TAK-285 Gene Set

Dataset DeepCoverMOA Drug Mechanisms of Action
Category proteomics
Type drug perturbation
External Link https://pubchem.ncbi.nlm.nih.gov/compound/11620908
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Genes

200 proteins with high or low expression in TAK-285 relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.

high expression

Symbol Name Standardized Value
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 2.74
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 1.82
PIP prolactin-induced protein 1.4
ABHD2 abhydrolase domain containing 2 1.31
DNAH12 dynein, axonemal, heavy chain 12 1.14
TMEM200A transmembrane protein 200A 1.0
APOB apolipoprotein B 0.99
FADS1 fatty acid desaturase 1 0.98
MCL1 myeloid cell leukemia 1 0.95
FGFBP1 fibroblast growth factor binding protein 1 0.92
SQLE squalene epoxidase 0.9
PRELID3B PRELI domain containing 3B 0.86
ALKBH5 AlkB family member 5, RNA demethylase 0.8
LPIN1 lipin 1 0.79
MFAP3 microfibrillar-associated protein 3 0.79
FDFT1 farnesyl-diphosphate farnesyltransferase 1 0.78
FAM219A family with sequence similarity 219, member A 0.75
EHF ets homologous factor 0.75
IDI1 isopentenyl-diphosphate delta isomerase 1 0.73
DGKD diacylglycerol kinase, delta 130kDa 0.7
TMEM135 transmembrane protein 135 0.7
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 0.69
TSPAN3 tetraspanin 3 0.68
MFAP3L microfibrillar-associated protein 3-like 0.68
INPP5J inositol polyphosphate-5-phosphatase J 0.68
CACNB3 calcium channel, voltage-dependent, beta 3 subunit 0.66
MT2A metallothionein 2A 0.66
GEM GTP binding protein overexpressed in skeletal muscle 0.66
CHPF chondroitin polymerizing factor 0.63
NOTCH3 notch 3 0.62
ADGRF1 adhesion G protein-coupled receptor F1 0.62
C1QTNF3 C1q and tumor necrosis factor related protein 3 0.62
ELOVL6 ELOVL fatty acid elongase 6 0.61
NCOA4 nuclear receptor coactivator 4 0.6
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9 0.58
LDLR low density lipoprotein receptor 0.58
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 0.58
CORO2B coronin, actin binding protein, 2B 0.57
PCSK9 proprotein convertase subtilisin/kexin type 9 0.57
ZBTB8A zinc finger and BTB domain containing 8A 0.56
MSMO1 methylsterol monooxygenase 1 0.56
GDF15 growth differentiation factor 15 0.54
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2 0.53
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 0.53
NBPF20 neuroblastoma breakpoint family, member 20 0.52
TSPYL2 TSPY-like 2 0.51
JARID2 jumonji, AT rich interactive domain 2 0.51
ZFHX4 zinc finger homeobox 4 0.51
DMD dystrophin 0.51
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 0.49
SDCBP syndecan binding protein (syntenin) 0.49
LRRK2 leucine-rich repeat kinase 2 0.49
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.49
KIAA1217 KIAA1217 0.49
MT1X metallothionein 1X 0.48
BHLHA15 basic helix-loop-helix family, member a15 0.48
FTH1 ferritin, heavy polypeptide 1 0.48
TMEM59 transmembrane protein 59 0.48
BMERB1 bMERB domain containing 1 0.48
UGCG UDP-glucose ceramide glucosyltransferase 0.48
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.47
ZNF518B zinc finger protein 518B 0.46
HMOX1 heme oxygenase 1 0.46
RABAC1 Rab acceptor 1 (prenylated) 0.46
LRP10 low density lipoprotein receptor-related protein 10 0.45
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7 0.45
STX1A syntaxin 1A (brain) 0.45
AREG amphiregulin 0.44
NRP1 neuropilin 1 0.44
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.44
RBPJL recombination signal binding protein for immunoglobulin kappa J region-like 0.44
ALAS1 5'-aminolevulinate synthase 1 0.44
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.44
CASKIN1 CASK interacting protein 1 0.43
SH3TC1 SH3 domain and tetratricopeptide repeats 1 0.43
STYK1 serine/threonine/tyrosine kinase 1 0.43
COL13A1 collagen, type XIII, alpha 1 0.43
SETMAR SET domain and mariner transposase fusion gene 0.43
PCDH1 protocadherin 1 0.43
ZFYVE28 zinc finger, FYVE domain containing 28 0.43
NDFIP1 Nedd4 family interacting protein 1 0.42
SLC16A6 solute carrier family 16, member 6 0.42
SC5D sterol-C5-desaturase 0.42
CD63 CD63 molecule 0.42
ANGPTL4 angiopoietin-like 4 0.42
COMMD8 COMM domain containing 8 0.42
FKBP14 FK506 binding protein 14, 22 kDa 0.41
PFKFB1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 0.41
PLIN2 perilipin 2 0.41
CHPF2 chondroitin polymerizing factor 2 0.41
SEC24D SEC24 family member D 0.41
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A 0.41
ZNF689 zinc finger protein 689 0.4
NDFIP2 Nedd4 family interacting protein 2 0.4
MFSD6 major facilitator superfamily domain containing 6 0.4
OBSL1 obscurin-like 1 0.4
FTL ferritin, light polypeptide 0.4
BCL3 B-cell CLL/lymphoma 3 0.39
ERCC6 excision repair cross-complementation group 6 0.39
MT1L metallothionein 1L (gene/pseudogene) 0.39

