TADA2A Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description transcriptional adaptor 2A|Many DNA-binding transcriptional activator proteins enhance the initiation rate of RNA polymerase II-mediated gene transcription by interacting functionally with the general transcription machinery bound at the basal promoter. Adaptor proteins are usually required for this activation, possibly to acetylate and destabilize nucleosomes, thereby relieving chromatin constraints at the promoter. The protein encoded by this gene is a transcriptional activator adaptor and has been found to be part of the PCAF histone acetylase complex. Several alternatively spliced transcript variants encoding different isoforms of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Oct 2009] (NCBI Entrez Gene Database, 6871)
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Genes

353 genes differentially expressed following the TADA2A gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
IZUMO1 izumo sperm-egg fusion 1 3.68617
GNLY granulysin 3.68617
TXNDC8 thioredoxin domain containing 8 (spermatozoa) 3.68617
NXPH4 neurexophilin 4 3.68617
MUC6 mucin 6, oligomeric mucus/gel-forming 3.68617
FOXA2 forkhead box A2 3.68617
HGF hepatocyte growth factor (hepapoietin A; scatter factor) 3.68617
TOMM20L translocase of outer mitochondrial membrane 20 homolog (yeast)-like 3.68617
RASSF10 Ras association (RalGDS/AF-6) domain family (N-terminal) member 10 3.68617
CCL5 chemokine (C-C motif) ligand 5 3.68617
DCDC2 doublecortin domain containing 2 3.68617
RXFP1 relaxin/insulin-like family peptide receptor 1 3.68617
SCG2 secretogranin II 3.68617
C1ORF53 chromosome 1 open reading frame 53 3.68617
TAS2R31 taste receptor, type 2, member 31 3.68617
ZNF99 zinc finger protein 99 3.68617
USH1G Usher syndrome 1G (autosomal recessive) 3.68617
TAS2R5 taste receptor, type 2, member 5 3.68617
WEE2 WEE1 homolog 2 (S. pombe) 3.68617
CFHR3 complement factor H-related 3 3.68617
HRH4 histamine receptor H4 3.68617
CD6 CD6 molecule 3.68617
ASB15 ankyrin repeat and SOCS box containing 15 3.68617
FAM167B family with sequence similarity 167, member B 3.68617
KCNJ4 potassium channel, inwardly rectifying subfamily J, member 4 3.68617
ARHGAP30 Rho GTPase activating protein 30 3.68617
ATP8B3 ATPase, aminophospholipid transporter, class I, type 8B, member 3 3.68617
SHE Src homology 2 domain containing E 3.68617
COPZ2 coatomer protein complex, subunit zeta 2 3.68617
PNOC prepronociceptin 3.68617
PTK6 protein tyrosine kinase 6 3.68617
SLC37A2 solute carrier family 37 (glucose-6-phosphate transporter), member 2 3.68617
CORO6 coronin 6 3.68617
MYO16 myosin XVI 3.68617
SULT6B1 sulfotransferase family, cytosolic, 6B, member 1 3.68617
MYO1A myosin IA 3.68617
CRIP1 cysteine-rich protein 1 (intestinal) 3.68617
SLC28A2 solute carrier family 28 (concentrative nucleoside transporter), member 2 3.68617
GUCY2D guanylate cyclase 2D, membrane (retina-specific) 3.68617
SLC16A8 solute carrier family 16 (monocarboxylate transporter), member 8 3.68617
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 3.68617
ZNF233 zinc finger protein 233 3.68617
REN renin 3.68617
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 3.68617
THRSP thyroid hormone responsive 3.68617
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 3.68617
RGL4 ral guanine nucleotide dissociation stimulator-like 4 3.68617
HAS1 hyaluronan synthase 1 3.68617
ABCG5 ATP-binding cassette, sub-family G (WHITE), member 5 3.68617
SP9 Sp9 transcription factor 3.68617
C5ORF58 chromosome 5 open reading frame 58 3.68617
ERLN endoregulin 3.68617
TRAPPC3L trafficking protein particle complex 3-like 3.68617
ALX4 ALX homeobox 4 3.68617
