interleukin 4 receptor 1.08201
MXD4 MAX dimerization protein 4 1.08194
RAB33A RAB33A, member RAS oncogene family 1.08156
KCTD3 potassium channel tetramerization domain containing 3 1.08152
SLC6A10P solute carrier family 6 (neurotransmitter transporter), member 10, pseudogene 1.08125
TAF13 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa 1.0811
EIF3J eukaryotic translation initiation factor 3, subunit J 1.08066
LTBR lymphotoxin beta receptor (TNFR superfamily, member 3) 1.0798
DHPS deoxyhypusine synthase 1.07356
BCL7A B-cell CLL/lymphoma 7A 1.07305
UBL3 ubiquitin-like 3 1.07236
USP17L1 ubiquitin specific peptidase 17-like family member 1 1.06994
UBTF upstream binding transcription factor, RNA polymerase I 1.06753
RBM25 RNA binding motif protein 25 1.06752
SLC25A33 solute carrier family 25 (pyrimidine nucleotide carrier), member 33 1.06333
ISY1-RAB43 ISY1-RAB43 readthrough 1.06248
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7 1.06067
PDE12 phosphodiesterase 12 1.05858
CTSC cathepsin C 1.05816
GPR155 G protein-coupled receptor 155 1.05655
ABCA6 ATP-binding cassette, sub-family A (ABC1), member 6 1.05342
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1 1.05227
ISY1 ISY1 splicing factor homolog (S. cerevisiae) 1.05078
KLK4 kallikrein-related peptidase 4 1.0505
BST2 bone marrow stromal cell antigen 2 1.05039
FOXD1 forkhead box D1 1.04507
S1PR3 sphingosine-1-phosphate receptor 3 1.04374
SIRT7 sirtuin 7 1.04087
RPS15A ribosomal protein S15a 1.03473
INPP5D inositol polyphosphate-5-phosphatase, 145kDa 1.03147
RNF181 ring finger protein 181 1.0313
PIAS4 protein inhibitor of activated STAT, 4 1.02831
NME7 NME/NM23 family member 7 1.02698
SCAP SREBF chaperone 1.02191
STAT5B signal transducer and activator of transcription 5B 1.0204
ADRA1B adrenoceptor alpha 1B 1.01948
AATF apoptosis antagonizing transcription factor 1.01781
ZNF787 zinc finger protein 787 1.01643
WNT7B wingless-type MMTV integration site family, member 7B 1.01248
DDB1 damage-specific DNA binding protein 1, 127kDa 1.0114
USP17L4 ubiquitin specific peptidase 17-like family member 4 1.00991
GCM1 glial cells missing homolog 1 (Drosophila) 1.00948
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial 1.00735
THBS1 thrombospondin 1 1.00611
PSMC5 proteasome (prosome, macropain) 26S subunit, ATPase, 5 1.00598
ALG8 ALG8, alpha-1,3-glucosyltransferase 1.0043
BCS1L BC1 (ubiquinol-cytochrome c reductase) synthesis-like 1.00229
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 1.00171
LOC390877 adenylate kinase isoenzyme 1-like 1.00073
LOC441528 zinc finger protein 839-like 1.0007

decreased fitness

Symbol Name Standardized Value
CENPJ centromere protein J -3.52874
ZNF140 zinc finger protein 140 -3.31002
ETFDH electron-transferring-flavoprotein dehydrogenase -3.11697
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 -3.05998
NR3C2 nuclear receptor subfamily 3, group C, member 2 -2.97011
MFAP1 microfibrillar-associated protein 1 -2.88844
MMP2 matrix metallopeptidase 2 -2.88819
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6 -2.88012
MED13L mediator complex subunit 13-like -2.81675
PLOD3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 -2.81101
FAM120A family with sequence similarity 120A -2.77791
PCSK9 proprotein convertase subtilisin/kexin type 9 -2.58366
DPP3 dipeptidyl-peptidase 3 -2.54648
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1 -2.51083
ALG1L ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase-like -2.48122
GPR19 G protein-coupled receptor 19 -2.44604
ATP6V1H ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H -2.42376
