TAK-733_A-427 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description TAK-733 perturbation in A-427 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the TAK-733_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.162857
NLGN1 neuroligin 1 0.138216
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.134523
YAP1 Yes-associated protein 1 0.133512
PDE4D phosphodiesterase 4D, cAMP-specific 0.12828
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.126369
VIM vimentin 0.106844
HMGA2 high mobility group AT-hook 2 0.102781
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.102156
ANXA1 annexin A1 0.101551
ASPH aspartate beta-hydroxylase 0.0993188
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 0.0962098
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0904981
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 0.083836
RRM2 ribonucleotide reductase M2 0.0833944
MKI67 marker of proliferation Ki-67 0.0793964
MMP12 matrix metallopeptidase 12 0.0787747
ERRFI1 ERBB receptor feedback inhibitor 1 0.0711252
MACF1 microtubule-actin crosslinking factor 1 0.071086
HSPA8 heat shock 70kDa protein 8 0.0669808
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0630375
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0623342
CUBN cubilin (intrinsic factor-cobalamin receptor) 0.0612522
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0587265
DST dystonin 0.0568801
NHSL1 NHS-like 1 0.056223
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0559464
TXNRD1 thioredoxin reductase 1 0.0550543
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0536361
ADGRG6 adhesion G protein-coupled receptor G6 0.0531531
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0511646
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0504493
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0499595
ANKRD12 ankyrin repeat domain 12 0.0490109
JMJD1C jumonji domain containing 1C 0.048814
ZNF217 zinc finger protein 217 0.0473323
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0468935
TENM3 teneurin transmembrane protein 3 0.0462123
CLTC clathrin, heavy chain (Hc) 0.0453885
TPM3 tropomyosin 3 0.0450988
CALR calreticulin 0.0437395
PCDH7 protocadherin 7 0.0436015
LMO7 LIM domain 7 0.0425519
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0422183
PDGFC platelet derived growth factor C 0.0420313
PCDH9 protocadherin 9 0.0418043
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0417061
XPO1 exportin 1 0.0415479
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0415067
WWOX WW domain containing oxidoreductase 0.0414305
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0413198
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1 0.0411762
NCAPD2 non-SMC condensin I complex, subunit D2 0.0409813
CANX calnexin 0.0407127
LRRTM4 leucine rich repeat transmembrane neuronal 4 0.0406119
WNK1 WNK lysine deficient protein kinase 1 0.040149
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0399854
SPATS2 spermatogenesis associated, serine-rich 2 0.0395801
MED13L mediator complex subunit 13-like 0.0395194
CSNK1A1 casein kinase 1, alpha 1 0.0390151
TBC1D5 TBC1 domain family, member 5 0.038656
FUS FUS RNA binding protein 0.0383409
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.037948
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0374566
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0374255
AHNAK AHNAK nucleoprotein 0.0372154
H1-0 H1.0 linker histone 0.0369962
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0369252
BCHE butyrylcholinesterase 0.0366558
LOC112694756 uncharaterized LOC112694756 0.0360138
USP9X ubiquitin specific peptidase 9, X-linked 0.0358309
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) 0.0354019
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.035044
IPO7 importin 7 0.0349432
PDE4B phosphodiesterase 4B, cAMP-specific 0.0347286
R3HDM2 R3H domain containing 2 0.0347186
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0343909
ENO1 enolase 1, (alpha) 0.0336323
ACTG1 actin gamma 1 0.0330581
LRMDA leucine rich melanocyte differentiation associated 0.0329976
LPP LIM domain containing preferred translocation partner in lipoma 0.0318399
ATP11A ATPase, class VI, type 11A 0.0311413
TAS2R14 taste receptor, type 2, member 14 0.0310291
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0309397
ACTR2 ARP2 actin-related protein 2 homolog (yeast) 0.030794
TMEM123 transmembrane protein 123 0.0307778
NR5A2 nuclear receptor subfamily 5, group A, member 2 0.0307421
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa 0.0303656
PARD3 par-3 family cell polarity regulator 0.030296
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0299736
STAG2 stromal antigen 2 0.0299655
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0298675
CUX1 cut-like homeobox 1 0.0293796
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0292353
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0290289
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.028929