MGAM maltase-glucoamylase 3.68617
ADGRG3 adhesion G protein-coupled receptor G3 3.68617
FRG2C FSHD region gene 2 family, member C 3.68617
MYZAP myocardial zonula adherens protein 3.68617
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 3.68617
CYLC2 cylicin, basic protein of sperm head cytoskeleton 2 3.68617
TTR transthyretin 3.68617
WNT16 wingless-type MMTV integration site family, member 16 3.68617
GPX5 glutathione peroxidase 5 3.68617
OPRM1 opioid receptor, mu 1 3.68617
ROPN1L rhophilin associated tail protein 1-like 3.68617
DUSP13B dual specificity phosphatase 13B 3.68617
CIMAP1B ciliary microtubule associated protein 1B 3.68617
PNMA8C PNMA family member 8C 3.68617
H4C14 H4 clustered histone 14 3.68617
TMEM272 transmembrane protein 272 3.68617
DEUP1 deuterosome assembly protein 1 3.68617
SLC66A1 solute carrier family 66 member 1 3.68617
CFAP119 cilia and flagella associated protein 119 3.68617
ODAD1 outer dynein arm docking complex subunit 1 3.68617
YPEL4 yippee-like 4 (Drosophila) 3.68617
ZNF441 zinc finger protein 441 3.68617
GCSAM germinal center-associated, signaling and motility 3.68617
BBS12 Bardet-Biedl syndrome 12 3.68617
REC114 REC114 meiotic recombination protein 3.68617
BHLHA9 basic helix-loop-helix family, member a9 3.68617
TFEB transcription factor EB 3.68617
TLR8 toll-like receptor 8 3.68617
OR2A12 olfactory receptor, family 2, subfamily A, member 12 3.68617
GGACT gamma-glutamylamine cyclotransferase 3.68617
CXCL14 chemokine (C-X-C motif) ligand 14 3.68617
PSAPL1 prosaposin-like 1 (gene/pseudogene) 3.68617
ACTA1 actin, alpha 1, skeletal muscle 3.68617
APOBEC1 apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 3.68617
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2 3.68617
LECT2 leukocyte cell-derived chemotaxin 2 3.68617
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3 3.68617
HNF1B HNF1 homeobox B 3.68617
PCDHGC3 protocadherin gamma subfamily C, 3 3.68617
MOV10L1 Mov10 RISC complex RNA helicase like 1 3.68617
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 3.68617
PLEK2 pleckstrin 2 3.68617
VCX3B variable charge, X-linked 3B 3.68617
ALG10B ALG10B, alpha-1,2-glucosyltransferase 3.68617
S100G S100 calcium binding protein G 3.68617
MYOT myotilin 3.68617
TUBA3D tubulin, alpha 3d 3.68617
CRYBA1 crystallin, beta A1 3.68617
IER5L immediate early response 5-like 3.68617
ITGA11 integrin, alpha 11 3.68617
KPNA7 karyopherin alpha 7 (importin alpha 8) 3.68617
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7 3.68617
CTXN2 cortexin 2 3.68617
APOB apolipoprotein B 3.68617
MAP6 microtubule-associated protein 6 3.68617
DUSP26 dual specificity phosphatase 26 (putative) 3.68617
TMIGD3 transmembrane and immunoglobulin domain containing 3 3.68617
ANKRD33 ankyrin repeat domain 33 3.68617
ABCA12 ATP-binding cassette, sub-family A (ABC1), member 12 3.68617
CD8B CD8b molecule 3.68617
CD86 CD86 molecule 3.68617
CELA2B chymotrypsin-like elastase family, member 2B 3.68617
ITPKA inositol-trisphosphate 3-kinase A 3.68617
APOL6 apolipoprotein L, 6 3.68617
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 3.68617
DDX4 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 3.68617
ADIRF adipogenesis regulatory factor 3.68617
DACT3 dishevelled-binding antagonist of beta-catenin 3 3.68617
NACAD NAC alpha domain containing 3.68617
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 3.68617
SPINK9 serine peptidase inhibitor, Kazal type 9 3.68617
ARG1 arginase 1 3.68617
KLK7 kallikrein-related peptidase 7 3.68617
CCDC27 coiled-coil domain containing 27 3.68617
IGF2 insulin-like growth factor 2 3.68617
BCO1 beta-carotene oxygenase 1 3.68617
TEX19 testis expressed 19 3.68617