DNAJC8 DnaJ (Hsp40) homolog, subfamily C, member 8 -2.30165
ZNF37A zinc finger protein 37A -2.24012
CCL7 chemokine (C-C motif) ligand 7 -2.21672
SATL1 spermidine/spermine N1-acetyl transferase-like 1 -2.21291
USP30 ubiquitin specific peptidase 30 -2.19639
ZNF41 zinc finger protein 41 -2.18193
BMP7 bone morphogenetic protein 7 -2.1708
ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa -2.1234
LBX1 ladybird homeobox 1 -2.12197
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -2.08932
SOX18 SRY (sex determining region Y)-box 18 -2.08292
PKD2L2 polycystic kidney disease 2-like 2 -2.07475
RXRG retinoid X receptor, gamma -2.05088
PARK2 parkin RBR E3 ubiquitin protein ligase -2.03228
ABHD10 abhydrolase domain containing 10 -2.02357
RHOB ras homolog family member B -1.96709
CCR7 chemokine (C-C motif) receptor 7 -1.96598
ETV6 ets variant 6 -1.96039
C14ORF39 chromosome 14 open reading frame 39 -1.95734
OR1E1 olfactory receptor, family 1, subfamily E, member 1 -1.95214
RASAL1 RAS protein activator like 1 (GAP1 like) -1.94265
DDX50 DEAD (Asp-Glu-Ala-Asp) box polypeptide 50 -1.9351
SERPINA12 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12 -1.93178
GYS2 glycogen synthase 2 (liver) -1.92778
SP5 Sp5 transcription factor -1.92689
RSG1 REM2 and RAB-like small GTPase 1 -1.91879
PAWR PRKC, apoptosis, WT1, regulator -1.90772
ISL1 ISL LIM homeobox 1 -1.8999
ROBO3 roundabout, axon guidance receptor, homolog 3 (Drosophila) -1.89726
SOX30 SRY (sex determining region Y)-box 30 -1.8965
GPX5 glutathione peroxidase 5 -1.89284
GALNTL5 polypeptide N-acetylgalactosaminyltransferase-like 5 -1.89116
ADAMTS10 ADAM metallopeptidase with thrombospondin type 1 motif, 10 -1.88393
MOGAT1 monoacylglycerol O-acyltransferase 1 -1.87984
GMDS GDP-mannose 4,6-dehydratase -1.8362
SLC10A3 solute carrier family 10, member 3 -1.8339
WDR83 WD repeat domain 83 -1.82998
PDXK pyridoxal (pyridoxine, vitamin B6) kinase -1.82792
IL1B interleukin 1, beta -1.81954
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa -1.79982
KAT2B K(lysine) acetyltransferase 2B -1.76324
SARDH sarcosine dehydrogenase -1.76202
LIG4 ligase IV, DNA, ATP-dependent -1.75995
TMEM14A transmembrane protein 14A -1.75835
XYLB xylulokinase homolog (H. influenzae) -1.7568
ADGRD2 adhesion G protein-coupled receptor D2 -1.74996
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 -1.73205
BRD8 bromodomain containing 8 -1.73013
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) -1.72794
NPTN neuroplastin -1.72093
NFX1 nuclear transcription factor, X-box binding 1 -1.71675
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta -1.7147
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2 -1.71201
PHF11 PHD finger protein 11 -1.70448
NDUFB4 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4, 15kDa -1.68882
DSCAM Down syndrome cell adhesion molecule -1.68591
GTF2A1L general transcription factor IIA, 1-like -1.67899
SSX8 synovial sarcoma, X breakpoint 8 -1.67465
MLC1 megalencephalic leukoencephalopathy with subcortical cysts 1 -1.67083
CARD14 caspase recruitment domain family, member 14 -1.64856
KIF5A kinesin family member 5A -1.63687
USP40 ubiquitin specific peptidase 40 -1.61096
HIST1H3G histone cluster 1, H3g -1.59844
DCP1B decapping mRNA 1B -1.59613
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -1.589
BCL2L10 BCL2-like 10 (apoptosis facilitator) -1.57944
CAPN2 calpain 2, (m/II) large subunit -1.57924
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 -1.5745
RAB9A RAB9A, member RAS oncogene family -1.56881
RNF144A ring finger protein 144A -1.56627