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0288113
TM4SF1 transmembrane 4 L six family member 1 0.0286758
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0283648
CENPF centromere protein F, 350/400kDa 0.0274321

decreased expression

Symbol Name Standardized Value
AREG amphiregulin -0.118454
RPL35A ribosomal protein L35a -0.04741
RPS27A ribosomal protein S27a -0.0423135
RPS23 ribosomal protein S23 -0.0403719
CCNL1 cyclin L1 -0.0393419
RPL11 ribosomal protein L11 -0.0385691
RPL37A ribosomal protein L37a -0.0369143
RPLP2 ribosomal protein, large, P2 -0.0357384
RPS6 ribosomal protein S6 -0.0353895
ATP5F1B ATP synthase F1 subunit beta -0.033667
RPL19 ribosomal protein L19 -0.0329836
RPS3 ribosomal protein S3 -0.0320315
RPS13 ribosomal protein S13 -0.0319632
RPL23 ribosomal protein L23 -0.0312723
RPS12 ribosomal protein S12 -0.031254
RPL26 ribosomal protein L26 -0.0301629
TSC22D2 TSC22 domain family, member 2 -0.030132
RPL12 ribosomal protein L12 -0.0297899
RPS29 ribosomal protein S29 -0.0292785
TMSB10 thymosin beta 10 -0.0291226
MEMO1 mediator of cell motility 1 -0.0277485
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0265585
RPL34 ribosomal protein L34 -0.02562
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0244657
RPS8 ribosomal protein S8 -0.024055
CHD1 chromodomain helicase DNA binding protein 1 -0.0237895
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0233145
WDR43 WD repeat domain 43 -0.0232973
RPL28 ribosomal protein L28 -0.0229345
RPS2 ribosomal protein S2 -0.0227694
RPL37 ribosomal protein L37 -0.0223682
CLDN1 claudin 1 -0.0220736
RPL9 ribosomal protein L9 -0.0219634
RPLP1 ribosomal protein, large, P1 -0.0218616
RPS5 ribosomal protein S5 -0.0218399
RPS21 ribosomal protein S21 -0.0215049
DDIT3 DNA-damage-inducible transcript 3 -0.0206011
RPL32 ribosomal protein L32 -0.0203286
RPS14 ribosomal protein S14 -0.0202843
DHX36 DEAH (Asp-Glu-Ala-His) box polypeptide 36 -0.0200609
HLA-A major histocompatibility complex, class I, A -0.020035
RPL13A ribosomal protein L13a -0.0200153
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0200058
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0197216
EIF5B eukaryotic translation initiation factor 5B -0.019638
RTN4 reticulon 4 -0.0193153
GOLGA4 golgin A4 -0.0192252
RPL8 ribosomal protein L8 -0.0192088
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0187927
THOC2 THO complex 2 -0.0187342
RPL5 ribosomal protein L5 -0.0183449
RPL31 ribosomal protein L31 -0.018035
GARS1 glycyl-tRNA synthetase 1 -0.0177074
DPYD dihydropyrimidine dehydrogenase -0.0177037
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 -0.0174226
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0170556
YBX1 Y box binding protein 1 -0.0169273
PHF14 PHD finger protein 14 -0.0167744
ANKUB1 ankyrin repeat and ubiquitin domain containing 1 -0.0166044
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0165933
NOP58 NOP58 ribonucleoprotein -0.0165079
LARS1 leucyl-tRNA synthetase 1 -0.0163106
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) -0.0160752
RPS19 ribosomal protein S19 -0.0158358
RBM25 RNA binding motif protein 25 -0.0156692
EIF3A eukaryotic translation initiation factor 3, subunit A -0.0155893
NDUFAF2 NADH dehydrogenase (ubiquinone) complex I, assembly factor 2 -0.0154584
RPS16 ribosomal protein S16 -0.0153185
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 -0.015159
CNRIP1 cannabinoid receptor interacting protein 1 -0.0151531
DDX56 DEAD (Asp-Glu-Ala-Asp) box helicase 56 -0.0150941
RPS20 ribosomal protein S20 -0.0150414
USP15 ubiquitin specific peptidase 15 -0.0150361
RPS10 ribosomal protein S10 -0.014999
RPL38 ribosomal protein L38 -0.0145977
NACA nascent polypeptide-associated complex alpha subunit -0.0142102
AKAP9 A kinase (PRKA) anchor protein 9 -0.0142079
LRP6 low density lipoprotein receptor-related protein 6 -0.0141359
MON2 MON2 homolog (S. cerevisiae) -0.0139312
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 -0.0138628
SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae) -0.0138311
AP3S1 adaptor-related protein complex 3, sigma 1 subunit -0.0137383
RPS11 ribosomal protein S11 -0.0135535
RPL36 ribosomal protein L36 -0.013511
PDCD5 programmed cell death 5 -0.0134567
RPS27 ribosomal protein S27 -0.0133965
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.0133697
RPL27 ribosomal protein L27 -0.0133088
MYL12B myosin, light chain 12B, regulatory -0.0132472
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -0.0131718
STARD4 StAR-related lipid transfer (START) domain containing 4 -0.0131097
RPS15 ribosomal protein S15 -0.0130836
NABP1 nucleic acid binding protein 1 -0.012984
CALD1 caldesmon 1 -0.0129785
STRN3 striatin, calmodulin binding protein 3 -0.0129584
RPS24 ribosomal protein S24 -0.0128214
ETNK1 ethanolamine kinase 1 -0.0126973
NME2 NME/NM23 nucleoside diphosphate kinase 2 -0.0125669
RASA2 RAS p21 protein activator 2 -0.012544
PDCD11 programmed cell death 11 -0.0125253