WFDC1 WAP four-disulfide core domain 1 3.68617
PRPH peripherin 3.68617
MAMDC4 MAM domain containing 4 3.68617
GAL3ST2 galactose-3-O-sulfotransferase 2 3.68617
CCDC158 coiled-coil domain containing 158 3.68617
LRRC43 leucine rich repeat containing 43 3.68617
GAB3 GRB2-associated binding protein 3 3.68617
BRDT bromodomain, testis-specific 3.68617
MRLN myoregulin 3.68617
MSR1 macrophage scavenger receptor 1 3.68617
EDN3 endothelin 3 3.68617
P2RX2 purinergic receptor P2X, ligand gated ion channel, 2 3.68617
DGAT2 diacylglycerol O-acyltransferase 2 3.68617
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal) 3.68617
GPR78 G protein-coupled receptor 78 3.68617
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group) 3.68617
IGIP IgA-inducing protein 3.68617
CLEC2A C-type lectin domain family 2, member A 3.68617
RIBC1 RIB43A domain with coiled-coils 1 3.68617
CLNK cytokine-dependent hematopoietic cell linker 3.68617
SOX30 SRY (sex determining region Y)-box 30 3.68617
SOSTDC1 sclerostin domain containing 1 3.68617
NXF3 nuclear RNA export factor 3 3.68617
SCIN scinderin 3.68617
ACRBP acrosin binding protein 3.68617
SPTB spectrin, beta, erythrocytic 3.68617
FAM110D family with sequence similarity 110, member D 3.68617
RNF39 ring finger protein 39 3.68617
GSDMA gasdermin A 3.68617
LOC105378220 macrophage receptor MARCO-like 3.68617
LY6G6C lymphocyte antigen 6 complex, locus G6C 3.68617
MIXL1 Mix paired-like homeobox 3.68617
RIIAD1 regulatory subunit of type II PKA R-subunit (RIIa) domain containing 1 3.68617
ETV3L ets variant 3-like 3.68617
POU5F2 POU domain class 5, transcription factor 2 3.68617
VAV1 vav 1 guanine nucleotide exchange factor 3.68617
ATP10B ATPase, class V, type 10B 3.68617
LYZL4 lysozyme-like 4 3.68617
SYTL5 synaptotagmin-like 5 3.68617
TMEM156 transmembrane protein 156 3.68617
TGM2 transglutaminase 2 3.68617
AZU1 azurocidin 1 3.68617
RBM24 RNA binding motif protein 24 3.68617
TGM5 transglutaminase 5 3.68617
GREM2 gremlin 2, DAN family BMP antagonist 3.68617
PF4V1 platelet factor 4 variant 1 3.68617
SLC17A8 solute carrier family 17 (vesicular glutamate transporter), member 8 3.68617
FANCD2OS FANCD2 opposite strand 3.55082
CECR2 cat eye syndrome chromosome region, candidate 2 3.46542
PNPLA8 patatin-like phospholipase domain containing 8 2.92988
CASP7 caspase 7, apoptosis-related cysteine peptidase 2.84661
LAMC2 laminin, gamma 2 2.82037
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal) 2.81709
HECA headcase homolog (Drosophila) 2.79125
ARFGEF3 ARFGEF family member 3 2.78834
ZFAND6 zinc finger, AN1-type domain 6 2.73935
DSTN destrin (actin depolymerizing factor) 2.70908
PHF7 PHD finger protein 7 2.7043
RBM19 RNA binding motif protein 19 2.65235
PLCL1 phospholipase C-like 1 2.64361
TMEM26 transmembrane protein 26 2.61145
SSBP4 single stranded DNA binding protein 4 2.60843
NREP neuronal regeneration related protein 2.58741
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 2.53789
MAPK8IP2 mitogen-activated protein kinase 8 interacting protein 2 2.53619
ECEL1 endothelin converting enzyme-like 1 2.53619
ADAM11 ADAM metallopeptidase domain 11 2.53619
PTGES3L prostaglandin E synthase 3 (cytosolic)-like 2.53295
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D 2.53295
GEM GTP binding protein overexpressed in skeletal muscle 2.53295
SPESP1 sperm equatorial segment protein 1 2.53295
CFAP70 cilia and flagella associated protein 70 2.53295
BCL6B B-cell CLL/lymphoma 6, member B 2.53295
G0S2 G0/G1 switch 2 2.53295
CHD2 chromodomain helicase DNA binding protein 2 2.52052
ZNF160 zinc finger protein 160 2.51199
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 2.42088
CS citrate synthase 2.41921
