| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | TAK-733 perturbation in A498 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the TAK-733_A498 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MYH9 | myosin, heavy chain 9, non-muscle | 0.225806 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.148537 |
| EXT1 | exostosin glycosyltransferase 1 | 0.125438 |
| PLEC | plectin | 0.112199 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | 0.110434 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.110009 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.104696 |
| NAV2 | neuron navigator 2 | 0.103536 |
| ICAM1 | intercellular adhesion molecule 1 | 0.0983316 |
| SEPTIN9 | septin 9 | 0.0942067 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0908579 |
| FAT1 | FAT atypical cadherin 1 | 0.0903482 |
| PAX8 | paired box 8 | 0.0901026 |
| GPC6 | glypican 6 | 0.0894668 |
| VEGFA | vascular endothelial growth factor A | 0.0863065 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0858984 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0813679 |
| CD44 | CD44 molecule (Indian blood group) | 0.0794475 |
| SMAD3 | SMAD family member 3 | 0.0792209 |
| APP | amyloid beta (A4) precursor protein | 0.07809 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0747511 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0746283 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0741264 |
| PDLIM5 | PDZ and LIM domain 5 | 0.073554 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0716049 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0708981 |
| RNF213 | ring finger protein 213 | 0.0654701 |
| KYNU | kynureninase | 0.0645802 |
| FLNA | filamin A, alpha | 0.0608961 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.060463 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0603366 |
| TLE4 | transducin-like enhancer of split 4 | 0.0592683 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0579661 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0578702 |
| CREB5 | cAMP responsive element binding protein 5 | 0.0557537 |
| MSN | moesin | 0.0548331 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0528619 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0524555 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.050881 |
| INTS6 | integrator complex subunit 6 | 0.0500533 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0494523 |
| NDRG1 | N-myc downstream regulated 1 | 0.0475912 |
| TGM2 | transglutaminase 2 | 0.0469515 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0460936 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.046013 |
| CTBP2 | C-terminal binding protein 2 | 0.0453792 |
| MPRIP | myosin phosphatase Rho interacting protein | 0.0448701 |
| GALNT2 | polypeptide N-acetylgalactosaminyltransferase 2 | 0.0442326 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.043983 |
| FUS | FUS RNA binding protein | 0.0430569 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0428853 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0428304 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0423848 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0423506 |
| TPM3 | tropomyosin 3 | 0.0421528 |
| EPAS1 | endothelial PAS domain protein 1 | 0.0419472 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0414972 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0414822 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0412956 |
| MYOF | myoferlin | 0.040908 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0408564 |
| EGFR | epidermal growth factor receptor | 0.0406021 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0405389 |
| SFTPA2 | surfactant protein A2 | 0.0405378 |
| LHFPL2 | lipoma HMGIC fusion partner-like 2 | 0.0404462 |
| CSF1 | colony stimulating factor 1 (macrophage) | 0.0397666 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0395426 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0394434 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | 0.0394238 |
| ADAR | adenosine deaminase, RNA-specific | 0.0394142 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0393368 |
| NRP2 | neuropilin 2 | 0.0389856 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | 0.0380134 |
| JAK1 | Janus kinase 1 | 0.0374676 |
| LRRC59 | leucine rich repeat containing 59 | 0.0362799 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0360931 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0360012 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | 0.035775 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0354549 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0349978 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0349084 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.0348345 |
| AFF1 | AF4/FMR2 family, member 1 | 0.034805 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0344864 |
| ENAH | enabled homolog (Drosophila) | 0.0343181 |
| NUP98 | nucleoporin 98kDa | 0.0339325 |
| SUPT6H | suppressor of Ty 6 homolog (S. cerevisiae) | 0.0337266 |
| TMED2 | transmembrane emp24 domain trafficking protein 2 | 0.0330832 |
| FRMD5 | FERM domain containing 5 | 0.0329139 |
| ANXA5 | annexin A5 | 0.0328377 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0327588 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0320918 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0319262 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0309135 |
| TLN1 | talin 1 | 0.0308844 |
| COPA | coatomer protein complex, subunit alpha | 0.0307642 |
| TUFT1 | tuftelin 1 | 0.030569 |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.0304853 |
