TACO1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description translational activator of mitochondrially encoded cytochrome c oxidase I|This gene encodes a mitochondrial protein that function as a translational activator of mitochondrially-encoded cytochrome c oxidase 1. Mutations in this gene are associated with Leigh syndrome.[provided by RefSeq, Mar 2010] (NCBI Entrez Gene Database, 51204)
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Genes

284 genes differentially expressed following the TACO1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
FOXD1 forkhead box D1 2.50149
TXNDC8 thioredoxin domain containing 8 (spermatozoa) 2.50149
CELA3A chymotrypsin-like elastase family, member 3A 2.50149
HES3 hes family bHLH transcription factor 3 2.50149
ZDHHC9 zinc finger, DHHC-type containing 9 2.50149
GLYAT glycine-N-acyltransferase 2.50149
NOD2 nucleotide-binding oligomerization domain containing 2 2.50149
CES5A carboxylesterase 5A 2.50149
CCL5 chemokine (C-C motif) ligand 5 2.50149
LRRC53 leucine rich repeat containing 53 2.50149
MC4R melanocortin 4 receptor 2.50149
OR52A5 olfactory receptor, family 52, subfamily A, member 5 2.50149
SECTM1 secreted and transmembrane 1 2.50149
PRKAG3 protein kinase, AMP-activated, gamma 3 non-catalytic subunit 2.50149
FAM153A family with sequence similarity 153, member A 2.50149
PRB1 proline-rich protein BstNI subfamily 1 2.50149
TAS2R5 taste receptor, type 2, member 5 2.50149
SOX1 SRY (sex determining region Y)-box 1 2.50149
PDE6A phosphodiesterase 6A, cGMP-specific, rod, alpha 2.50149
FGF23 fibroblast growth factor 23 2.50149
IGFL2 IGF-like family member 2 2.50149
FETUB fetuin B 2.50149
ESX1 ESX homeobox 1 2.50149
ABI3BP ABI family, member 3 (NESH) binding protein 2.50149
GNRHR gonadotropin-releasing hormone receptor 2.50149
NAA11 N(alpha)-acetyltransferase 11, NatA catalytic subunit 2.50149
CRYGB crystallin, gamma B 2.50149
SP5 Sp5 transcription factor 2.50149
ETV7 ets variant 7 2.50149
C2ORF78 chromosome 2 open reading frame 78 2.50149
AIPL1 aryl hydrocarbon receptor interacting protein-like 1 2.50149
MAS1 MAS1 proto-oncogene, G protein-coupled receptor 2.50149
ADIPOQ adiponectin, C1Q and collagen domain containing 2.50149
APOBR apolipoprotein B receptor 2.50149
XCL1 chemokine (C motif) ligand 1 2.50149
GRIA1 glutamate receptor, ionotropic, AMPA 1 2.50149
GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4 2.50149
MYOM3 myomesin 3 2.50149
TRIM73 tripartite motif containing 73 2.50149
REN renin 2.50149
NRROS negative regulator of reactive oxygen species 2.50149
TNS4 tensin 4 2.50149
SLC28A2 solute carrier family 28 (concentrative nucleoside transporter), member 2 2.50149
NBEAL2 neurobeachin-like 2 2.50149
DRC11L dynein regulatory complex subunit 11 like 2.50149
RTTN rotatin 2.50149
KRT81 keratin 81, type II 2.50149
JADE1 jade family PHD finger 1 2.50149
PDF peptide deformylase (mitochondrial) 2.50149
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 2.50149
TMPRSS7 transmembrane protease, serine 7 2.50149
XKR3 XK, Kell blood group complex subunit-related family, member 3 2.50149
LOC124900192 uncharacterized LOC124900192 2.50149
GATA3 GATA binding protein 3 2.50149
ALX3 ALX homeobox 3 2.50149
ROPN1L rhophilin associated tail protein 1-like 2.50149
SAXO5 stabilizer of axonemal microtubules 5 2.50149
WASH8P WAS protein family homolog 8, pseudogene 2.50149
KIF1C-AS1 KIF1C antisense RNA 1 2.50149
C1ORF232 chromosome 1 open reading frame 230 2.50149
PEAK3 PEAK family member 3 2.50149
ODAD3 outer dynein arm docking complex subunit 3 2.50149
AJM1 apical junction component 1 homolog 2.50149
TMEM275 transmembrane protein 275 2.50149
STING1 stimulator of interferon response cGAMP interactor 1 2.50149