NBPF10 neuroblastoma breakpoint family, member 10 2.36397
BLCAP bladder cancer associated protein 2.35266
ASL argininosuccinate lyase 2.35204
WDR26 WD repeat domain 26 2.34958
ELAC2 elaC ribonuclease Z 2 2.3162
MCM9 minichromosome maintenance complex component 9 2.29134
STYXL1 serine/threonine/tyrosine interacting-like 1 2.27196
MFSD11 major facilitator superfamily domain containing 11 2.26733
MED6 mediator complex subunit 6 2.15444
P4HA3 prolyl 4-hydroxylase, alpha polypeptide III 2.12649
RAB18 RAB18, member RAS oncogene family 2.11065
DCTN1 dynactin 1 2.07709
RNPEP arginyl aminopeptidase (aminopeptidase B) 2.07664
SHISA6 shisa family member 6 2.07086
BRWD1 bromodomain and WD repeat domain containing 1 2.01312
RNF213 ring finger protein 213 2.0122
SMCO2 single-pass membrane protein with coiled-coil domains 2 2.0099
SLC4A10 solute carrier family 4, sodium bicarbonate transporter, member 10 2.0099
DDX23 DEAD (Asp-Glu-Ala-Asp) box polypeptide 23 2.00701
GYS1 glycogen synthase 1 (muscle) 2.00599
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 2.00599

decreased expression

Symbol Name Standardized Value
PROM2 prominin 2 -3.68617
GCKR glucokinase (hexokinase 4) regulator -3.68617
NOS2 nitric oxide synthase 2, inducible -3.68617
KCNJ11 potassium channel, inwardly rectifying subfamily J, member 11 -3.68617
REV1 REV1, polymerase (DNA directed) -3.68617
IFI16 interferon, gamma-inducible protein 16 -3.68617
ZBTB42 zinc finger and BTB domain containing 42 -3.68617
PCDHB4 protocadherin beta 4 -3.68617
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor) -3.68617
C22ORF23 chromosome 22 open reading frame 23 -3.68617
TTPA tocopherol (alpha) transfer protein -3.68617
LGR6 leucine-rich repeat containing G protein-coupled receptor 6 -3.68617
ZSCAN22 zinc finger and SCAN domain containing 22 -3.68617
TIE1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1 -3.68617
ZNF804A zinc finger protein 804A -3.68617
NWD1 NACHT and WD repeat domain containing 1 -3.68617
ICAM1 intercellular adhesion molecule 1 -3.68617
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4 -3.68617
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide -3.68617
ADAM29 ADAM metallopeptidase domain 29 -3.68617
EXO5 exonuclease 5 -3.68617
RPS15A ribosomal protein S15a -3.68617
SERP2 stress-associated endoplasmic reticulum protein family member 2 -3.68617
TLR3 toll-like receptor 3 -3.68617
RGS22 regulator of G-protein signaling 22 -3.68617
ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase) -3.68617
VSIG1 V-set and immunoglobulin domain containing 1 -3.68617
SPEF2 sperm flagellar 2 -3.68617
MESP2 mesoderm posterior basic helix-loop-helix transcription factor 2 -3.68617
NBPF12 neuroblastoma breakpoint family, member 12 -3.68617
ACSL6 acyl-CoA synthetase long-chain family member 6 -3.68617
REEP1 receptor accessory protein 1 -3.68617
STAR steroidogenic acute regulatory protein -3.68617
LRRC8E leucine rich repeat containing 8 family, member E -3.68617
NPAP1 nuclear pore associated protein 1 -3.68617
ANGPT4 angiopoietin 4 -3.68617
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1 -3.68617
RAMACL RNA guanine-7 methyltransferase activating subunit like -3.68617
PCDHA1 protocadherin alpha 1 -3.68617
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -3.68617
ACHE acetylcholinesterase (Yt blood group) -3.68617
ATOX1 antioxidant 1 copper chaperone -3.51693
WDR7 WD repeat domain 7 -3.37981
RPL12 ribosomal protein L12 -3.34881
SNX11 sorting nexin 11 -3.25411
MBD6 methyl-CpG binding domain protein 6 -3.18481
MEIOC meiosis specific with coiled-coil domain -3.15677
SMAD5 SMAD family member 5 -3.04275
RGS14 regulator of G-protein signaling 14 -2.93837