low expression

Symbol Name Standardized Value
COL17A1 collagen, type XVII, alpha 1 -2.27
PEX7 peroxisomal biogenesis factor 7 -1.38
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B -0.99
MRPL57 mitochondrial ribosomal protein L57 -0.87
JMJD8 jumonji domain containing 8 -0.87
FCHSD2 FCH and double SH3 domains 2 -0.87
TMEM248 transmembrane protein 248 -0.68
TIMM10B translocase of inner mitochondrial membrane 10 homolog B (yeast) -0.65
METTL22 methyltransferase like 22 -0.65
AHR aryl hydrocarbon receptor -0.64
MICOS10 mitochondrial contact site and cristae organizing system subunit 10 -0.64
RUBCN rubicon autophagy regulator -0.6
VMA21 VMA21 vacuolar H+-ATPase homolog (S. cerevisiae) -0.53
RPL37A ribosomal protein L37a -0.53
NUCB1 nucleobindin 1 -0.52
TMEM222 transmembrane protein 222 -0.52
STK16 serine/threonine kinase 16 -0.52
JPT1 Jupiter microtubule associated homolog 1 -0.51
TRIM29 tripartite motif containing 29 -0.5
DESI2 desumoylating isopeptidase 2 -0.47
COA5 cytochrome c oxidase assembly factor 5 -0.47
NHEJ1 nonhomologous end-joining factor 1 -0.47
CMC1 C-x(9)-C motif containing 1 -0.46
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa -0.45
S100A6 S100 calcium binding protein A6 -0.45
CHCHD4 coiled-coil-helix-coiled-coil-helix domain containing 4 -0.45
ARSK arylsulfatase family, member K -0.44
AMPD1 adenosine monophosphate deaminase 1 -0.44
F3 coagulation factor III (thromboplastin, tissue factor) -0.44
ABRAXAS1 abraxas 1, BRCA1 A complex subunit -0.44
SIL1 SIL1 nucleotide exchange factor -0.44
SLC39A4 solute carrier family 39 (zinc transporter), member 4 -0.44
DOCK3 dedicator of cytokinesis 3 -0.44
BCAM basal cell adhesion molecule (Lutheran blood group) -0.44
CCDC9B coiled-coil domain containing 9B -0.42
TNNC2 troponin C type 2 (fast) -0.42
TMBIM6 transmembrane BAX inhibitor motif containing 6 -0.42
RPL34 ribosomal protein L34 -0.42
NTSR1 neurotensin receptor 1 (high affinity) -0.42
CIAO2B cytosolic iron-sulfur assembly component 2B -0.41
TSPAN4 tetraspanin 4 -0.41
B2M beta-2-microglobulin -0.41
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.4
SH3PXD2A SH3 and PX domains 2A -0.4
CYBA cytochrome b-245, alpha polypeptide -0.4
TSLIG3B tRNA splicing ligase complex subunit 3B -0.39
CMTM4 CKLF-like MARVEL transmembrane domain containing 4 -0.39
CFAP58 cilia and flagella associated protein 58 -0.38
CCDC112 coiled-coil domain containing 112 -0.38
C19ORF25 chromosome 19 open reading frame 25 -0.37
