TADA3 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description transcriptional adaptor 3|DNA-binding transcriptional activator proteins increase the rate of transcription by interacting with the transcriptional machinery bound to the basal promoter in conjunction with adaptor proteins, possibly by acetylation and destabilization of nucleosomes. The protein encoded by this gene is a transcriptional activator adaptor and a component of the histone acetyl transferase (HAT) coactivator complex which plays a crucial role in chromatin modulation and cell cycle progression. Along with the other components of the complex, this protein links transcriptional activators bound to specific promoters, to histone acetylation and the transcriptional machinery. The protein is also involved in the stabilization and activation of the p53 tumor suppressor protein that plays a role in the cellular response to DNA damage. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013] (NCBI Entrez Gene Database, 10474)
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Genes

315 genes differentially expressed following the TADA3 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
OCM oncomodulin 2.69897
CLEC14A C-type lectin domain family 14, member A 2.69897
SLC6A5 solute carrier family 6 (neurotransmitter transporter), member 5 2.69897
DNAAF1 dynein, axonemal, assembly factor 1 2.69897
RBM24 RNA binding motif protein 24 2.69897
STOML2 stomatin (EPB72)-like 2 2.69897
OR14A16 olfactory receptor, family 14, subfamily A, member 16 2.69897
ALG10B ALG10B, alpha-1,2-glucosyltransferase 2.69897
PCDH12 protocadherin 12 2.69897
SLC35G5 solute carrier family 35, member G5 2.69897
H4C12 H4 clustered histone 12 2.69897
OAZ3 ornithine decarboxylase antizyme 3 2.69897
LGALS12 lectin, galactoside-binding, soluble, 12 2.69897
ATP13A4 ATPase type 13A4 2.69897
FAM3D family with sequence similarity 3, member D 2.69897
FGD2 FYVE, RhoGEF and PH domain containing 2 2.69777
TCHH trichohyalin 2.69777
SLC30A2 solute carrier family 30 (zinc transporter), member 2 2.69777
ADGRE1 adhesion G protein-coupled receptor E1 2.69777
SLC30A4 solute carrier family 30 (zinc transporter), member 4 2.69777
UCN2 urocortin 2 2.69777
GJA10 gap junction protein, alpha 10, 62kDa 2.69777
ARSH arylsulfatase family, member H 2.69777
IL22RA1 interleukin 22 receptor, alpha 1 2.69777
TM4SF4 transmembrane 4 L six family member 4 2.69777
RAX retina and anterior neural fold homeobox 2.69777
GLUD2 glutamate dehydrogenase 2 2.69777
TXNDC2 thioredoxin domain containing 2 (spermatozoa) 2.69777
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 2.69777
RFPL3 ret finger protein-like 3 2.69777
RGPD1 RANBP2-like and GRIP domain containing 1 2.69777
PODN podocan 2.69777
CD180 CD180 molecule 2.69777
FGF7 fibroblast growth factor 7 2.69777
TMEM132C transmembrane protein 132C 2.69777
EFNB2 ephrin-B2 2.69777
NMUR1 neuromedin U receptor 1 2.69777
MPP4 membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4) 2.69777
RPEL1 ribulose-5-phosphate-3-epimerase-like 1 2.69777
SP6 Sp6 transcription factor 2.69777
ABCC12 ATP-binding cassette, sub-family C (CFTR/MRP), member 12 2.69777
ATOH8 atonal homolog 8 (Drosophila) 2.69777
BFSP2 beaded filament structural protein 2, phakinin 2.69777
SPINK13 serine peptidase inhibitor, Kazal type 13 (putative) 2.69777
S100A1 S100 calcium binding protein A1 2.69777
