TAF4 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa|Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the larger subunits of TFIID that has been shown to potentiate transcriptional activation by retinoic acid, thyroid hormone and vitamin D3 receptors. In addition, this subunit interacts with the transcription factor CREB, which has a glutamine-rich activation domain, and binds to other proteins containing glutamine-rich regions. Aberrant binding to this subunit by proteins with expanded polyglutamine regions has been suggested as one of the pathogenetic mechanisms underlying a group of neurodegenerative disorders referred to as polyglutamine diseases. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 6874)
External Link http://www.ncbi.nlm.nih.gov/gene/6874
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132 interacting proteins for TAF4 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
AFF1 AF4/FMR2 family, member 1
AHR aryl hydrocarbon receptor
ASH2L ash2 (absent, small, or homeotic)-like (Drosophila)
ATF7 activating transcription factor 7
BPTF bromodomain PHD finger transcription factor
C17ORF49 chromosome 17 open reading frame 49
CBX3 chromobox homolog 3
CBX5 chromobox homolog 5
CCNC cyclin C
CCNT1 cyclin T1
CCNT2 cyclin T2
CDK19 cyclin-dependent kinase 19
CDK8 cyclin-dependent kinase 8
CDK9 cyclin-dependent kinase 9
CHD1 chromodomain helicase DNA binding protein 1
CHD8 chromodomain helicase DNA binding protein 8
CREB1 cAMP responsive element binding protein 1
CREB3 cAMP responsive element binding protein 3
CREBZF CREB/ATF bZIP transcription factor
CREM cAMP responsive element modulator
E2F6 E2F transcription factor 6
EAF1 ELL associated factor 1
EAF2 ELL associated factor 2
ELAVL1 ELAV like RNA binding protein 1
ELL elongation factor RNA polymerase II
ELL2 elongation factor, RNA polymerase II, 2
ELL3 elongation factor RNA polymerase II-like 3
EMD emerin
FBXO6 F-box protein 6
GTF2A1 general transcription factor IIA, 1, 19/37kDa
GTF2A2 general transcription factor IIA, 2, 12kDa
GTF2F2 general transcription factor IIF, polypeptide 2, 30kDa
HCFC1 host cell factor C1
HIST3H3 histone cluster 3, H3
HTT huntingtin
ING1 inhibitor of growth family, member 1
ING2 inhibitor of growth family, member 2
INO80C INO80 complex subunit C
JUN jun proto-oncogene
KANSL1 KAT8 regulatory NSL complex subunit 1
KAT2A K(lysine) acetyltransferase 2A
KAT2B K(lysine) acetyltransferase 2B
KAT8 K(lysine) acetyltransferase 8
KDM5A lysine (K)-specific demethylase 5A
KMT2A lysine (K)-specific methyltransferase 2A
LAS1L LAS1-like (S. cerevisiae)
LRRK2 leucine-rich repeat kinase 2
MCRS1 microspherule protein 1
MED1 mediator complex subunit 1
MED10 mediator complex subunit 10
MED11 mediator complex subunit 11
MED12 mediator complex subunit 12
MED13 mediator complex subunit 13
MED13L mediator complex subunit 13-like
MED14 mediator complex subunit 14
MED15 mediator complex subunit 15
MED16 mediator complex subunit 16
MED17 mediator complex subunit 17
MED18 mediator complex subunit 18
MED19 mediator complex subunit 19
MED20 mediator complex subunit 20
MED21 mediator complex subunit 21
MED23 mediator complex subunit 23
MED25 mediator complex subunit 25
MED26 mediator complex subunit 26
MED27 mediator complex subunit 27
MED28 mediator complex subunit 28
MED29 mediator complex subunit 29
MED31 mediator complex subunit 31
MED4 mediator complex subunit 4
MED6 mediator complex subunit 6
MED7 mediator complex subunit 7
MED8 mediator complex subunit 8
MED9 mediator complex subunit 9
MGA MGA, MAX dimerization protein
NRF1 nuclear respiratory factor 1
PELP1 proline, glutamate and leucine rich protein 1
PHF20 PHD finger protein 20
PHF8 PHD finger protein 8
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa
POLR2C polymerase (RNA) II (DNA directed) polypeptide C, 33kDa
POLR2D polymerase (RNA) II (DNA directed) polypeptide D
POLR2E polymerase (RNA) II (DNA directed) polypeptide E, 25kDa
POLR2F polymerase (RNA) II (DNA directed) polypeptide F
POLR2G polymerase (RNA) II (DNA directed) polypeptide G
POLR2H polymerase (RNA) II (DNA directed) polypeptide H
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
POLR2J polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa
POLR2K polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PRPF31 pre-mRNA processing factor 31
RBBP5 retinoblastoma binding protein 5
RNF2 ring finger protein 2
RUVBL1 RuvB-like AAA ATPase 1
RUVBL2 RuvB-like AAA ATPase 2
SAP130 Sin3A-associated protein, 130kDa
SENP3 SUMO1/sentrin/SMT3 specific peptidase 3
SF3B3 splicing factor 3b, subunit 3, 130kDa
SP1 Sp1 transcription factor
SUMO2 small ubiquitin-like modifier 2
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae)
TADA2A transcriptional adaptor 2A
TADA3 transcriptional adaptor 3
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa
TAF10 TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa
TAF11 TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa
TAF12 TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa
TAF13 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TAF1B TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa
TAF1L TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like
TAF2 TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa
TAF3 TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
TAF5 TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa
TAF5L TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa
TAF6 TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
TAF6L TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa
TAF7 TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa
TAF8 TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa
TAF9 TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa
TBP TATA box binding protein
TBPL1 TBP-like 1
TCF12 transcription factor 12
TCF3 transcription factor 3
TEX10 testis expressed 10
TRRAP transformation/transcription domain-associated protein
UBC ubiquitin C
UHRF2 ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase
WDR5 WD repeat domain 5