RCSD1 RCSD domain containing 1 -1.55931
TTLL4 tubulin tyrosine ligase-like family member 4 -1.55848
DNASE1L2 deoxyribonuclease I-like 2 -1.54839
KCNJ10 potassium channel, inwardly rectifying subfamily J, member 10 -1.54812
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) -1.54589
LRP3 low density lipoprotein receptor-related protein 3 -1.53974
CIR1 corepressor interacting with RBPJ, 1 -1.53076
PCDHGA2 protocadherin gamma subfamily A, 2 -1.52579
MYF6 myogenic factor 6 (herculin) -1.52455
HIST1H4L histone cluster 1, H4l -1.52102
ARL13B ADP-ribosylation factor-like 13B -1.51909
SNTB2 syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2) -1.51883
USP20 ubiquitin specific peptidase 20 -1.51671
ERBB3 erb-b2 receptor tyrosine kinase 3 -1.51281
PLCD3 phospholipase C, delta 3 -1.5109
ITGB4 integrin, beta 4 -1.50029
PRKCZ protein kinase C, zeta -1.49459
AGPAT2 1-acylglycerol-3-phosphate O-acyltransferase 2 -1.48812
PHKB phosphorylase kinase, beta -1.48592
MXD3 MAX dimerization protein 3 -1.48152
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1 -1.47906
PRDM12 PR domain containing 12 -1.47734
PSAT1 phosphoserine aminotransferase 1 -1.47702
CYP27C1 cytochrome P450, family 27, subfamily C, polypeptide 1 -1.47558
AGBL3 ATP/GTP binding protein-like 3 -1.47549
SKAP1 src kinase associated phosphoprotein 1 -1.46557
LRMP lymphoid-restricted membrane protein -1.45905
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) -1.45677
KIR2DS1 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1 -1.45648
TRIB3 tribbles pseudokinase 3 -1.45531
GPX1 glutathione peroxidase 1 -1.4464
TMOD1 tropomodulin 1 -1.44496
ACO2 aconitase 2, mitochondrial -1.44197
SERPINA2 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 2 (gene/pseudogene) -1.44084
GSC goosecoid homeobox -1.43845
XRN2 5'-3' exoribonuclease 2 -1.43562
RGS18 regulator of G-protein signaling 18 -1.42586
PDCD1LG2 programmed cell death 1 ligand 2 -1.40654
POLR1C polymerase (RNA) I polypeptide C, 30kDa -1.40364
PVRL2 poliovirus receptor-related 2 (herpesvirus entry mediator B) -1.39745
EFNA3 ephrin-A3 -1.3919
CELF3 CUGBP, Elav-like family member 3 -1.39156
ZNF461 zinc finger protein 461 -1.38927
HNRNPA0 heterogeneous nuclear ribonucleoprotein A0 -1.385
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6 -1.38255
PTGER1 prostaglandin E receptor 1 (subtype EP1), 42kDa -1.3809
RSPO3 R-spondin 3 -1.38041
DICER1 dicer 1, ribonuclease type III -1.37808
APOA5 apolipoprotein A-V -1.37698
MOCS2 molybdenum cofactor synthesis 2 -1.37602
STK32C serine/threonine kinase 32C -1.36058
PIK3C2G phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma -1.35709
GIPR gastric inhibitory polypeptide receptor -1.3504
GALNS galactosamine (N-acetyl)-6-sulfatase -1.34517
OR2T1 olfactory receptor, family 2, subfamily T, member 1 -1.34431
ATP6V0A1 ATPase, H+ transporting, lysosomal V0 subunit a1 -1.34092
PCDHB11 protocadherin beta 11 -1.33894
SNAPC4 small nuclear RNA activating complex, polypeptide 4, 190kDa -1.3387
ZNF45 zinc finger protein 45 -1.33649
RAB43 RAB43, member RAS oncogene family -1.3298
HOXC11 homeobox C11 -1.32663
ZNF473 zinc finger protein 473 -1.32563
ZNF621 zinc finger protein 621 -1.32336
CP ceruloplasmin (ferroxidase) -1.32317
ZNF788 zinc finger family member 788 -1.32116
NDUFB7 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa -1.31816
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9 -1.31542
BCORL1 BCL6 corepressor-like 1 -1.30988
IL1R1 interleukin 1 receptor, type I -1.30178
CNGA3 cyclic nucleotide gated channel alpha 3 -1.29937
NPHP4 nephronophthisis 4 -1.29721
