TAE 226 Gene Set

Dataset DeepCoverMOA Drug Mechanisms of Action
Category proteomics
Type drug perturbation
External Link https://pubchem.ncbi.nlm.nih.gov/compound/9934347
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Genes

197 proteins with high or low expression in TAE 226 relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.

high expression

Symbol Name Standardized Value
CLK1 CDC-like kinase 1 3.08
COL11A1 collagen, type XI, alpha 1 2.76
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor) 2.26
NR4A2 nuclear receptor subfamily 4, group A, member 2 2.05
TP53 tumor protein p53 1.65
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 1.58
ABTB1 ankyrin repeat and BTB (POZ) domain containing 1 1.56
CLK4 CDC-like kinase 4 1.54
H1FX H1 histone family, member X 1.5
F5 coagulation factor V (proaccelerin, labile factor) 1.49
DHRS2 dehydrogenase/reductase (SDR family) member 2 1.48
GDF15 growth differentiation factor 15 1.43
FZD2 frizzled class receptor 2 1.41
IFRD1 interferon-related developmental regulator 1 1.39
COQ8A coenzyme Q8A 1.39
METTL7A methyltransferase like 7A 1.37
SYTL1 synaptotagmin-like 1 1.34
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 1.33
H1-0 H1.0 linker histone 1.3
SLC16A6 solute carrier family 16, member 6 1.28
SDHAF4 succinate dehydrogenase complex assembly factor 4 1.27
TMUB1 transmembrane and ubiquitin-like domain containing 1 1.23
FAM120C family with sequence similarity 120C 1.2
RNASE4 ribonuclease, RNase A family, 4 1.18
PLCD1 phospholipase C, delta 1 1.18
COL6A3 collagen, type VI, alpha 3 1.18
MEGF8 multiple EGF-like-domains 8 1.18
RBL2 retinoblastoma-like 2 1.18
COL14A1 collagen, type XIV, alpha 1 1.17
GSTA1 glutathione S-transferase alpha 1 1.17
ZSCAN32 zinc finger and SCAN domain containing 32 1.17
PNPLA2 patatin-like phospholipase domain containing 2 1.16
ALDH6A1 aldehyde dehydrogenase 6 family, member A1 1.15
CLK2 CDC-like kinase 2 1.15
SLC49A4 solute carrier family 49 member 4 1.12
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 1.12
NAA80 N-alpha-acetyltransferase 80, NatH catalytic subunit 1.09
TP53I3 tumor protein p53 inducible protein 3 1.07
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 1.06
DDB2 damage-specific DNA binding protein 2, 48kDa 1.06
TRIM2 tripartite motif containing 2 1.03
NKAPD1 NKAP domain containing 1 1.03
TCEA2 transcription elongation factor A (SII), 2 1.02
SULF2 sulfatase 2 1.01
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18 1.01
PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2 1.01
VTN vitronectin 1.0
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1 1.0
FGG fibrinogen gamma chain 1.0
YPEL5 yippee-like 5 (Drosophila) 1.0
CLK3 CDC-like kinase 3 0.99
PLIN2 perilipin 2 0.98
INHBA inhibin, beta A 0.97
PPL periplakin 0.97
RTN2 reticulon 2 0.96
NRXN3 neurexin 3 0.96
FBXL8 F-box and leucine-rich repeat protein 8 0.95
FDXR ferredoxin reductase 0.95
PLD3 phospholipase D family, member 3 0.93
CCDC158 coiled-coil domain containing 158 0.93
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.93
PDLIM3 PDZ and LIM domain 3 0.93
IGFBP5 insulin-like growth factor binding protein 5 0.92
ENPP5 ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative) 0.91
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.91
F2 coagulation factor II (thrombin) 0.89
DLEC1 deleted in lung and esophageal cancer 1 0.89
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2) 0.88
TIMP3 TIMP metallopeptidase inhibitor 3 0.88
ZNF691 zinc finger protein 691 0.88
KIAA1191 KIAA1191 0.88
GRB7 growth factor receptor-bound protein 7 0.87
RNF13 ring finger protein 13 0.87
TBX3 T-box 3 0.87
FN1 fibronectin 1 0.87
GRN granulin 0.87
ACAD10 acyl-CoA dehydrogenase family, member 10 0.87
MTHFR methylenetetrahydrofolate reductase (NAD(P)H) 0.87
PCIF1 PDX1 C-terminal inhibiting factor 1 0.87
NDUFA11 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 11, 14.7kDa 0.86
H6PD hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) 0.86
CTHRC1 collagen triple helix repeat containing 1 0.86
SIX5 SIX homeobox 5 0.86
PLEK pleckstrin 0.86
SPATA13 spermatogenesis associated 13 0.85
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.85
SRD5A3 steroid 5 alpha-reductase 3 0.85
F13A1 coagulation factor XIII, A1 polypeptide 0.84
IGFBP3 insulin-like growth factor binding protein 3 0.84
IRS2 insulin receptor substrate 2 0.84
COL17A1 collagen, type XVII, alpha 1 0.83
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial) 0.83
ICAM5 intercellular adhesion molecule 5, telencephalin 0.83
CTBS chitobiase, di-N-acetyl- 0.83
SLC26A11 solute carrier family 26 (anion exchanger), member 11 0.83
SLFN5 schlafen family member 5 0.82
NEIL1 nei endonuclease VIII-like 1 (E. coli) 0.81
GDAP1 ganglioside induced differentiation associated protein 1 0.81
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 0.81