NOTCH2NLA notch 2 N-terminal like A -2.90663
RPL27 ribosomal protein L27 -2.8726
EYS eyes shut homolog (Drosophila) -2.84008
G6PD glucose-6-phosphate dehydrogenase -2.83143
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -2.78596
WRNIP1 Werner helicase interacting protein 1 -2.73042
TM9SF1 transmembrane 9 superfamily member 1 -2.70992
EEF2 eukaryotic translation elongation factor 2 -2.70908
ALKBH2 alkB, alkylation repair homolog 2 (E. coli) -2.68592
TOM1L2 target of myb1-like 2 (chicken) -2.60851
RPL7L1 ribosomal protein L7-like 1 -2.59478
CD82 CD82 molecule -2.54455
TTC39A tetratricopeptide repeat domain 39A -2.54455
CCDC33 coiled-coil domain containing 33 -2.54455
PPP1R9B protein phosphatase 1, regulatory subunit 9B -2.54455
PKD2L2 polycystic kidney disease 2-like 2 -2.54455
MEDAG mesenteric estrogen-dependent adipogenesis -2.53879
ZNF600 zinc finger protein 600 -2.53572
SNAI3 snail family zinc finger 3 -2.53572
CCNE1 cyclin E1 -2.53085
RAD51B RAD51 paralog B -2.51517
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 -2.50836
PPP1R3E protein phosphatase 1, regulatory subunit 3E -2.46402
LETM2 leucine zipper-EF-hand containing transmembrane protein 2 -2.46402
ACRV1 acrosomal vesicle protein 1 -2.46402
AMIGO2 adhesion molecule with Ig-like domain 2 -2.46402
EXOSC9 exosome component 9 -2.45946
RUFY3 RUN and FYVE domain containing 3 -2.45946
CASZ1 castor zinc finger 1 -2.45314
RABEP1 rabaptin, RAB GTPase binding effector protein 1 -2.43322
TBCA tubulin folding cofactor A -2.42986
THAP2 THAP domain containing, apoptosis associated protein 2 -2.42872
RPL27A ribosomal protein L27a -2.38454
YKT6 YKT6 v-SNARE homolog (S. cerevisiae) -2.35165
SMIM10L2A small integral membrane protein 10 like 2A -2.33639
DHX33 DEAH (Asp-Glu-Ala-His) box polypeptide 33 -2.33366
ANO5 anoctamin 5 -2.33366
TMEM198 transmembrane protein 198 -2.31957
RPL8 ribosomal protein L8 -2.27368
SDK2 sidekick cell adhesion molecule 2 -2.24567
RPS17 ribosomal protein S17 -2.23574
ZNF432 zinc finger protein 432 -2.21901
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 -2.21557
EEF1G eukaryotic translation elongation factor 1 gamma -2.20075
RPS8 ribosomal protein S8 -2.19437
EEF1A2 eukaryotic translation elongation factor 1 alpha 2 -2.19388
COL1A2 collagen, type I, alpha 2 -2.16777
STARD3 StAR-related lipid transfer (START) domain containing 3 -2.16422
PPP1R11 protein phosphatase 1, regulatory (inhibitor) subunit 11 -2.16422
PIGG phosphatidylinositol glycan anchor biosynthesis, class G -2.16422
NIT1 nitrilase 1 -2.15444
PCBP2 poly(rC) binding protein 2 -2.14518
TET1 tet methylcytosine dioxygenase 1 -2.13472
C9ORF72 chromosome 9 open reading frame 72 -2.12734
KLHL9 kelch-like family member 9 -2.11065
RPS18 ribosomal protein S18 -2.10861
ATF7IP2 activating transcription factor 7 interacting protein 2 -2.10511
FXYD1 FXYD domain containing ion transport regulator 1 -2.09201
SNORC secondary ossification center associated regulator of chondrocyte maturation -2.07463
CRYAB crystallin, alpha B -2.0718
EIF3E eukaryotic translation initiation factor 3, subunit E -2.07136
INTS1 integrator complex subunit 1 -2.07086
CPT2 carnitine palmitoyltransferase 2 -2.07086
DEAF1 DEAF1 transcription factor -2.06704
ORMDL3 ORMDL sphingolipid biosynthesis regulator 3 -2.06061
ACADM acyl-CoA dehydrogenase, C-4 to C-12 straight chain -2.0566
TSC22D3 TSC22 domain family, member 3 -2.03895
RPL36 ribosomal protein L36 -2.03895
RPL37 ribosomal protein L37 -2.03374
ARFIP2 ADP-ribosylation factor interacting protein 2 -2.02052
PTER phosphotriesterase related -2.02052
RPL34 ribosomal protein L34 -2.00599
PXMP2 peroxisomal membrane protein 2, 22kDa -2.00599
RPS10 ribosomal protein S10 -2.00414