TAS2R9 taste receptor, type 2, member 9 -1.29079
CCL25 chemokine (C-C motif) ligand 25 -1.28546
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) -1.28478
FOXK2 forkhead box K2 -1.28319
SLC6A9 solute carrier family 6 (neurotransmitter transporter, glycine), member 9 -1.28264
C8G complement component 8, gamma polypeptide -1.28114
TASP1 taspase, threonine aspartase, 1 -1.27973
ZNF800 zinc finger protein 800 -1.27577
FZD8 frizzled class receptor 8 -1.27469
TSC22D2 TSC22 domain family, member 2 -1.27301
SIRT1 sirtuin 1 -1.27178
DSG4 desmoglein 4 -1.26965
ALG12 ALG12, alpha-1,6-mannosyltransferase -1.26896
ZNF600 zinc finger protein 600 -1.26707
EXOSC2 exosome component 2 -1.26609
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal) -1.26549
THOP1 thimet oligopeptidase 1 -1.25912
SMAD9 SMAD family member 9 -1.25907
ADGRF5 adhesion G protein-coupled receptor F5 -1.25807
TRIM45 tripartite motif containing 45 -1.25653
ENO1 enolase 1, (alpha) -1.24896
CYP11B2 cytochrome P450, family 11, subfamily B, polypeptide 2 -1.24869
SLC35B4 solute carrier family 35 (UDP-xylose/UDP-N-acetylglucosamine transporter), member B4 -1.24602
ARHGAP35 Rho GTPase activating protein 35 -1.2455
GRK7 G protein-coupled receptor kinase 7 -1.24472
JAG2 jagged 2 -1.24472
MUSK muscle, skeletal, receptor tyrosine kinase -1.24344
NUDT13 nudix (nucleoside diphosphate linked moiety X)-type motif 13 -1.23844
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2 -1.23824
RNF130 ring finger protein 130 -1.23456
MS4A7 membrane-spanning 4-domains, subfamily A, member 7 -1.23046
DTX3L deltex 3 like, E3 ubiquitin ligase -1.23013
RCN1 reticulocalbin 1, EF-hand calcium binding domain -1.22368
AP4S1 adaptor-related protein complex 4, sigma 1 subunit -1.2191
CX3CL1 chemokine (C-X3-C motif) ligand 1 -1.2191
IL3RA interleukin 3 receptor, alpha (low affinity) -1.21896
CELA2B chymotrypsin-like elastase family, member 2B -1.21617
CBS cystathionine-beta-synthase -1.21564
EPB41 erythrocyte membrane protein band 4.1 -1.2127
QKI QKI, KH domain containing, RNA binding -1.21056
PRSS12 protease, serine, 12 (neurotrypsin, motopsin) -1.20846
CUL1 cullin 1 -1.20374
DUSP22 dual specificity phosphatase 22 -1.19616
HOXA10 homeobox A10 -1.19249
NUDT1 nudix (nucleoside diphosphate linked moiety X)-type motif 1 -1.19003
LHX8 LIM homeobox 8 -1.18787
GEN1 GEN1 Holliday junction 5' flap endonuclease -1.18566
CAPN7 calpain 7 -1.18487
TMPO thymopoietin -1.18388
LHX5 LIM homeobox 5 -1.18188
FZD9 frizzled class receptor 9 -1.18138
MAT2B methionine adenosyltransferase II, beta -1.17672
MNT MAX network transcriptional repressor -1.1734
AQR aquarius intron-binding spliceosomal factor -1.16189
PDHA2 pyruvate dehydrogenase (lipoamide) alpha 2 -1.15988
OR2S2 olfactory receptor, family 2, subfamily S, member 2 (gene/pseudogene) -1.15918
TRIP12 thyroid hormone receptor interactor 12 -1.15502
HNMT histamine N-methyltransferase -1.15478
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) -1.15311
SYT9 synaptotagmin IX -1.15179
EXOSC9 exosome component 9 -1.15058
CLDN14 claudin 14 -1.14965
ADGRE3 adhesion G protein-coupled receptor E3 -1.14934
ARID3A AT rich interactive domain 3A (BRIGHT-like) -1.14684
IRF2BP1 interferon regulatory factor 2 binding protein 1 -1.14609
NTAN1 N-terminal asparagine amidase -1.13968
ACCS 1-aminocyclopropane-1-carboxylate synthase homolog (Arabidopsis)(non-functional) -1.13854
CACNB4 calcium channel, voltage-dependent, beta 4 subunit -1.1367
LPAR1 lysophosphatidic acid receptor 1 -1.13596
POP1 processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae) -1.12993
PAK7 p21 protein (Cdc42/Rac)-activated kinase 7 -1.12702