TCP11 t-complex 11, testis-specific 2.69777
CRH corticotropin releasing hormone 2.69777
SMIM5 small integral membrane protein 5 2.69777
CTAG2 cancer/testis antigen 2 2.69777
CARD16 caspase recruitment domain family, member 16 2.69777
TMEM212 transmembrane protein 212 2.69777
TEX53 testis expressed 53 2.69777
SMLR1 small leucine-rich protein 1 2.69777
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) 2.69777
SCEL sciellin 2.69777
GBP3 guanylate binding protein 3 2.69777
PLG plasminogen 2.69777
VSIR V-set immunoregulatory receptor 2.69777
FAM240B family with sequence similarity 240 member B 2.69777
TMEM271 transmembrane protein 271 2.69777
TBXT T-box transcription factor T 2.69777
MSANTD5 Myb/SANT DNA binding domain containing 5 2.69777
SPDYE9 speedy/RINGO cell cycle regulator family member E9 2.69777
GARIN5B golgi associated RAB2 interactor family member 5B 2.69777
CFAP276 cilia and flagella associated protein 276 2.69777
LOC124902436 talanin 2.69777
CIMAP1B ciliary microtubule associated protein 1B 2.69777
SPEM3 SPEM family member 3 2.69777
PROX2 prospero homeobox 2 2.69777
FCMR Fc fragment of IgM receptor 2.69777
SBK3 SH3 domain binding kinase family, member 3 2.69777
RGS9BP regulator of G protein signaling 9 binding protein 2.69777
LIPK lipase, family member K 2.69777
SPMIP9 sperm microtubule inner protein 9 2.69777
VSX2 visual system homeobox 2 2.69777
UROC1 urocanate hydratase 1 2.69777
GZMM granzyme M (lymphocyte met-ase 1) 2.69777
ARMS2 age-related maculopathy susceptibility 2 2.69777
S100P S100 calcium binding protein P 2.69777
GSC goosecoid homeobox 2.69777
NR0B1 nuclear receptor subfamily 0, group B, member 1 2.69777
GDF7 growth differentiation factor 7 2.69777
LGSN lengsin, lens protein with glutamine synthetase domain 2.69777
ASIC3 acid sensing (proton gated) ion channel 3 2.69777
SOAT2 sterol O-acyltransferase 2 2.69777
SDR16C5 short chain dehydrogenase/reductase family 16C, member 5 2.69777
CSAG1 chondrosarcoma associated gene 1 2.69777
SMIM32 small integral membrane protein 32 2.69777
HOXB1 homeobox B1 2.69777
OR52N4 olfactory receptor, family 52, subfamily N, member 4 (gene/pseudogene) 2.69777
WFDC6 WAP four-disulfide core domain 6 2.69777
SLC52A1 solute carrier family 52 (riboflavin transporter), member 1 2.69777
HAVCR1 hepatitis A virus cellular receptor 1 2.69777
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 2.69777
CYP4F22 cytochrome P450, family 4, subfamily F, polypeptide 22 2.69777
TREH trehalase (brush-border membrane glycoprotein) 2.69777
SMR3B submaxillary gland androgen regulated protein 3B 2.69777
ENTPD8 ectonucleoside triphosphate diphosphohydrolase 8 2.69777
C2ORF66 chromosome 2 open reading frame 66 2.69777
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 2.69777
APOD apolipoprotein D 2.69777
ZNF366 zinc finger protein 366 2.69777
SPATA3 spermatogenesis associated 3 2.69777
KRT9 keratin 9, type I 2.69777
CCDC154 coiled-coil domain containing 154 2.69777
KCNK3 potassium channel, two pore domain subfamily K, member 3 2.69777
HDAC1 histone deacetylase 1 2.69777
VNN2 vanin 2 2.69777
FOXE3 forkhead box E3 2.69777
NUPR1 nuclear protein, transcriptional regulator, 1 2.69777
TRIM7 tripartite motif containing 7 2.69777
LGALS14 lectin, galactoside-binding, soluble, 14 2.69777
NKX6-3 NK6 homeobox 3 2.69777
TYR tyrosinase 2.69777
REG1A regenerating islet-derived 1 alpha 2.69777