GATA6 GATA binding protein 6 2.50149
ACE2 angiotensin I converting enzyme 2 2.50149
RNF113A ring finger protein 113A 2.50149
EID2 EP300 interacting inhibitor of differentiation 2 2.50149
NHLRC1 NHL repeat containing E3 ubiquitin protein ligase 1 2.50149
ZNF579 zinc finger protein 579 2.50149
OR2A12 olfactory receptor, family 2, subfamily A, member 12 2.50149
MSX2 msh homeobox 2 2.50149
CD79A CD79a molecule, immunoglobulin-associated alpha 2.50149
CLIP4 CAP-GLY domain containing linker protein family, member 4 2.50149
AGA aspartylglucosaminidase 2.50149
TBX3 T-box 3 2.50149
C1QTNF8 C1q and tumor necrosis factor related protein 8 2.50149
GPR85 G protein-coupled receptor 85 2.50149
LRRC73 leucine rich repeat containing 73 2.50149
TIMD4 T-cell immunoglobulin and mucin domain containing 4 2.50149
RGS21 regulator of G-protein signaling 21 2.50149
BARX2 BARX homeobox 2 2.50149
CNTFR ciliary neurotrophic factor receptor 2.50149
GSC goosecoid homeobox 2.50149
CDKN2A cyclin-dependent kinase inhibitor 2A 2.50149
OR2L2 olfactory receptor, family 2, subfamily L, member 2 2.50149
RAB11A RAB11A, member RAS oncogene family 2.50149
ABCA4 ATP-binding cassette, sub-family A (ABC1), member 4 2.50149
SLC13A2 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2 2.50149
HAVCR1 hepatitis A virus cellular receptor 1 2.50149
PLGRKT plasminogen receptor, C-terminal lysine transmembrane protein 2.50149
C16ORF78 chromosome 16 open reading frame 78 2.50149
IL36R interleukin 36 receptor 2.50149
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2 2.50149
ISL1 ISL LIM homeobox 1 2.50149
CHI3L2 chitinase 3-like 2 2.50149
DHH desert hedgehog 2.50149
KISS1 KiSS-1 metastasis-suppressor 2.50149
HPD 4-hydroxyphenylpyruvate dioxygenase 2.50149
WDR48 WD repeat domain 48 2.50149
BTNL3 butyrophilin-like 3 2.50149
C11ORF91 chromosome 11 open reading frame 91 2.50149
HHATL hedgehog acyltransferase-like 2.50149
C9ORF64 chromosome 9 open reading frame 64 2.50149
DUOX2 dual oxidase 2 2.50149
LRRIQ3 leucine-rich repeats and IQ motif containing 3 2.50149
KLF2 Kruppel-like factor 2 2.50149
EMX2 empty spiracles homeobox 2 2.50149
IL21R interleukin 21 receptor 2.50149
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1 2.50149
P2RX3 purinergic receptor P2X, ligand gated ion channel, 3 2.50149
CLEC1A C-type lectin domain family 1, member A 2.50149
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 2.50149
LGALS14 lectin, galactoside-binding, soluble, 14 2.50149
ADCY4 adenylate cyclase 4 2.50149
ADAM18 ADAM metallopeptidase domain 18 2.50149
ZPBP zona pellucida binding protein 2.50149
ZNF831 zinc finger protein 831 2.50149
MB myoglobin 2.50149
GOLGA8T golgin A8 family, member T 2.50149
CTSF cathepsin F 2.50149
PRH2 proline-rich protein HaeIII subfamily 2 2.50149
PATE4 prostate and testis expressed 4 2.50149
SPATA9 spermatogenesis associated 9 2.50149
UTS2B urotensin 2B 2.50149
BEAN1 brain expressed, associated with NEDD4, 1 2.50149
MESP1 mesoderm posterior basic helix-loop-helix transcription factor 1 2.50149
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3 2.50149
GSTA1 glutathione S-transferase alpha 1 2.50149
VAV1 vav 1 guanine nucleotide exchange factor 2.50149
DLX3 distal-less homeobox 3 2.50149
PDK4 pyruvate dehydrogenase kinase, isozyme 4 2.50149
KRT3 keratin 3, type II 2.50149
ABRA actin binding Rho activating protein 2.50149
MAGEC3 melanoma antigen family C3 2.50149
DKK2 dickkopf WNT signaling pathway inhibitor 2 2.50149
FOSB FBJ murine osteosarcoma viral oncogene homolog B 2.50149
AGR2 anterior gradient 2 2.50149
GGN gametogenetin 2.50149
ERAP1 endoplasmic reticulum aminopeptidase 1 2.50149