STON1-GTF2A1L STON1-GTF2A1L readthrough -1.12209
TRIM26 tripartite motif containing 26 -1.12113
CLIP1 CAP-GLY domain containing linker protein 1 -1.12029
CSF3R colony stimulating factor 3 receptor (granulocyte) -1.11828
SLC16A5 solute carrier family 16 (monocarboxylate transporter), member 5 -1.11527
CXCL16 chemokine (C-X-C motif) ligand 16 -1.11245
HDAC1 histone deacetylase 1 -1.10786
UTRN utrophin -1.10536
CHD5 chromodomain helicase DNA binding protein 5 -1.10389
GRIK3 glutamate receptor, ionotropic, kainate 3 -1.10286
ZRANB2 zinc finger, RAN-binding domain containing 2 -1.09973
PCDHGB3 protocadherin gamma subfamily B, 3 -1.09966
CRYBB1 crystallin, beta B1 -1.09649
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4 -1.0963
ZSCAN4 zinc finger and SCAN domain containing 4 -1.09486
FNDC3B fibronectin type III domain containing 3B -1.09289
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast) -1.09062
MSANTD2 Myb/SANT-like DNA-binding domain containing 2 -1.08616
ZNF407 zinc finger protein 407 -1.08563
FGD1 FYVE, RhoGEF and PH domain containing 1 -1.0855
CALML3 calmodulin-like 3 -1.08107
SPEN spen family transcriptional repressor -1.08051
SOX10 SRY (sex determining region Y)-box 10 -1.07668
ADORA1 adenosine A1 receptor -1.075
OR51T1 olfactory receptor, family 51, subfamily T, member 1 -1.07444
MTA1 metastasis associated 1 -1.06987
NDUFB9 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9, 22kDa -1.06699
CCL5 chemokine (C-C motif) ligand 5 -1.06541
LRP1B low density lipoprotein receptor-related protein 1B -1.06537
ST8SIA6 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 -1.06379
IL10RB interleukin 10 receptor, beta -1.06342
CLASRP CLK4-associating serine/arginine rich protein -1.06323
SLC39A7 solute carrier family 39 (zinc transporter), member 7 -1.06038
SYT3 synaptotagmin III -1.0552
HSF1 heat shock transcription factor 1 -1.0551
NAE1 NEDD8 activating enzyme E1 subunit 1 -1.05203
PA2G4 proliferation-associated 2G4, 38kDa -1.05183
CRK v-crk avian sarcoma virus CT10 oncogene homolog -1.05089
SULT1C4 sulfotransferase family, cytosolic, 1C, member 4 -1.05016
EXOC2 exocyst complex component 2 -1.04804
CNGA2 cyclic nucleotide gated channel alpha 2 -1.04721
DCLK3 doublecortin-like kinase 3 -1.04632
GRIA4 glutamate receptor, ionotropic, AMPA 4 -1.04274
PSKH2 protein serine kinase H2 -1.04124
CYP4A22 cytochrome P450, family 4, subfamily A, polypeptide 22 -1.0397
CACNA1F calcium channel, voltage-dependent, L type, alpha 1F subunit -1.03953
TRIM41 tripartite motif containing 41 -1.0373
ZNF197 zinc finger protein 197 -1.03388
GPR142 G protein-coupled receptor 142 -1.03146
HSPA1A heat shock 70kDa protein 1A -1.03106
TNPO3 transportin 3 -1.03009
FAM207A family with sequence similarity 207, member A -1.02884
CHGA chromogranin A -1.02828
CHEK2 checkpoint kinase 2 -1.02798
SLC4A8 solute carrier family 4, sodium bicarbonate cotransporter, member 8 -1.02777
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3 -1.02357
TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) -1.02312
CHD9 chromodomain helicase DNA binding protein 9 -1.02105
GPR31 G protein-coupled receptor 31 -1.02051
SGK1 serum/glucocorticoid regulated kinase 1 -1.01789
SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 -1.01589
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D -1.01386
PLCZ1 phospholipase C, zeta 1 -1.01155
PCSK6 proprotein convertase subtilisin/kexin type 6 -1.00992
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 -1.00846
BCL7C B-cell CLL/lymphoma 7C -1.00843
PROKR2 prokineticin receptor 2 -1.00503