GPRC6A G protein-coupled receptor, class C, group 6, member A 2.69777
CCDC70 coiled-coil domain containing 70 2.69777
GOLGA8T golgin A8 family, member T 2.69777
GCGR glucagon receptor 2.69777
TCAP titin-cap 2.69777
PRR23A proline rich 23A 2.69777
IL19 interleukin 19 2.69777
SUPT20HL2 suppressor of Ty 20 homolog (S. cerevisiae)-like 2 2.69777
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 2.69777
TH tyrosine hydroxylase 2.69777
TPPP3 tubulin polymerization-promoting protein family member 3 2.69777
SI sucrase-isomaltase (alpha-glucosidase) 2.69777
IBSP integrin-binding sialoprotein 2.69777
PMP2 peripheral myelin protein 2 2.69777
TEX38 testis expressed 38 2.69777
CDCP2 CUB domain containing protein 2 2.69777
GALNT4 polypeptide N-acetylgalactosaminyltransferase 4 2.69777
PARD3B par-3 family cell polarity regulator beta 2.69777
MMP12 matrix metallopeptidase 12 2.69777
AGR2 anterior gradient 2 2.69777
OR10G3 olfactory receptor, family 10, subfamily G, member 3 2.69777
FGF10 fibroblast growth factor 10 2.69777
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15 2.69777
APOL1 apolipoprotein L, 1 2.69777
ISX intestine-specific homeobox 2.69777
CYP3A43 cytochrome P450, family 3, subfamily A, polypeptide 43 2.69777
GCSAML germinal center-associated, signaling and motility-like 2.69777
PRSS54 protease, serine, 54 2.69777
MT1A metallothionein 1A 2.69777
TBPL2 TATA box binding protein like 2 2.69777
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) 2.69777
OR3A1 olfactory receptor, family 3, subfamily A, member 1 2.69777
ZC3H11B zinc finger CCCH-type containing 11B pseudogene 2.69777
AOC1 amine oxidase, copper containing 1 2.69777
NEUROD1 neuronal differentiation 1 2.69777
IL17B interleukin 17B 2.69777
NOVA1 neuro-oncological ventral antigen 1 2.69162
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 2.64822
GMNC geminin coiled-coil domain containing 2.64271
KYNU kynureninase 2.64271
GYG1 glycogenin 1 2.59349
PRELID2 PRELI domain containing 2 2.58372
DPM2 dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit 2.57875
COL13A1 collagen, type XIII, alpha 1 2.55611
PARD6G par-6 family cell polarity regulator gamma 2.52935
WSCD2 WSC domain containing 2 2.45603
TMC2 transmembrane channel-like 2 2.44788
CELA2B chymotrypsin-like elastase family, member 2B 2.44788
CRYZL1 crystallin, zeta (quinone reductase)-like 1 2.42083
WDR33 WD repeat domain 33 2.41702
PCBP1 poly(rC) binding protein 1 2.38298
RHEBL1 Ras homolog enriched in brain like 1 2.36315
SLC39A10 solute carrier family 39 (zinc transporter), member 10 2.34111
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin) 2.34085
MUCL3 mucin like 3 2.34085
ITPKA inositol-trisphosphate 3-kinase A 2.34085
RDH12 retinol dehydrogenase 12 (all-trans/9-cis/11-cis) 2.34085
HIGD1C HIG1 hypoxia inducible domain family, member 1C 2.34085
RBBP6 retinoblastoma binding protein 6 2.31989
TMEM216 transmembrane protein 216 2.31046
ELMO3 engulfment and cell motility 3 2.22478
COL8A1 collagen, type VIII, alpha 1 2.22143
STIM2 stromal interaction molecule 2 2.22143
ELFN2 extracellular leucine-rich repeat and fibronectin type III domain containing 2 2.22143
ADH6 alcohol dehydrogenase 6 (class V) 2.21436
ZNF565 zinc finger protein 565 2.19834
SLC7A10 solute carrier family 7 (neutral amino acid transporter light chain, asc system), member 10 2.19834