| LOXL2 | lysyl oxidase-like 2 | 0.0303867 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0303162 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.147673 |
| TMSB10 | thymosin beta 10 | -0.12559 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0971576 |
| PTMA | prothymosin, alpha | -0.0770775 |
| CP | ceruloplasmin (ferroxidase) | -0.0676877 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0626094 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0621938 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0593115 |
| FTL | ferritin, light polypeptide | -0.0556542 |
| RTN4 | reticulon 4 | -0.0524415 |
| RPS24 | ribosomal protein S24 | -0.0521725 |
| RPL35A | ribosomal protein L35a | -0.0503703 |
| RPS6 | ribosomal protein S6 | -0.0493856 |
| FRMD4A | FERM domain containing 4A | -0.0486714 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0465252 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.045586 |
| RAI14 | retinoic acid induced 14 | -0.0446752 |
| S100A6 | S100 calcium binding protein A6 | -0.0408278 |
| CTSD | cathepsin D | -0.0395413 |
| PLIN2 | perilipin 2 | -0.0375658 |
| UBE2D2 | ubiquitin-conjugating enzyme E2D 2 | -0.0371024 |
| RPL34 | ribosomal protein L34 | -0.0361844 |
| HMGB1 | high mobility group box 1 | -0.035742 |
| GNAS | GNAS complex locus | -0.0356476 |
| MT2A | metallothionein 2A | -0.0350915 |
| DIAPH3 | diaphanous-related formin 3 | -0.034863 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0343415 |
| GDF15 | growth differentiation factor 15 | -0.0333435 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0331434 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.033111 |
| CBX3 | chromobox homolog 3 | -0.0330555 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | -0.0327347 |
| MTDH | metadherin | -0.0313484 |
| AKR1B1 | aldo-keto reductase family 1, member B1 (aldose reductase) | -0.0313144 |
| PFN1 | profilin 1 | -0.0308668 |
| RPLP2 | ribosomal protein, large, P2 | -0.0308211 |
| ASPH | aspartate beta-hydroxylase | -0.0307252 |
| CAVIN1 | caveolae associated protein 1 | -0.0306293 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0303998 |
| RPS21 | ribosomal protein S21 | -0.0302236 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0300518 |
| RPLP1 | ribosomal protein, large, P1 | -0.0298186 |
| CD70 | CD70 molecule | -0.0295128 |
| OXR1 | oxidation resistance 1 | -0.0290381 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0288693 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0287158 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | -0.0286072 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | -0.028486 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0284807 |
| THOC2 | THO complex 2 | -0.0280976 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.0279802 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0272306 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.026065 |
| PTBP3 | polypyrimidine tract binding protein 3 | -0.0260336 |
| GOLGA4 | golgin A4 | -0.0250411 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | -0.0249617 |
| TCEAL9 | transcription elongation factor A like 9 | -0.0248043 |
| LAPTM4A | lysosomal protein transmembrane 4 alpha | -0.0247968 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0246347 |
| RBM25 | RNA binding motif protein 25 | -0.0245184 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.0242055 |
| MAP1B | microtubule-associated protein 1B | -0.0241984 |
| UBC | ubiquitin C | -0.024081 |
| LY6E | lymphocyte antigen 6 complex, locus E | -0.0236313 |
| TUBA1B | tubulin, alpha 1b | -0.0234851 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.0234046 |
| UBE2K | ubiquitin-conjugating enzyme E2K | -0.0233599 |
| DEK | DEK proto-oncogene | -0.0229402 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0228412 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0227523 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0225385 |
| TPM4 | tropomyosin 4 | -0.0224822 |
| MMP7 | matrix metallopeptidase 7 | -0.0224729 |
| HLA-A | major histocompatibility complex, class I, A | -0.0223467 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.0220288 |
| CKAP4 | cytoskeleton-associated protein 4 | -0.021946 |
| ARPC1B | actin related protein 2/3 complex, subunit 1B, 41kDa | -0.0218439 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0218269 |
| RPS14 | ribosomal protein S14 | -0.0217771 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0217765 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0217006 |
| RPS5 | ribosomal protein S5 | -0.0216941 |
| PTGR1 | prostaglandin reductase 1 | -0.0216353 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0216016 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0214777 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0214451 |
| USP3 | ubiquitin specific peptidase 3 | -0.0213902 |
| RPL27A | ribosomal protein L27a | -0.0213341 |
| ADAM10 | ADAM metallopeptidase domain 10 | -0.0211202 |
| CMSS1 | cms1 ribosomal small subunit homolog (yeast) | -0.0210322 |
| ANAPC5 | anaphase promoting complex subunit 5 | -0.020632 |
| POTEF | POTE ankyrin domain family, member F | -0.0202098 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.0201342 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0201341 |
| COTL1 | coactosin-like F-actin binding protein 1 | -0.0201318 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0201164 |
| GLG1 | golgi glycoprotein 1 | -0.0200244 |
| S100A9 | S100 calcium binding protein A9 | -0.0199697 |
| RAB2A | RAB2A, member RAS oncogene family | -0.0198704 |
| HMGA1 | high mobility group AT-hook 1 | -0.0198634 |