low expression

Symbol Name Standardized Value
PCLAF PCNA clamp associated factor -2.36
RRM2 ribonucleotide reductase M2 -2.23
ODC1 ornithine decarboxylase 1 -2.03
RPS6KA6 ribosomal protein S6 kinase, 90kDa, polypeptide 6 -2.01
DNAJB5 DnaJ (Hsp40) homolog, subfamily B, member 5 -1.84
CDC6 cell division cycle 6 -1.83
ZUP1 zinc finger containing ubiquitin peptidase 1 -1.82
CFAP54 cilia and flagella associated 54 -1.81
EGR1 early growth response 1 -1.8
JUN jun proto-oncogene -1.78
PARPBP PARP1 binding protein -1.77
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -1.75
KCTD12 potassium channel tetramerization domain containing 12 -1.75
AEN apoptosis enhancing nuclease -1.72
REXO5 RNA exonuclease 5 -1.67
FBXO5 F-box protein 5 -1.63
MELK maternal embryonic leucine zipper kinase -1.62
PHLDA2 pleckstrin homology-like domain, family A, member 2 -1.6
BAIAP2 BAI1-associated protein 2 -1.59
SYTL3 synaptotagmin-like 3 -1.57
TMEM102 transmembrane protein 102 -1.55
MLPH melanophilin -1.55
EXO1 exonuclease 1 -1.55
UBE2C ubiquitin-conjugating enzyme E2C -1.54
STMN3 stathmin-like 3 -1.54
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 -1.53
CCNA2 cyclin A2 -1.52
BUB1 BUB1 mitotic checkpoint serine/threonine kinase -1.51
CLSPN claspin -1.51
PRELID1 PRELI domain containing 1 -1.51
RAD51AP1 RAD51 associated protein 1 -1.5
TNS4 tensin 4 -1.49
LDLR low density lipoprotein receptor -1.48
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila) -1.46
AMD1 adenosylmethionine decarboxylase 1 -1.45
TRIB1 tribbles pseudokinase 1 -1.45
CCNF cyclin F -1.45
F3 coagulation factor III (thromboplastin, tissue factor) -1.42
NES nestin -1.42
RAD51 RAD51 recombinase -1.41
GMNN geminin, DNA replication inhibitor -1.37
MCM10 minichromosome maintenance complex component 10 -1.36
CLTA clathrin, light chain A -1.36
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -1.35
ESCO2 establishment of sister chromatid cohesion N-acetyltransferase 2 -1.34
FANCM Fanconi anemia, complementation group M -1.33
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -1.32
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase -1.31
CPA4 carboxypeptidase A4 -1.31
CEP55 centrosomal protein 55kDa -1.3
UCK2 uridine-cytidine kinase 2 -1.3
KIF20B kinesin family member 20B -1.29
CDC123 cell division cycle 123 -1.29
GCH1 GTP cyclohydrolase 1 -1.27
CCNB1 cyclin B1 -1.26
ANLN anillin, actin binding protein -1.26
AURKA aurora kinase A -1.24
HAS3 hyaluronan synthase 3 -1.23
GABARAPL2 GABA(A) receptor-associated protein-like 2 -1.23
RPGRIP1L RPGRIP1-like -1.23
PLK1 polo-like kinase 1 -1.23
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 -1.23
CDC20 cell division cycle 20 -1.22
TK1 thymidine kinase 1, soluble -1.22
DONSON downstream neighbor of SON -1.22
PRELID3B PRELI domain containing 3B -1.21
CDKN3 cyclin-dependent kinase inhibitor 3 -1.2
UBE2S ubiquitin-conjugating enzyme E2S -1.2
SCD stearoyl-CoA desaturase (delta-9-desaturase) -1.2
SASS6 spindle assembly 6 homolog (C. elegans) -1.18
MICA MHC class I polypeptide-related sequence A -1.17
GTSE1 G-2 and S-phase expressed 1 -1.17
WDR76 WD repeat domain 76 -1.16
FADS1 fatty acid desaturase 1 -1.16
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 -1.16
TINAGL1 tubulointerstitial nephritis antigen-like 1 -1.15
DUSP5 dual specificity phosphatase 5 -1.15
ENC1 ectodermal-neural cortex 1 (with BTB domain) -1.15
ACBD6 acyl-CoA binding domain containing 6 -1.15
SCARA3 scavenger receptor class A, member 3 -1.14
USP1 ubiquitin specific peptidase 1 -1.13
TYMS thymidylate synthetase -1.13
OBSL1 obscurin-like 1 -1.13
CCNE2 cyclin E2 -1.12
RAP1GAP RAP1 GTPase activating protein -1.12
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -1.11
TTPA tocopherol (alpha) transfer protein -1.11
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -1.11
PHLPP2 PH domain and leucine rich repeat protein phosphatase 2 -1.1
MCPH1 microcephalin 1 -1.1
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2 -1.1
CDC25B cell division cycle 25B -1.1
NKIRAS1 NFKB inhibitor interacting Ras-like 1 -1.09
CCNB2 cyclin B2 -1.09
ZMYND19 zinc finger, MYND-type containing 19 -1.09
TET2 tet methylcytosine dioxygenase 2 -1.09
UBE2T ubiquitin-conjugating enzyme E2T -1.09
CENPM centromere protein M -1.08