DYNLL2 dynein, light chain, LC8-type 2 -0.37
PRRG1 proline rich Gla (G-carboxyglutamic acid) 1 -0.37
TRIM35 tripartite motif containing 35 -0.37
ACTL8 actin-like 8 -0.37
HTT huntingtin -0.37
PEX12 peroxisomal biogenesis factor 12 -0.37
RPL26 ribosomal protein L26 -0.37
RPL28 ribosomal protein L28 -0.37
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.37
MPHOSPH6 M-phase phosphoprotein 6 -0.36
KMT2C lysine (K)-specific methyltransferase 2C -0.36
ESAM endothelial cell adhesion molecule -0.36
MYC v-myc avian myelocytomatosis viral oncogene homolog -0.36
GABPB2 GA binding protein transcription factor, beta subunit 2 -0.36
SLC44A2 solute carrier family 44 (choline transporter), member 2 -0.35
PXMP2 peroxisomal membrane protein 2, 22kDa -0.35
RPS15 ribosomal protein S15 -0.35
RNF145 ring finger protein 145 -0.34
F5 coagulation factor V (proaccelerin, labile factor) -0.34
RBM3 RNA binding motif (RNP1, RRM) protein 3 -0.34
HYKK hydroxylysine kinase -0.34
POMP proteasome maturation protein -0.33
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa) -0.33
NEDD8 neural precursor cell expressed, developmentally down-regulated 8 -0.33
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein) -0.33
NDUFA3 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa -0.33
SUSD2 sushi domain containing 2 -0.33
PRKACA protein kinase, cAMP-dependent, catalytic, alpha -0.33
PTGES prostaglandin E synthase -0.33
METRN meteorin, glial cell differentiation regulator -0.32
SYDE1 synapse defective 1, Rho GTPase, homolog 1 (C. elegans) -0.32
GBA glucosidase, beta, acid -0.32
COQ5 coenzyme Q5 homolog, methyltransferase (S. cerevisiae) -0.32
NECTIN3 nectin cell adhesion molecule 3 -0.32
ODC1 ornithine decarboxylase 1 -0.31
MED12L mediator complex subunit 12-like -0.31
DNAH2 dynein, axonemal, heavy chain 2 -0.31
HS6ST1 heparan sulfate 6-O-sulfotransferase 1 -0.31
TNS3 tensin 3 -0.31
MIDN midnolin -0.31
MTARC1 mitochondrial amidoxime reducing component 1 -0.31
SLC7A6 solute carrier family 7 (amino acid transporter light chain, y+L system), member 6 -0.31
AFAP1L1 actin filament associated protein 1-like 1 -0.3
HGH1 HGH1 homolog (S. cerevisiae) -0.3
FNIP1 folliculin interacting protein 1 -0.3
IFITM3 interferon induced transmembrane protein 3 -0.3
DAD1 defender against cell death 1 -0.3
LIPT1 lipoyltransferase 1 -0.3
FAM177A1 family with sequence similarity 177, member A1 -0.3
DKK1 dickkopf WNT signaling pathway inhibitor 1 -0.3