LAMP5 lysosomal-associated membrane protein family, member 5 2.50149
SUN3 Sad1 and UNC84 domain containing 3 2.50149
ACKR2 atypical chemokine receptor 2 2.50149
SCN3A sodium channel, voltage gated, type III alpha subunit 2.50149
BANF2 barrier to autointegration factor 2 2.50149
LRRC31 leucine rich repeat containing 31 2.50149
OR2AP1 olfactory receptor, family 2, subfamily AP, member 1 2.50149
CD33 CD33 molecule 2.50149
FAM81B family with sequence similarity 81, member B 2.50149
TWIST1 twist family bHLH transcription factor 1 2.50149
TMEM132C transmembrane protein 132C 2.50149
LYPLA1 lysophospholipase I 2.50149
SHISA8 shisa family member 8 2.50149
SLC10A6 solute carrier family 10 (sodium/bile acid cotransporter), member 6 2.50149
ARSH arylsulfatase family, member H 2.50149
SMCO1 single-pass membrane protein with coiled-coil domains 1 2.50149
ARHGAP20 Rho GTPase activating protein 20 2.50149
APOF apolipoprotein F 2.50149
SNAI2 snail family zinc finger 2 2.50149
DYTN dystrotelin 2.50149
OR56B1 olfactory receptor, family 56, subfamily B, member 1 2.50149
FAM89B family with sequence similarity 89, member B 2.49354
FAM78B family with sequence similarity 78, member B 2.48247
NGLY1 N-glycanase 1 2.46633
ATP5MC1 ATP synthase membrane subunit c locus 1 2.46633
HSCB HscB mitochondrial iron-sulfur cluster co-chaperone 2.43447
ZMYND15 zinc finger, MYND-type containing 15 2.43145
PXDNL peroxidasin-like 2.43145
ZNF843 zinc finger protein 843 2.41928
SNX9 sorting nexin 9 2.40166
MCUR1 mitochondrial calcium uniporter regulator 1 2.31977
B3GALT5 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5 2.31597
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2.31597
FAM3B family with sequence similarity 3, member B 2.31597
CILP2 cartilage intermediate layer protein 2 2.2908
PLAAT4 phospholipase A and acyltransferase 4 2.28485
GSTT4 glutathione S-transferase theta 4 2.28485
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 2.26026
CLDN18 claudin 18 2.2558
ZSWIM3 zinc finger, SWIM-type containing 3 2.24982
TMEM64 transmembrane protein 64 2.22789
EEF1A2 eukaryotic translation elongation factor 1 alpha 2 2.20288
ACSM3 acyl-CoA synthetase medium-chain family member 3 2.19649
CXXC1 CXXC finger protein 1 2.14526
BTN2A1 butyrophilin, subfamily 2, member A1 2.14226
CTNNBL1 catenin, beta like 1 2.13569
ECRG4 ECRG4 augurin precursor 2.09374
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2 2.07274
S100A11 S100 calcium binding protein A11 2.06321
FGD6 FYVE, RhoGEF and PH domain containing 6 2.06321
TXNL1 thioredoxin-like 1 2.0591
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 2.0591
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4) 2.05547
FGD3 FYVE, RhoGEF and PH domain containing 3 2.04122
C19ORF81 chromosome 19 open reading frame 81 2.03992
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 2.02055
SPNS2 spinster homolog 2 (Drosophila) 2.0116
C4ORF50 chromosome 4 open reading frame 50 2.0116
WDR93 WD repeat domain 93 2.0116

decreased expression

Symbol Name Standardized Value
GPS2 G protein pathway suppressor 2 -2.50149
TRABD TraB domain containing -2.50149
SYNPO2L synaptopodin 2-like -2.50149
DENND1C DENN/MADD domain containing 1C -2.50149
NRIP2 nuclear receptor interacting protein 2 -2.50149
PKP3 plakophilin 3 -2.50149
SAMD15 sterile alpha motif domain containing 15 -2.50149
DIABLO diablo, IAP-binding mitochondrial protein -2.50149
CIDEB cell death-inducing DFFA-like effector b -2.50149
HEXIM2 hexamethylene bis-acetamide inducible 2 -2.50149
MTERF2 mitochondrial transcription termination factor 2 -2.50149
SMIM31 small integral membrane protein 31 -2.50149
VCP valosin containing protein -2.50149
SLC10A4 solute carrier family 10, member 4 -2.50149