IKBIP IKBKB interacting protein 2.19282
SIPA1 signal-induced proliferation-associated 1 2.19282
MED29 mediator complex subunit 29 2.18659
CFAP44 cilia and flagella associated protein 44 2.1809
VIL1 villin 1 2.15664
BGLAP bone gamma-carboxyglutamate (gla) protein 2.15664
DXO decapping exoribonuclease 2.15028
RSAD1 radical S-adenosyl methionine domain containing 1 2.14607
PRKCB protein kinase C, beta 2.14516
DRAM2 DNA-damage regulated autophagy modulator 2 2.1417
RNF24 ring finger protein 24 2.12248
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4 2.11766
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 2.11494
FAM209A family with sequence similarity 209, member A 2.07618
MAP3K13 mitogen-activated protein kinase kinase kinase 13 2.05587
AHCTF1 AT hook containing transcription factor 1 2.05046
PGRMC1 progesterone receptor membrane component 1 2.03507
MRPS9 mitochondrial ribosomal protein S9 2.03176
PPAN peter pan homolog (Drosophila) 2.01501
STK32C serine/threonine kinase 32C 2.01501
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 2.00853
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 2.00727

decreased expression

Symbol Name Standardized Value
PIK3C2G phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma -2.69897
NDNF neuron-derived neurotrophic factor -2.69897
CATSPERD catsper channel auxiliary subunit delta -2.69897
SMAD9 SMAD family member 9 -2.69897
CARM1 coactivator-associated arginine methyltransferase 1 -2.69897
SPACDR sperm acrosome developmental regulator -2.69897
THAP10 THAP domain containing 10 -2.69897
ATG9B autophagy related 9B -2.69897
UTS2 urotensin 2 -2.69777
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -2.69777
EXTL1 exostosin-like glycosyltransferase 1 -2.69777
SPATC1 spermatogenesis and centriole associated 1 -2.69777
RSPH10B2 radial spoke head 10 homolog B2 (Chlamydomonas) -2.69777
GRK7 G protein-coupled receptor kinase 7 -2.69777
MTURN maturin, neural progenitor differentiation regulator homolog (Xenopus) -2.69777
FEM1B fem-1 homolog b (C. elegans) -2.69777
GPR75 G protein-coupled receptor 75 -2.69777
SOST sclerostin -2.69777
EBI3 Epstein-Barr virus induced 3 -2.69777
TMEM184A transmembrane protein 184A -2.69777
TPBGL trophoblast glycoprotein-like -2.69777
MYOZ2 myozenin 2 -2.69777
TMEM45B transmembrane protein 45B -2.69777
SLC28A1 solute carrier family 28 (concentrative nucleoside transporter), member 1 -2.69777
LBHD1 LBH domain containing 1 -2.69777
PCDHA7 protocadherin alpha 7 -2.69777
IMPG1 interphotoreceptor matrix proteoglycan 1 -2.69777
TSPAN8 tetraspanin 8 -2.69777
DMRT1 doublesex and mab-3 related transcription factor 1 -2.69777
SCRIB scribbled planar cell polarity protein -2.69777
IDI2 isopentenyl-diphosphate delta isomerase 2 -2.69777
PCDHGA9 protocadherin gamma subfamily A, 9 -2.69777
QRFP pyroglutamylated RFamide peptide -2.69777
LOXHD1 lipoxygenase homology domains 1 -2.69777
MRPL58 mitochondrial ribosomal protein L58 -2.69777
PLAAT4 phospholipase A and acyltransferase 4 -2.69777
ESPNL espin-like -2.69777
ERFE erythroferrone -2.69777
SCNN1B sodium channel, non voltage gated 1 beta subunit -2.69777
HTRA4 HtrA serine peptidase 4 -2.69777
GRIN3B glutamate receptor, ionotropic, N-methyl-D-aspartate 3B -2.69777
MROH7 maestro heat-like repeat family member 7 -2.69777
STMN4 stathmin-like 4 -2.69777
PDF peptide deformylase (mitochondrial) -2.69777