PIERCE2 piercer of microtubule wall 2 -2.50149
NIBAN3 niban apoptosis regulator 3 -2.50149
PNMA8B PNMA family member 8B -2.50149
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 -2.50149
PTGER3 prostaglandin E receptor 3 (subtype EP3) -2.50149
JAGN1 jagunal homolog 1 (Drosophila) -2.50149
PRKG2 protein kinase, cGMP-dependent, type II -2.4947
SPATA6L spermatogenesis associated 6-like -2.4947
PPP1R17 protein phosphatase 1, regulatory subunit 17 -2.48208
ZNF846 zinc finger protein 846 -2.4341
DNAAF6 dynein axonemal assembly factor 6 -2.43145
ATP5MGL ATP synthase membrane subunit g like -2.43145
MCRIP2 MAPK regulated corepressor interacting protein 2 -2.43145
TRIM72 tripartite motif containing 72, E3 ubiquitin protein ligase -2.43145
EBI3 Epstein-Barr virus induced 3 -2.43145
WNT16 wingless-type MMTV integration site family, member 16 -2.43145
SLC22A13 solute carrier family 22 (organic anion/urate transporter), member 13 -2.43145
ASIC4 acid sensing (proton gated) ion channel family member 4 -2.43145
SAMD11 sterile alpha motif domain containing 11 -2.43145
VCX3B variable charge, X-linked 3B -2.43145
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 -2.43145
RASL10A RAS-like, family 10, member A -2.43145
GAPDHS glyceraldehyde-3-phosphate dehydrogenase, spermatogenic -2.43145
MPP7 membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7) -2.43145
PPP1R3A protein phosphatase 1, regulatory subunit 3A -2.43145
GREP1 glycine rich extracellular protein 1 -2.43145
ANKRD63 ankyrin repeat domain 63 -2.43145
ANXA8 annexin A8 -2.43145
CD200R1 CD200 receptor 1 -2.43145
OR4D1 olfactory receptor, family 4, subfamily D, member 1 -2.43145
CDCP2 CUB domain containing protein 2 -2.43145
LANCL3 LanC lantibiotic synthetase component C-like 3 (bacterial) -2.43145
PCDHAC1 protocadherin alpha subfamily C, 1 -2.43145
CPZ carboxypeptidase Z -2.43145
GBX2 gastrulation brain homeobox 2 -2.43145
RSPH10B radial spoke head 10 homolog B (Chlamydomonas) -2.43145
CNTN3 contactin 3 (plasmacytoma associated) -2.35638
CCDC183 coiled-coil domain containing 183 -2.35638
HIPK4 homeodomain interacting protein kinase 4 -2.35638
ESYT3 extended synaptotagmin-like protein 3 -2.30395
NUDC nudC nuclear distribution protein -2.2903
FZD9 frizzled class receptor 9 -2.2903
FBXO48 F-box protein 48 -2.27792
STRIP1 striatin interacting protein 1 -2.27012
PKP4 plakophilin 4 -2.2652
F10 coagulation factor X -2.19649
EIF4E1B eukaryotic translation initiation factor 4E family member 1B -2.19649
C1ORF167 chromosome 1 open reading frame 167 -2.19649
KCNN3 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 3 -2.18302
TIMM8A translocase of inner mitochondrial membrane 8 homolog A (yeast) -2.16512
PTAFR platelet-activating factor receptor -2.14526
RER1 retention in endoplasmic reticulum sorting receptor 1 -2.14526
RGS8 regulator of G-protein signaling 8 -2.14526
ADPRH ADP-ribosylarginine hydrolase -2.14526
ENG endoglin -2.14226
PNMA2 paraneoplastic Ma antigen 2 -2.14226
CSRNP2 cysteine-serine-rich nuclear protein 2 -2.08836
EDNRA endothelin receptor type A -2.08057
FA2H fatty acid 2-hydroxylase -2.07735
LRP1 low density lipoprotein receptor-related protein 1 -2.06355
CLDN15 claudin 15 -2.06321
CDK3 cyclin-dependent kinase 3 -2.0591
WDR31 WD repeat domain 31 -2.05872
RHOF ras homolog family member F (in filopodia) -2.05547
MRPL12 mitochondrial ribosomal protein L12 -2.05547
KCNK12 potassium channel, two pore domain subfamily K, member 12 -2.05547
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -2.01867
EIF4H eukaryotic translation initiation factor 4H -2.01867
MEF2D myocyte enhancer factor 2D -2.01323
PM20D2 peptidase M20 domain containing 2 -2.0115