TEX19 testis expressed 19 -2.69777
FAM177B family with sequence similarity 177, member B -2.69777
TTC19 tetratricopeptide repeat domain 19 -2.68388
NLRP1 NLR family, pyrin domain containing 1 -2.66543
WBP2NL WBP2 N-terminal like -2.65875
IRGQ immunity-related GTPase family, Q -2.64766
LIFR leukemia inhibitory factor receptor alpha -2.64369
CNP 2',3'-cyclic nucleotide 3' phosphodiesterase -2.6429
EIF2AK4 eukaryotic translation initiation factor 2 alpha kinase 4 -2.57875
ZNF660 zinc finger protein 660 -2.55024
PRKCQ protein kinase C, theta -2.55024
ATP6V1C2 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C2 -2.51632
PRDM6 PR domain containing 6 -2.49971
CCDC152 coiled-coil domain containing 152 -2.49971
APOH apolipoprotein H (beta-2-glycoprotein I) -2.49971
GUF1 GUF1 GTPase homolog (S. cerevisiae) -2.49971
GPC2 glypican 2 -2.45603
TADA3 transcriptional adaptor 3 -2.40895
CHMP7 charged multivesicular body protein 7 -2.40895
YBX2 Y box binding protein 2 -2.37956
KIF21A kinesin family member 21A -2.37338
SPTB spectrin, beta, erythrocytic -2.34721
MCL1 myeloid cell leukemia 1 -2.2896
ESCO1 establishment of sister chromatid cohesion N-acetyltransferase 1 -2.26299
FAM110B family with sequence similarity 110, member B -2.26181
HSPA1B heat shock 70kDa protein 1B -2.26043
SSC5D scavenger receptor cysteine rich family, 5 domains -2.22143
ONECUT1 one cut homeobox 1 -2.22143
USP44 ubiquitin specific peptidase 44 -2.22143
TULP2 tubby like protein 2 -2.22143
STAMBPL1 STAM binding protein-like 1 -2.20889
BCO2 beta-carotene oxygenase 2 -2.20624
GLB1L galactosidase, beta 1-like -2.20624
ZNF536 zinc finger protein 536 -2.19834
KCNMB1 potassium channel subfamily M regulatory beta subunit 1 -2.19834
DPRX divergent-paired related homeobox -2.19834
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase -2.19282
ZNF264 zinc finger protein 264 -2.19282
PARP8 poly (ADP-ribose) polymerase family, member 8 -2.1708
ARRDC2 arrestin domain containing 2 -2.15028
MRTFA myocardin related transcription factor A -2.15028
ZNRF2 zinc and ring finger 2, E3 ubiquitin protein ligase -2.14655
GEM GTP binding protein overexpressed in skeletal muscle -2.14655
PCDHB10 protocadherin beta 10 -2.14655
VCX3B variable charge, X-linked 3B -2.14655
MST1R macrophage stimulating 1 receptor -2.1417
DCDC2B doublecortin domain containing 2B -2.1417
AKAP10 A kinase (PRKA) anchor protein 10 -2.1417
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 -2.1417
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1 -2.13998
GDI2 GDP dissociation inhibitor 2 -2.11876
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 -2.11766
TMEM120A transmembrane protein 120A -2.11743
DPYS dihydropyrimidinase -2.11494
TOP1 topoisomerase (DNA) I -2.10587
GNAO1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O -2.10574
RGPD8 RANBP2-like and GRIP domain containing 8 -2.10019
DYDC2 DPY30 domain containing 2 -2.08532
NAXD NAD(P)HX dehydratase -2.07967
RGMA repulsive guidance molecule family member a -2.06287
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 -2.05046
SPATA17 spermatogenesis associated 17 -2.0452
CHMP2B charged multivesicular body protein 2B -2.0452
WIPF1 WAS/WASL interacting protein family, member 1 -2.0452
CNOT6L CCR4-NOT transcription complex, subunit 6-like -2.02061
LUC7L2 LUC7-like 2 (S. cerevisiae) -2.01501
H2AC7 H2A clustered histone 7 -2.00195